Clinical Trials on Mitochondrial Pathology

Total 238608 results

Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia in Remission | Childhood Acute Myeloid Leukemia in Remission | Adult Acute Lymphoblastic Leukemia in Remission | Childhood Acute Lymphoblastic Leukemia in Remission | Recurrent Adult Acute Lymphoblastic Leukemia | Recurrent... and other conditions

United States
University of Chicago
National Cancer Institute (NCI)

Active, not recruiting

Paclitaxel Albumin-Stabilized Nanoparticle Formulation and Carboplatin Followed By Chemoradiation in Treating Patients With Recurrent Head and Neck Cancer

Tongue Cancer | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous Cell Carcinoma of the Oropharynx | Recurrent Squamous Cell... and other conditions

United States
Mayo Clinic
National Cancer Institute (NCI)

Completed

Pembrolizumab Alone or With Idelalisib or Ibrutinib in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia or Other Low-Grade B-Cell Non-Hodgkin Lymphomas

Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Marginal Zone Lymphoma | Waldenstrom Macroglobulinemia | Refractory B-Cell Non-Hodgkin Lymphoma | Recurrent Small Lymphocytic Lymphoma | Recurrent B-Cell Non-Hodgkin Lymphoma and other conditions

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Active, not recruiting

Flotetuzumab for the Treatment of Relapsed or Refractory Advanced CD123-Positive Hematological Malignancies

Recurrent Hodgkin Lymphoma | Refractory Hodgkin Lymphoma | Recurrent B Acute Lymphoblastic Leukemia | Refractory B Acute Lymphoblastic Leukemia | Recurrent Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive | Systemic Mastocytosis | Recurrent... and other conditions

United States
Rutgers, The State University of New Jersey
National Cancer Institute (NCI)

Terminated

Irradiated Donor Cells Following Stem Cell Transplant in Controlling Cancer in Patients With Hematologic Malignancies

Acute Lymphoblastic Leukemia | Mantle Cell Lymphoma | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Recurrent Diffuse Large B-Cell Lymphoma | Refractory Diffuse Large B-Cell Lymphoma | Minimal Residual Disease | Therapy-Related Acute Myeloid Leukemia | Therapy-Related Myelodysplastic... and other conditions

United States
University of Pennsylvania

Completed

CART19 to Treat B-Cell Leukemia or Lymphoma That Are Resistant or Refractory to Chemotherapy

Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Hematopoietic/Lymphoid Cancer | Adult Acute Lymphoblastic Leukemia in Remission | B-cell Chronic Lymphocytic... and other conditions

United States
Atara Biotherapeutics

No longer available

Expanded Access Protocol for Tabelecleucel for Patients With Epstein-Barr Virus-Associated Viremia or Malignancies

Lymphoproliferative Disorders | Stem Cell Transplant Complications | Epstein-Barr Virus (EBV) Infections | EBV+ Associated Lymphoma | EBV+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD) | Epstein-Barr Viremia | Lymphoma, AIDS-related | Epstein-Barr Virus-associated Lymphoproliferative... and other conditions
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Engineered Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Acute Myeloid Leukemia | Recurrent Hodgkin Lymphoma | Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Aplastic Anemia | Recurrent Non-Hodgkin... and other conditions

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...
National Cancer Institute (NCI)

Completed

Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Malignancies

Follicular Lymphoma | Myeloid Leukemia | Polycythemia Vera | Hodgkin Lymphoma | Myelofibrosis | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Chronic Lymphocytic Leukemia | Secondary Acute Myeloid Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Plasma Cell Myeloma | Refractory... and other conditions

United States
National Cancer Institute (NCI)

Completed

Busulfan, Fludarabine Phosphate, and Anti-Thymocyte Globulin Followed By Donor Stem Cell Transplant and Azacitidine in Treating Patients With High-Risk Myelodysplastic Syndrome and Older Patients With Acute Myeloid Leukemia

Acute Myeloid Leukemia | Recurrent Adult Acute Myeloid Leukemia | Myelodysplastic Syndrome | Myelodysplastic Syndrome With Excess Blasts | Secondary Myelodysplastic Syndrome | de Novo Myelodysplastic Syndrome | Adult Acute Monoblastic Leukemia | Adult Acute Monocytic Leukemia | Adult Acute Myeloid Leukemia... and other conditions

