Clinical Trials on Mismatch Repair-deficient (dMMR) in United States
Total 242 results
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The Hospital for Sick ChildrenBristol-Myers SquibbTerminatedRefractory or Recurrent Hypermutated Malignancies | Biallelic Mismatch Repair Deficiency (bMMRD) Positive PatientsUnited States, France, Canada, Australia, Israel
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Bristol-Myers SquibbActive, not recruitingMicrosatellite Stable Colorectal Cancer | Mismatch Repair Proficient Colorectal Cancer | Microsatellite Unstable Colorectal Cancer | Mismatch Repair Deficient Colorectal CancerUnited States, Australia, Belgium, Canada, Ireland, Italy, Spain, France
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University of Colorado, DenverNational Cancer Institute (NCI); Cancer League of ColoradoWithdrawnColorectal Cancer | Microsatellite Instability High | Mismatch Repair DeficiencyUnited States
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VA Office of Research and DevelopmentMerck Sharp & Dohme LLCRecruitingMetastatic Castration Resistant Prostate CancerUnited States
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WellSpan HealthActive, not recruitingEndometrial Hyperplasia | Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Mismatch Repair DeficiencyUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)CompletedHigh-Frequency Microsatellite Instability | Mismatch Repair Gene Mutation | Mutation-Negative Lynch Syndrome | Mutation-Positive Lynch SyndromeUnited States
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BeiGeneRecruitingUnresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal CancerChina, United States, Australia, Puerto Rico
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Incyte CorporationRecruitingMelanoma | Hepatocellular Carcinoma (HCC) | Renal Cell Carcinoma (RCC) | Colorectal Carcinoma (CRC) | Microsatellite Instability - High (MSI-H) | Mismatch Repair Deficient (dMMR)United States, Canada, South Africa, Mexico
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National Cancer Institute (NCI)CompletedHematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Plasma Cell MyelomaUnited States
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Virginia Commonwealth UniversityRecruitingEndometrial Cancer | Recurrent Endometrial Cancer | Mismatch Repair-ProficientUnited States
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Replimune Inc.RecruitingCancer | NSCLC | Melanoma (Skin) | Microsatellite Instability | Cutaneous Melanoma | Mismatch Repair Deficiency | Non-melanoma Skin CancerUnited States, Spain, France, United Kingdom, Germany
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Floor BackesTerminatedLynch Syndrome | Recurrent Endometrial Carcinoma | Recurrent Endometrial Clear Cell Adenocarcinoma | Recurrent Endometrial Cancer | Metastatic Endometrial Cancer | Mismatch Repair Deficiency | Recurrent Uterine Corpus CarcinosarcomaUnited States
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National Institute of Allergy and Infectious Diseases...Enrolling by invitationSevere Combined Immune Deficiency (SCID)United States
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Udai KammulaRecruitingSarcoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Neuroendocrine Tumors | Mesothelioma | Merkel Cell Carcinoma | Microsatellite Instability | Squamous Cell Cancer | Mismatch Repair DeficiencyUnited States
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Emory UniversityCompletedSevere Combined Immunodeficiency | T-Cell Immune Deficiency DiseasesUnited States
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University of California, Los AngelesRecruitingAdenosine Deaminase Severe Combined Immune DeficiencyUnited States
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Seattle Institute for Biomedical and Clinical ResearchVA Puget Sound Health Care System; Prostate Cancer FoundationTerminatedMetastatic Prostate Carcinoma | Recurrent Prostate Carcinoma | Stage IV Prostate Cancer | Hormone-Resistant Prostate CancerUnited States
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Rutgers, The State University of New JerseyNational Cancer Institute (NCI)RecruitingGastric Adenocarcinoma | Epstein-Barr Virus Positive | Mismatch Repair Protein Deficiency | Stage IB Gastric Cancer AJCC v7 | Stage II Gastric Cancer AJCC v7 | Stage IIA Gastric Cancer AJCC v7 | Stage IIB Gastric Cancer AJCC v7 | Stage III Gastric Cancer AJCC v7 | Stage IIIA Gastric Cancer AJCC v7 | Stage... and other conditionsUnited States
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University of California, San FranciscoMerck Sharp & Dohme LLCCompletedStage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Microsatellite Stable | Stage III Colorectal Cancer AJCC v7 | Stage IIIB Colorectal Cancer AJCC v7 | Stage IIIC Colorectal Cancer AJCC v7 | Mismatch Repair Protein ProficientUnited States
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University of California, Los AngelesGreat Ormond Street Hospital for Children NHS Foundation TrustEnrolling by invitationAdenosine Deaminase Deficiency | Severe Combined Immunodeficiency (SCID)United States, United Kingdom
