Clinical Trials on Medical Disorders

Total 145661 results

Sarcoma Alliance for Research through Collaboration
United States Department of Defense; AstraZeneca

Completed

SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

Neurofibromatosis 1 | Malignant Peripheral Nerve Sheath Tumors

United States
Tisento Therapeutics
Children's Hospital of Philadelphia

Terminated

Phase 2a Study of IW-6463 in Adults Diagnosed With Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes (MELAS)

MELAS

United States
Regeneron Pharmaceuticals

Available

Compassionate Use of Dupilumab

Bullous Pemphigoid | Pediatric Asthma | Pediatric Eosinophilic Esophagitis (EoE) | Pediatric and Adolescent Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)
Leidos Life Sciences
United States Department of Defense

Withdrawn

Leidos-Enabled Adaptive Protocol for Clinical Trials (LEAP-CT) in Hospitalized Patients With COVID-19 (Addendum 1)

COVID-19 | Covid19 | Coronavirus Disease 2019 | SARS-CoV-2 Infection | SARS-CoV-2 Acute Respiratory Disease | COVID-19 Pandemic | COVID-19 Virus Infection | COVID-19 Virus Disease | 2019 Novel Coronavirus Disease | 2019 Novel Coronavirus Infection | 2019-nCoV Disease | 2019-nCoV Infection
Canadian Cancer Trials Group
National Cancer Institute (NCI); Cancer Research UK; Grupo Español de Investigación... and other collaborators

Completed

Intraperitoneal vs Intravenous Chemotherapy Following Neoadjuvant Chemotherapy in Ovarian Cancer

Ovarian Cancer | Fallopian Tube Cancer | Peritoneal Cavity Cancer | Metastatic Cancer

Canada, Spain, United States, United Kingdom
University Hospital, Tours

Completed

French National Cohort of Children With Port Wine Stain (CONAPE)

Port Wine Stain | Parkes Weber Syndrome | Klippel Trenaunay Syndrome

France
University of Minnesota

Available

Islet Transplant for Type 1 or Surgical Diabetes (EXAX)

Hypoglycemia | Type 1 Diabetes Mellitus | End-stage Renal Disease | Labile Diabetes

United States
Bezmialem Vakif University

Completed

Anticoagulant/Antiaggregant Use and Postoperative Bleeding Risk in Patients With Bladder Tumor and Benign Prostatic Hyperplasia

Hematuria | Retention, Urinary | Operative Bleeding | Blood Transfusion Complication

Turkey
Rigshospitalet, Denmark
University of Copenhagen; Herlev Hospital; Steno Diabetes Center Copenhagen; Holbaek... and other collaborators

Active, not recruiting

Cardiac Arrhythmia in Patients With End-Stage Renal Disease (CADDY)

Diabetes Mellitus | Hypoglycemia | Cardiac Arrhythmia | End Stage Renal Disease on Dialysis

Denmark
EyePoint Pharmaceuticals, Inc.
Medical Technology Enterprise Consortium (MTEC)

Terminated

Evaluation of the Safety and Efficacy of Razuprotafib in Hospitalized Subjects With Coronavirus Disease 2019 (RESCUE)

COVID-19 | Acute Respiratory Distress Syndrome (ARDS)

United States
University of Chicago

Active, not recruiting

Inhaled Nitric Oxide and Neuroprotection in Premature Infants (NOVA2)

Intraventricular Hemorrhage | Bronchopulmonary Dysplasia | Prematurity | Periventricular Leukomalacia

United States
Centre Hospitalier Universitaire de Nice

Completed

Frequency of Pompe's Disease and Neuromuscular Etiologies in Patients With Restrictive Respiratory Failure Associated With Signs of Muscle Weakness (POPS3)

Pompe Disease

France
WellSpan Health

Active, not recruiting

Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome

Endometrial Hyperplasia | Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Mismatch Repair Deficiency

United States
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Farber Disease (BioFarber) (BioFarber)

Splenomegaly | Hepatomegaly | Ceramidase Deficiency | Farber's Lipogranulomatosis