United States
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Combination Chemotherapy in Treating Young Patients With Down Syndrome and Acute Myeloid Leukemia or Myelodysplastic Syndromes

Secondary Acute Myeloid Leukemia | Childhood Acute Erythroleukemia (M6) | Childhood Acute Megakaryocytic Leukemia (M7) | Childhood Acute Monoblastic Leukemia (M5a) | Childhood Acute Monocytic Leukemia (M5b) | Childhood Acute Myeloblastic Leukemia With Maturation (M2) | Childhood Acute Myeloblastic... and other conditions

United States, Canada, Australia, Puerto Rico
Roswell Park Cancer Institute
National Cancer Institute (NCI); Sanofi Pasteur, a Sanofi Company

Completed

Sirolimus and Vaccine Therapy in Treating Patients With Stage II-IV Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cavity Cancer

Stage IV Ovarian Epithelial Cancer | Recurrent Ovarian Epithelial Cancer | Recurrent Primary Peritoneal Cavity Cancer | Stage IV Primary Peritoneal Cavity Cancer | Recurrent Fallopian Tube Cancer | Stage IIA Fallopian Tube Cancer | Stage IIB Fallopian Tube Cancer | Stage IIC Fallopian Tube Cancer | Stage... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant

Hematopoietic and Lymphoid Cell Neoplasm | Diffuse Large B-Cell Lymphoma | Acute Myeloid Leukemia | Refractory Hodgkin Lymphoma | Waldenstrom Macroglobulinemia | Acute Lymphoblastic Leukemia | Mantle Cell Lymphoma | Chronic Lymphocytic Leukemia | Myelodysplastic Syndrome | Prolymphocytic Leukemia | Refractory... and other conditions

United States, Germany, Denmark
Stanford University

Terminated

Sirolimus and Mycophenolate Mofetil in Preventing GVHD in Patients With Hematologic Malignancies Undergoing HSCT

Primary Myelofibrosis | Myelofibrosis | Recurrent Adult Acute Myeloid Leukemia | Recurrent Adult Acute Lymphoblastic Leukemia | Recurrent Adult Non-Hodgkin Lymphoma | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Refractory Non-Hodgkin Lymphoma | Blast... and other conditions

United States
Wake Forest University Health Sciences

Completed

Quality of Life and Survivorship Care in Patients Undergoing Hyperthermic Intraperitoneal Chemotherapy (HIPEC) (HOPE)

Unspecified Childhood Solid Tumor, Protocol Specific | Pseudomyxoma Peritonei | Stage IV Ovarian Epithelial Cancer | Stage IV Ovarian Germ Cell Tumor | Ovarian Sarcoma | Recurrent Ovarian Epithelial Cancer | Stage IV Colon Cancer | Recurrent Colon Cancer | Carcinoma of the Appendix | Ovarian Stromal Cancer and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Cyclophosphamide and Busulfan Followed by Donor Stem Cell Transplant in Treating Patients With Myelofibrosis, Acute Myeloid Leukemia, or Myelodysplastic Syndrome

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Del(5q) | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia... and other conditions

United States
Emory University
Children's Healthcare of Atlanta

Terminated

Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation

Sickle Cell Disease | Fanconi Anemia | Thalassemia | Severe Congenital Neutropenia | Wiskott-Aldrich Syndrome | Diamond-Blackfan Anemia | Severe Aplastic Anemia | Glanzmann Thrombasthenia | Leukocyte Adhesion Deficiency | Dyskeratosis-congenita | Chediak-Higashi Syndrome | Chronic-granulomatous Disease | Schwachman-Diamond...

