Clinical Trials on Mismatch Repair Gene Mutation
Total 446 results
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TransThera Sciences (Nanjing), Inc.CompletedCholangiocarcinoma | FGFR2 Gene Mutation | FGFR2 Fusion | FGFR1 Alteration | FGFR3 AlterationUnited States
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RWJ Barnabas Health at Jersey City Medical CenterUnknownLynch Syndrome | Endometrial Cancer | Somatic Mutation | Cancer Gene MutationUnited States
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OnKure, Inc.Active, not recruitingMelanoma | NRAS Gene Mutation | RAS MutationUnited States
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University Medical Center NijmegenActive, not recruitingOvarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene MutationNetherlands
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Ying LinRecruitingHer-2 Negative Breast Cancer | HRR Gene MutationChina
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)CompletedMetastatic Malignant Neoplasm | Advanced Malignant Neoplasm | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | BRAF Gene MutationUnited States
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Fondazione Policlinico Universitario Agostino Gemelli...RecruitingNSCLC Stage IV | ALK Gene Mutation | ALK Sensitizing MutationItaly
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Aarhus University HospitalRoche Pharma AGEnrolling by invitationLung Cancer | ALK Gene Mutation | Resistance, Disease | MutationDenmark
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Rottapharm BiotechAgenus Inc.Active, not recruitingSolid Tumor | Metastatic Microsatellite-stable Colorectal Cancer | Mismatch Repair Protein Proficient | Refractory Metastatic Colorectal CancerItaly
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University of California, San FranciscoBeiGene USA, Inc.; Pacific Pediatric Neuro-Oncology ConsortiumRecruitingGlioblastoma | Malignant Glioma | Recurrent Glioblastoma | Recurrent WHO Grade III Glioma | WHO Grade III Glioma | IDH2 Gene Mutation | IDH1 Gene Mutation | Low Grade Glioma | Recurrent WHO Grade II Glioma | WHO Grade II GliomaUnited States
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Fudan UniversityPeking University First Hospital; Xiangya Hospital of Central South University and other collaboratorsUnknownGene Mutation | Epilepsy Idiopathic | Clinical Disease and/or SyndromeChina
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Universiti Sains MalaysiaCompletedOpioid Dependence | Methadone Toxicity | HERG Gene MutationMalaysia
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UNICANCERARCAGY/ GINECO GROUP; SOLTI Breast Cancer Research GroupActive, not recruitingER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancer | a Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI StatusFrance
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VA Office of Research and DevelopmentMerck Sharp & Dohme LLCRecruitingMetastatic Castration Resistant Prostate CancerUnited States
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Myat Htut NyuntKangwon National UniversityCompletedDay-3 Positive of Parasitaemia | Prevalence of Drug Resistance Gene MutationMyanmar
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University of ChicagoNovartisTerminatedHead and Neck Squamous Cell Carcinoma | Recurrent Head and Neck Carcinoma | Human Papillomavirus Infection | Recurrent Oropharyngeal Squamous Cell Carcinoma | FGFR Gene Amplification | FGFR1 Gene Amplification | FGFR2 Gene Amplification | FGFR2 Gene Mutation | FGFR3 Gene Mutation | Recurrent Nasopharynx...United States
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Sebastian BauerHannover Medical School; University Hospital Tuebingen; Universitätsmedizin Mannheim and other collaboratorsUnknownGIST, Malignant | KIT Gene Mutation | KIT Exon 13 MutationGermany
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingEGFR NP_005219.2:p.S492R | KRAS Gene Mutation | MAP2K1 Gene Mutation | Metastatic Colorectal Adenocarcinoma | Refractory Colorectal Adenocarcinoma | Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7United States
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Rhythm Pharmaceuticals, Inc.CompletedPro-opiomelanocortin (POMC), Proprotein Convertase Subtilisin/Kexin Type 1 (PCSK1) and Leptin Receptor (LepR) Gene MutationsUnited States, Israel, Canada, Germany, Greece, Italy, Portugal
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Daiichi Sankyo, Inc.No longer availableAcute Myeloid Leukemia With Gene Mutations
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Jonsson Comprehensive Cancer CenterAstraZenecaActive, not recruitingGlioblastoma | Recurrent Glioblastoma | EGFR Gene Mutation | Supratentorial Glioblastoma | EGFR Gene Amplification | TP53 wt AlleleUnited States
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National Taiwan University HospitalRecruitingCancer | Drug-Related Side Effects and Adverse Reactions | Cancer, Treatment-Related | EGFR Gene MutationTaiwan
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RenJi HospitalPeking University First Hospital; Shanghai Zhongshan Hospital; First Affiliated... and other collaboratorsRecruitingKidney Cancer | Renal Cell Carcinoma | ALK Gene Mutation | MET Gene Mutation | HLRCC | Renal Tumor Histology | Cutaneous Leiomyoma | BAP1 Tumor Predisposition Syndrome | VHL Syndrome | Birt-Hogg-Dube Syndrome | Familial Renal Cancer | FLCN Gene Mutation | FH Gene Mutation | Cutaneous Leiomyomata With Uterine LeiomyomataChina
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Centro di Riferimento Oncologico - AvianoRecruitingBreast Neoplasms | Breast Diseases | Antineoplastic Agents | Aromatase Inhibitors | Neoplasms, Breast | Hormone Receptor Positive Breast Carcinoma | ESR1 Gene MutationItaly