Germany, India, Egypt
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Metachromatic Leukodystrophy (BioMeta) Disease (BioMeta)

Muscle Weakness | Peripheral Neuropathy

Egypt, Germany, India, Sri Lanka
Masonic Cancer Center, University of Minnesota

Active, not recruiting

Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)

Acute Respiratory Distress Syndrome | COVID-19 Pneumonia | ARDS (Moderate or Severe)

United States
University of California, San Diego

Active, not recruiting

Biomarkers, Genomics, Physiology in Critically Ill and ECMO Patients (IGNITE)

Critical Illness | Respiratory Failure | Renal Failure | Acute Respiratory Distress Syndrome | Pulmonary Disease | Extracorporeal Membrane Oxygenation Complication | Cardiac Failure

United States
Dr. Jurjan Aman
Exvastat Ltd.; Simbec-Orion Group; KABS laboratories

Terminated

Intravenous Imatinib in Mechanically Ventilated COVID-19 Patients (INVENT COVID)

Covid19 | Endothelial Dysfunction | Acute Respiratory Distress Syndrome | ARDS | Pulmonary Edema

Netherlands
Rush University Medical Center
Icahn School of Medicine at Mount Sinai

Withdrawn

Telerobotic Ultrasound for Carotid Imaging - Feasibility Study

Myocardial Infarction | Myocardial Ischemia | Heart Diseases | Coronary Artery Disease | Stroke | Cerebrovascular Disorders | Coronary Disease | Arteriosclerosis | Arterial Occlusive Diseases | Cardiovascular Disease | Atherosclerosis | Peripheral Vascular Disease | Cerebral Infarction | Coronary Arteriosclerosis | Cerebrovascular... and other conditions
University Hospital, Grenoble

Completed

Detection of Right Ventricular Dysfunction by 2D Strain During Acute Respiratory Distress Syndrom (ARDS) (STRAIN)

Acute Respiratory Distress Syndrome | Right Ventricular Dysfunction | Right Heart Failure | Acute Cor Pulmonale

France
University of New Mexico

Completed

Stroke and Cerebrovascular Diseases Registry

Stroke | Ischemic Stroke | Transient Ischemic Attack | Cerebral Infarction | Subarachnoid Hemorrhage | Hemorrhagic Stroke | Acute Brain Injury | Acute Stroke | Cerebral Stroke | Cerebral Ischemia | Venous Sinus Thrombosis, Cranial

United States
Leidos Life Sciences
United States Department of Defense

Terminated

Leidos-Enabled Adaptive Protocol (LEAP-CT) for Evaluation of Post-exposure Prophylaxis for Newly-infected COVID-19 Patients (Addendum 2)

COVID-19 | Covid19 | Coronavirus Disease 2019 | SARS-CoV2 Infection | SARS-CoV-2 Acute Respiratory Disease | COVID-19 Pandemic | COVID-19 Virus Infection | COVID-19 Virus Disease | 2019 Novel Coronavirus Disease | 2019 Novel Coronavirus Infection | 2019-nCoV Disease | 2019-nCoV Infection

United States
Nasser Hanna, M.D.
Merck Sharp & Dohme LLC; Hoosier Cancer Research Network

Terminated

Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors

Genital Neoplasms, Female | Testicular Neoplasms | Genital Neoplasms, Male | Ovarian Neoplasms | Mediastinal Neoplasms | Germ Cell Neoplasms | Non Seminomatous Germ Cell Tumors

United States
University of Minnesota

Completed

Losartan for Patients With COVID-19 Not Requiring Hospitalization

Acute Respiratory Distress Syndrome | Corona Virus Infection | SARS-CoV Infection

United States
Express Collaborative
Canadian Institutes of Health Research (CIHR); International Network for Simulation-based...

Completed

Impact of Aerosol Box Use on Healthcare Provider Contamination

Covid19 | Coronavirus | COVID-19 Acute Respiratory Distress Syndrome

United States, Canada
Agence Sanitaire et Sociale de Nouvelle Calédonie
Institut Pasteur; World Health Organization; Pacific Community; Institut de la...