United States
Ohio State University Comprehensive Cancer Center
American Cancer Society, Inc.; Lance Armstrong Foundation

Completed

Cognitive-Behavioral Intervention for Worry, Uncertainty, and Insomnia for Cancer Survivors (FOCUS)

Depression | Pain | Leukemia | Fatigue | Multiple Myeloma | Insomnia | Pancreatic Cancer | Esophageal Cancer | Lung Cancer | Glioblastoma Multiforme | Sleep Disorders | Uncertainty | Ovarian Neoplasm | Anxiety Disorder | Psychological Intervention | Relapsed Lymphoma | Worry | Cognitive-behavioral Therapy | Stage III or IV Cervical... and other conditions

United States
National Heart, Lung, and Blood Institute (NHLBI)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Completed

National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC)

Marfan Syndrome | Turner Syndrome | Ehlers-Danlos Syndrome | Loeys-Dietz Syndrome | Shprintzen-Goldberg Syndrome | FBN1, TGFBR1, TGFBR2, ACTA2 or MYH11 Genetic Mutation | Bicuspid Aortic Valve Without Known Family History | Bicuspid Aortic Valve With Family History | Bicuspid Aortic Valve With Coarctation and other conditions

United States
National Cancer Institute (NCI)

Completed

AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors

Recurrent Childhood Medulloblastoma | Recurrent Childhood Ependymoma | Childhood Atypical Teratoid/Rhabdoid Tumor | Childhood Grade I Meningioma | Childhood Grade II Meningioma | Childhood Grade III Meningioma | Childhood Infratentorial Ependymoma | Childhood Supratentorial Ependymoma | Recurrent Childhood... and other conditions

United States
Chinese PLA General Hospital

Unknown

Genetically Engineered Lymphocyte Therapy in Treating Patients With Lymphoma That is Resistant or Refractory to Chemotherapy

Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Grade 1 Follicular Lymphoma | Recurrent Grade 2 Follicular Lymphoma | Recurrent Grade 3 Follicular Lymphoma | Recurrent Mantle Cell Lymphoma | Hematopoietic/Lymphoid Cancer | Adult Acute Lymphoblastic Leukemia in Remission | B-cell Chronic Lymphocytic... and other conditions

China
Ann & Robert H Lurie Children's Hospital of Chicago
National Cancer Institute (NCI); Northwestern University

Completed

Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific | Lung Metastases | Recurrent Childhood Rhabdomyosarcoma | Recurrent Adult Soft Tissue Sarcoma | Stage IV Adult Soft Tissue Sarcoma | Recurrent Wilms Tumor and Other Childhood Kidney Tumors | Previously... and other conditions

United States
National Cancer Institute (NCI)

Completed

Topotecan Hydrochloride in Treating Children With Meningeal Cancer That Has Not Responded to Previous Treatment

Unspecified Childhood Solid Tumor, Protocol Specific | Recurrent Childhood Medulloblastoma | Recurrent Childhood Acute Lymphoblastic Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Leptomeningeal Metastases | Childhood Diffuse Large Cell Lymphoma | Childhood Immunoblastic Large Cell Lymphoma and other conditions

United States
National Cancer Institute (NCI)

Completed

CCI-779 in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Chronic Myelogenous Leukemia in Blastic Phase

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) and other conditions

United States
AC Camargo Cancer Center

Recruiting

Everolimus 5 mg vs 10 mg/Daily for Patients With Neuroendocrine Tumors (EVENET)

Progression | Neuroendocrine Tumors | Neuroendocrine Tumor of the Lung | Neuroendocrine Tumor Grade 2 | Neuroendocrine Tumor Grade 1 | Neuroendocrine Tumor of Pancreas | Neuroendocrine Tumor Carcinoid

Brazil
Universitätsklinikum Hamburg-Eppendorf

Recruiting

Cold Atmospheric Plasma for the Endoscopic Treatment of Duodenal Polyps in Patients With Familial Adenomatous Polyposis (coldAPC)

Familial Adenomatous Polyposis | Adenomatous Polyposis Coli | Duodenal Adenoma

Germany
The Geneva Foundation
Uniformed Services University of the Health Sciences; Brooke Army Medical Center and other collaborators

Recruiting

Passive Detection- SARS-CoV-2 (COVID-19) A&M Breathalyzer (PROTECT Kiosk) for Operational Medicine (COVID-19)

COVID-19 | COVID-19 Pneumonia | COVID-19 Respiratory Infection | COVID-19 Acute Respiratory Distress Syndrome | SARS CoV 2 Virus