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Massachusetts General HospitalGlaxoSmithKlineRecruitingRecurrent Glioma | Low-grade Glioma | Glioma, Malignant | IDH2 Gene Mutation | IDH1 MutationUnited States
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Chonnam National University HospitalCompletedLung Neoplasms | EGFR Gene MutationsKorea, Republic of
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Asan Medical CenterUnknownCancer | Lung Cancer Metastatic | MET Gene MutationKorea, Republic of
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SUNHO（China）BioPharmaceutical CO., Ltd.RecruitingHER2 Gene MutationChina
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Shimaa KamalActive, not recruitingGene Mutation in Infantile Onset Diabetes MellitusEgypt
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Roswell Park Cancer InstituteAstraZenecaActive, not recruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Fallopian Tube Carcinoma | Recurrent Ovarian Carcinoma | Recurrent Primary Peritoneal Carcinoma | Ovarian Serous AdenocarcinomaUnited States
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Zhejiang Cancer HospitalRecruitingColorectal Cancer Metastatic | Microsatellite Stable | Mismatch Repair-proficientChina
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Collin BlakelyPuma Biotechnology, Inc.Active, not recruitingLung Cancer Metastatic | EGFR Gene MutationUnited States
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Guangxi Medical UniversityCompletedFull Gene Sequences of c-KIT、PDGFRA and DOG1 Are Analyzed With the Screening-sequencing Approach | Investigate the Characteristics and Variations Associated With the Different Gene Mutations of c-KIT、PDGFRA and DOG1 in GIST Patients
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Memorial Sloan Kettering Cancer CenterRecruitingStudy of Cemiplimab Combined With Dabrafenib and Trametinib in People With Anaplastic Thyroid CancerThyroid Cancer | Anaplastic Thyroid Cancer | BRAF Gene Mutation | BRAF Mutation-Related TumorsUnited States
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Abramson Cancer Center at Penn MedicineRecruitingBreast Cancer | Gastric Cancer | Cancer Gene MutationUnited States
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Consorzio OncotechActive, not recruitingMetastatic Breast Cancer | Triple Negative Breast Cancer | PD-L1 Gene MutationItaly
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Taiho Oncology, Inc.TerminatedNon-Small Cell Lung Cancer | KRAS Gene Mutation | Advanced or Metastatic Solid Tumors Irrespective of Gene AlterationsUnited States
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Third Affiliated Hospital, Sun Yat-Sen UniversityRecruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Sun Yat-sen UniversityRecruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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Sun Yat-sen UniversityThe Second Affiliated Hospital of Kunming Medical UniversityCompletedColorectal Cancer Metastatic | Microsatellite Instability High | Mismatch Repair DeficiencyChina
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Instituto Nacional de Cancerologia de MexicoUnknownEGFR Gene Mutation | Tyrosine Kinase Mutation | Non-Small Cell AdenocarcinomaMexico
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LiuYingNot yet recruitingColorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)China
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University of California, San DiegoEpimed International; Myoscience (prior to merger with Pacira Pharmaceuticals)CompletedRotator Cuff Repair | Shoulder Arthroplasty | Mastectomy | Knee Arthropathy | Upper Limb Amputation Below Elbow | Upper Limb Amputation Above Elbow | Lower Limb Amputation Below Knee | Lower Limb Amputation Above Knee | Video-Assisted Thoracoscopic Surgery (VATS) | Skin GraftingUnited States
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Monaldi HospitalRecruitingHeart Failure | Lamin A/C Gene Mutation | LaminopathyItaly
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Memorial Sloan Kettering Cancer CenterAgios Pharmaceuticals, Inc.RecruitingChondrosarcoma | IDH1 Gene Mutation | Chondrosarcoma, Grade 2 | Chondrosarcoma, Grade 3United States
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University of Illinois at ChicagoWithdrawnVHL Gene Mutation | Polycythemia; Familial | Erythrocytosis; Familial | HIF-2alpha Erythrocytosis | PHD2 Erythrocytosis | Chuvash Erythrocytosis
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Kura Oncology, Inc.Active, not recruitingHNSCC | HRAS Gene MutationUnited States, Belgium, Spain, United Kingdom, Taiwan, Denmark, Korea, Republic of, Netherlands, Thailand, Germany, Malaysia, Austria, Italy, Greece, Australia, Norway
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Tesaro, Inc.European Organisation for Research and Treatment of Cancer - EORTC; Breast... and other collaboratorsTerminatedOvarian Neoplasms | BRCA1 Gene Mutation | BRCA2 Gene Mutation | Neoplasms, Breast | Human Epidermal Growth Factor 2 Negative Carcinoma of Breast | Carcinoma of BreastUnited States, Spain, Belgium, Israel, United Kingdom, Italy, Poland, Canada, Hungary, Netherlands, France, Portugal, Greece, Iceland
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University of Colorado, DenverNational Cancer Institute (NCI); Cancer League of ColoradoWithdrawnColorectal Cancer | Microsatellite Instability High | Mismatch Repair DeficiencyUnited States
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Università Politecnica delle MarcheNot yet recruitingLymphoma | Lung Neoplasms | Tuberculosis | EGF-R Positive Non-Small Cell Lung Cancer | Sarcoidosis | Mediastinal Lymphadenopathy | Hilar Lymphadenopathy | ROS1 Gene Mutation | PDL1 Gene Mutation | ALK TranslocationItaly