Suspended

Baromètre Santé Adulte 2021-2022

Diabetes | Renal Failure | Chronic Disease | Hypercholesterolemia | Malaria | SARS-CoV Infection | Dengue Fever | Chikungunya | Zika | Ross River

New Caledonia
Idorsia Pharmaceuticals Ltd.

Completed

Natural History Study for Pediatric Patients With Early Onset of Either GM1 Gangliosidosis, GM2 Gangliosidoses, or Gaucher Disease Type 2 (RETRIEVE)

GM2 Gangliosidosis | GM1 Gangliosidosis | Tay-Sachs Disease | Sandhoff Disease | Gaucher Disease, Type 2 | AB Variant Gangliosidosis GM2

United States, Spain, Germany, Italy, Belgium, Brazil, France, Portugal, Switzerland, United Kingdom
Acticor Biotech

Completed

Glenzocimab in SARS-Cov-2 Acute Respiratory DistrEss syNdrome Related to COVID-19 (GARDEN)

COVID-19 | Acute Respiratory Distress Syndrome | ARDS | SARS-CoV Infection

France
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Everolimus (Afinitor®) in Chinese Adult Patients With Angiomyolipoma Associated With Tuberous Sclerosis Complex.

Renal Angiomyolipoma

China
Mansoura University

Active, not recruiting

A Randomized Controlled Trial to Investigate The Role of Adjuvant Inhalable Sodium Bicarbonate Solution 8.4% in Treatment of COVID-19

Covid19 | COVID-19 Pneumonia | COVID-19 Acute Respiratory Distress Syndrome

Egypt
MaxCyte, Inc.
CTI Clinical Trial and Consulting Services

Terminated

Intraperitoneal MCY-M11 (Mesothelin-targeting CAR) for Treatment of Advanced Ovarian Cancer and Peritoneal Mesothelioma

Fallopian Tube Adenocarcinoma | Peritoneal Mesothelioma | Primary Peritoneal Carcinoma | Adenocarcinoma of the Ovary

United States
Centre Chirurgical Marie Lannelongue

Terminated

Dexamethasone Treatment for Severe Acute Respiratory Distress Syndrome Induced by COVID-19 (DHYSCO)

COVID-19 | Respiratory Distress Syndrome, Adult

France
Istanbul University

Completed

Effects of Low Molecular Weight Heparin Therapy With Soft-Mist Inhaler for COVID-19 Induced Hypoxemia

Hypoxemia | COVID-19 Acute Respiratory Distress Syndrome

Turkey
Rabin Medical Center

Terminated

Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19

Glucose Metabolism Disorders | Respiratory Tract Diseases | Diabetes Mellitus, Type 2 | Diabetes Mellitus | Endocrine System Diseases | COVID 19 | Coronavirus | Metabolic Disease | Severe Acute Respiratory Syndrome Coronavirus 2 | Sars-CoV2 | Hormones | Hypoglycemic Agents | Incretins | Dipeptidyl-Peptidase IV Inhibitors and other conditions

Israel
Cadent Therapeutics

Withdrawn

Study of CAD-1883 for Spinocerebellar Ataxia (Synchrony-1)

Spinocerebellar Ataxia Type 3 | Spinocerebellar Ataxias | Spinocerebellar Ataxia Type 1 | Spinocerebellar Ataxia Type 2 | Spinocerebellar Ataxia Type 6 | Spinocerebellar Ataxia Type 10 | Spinocerebellar Ataxia Type 7 | Spinocerebellar Ataxia Type 8 | Spinocerebellar Ataxia Type 17 | ARCA1 - Autosomal Recessive...

