Clinical Trials on Mismatch Repair Protein Deficiency

Total 595 results

The Hospital for Sick Children
Bristol-Myers Squibb

Terminated

Pilot Study of Nivolumab in Pediatric Patients With Hypermutant Cancers

Refractory or Recurrent Hypermutated Malignancies | Biallelic Mismatch Repair Deficiency (bMMRD) Positive Patients

United States, France, Canada, Australia, Israel
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Evaluation of the Reliability of the Determination of MisMatch Repair Deficiency Status by Endoscopic Biopsies in Oesophagus and Gastric Adenocarcinoma. (BIOPSYGAST MMR)

Gastro-oesophageal Adenocarcinoma
Yu jiren

Recruiting

Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma

Adenocarcinoma of the Stomach | Mismatch Repair Deficiency | Adenocarcinoma of Esophagogastric Junction

China
Bristol-Myers Squibb

Active, not recruiting

A Study of Nivolumab Alone or Nivolumab Combination Therapy in Colon Cancer That Has Come Back or Has Spread (CheckMate142)

Microsatellite Stable Colorectal Cancer | Mismatch Repair Proficient Colorectal Cancer | Microsatellite Unstable Colorectal Cancer | Mismatch Repair Deficient Colorectal Cancer

United States, Australia, Belgium, Canada, Ireland, Italy, Spain, France
Apollomics (Australia) Pty. Ltd.
Novotech (Australia) Pty Limited; Apollomics Inc. (formerly CBT Pharmaceuticals...

Completed

APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

Solid Tumor | Microsatellite Instability | Mismatch Repair Deficiency | Cancer of Unknown Primary Site

Australia
Peking Union Medical College Hospital

Recruiting

Neoadjuvant Immunotherapy for T4 dMMR Colon Cancer (NITDC)

Colon Cancer | Immunotherapy | Mismatch Repair Deficiency

China
National Center for Tumor Diseases, Heidelberg
AstraZeneca; German Cancer Research Center; PharmaMar

Completed

Study of Olaparib/Trabectedin vs. Doctor's Choice in Solid Tumors (NCT-PMO-1603)

Cancers With DNA Repair-Deficiency

Germany
Rottapharm Biotech
Agenus Inc.

Active, not recruiting

A Phase Ib/IIa Study of CR6086 in Combination With Balstilimab in pMMR-MSS Metastatic Colorectal Cancer Patients

Solid Tumor | Metastatic Microsatellite-stable Colorectal Cancer | Mismatch Repair Protein Proficient | Refractory Metastatic Colorectal Cancer

Italy
Yu jiren

Recruiting

Perioperative Chemotherapy Combined With Serplulimab or Placebo for pMMR Locally Advanced Gastric Adenocarcinoma (FOCUS-05)

Adenocarcinoma of the Stomach | Adenocarcinoma of Esophagogastric Junction | Proficient Mismatch Repair

China
VA Office of Research and Development
Merck Sharp & Dohme LLC

Recruiting

A Study of CHeckpoint Inhibitors in Men With prOgressive Metastatic Castrate Resistant Prostate Cancer Characterized by a Mismatch Repair Deficiency or Biallelic CDK12 Inactivation (CHOMP)

Metastatic Castration Resistant Prostate Cancer

United States
National Cancer Institute (NCI)

Withdrawn

Testing Nivolumab and BMS-986016 (Relatlimab) as Potentially Targeting Treatment in Cancers That Are LAG-3+ and Have Mismatch Repair Deficiency (MATCH - Subprotocol Z1M)

Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma
Sun Yat-sen University
The Second Affiliated Hospital of Kunming Medical University

Completed

The mCRC Patients With pMMR/MSS or dMMR/MSI-H Status Received Palliative Chemotherapy Efficacy and Survival

Colorectal Cancer Metastatic | Microsatellite Instability High | Mismatch Repair Deficiency

China
University of Colorado, Denver
National Cancer Institute (NCI); Cancer League of Colorado

Withdrawn

Anti-PD-1 +/- RT for MSI-H Solid Tumors

Colorectal Cancer | Microsatellite Instability High | Mismatch Repair Deficiency

United States
University Health Network, Toronto
AstraZeneca

Active, not recruiting

Basket Combination Study of Inhibitors of DNA Damage Response, Angiogenesis and Programmed Death Ligand 1 in Patients With Advanced Solid Tumors (DAPPER)

Pancreatic Adenocarcinoma | Leiomyosarcoma | Mismatch Repair Proficient Colorectal Cancer

Canada
University of British Columbia

Unknown

Melatonin and DNA Damage Study

Oxidative Stress | Sleep Quality | DNA Damage Repair Deficiency
National Cancer Institute (NCI)

Completed

Testing Nivolumab as a Potential Targeted Treatment in Cancers With Mismatch Repair Deficiency (MATCH-Subprotocol Z1D)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Plasma Cell Myeloma