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Virginia G. KaklamaniNot yet recruitingTriple Negative Breast Cancer | DNA Damage Repair DeficiencyUnited States
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University of California, Los AngelesOrchard Therapeutics; California Institute for Regenerative Medicine (CIRM)CompletedSevere Combined Immunodeficiency Due to ADA DeficiencyUnited States
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Donald B. Kohn, M.D.National Institutes of Health (NIH); FDA Office of Orphan Products DevelopmentCompletedSevere Combined ImmunodeficiencyUnited States
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National Heart, Lung, and Blood Institute (NHLBI)Recruiting
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St. Jude Children's Research HospitalCompletedSevere Combined ImmunodeficiencyUnited States
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University of California, Los AngelesWithdrawnSevere Combined Immunodeficiency Due to ADA DeficiencyUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingLi-Fraumeni SyndromeUnited States
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St. Jude Children's Research HospitalActive, not recruitingSevere Combined ImmunodeficiencyUnited States
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National Human Genome Research Institute (NHGRI)CompletedSevere Combined ImmunodeficiencyUnited States
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National Human Genome Research Institute (NHGRI)CompletedSevere Combined ImmunodeficiencyUnited States
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University of California, San FranciscoRecruiting
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University of California, San FranciscoTerminatedSevere Combined ImmunodeficiencyUnited States
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National Human Genome Research Institute (NHGRI)CompletedSevere Combined Immunodeficiency SyndromeUnited States
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David WilliamsUniversity of California, Los Angeles; Boston Children's Hospital; Children's...CompletedSevere Combined ImmunodeficiencyUnited States
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National Center for Research Resources (NCRR)Completed
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Leadiant Biosciences, Inc.CompletedSevere Combined Immunodeficiency | ADA-SCID | Adenosine Deaminase DeficiencyUnited States
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University of WashingtonActive, not recruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Castration-Resistant Prostate Carcinoma | Homologous Recombination Deficiency | PSA Progression | Stage IV Prostate Adenocarcinoma AJCC v7 | Castration Levels of Testosterone | ATM Gene Mutation | Prostate Carcinoma Metastatic in the Bone | PSA Level Greater...United States
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Neonc Technologies, Inc.RecruitingMelanoma | Renal Cell Carcinoma | Cervical Cancer | Small Cell Lung Cancer | Gastric Cancer | Colorectal Cancer | Esophageal Cancer | Non-small Cell Lung Cancer | Head and Neck Squamous Cell Carcinoma | Esophageal Squamous Cell Carcinoma | Urothelial Carcinoma | Merkel Cell Carcinoma | Gastroesophageal Junction... and other conditionsUnited States
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Neena Kapoor, M.D.Terminated
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University of California, San FranciscoWithdrawnSevere Combined Immunodeficiency | Stem Cell Transplant | Transplacental Maternal EngraftmentUnited States
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National Cancer Institute (NCI)CompletedLi-Fraumeni SyndromeUnited States
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National Cancer Institute (NCI)RecruitingNeoplasms | Li-Fraumeni Syndrome | Tp53 MutationsUnited States
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Great Ormond Street Hospital for Children NHS Foundation...Completed
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Chiesi Farmaceutici S.p.A.CompletedSevere Combined Immunodeficiency | Adenosine Deaminase DeficiencyUnited States
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Baylor College of MedicineCenter for Cell and Gene Therapy, Baylor College of MedicineTerminatedSevere Combined Immunodeficiency Disease | Severe Primary Immunodeficiency Disorder | Undefined T Cell Deficiency Disorder | Wiskott-Aldrick SyndromeUnited States
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Jasper Therapeutics, Inc.Recruiting
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Abramson Cancer Center of the University of PennsylvaniaChildren's Hospital of PhiladelphiaRecruiting
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Great Ormond Street Hospital for Children NHS Foundation...Orchard TherapeuticsCompletedAdenosine Deaminase Deficiency | Severe Combined Immunodeficiencies (SCID)United Kingdom
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National Institute of Allergy and Infectious Diseases...UnknownX-Linked Combined Immunodeficiency DiseasesUnited States
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National Institute of Allergy and Infectious Diseases...CompletedSevere Combined ImmunodeficiencyUnited States