United States
Alexion Pharmaceuticals

No longer available

SOLIRIS® (Eculizumab) Treatment of Participants With COVID-19

COVID-19 | Pneumonia, Viral | Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

United States, France
Mesoblast International Sàrl

No longer available

Intermediate-size Expanded Access Program (EAP), Mesenchymal Stromal Cells (MSC) for Acute Respiratory Distress Syndrome (ARDS) Due to COVID-19 Infection

Moderate to Severe Acute Respiratory Distress Syndrome Associated With COVID-19

United States
Maimónides Biomedical Research Institute of Córdoba

Completed

Pilot Study of Antithrombin as Prophylaxis of Acute Respiratory Distress Syndrome in Patients With COVID-19

Severe Acute Respiratory Syndrome | Covid19 | Distress Respiratory Syndrome

Spain
Rexecor

Unknown

Registry on the EXperience of Extracorporeal CO2 Removal in Intensive Care Units (REXECOR)

Patients With Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Patients With Acute Respiratory Distress Syndrome

France
Bin Li

Unknown

Efficacy Study of Gene Therapy for The Treatment of Acute LHON Onset Within Three Months (LHON)

Acute LHON | Onset Within Three Months | Onset Between 3 to 6 Months | Onset Between 6 to 12 Months | Onset Between 12 to 24 Months | Onset Between 24 to 60 Months | Onset Over 60 Months

China
Oslo University Hospital

Unknown

The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients

COVID 19 | SARS-CoV Infection | Acute Respiratory Distress Syndrome ARDS

Norway
Gynecologic Oncology Group
National Cancer Institute (NCI)

Completed

Zoledronate or Observation in Maintaining Bone Mineral Density in Patients Who Are Undergoing Surgery to Remove Both Ovaries

Osteoporosis | Ovarian Carcinoma | Hereditary Breast and Ovarian Cancer Syndrome

United States
COL George Peoples, MD, FACS
M.D. Anderson Cancer Center

Completed

Phase Ib Trial of Two Folate Binding Protein Peptide Vaccines (E39 and J65) in Breast and Ovarian Cancer Patients (J65)

Breast Cancer | Ovarian Cancer

United States
Enzyvant Therapeutics GmBH

Completed

Farber Disease Natural History Study

Farber Disease | Farber's Disease | Farber Lipogranulomatosis | Acid Ceramidase Deficiency | Ceramidase Deficiency | N-Laurylsphingosine Deacylase Deficiency | ASAH1 Mutation

United States, Egypt, Canada, Italy, Turkey, Argentina, Germany, India, Sweden
Georgetown University

Completed

Enhancing At-risk Latina Women's Use of Genetic Counseling for Hereditary Breast and Ovarian Cancer

Hereditary Breast and Ovarian Cancer

United States
University of Pisa

Completed

Defining Inflammation Related to Peritoneal Carcinomatosis in Women With Ovarian or Colon Cancer. (CarFlog)

Ovarian Cancer | Colon Cancer | Peritoneal Carcinomatosis

Italy
National Cancer Institute (NCI)

Completed

AZD2281 Plus Carboplatin to Treat Breast and Ovarian Cancer

Breast Cancer | Ovarian Cancer

United States
University of Southern California
National Cancer Institute (NCI); National Institute for Biomedical Imaging...

Terminated

Ultrasound and Biomarker Tests in Predicting Cancer Aggressiveness in Tissue Samples of Patients With Bladder Cancer

Stage II Bladder Urothelial Carcinoma | Stage IV Bladder Urothelial Carcinoma | Stage III Bladder Urothelial Carcinoma | Bladder Papillary Urothelial Carcinoma | Stage 0a Bladder Urothelial Carcinoma | Stage 0is Bladder Urothelial Carcinoma | Stage I Bladder Cancer With Carcinoma In Situ | Stage...

United States
Case Comprehensive Cancer Center

Completed

Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome

Myelodysplastic Syndromes | Thrombocytopenia | Chronic Myelomonocytic Leukemia | de Novo Myelodysplastic Syndromes | Refractory Anemia | Refractory Anemia With Excess Blasts | Refractory Cytopenia With Multilineage Dysplasia | Refractory Anemia With Ringed Sideroblasts

United States
Azienda USL 4 Prato

Completed

Impact of Geriatrician Interventions on Chemotherapy Delivery in Vulnerable Elderly Oncology Patients (GIVE)

Breast Cancer | Ovarian Cancer | Lung Cancer | Prostate Cancer | Bladder Cancer | Gastrointestinal Cancer

Italy

Clinical Trials on Medical Disorders

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