United States
Third Affiliated Hospital, Sun Yat-Sen University

Recruiting

Envafolimab as Neoadjuvant Immuntherapy in Resectable Local Advanced dMMR/MSI-H Colorectal Cancer

Colorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
Sun Yat-sen University

Recruiting

Toripalimab With or Without Celecoxib as Neoadjuvant Therapy in Resectable dMMR/MSI-H Colorectal Cancer (PICC)

Colorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
LiuYing

Not yet recruiting

Cadonilimab as Neoadjuvant Therapy in Resectable Stage II-III MSI-H/dMMR Colorectal Cancer (MSI-H/dMMR)

Colorectal Cancer | Neoadjuvant Therapy | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
Idience Co., Ltd.

Active, not recruiting

Basket Trial of IDX-1197, a PARP Inhibitor, in Patients With HRR Mutated Solid Tumors (VASTUS) (VASTUS)

Solid Tumors | Homologous Recombination Deficiency | Homologous Recombination Repair Gene Mutation

Korea, Republic of
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Recruiting

Pembrolizumab, Capecitabine, and Radiation Therapy in Treating Patients With Mismatch-Repair Deficient and Epstein-Barr Virus Positive Gastric Cancer

Gastric Adenocarcinoma | Epstein-Barr Virus Positive | Mismatch Repair Protein Deficiency | Stage IB Gastric Cancer AJCC v7 | Stage II Gastric Cancer AJCC v7 | Stage IIA Gastric Cancer AJCC v7 | Stage IIB Gastric Cancer AJCC v7 | Stage III Gastric Cancer AJCC v7 | Stage IIIA Gastric Cancer AJCC v7 | Stage... and other conditions

United States
Sun Yat-sen University

Recruiting

Cadonilimab for PD-1/PD-L1 Blockade-refractory, MSI-H/dMMR, Advanced Colorectal Cancer

Colorectal Cancer Stage IV | Mismatch Repair-deficient (dMMR) | Microsatellite Instability-high (MSI-H)

China
WellSpan Health

Active, not recruiting

Frequency of Endometrial Cancer Precursors Associated With Lynch Syndrome

Endometrial Hyperplasia | Lynch Syndrome | Endometrial Cancer | Microsatellite Instability | Mismatch Repair Deficiency

United States
An Hsin QingShui Clinic

Completed

Dialysis Model for Outcome and Nutrition Decision (DIAMOND)

Protein-Calorie Malnutrition

Taiwan
BeiGene

Recruiting

A Study Investigating the Efficacy and Safety of LBL-007 Plus Tislelizumab in Combination With Bevacizumab Plus Fluoropyrimidine Versus Bevacizumab Plus Fluoropyrimidine in Participants With Unresectable or Metastatic Colorectal Cancer

Unresectable or Metastatic Microsatellite Stable/Mismatch Repair Proficient Colorectal Cancer

China, United States, Australia, Puerto Rico
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Cycling in Preventing Colorectal Cancer in Participants With Lynch Syndrome

High-Frequency Microsatellite Instability | Mismatch Repair Gene Mutation | Mutation-Negative Lynch Syndrome | Mutation-Positive Lynch Syndrome

United States
University of Reading
Biotechnology and Biological Sciences Research Council; The Norwegian Institute... and other collaborators

Not yet recruiting

FortiPhy: Protein Bioavailability, Satiety and Appetite

Protein-Energy Malnutrition

United Kingdom
Hospital General Universitario Gregorio Marañon
Instituto de Salud Carlos III; European Regional Development Fund; Maternal,...

Unknown

Usefulness of Protein-enriched Infant Formula in Pediatric Intensive Care.

Protein-Energy Malnutrition

Spain
Assistance Publique - Hôpitaux de Paris

Completed

Evaluation of the Effectiveness of a Protein Pulse-Feeding Pattern in Elderly Patients (PRO-PULSé)

Protein-Energy Malnutrition

France
United States Army Research Institute of Environmental...

Recruiting

Effects of Varying Energy Deficits on Protein Turnover at Rest and Carbohydrate Oxidation During Steady-state Exercise

Stress, Physiological | Energy Supply; Deficiency | Energy Supply; Deficiency, Severe

United States
Replimune Inc.

Recruiting

Study of RP1 Monotherapy and RP1 in Combination With Nivolumab (IGNYTE)

Cancer | NSCLC | Melanoma (Skin) | Microsatellite Instability | Cutaneous Melanoma | Mismatch Repair Deficiency | Non-melanoma Skin Cancer

United States, Spain, France, United Kingdom, Germany
Maastricht University Medical Center

Not yet recruiting

Three Channel Food Concept: the Effect Meal Service on Food Intake During Hospitalization

Protein-Energy Malnutrition | Nutrition Poor

Netherlands
Oregon Health and Science University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Oregon...

Completed

Fatty Acid Oxidation Disorders & Body Weight Regulation Grant

Trifunctional Protein Deficiency

United States
The University of The West Indies
International Atomic Energy Agency

Completed

Quality of Protein From the Common Bean

Nutrition Deficiency Due to A Particular Kind of Food

Jamaica
Baylor College of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Study of Antioxidants and Oxidants in Malnourished Children

Kwashiorkor | Marasmus | Protein-energy Malnutrition

Jamaica
Seoul St. Mary's Hospital

Completed

Reducing In-Hospital and 60-Day Mortality in ICU Patients After Surgery With Strict Nutritional Supplementation

Protein-Energy Malnutrition

Korea, Republic of
Oregon Health and Science University

Completed

Oral Ketones and Exercise Among Patients With Long-chain Fatty Acid Oxidation Disorders

Trifunctional Protein Deficiency | Very Long Chain Acyl Coa Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency | Carnitine Palmitoyltransferase Deficiency 2

United States
Semarang Health Polytechnic

Unknown

NutFish and Nutrient Supplementation in Pregnancy Class to Improve Maternal and Birth Outcomes

Anemia | Pregnancy | Protein-Energy Malnutrition

Indonesia
Action Contre la Faim
Johns Hopkins University

Unknown

Effectiveness of Safe Drinking Water in Treatment of Severe Acute Malnutrition (Pakistan)

Marasmus
VU University of Amsterdam
Amsterdam UMC, location VUmc; University of Helsinki

Completed

The (Cost)Effectiveness of Increasing Protein Intake on Physical Funtioning in Older Adults

Physical Disability | Protein-Energy Malnutrition

Finland, Netherlands
University of California, San Francisco
Merck Sharp & Dohme LLC

Completed

Pembrolizumab, Capecitabine, and Bevacizumab in Treating Patients With Microsatellite Stable Colorectal Cancer That Is Locally Advanced, Metastatic, or Cannot Be Removed by Surgery

Stage IV Colorectal Cancer AJCC v7 | Stage IVA Colorectal Cancer AJCC v7 | Stage IVB Colorectal Cancer AJCC v7 | Microsatellite Stable | Stage III Colorectal Cancer AJCC v7 | Stage IIIB Colorectal Cancer AJCC v7 | Stage IIIC Colorectal Cancer AJCC v7 | Mismatch Repair Protein Proficient

United States
Washington University School of Medicine
Kamuzu University of Health Sciences

Withdrawn

Effectiveness of Oral Albendazole in the Treatment of Severe Acute Malnutrition

Kwashiorkor | Marasmus

Malawi
Washington University School of Medicine

Completed

Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition

Kwashiorkor | Marasmus

Malawi
Washington University School of Medicine
University of Malawi

Completed

Pilot Study of PUFA-optimized RUTF for Severe Acute Malnutrition

Kwashiorkor | Marasmus

Malawi
Oregon Health and Science University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Oregon...

Terminated

Vitamin E Treatment for Long-Chain 3-Hydroxyacyl Coenzyme A (CoA) Dehydrogenase (LCHAD) Associated Neuropathy

Peripheral Neuropathy | Mitochondrial Trifunctional Protein Deficiency

United States
Zhejiang Cancer Hospital

Recruiting

Radiotherapy Combined With Tislelizumab and Irinotecan in MSS/pMMR Recurrence and Metastatic Colorectal Cancer

Colorectal Cancer Metastatic | Microsatellite Stable | Mismatch Repair-proficient

China
Southeast Bariatrics, PA
University of North Carolina, Charlotte

Unknown

Comparison of Meal Replacements Versus Protein Supplements and Utilizing the Protein Digestibility Corrected Amino Acid Score (PDCAAS) Method (PDCAAS)

Protein Deficiency

United States
Oregon Health and Science University

Completed

High Protein Diet in Patients With Long-chain Fatty Acid Oxidation Disorders

Trifunctional Protein Deficiency | Carnitine Palmitoyltransferase 2 Deficiency | Very Long-chain Acyl-CoA Dehydrogenase Deficiency | Long-chain 3-hydroxyacyl-CoA Dehydrogenase Deficiency
University of Florida

Active, not recruiting

Examining the Impact of High-protein Oral Supplement on Protein Status of Adults on Peritoneal Dialysis

Renal Failure | Protein-Energy Malnutrition

United States
Alliance for International Medical Action
Bien Être de La femme et de L'Enfant au Niger

Completed

Mothers Understand And Can do it - Mid Upper Arm Circumference Screening for Malnutrition Performed by Mothers (MUAC)

Malnutrition | Kwashiorkor | Marasmus | Malnutrition; Degree, Moderate

Niger

Clinical Trials on Mismatch Repair Protein Deficiency

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