United States
IRCCS San Raffaele

Not yet recruiting

Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models

Pituitary Adenoma | Acromegaly | Hypopituitarism | Adiposity | Cushing Syndrome | Endocrine Disorders
Universitätsklinikum Hamburg-Eppendorf
Charite University, Berlin, Germany; University Hospital Tuebingen; Technical... and other collaborators

Recruiting

Exercise and Nutrition Intervention in Ovarian Cancer (BENITA)

Fatigue | Malnutrition | Ovarian Cancer | Muscle Wasting

Germany
David Porter
Kyverna Therapeutics

Not yet recruiting

CARTIMMUNE: Study of Patients With Autoimmune Diseases Receiving KYV-101 (CARTIMMUNE)

Diffuse Cutaneous Systemic Sclerosis | ANCA Associated Vasculitis | Idiopathic Inflammatory Myopathies | SLE Nephritis
Laurent Servais
SYSNAV

Recruiting

Assessments in Patients With Muscular Pathology and in Control Subjects : The ActiLiège Next Study

Duchenne Muscular Dystrophy | Myotonic Dystrophy 1 | Congenital Muscular Dystrophy | Centronuclear Myopathy | Charcot-Marie-Tooth | Fascioscapulohumeral Muscular Dystrophy

Belgium
University Hospital, Bordeaux

Recruiting

Study of Gynecological Follow-up of Patients With Autoimmune Disease or Inflammatory Rheumatism (MARIGYN)

Arthritis, Rheumatoid | Lupus Erythematosus, Systemic | Scleroderma, Systemic | Sjogren's Syndrome | Spondylitis, Ankylosing | Mixed Connective Tissue Disease

France
LG Chem

Not yet recruiting

A Study to Evaluate Safety and Immunogenicity of APV006 in Healthy Adults

Hepatitis B | Pertussis | Tetanus | Diphtheria | Poliomyelitis | Haemophilus Influenzae Type b Infection
Christiane Haase

Recruiting

Adherence in Global Airways - Steroid Intake and Effects on Chronic Rhinosinosinutis (AGAS 2023)

Asthma | Chronic Rhinosinusitis With Nasal Polyps | Chronic Rhinosinusitis Without Nasal Polyps | Steroid-Induced Osteopenia (Diagnosis) | Steroid-Induced Diabetes | Steroid-Induced Hyperglycemia

Denmark
Washington University School of Medicine
Massachusetts General Hospital; Mayo Clinic; McGill University; University of California... and other collaborators

Recruiting

North American Prodromal Synucleinopathy Consortium Stage 2 (NAPS2)

Parkinson Disease | Multiple System Atrophy | REM Sleep Behavior Disorder | Dementia With Lewy Bodies | REM Sleep Parasomnias | Lewy Body Dementia

United States, Canada
The Institute of Molecular and Translational Medicine...
University Hospital Olomouc; Cancer Research Czech Republic

Recruiting

Role of Liquid Biopsies in HPV-associated Cancer Treatment Monitoring

Cervical Cancer | Oropharyngeal Cancer | Human Papillomavirus Infection | Cervical Dysplasia

Czechia
Lisata Therapeutics, Inc.

Recruiting

A Study of LSTA1 When Added to Standard of Care Versus Standard of Care Alone in Patients With Advanced Solid Tumors (BOLSTER)

Cholangiocarcinoma | Bile Duct Cancer | Intrahepatic Cholangiocarcinoma | Gallbladder Carcinoma | Gallbladder Cancer | Gall Bladder Cancer | Extrahepatic Cholangiocarcinoma | Gall Bladder Carcinoma

United States, Spain
Leiden University Medical Center

Recruiting

89Zr-Bevacizumab PET/CT Imaging in NF2 Patients

Neurofibromatosis 2

Netherlands
Indiana University

Recruiting

Late Subclinical Cardiovascular Disease in Testicular Cancer Survivors

Coronary Artery Disease | Cisplatin Adverse Reaction | Lipid Disorder | Survivorship | Hypogonadism, Male | Testicular Cancer | Bone Marrow Transplant Complications | ASCVD

United States
Verismo Therapeutics

Recruiting

SynKIR-110 for Mesothelin Expressing Ovarian Cancer, Cholangiocarcinoma or Mesothelioma

Ovarian Cancer | Mesothelioma, Malignant | Cholangiocarcinoma Recurrent

United States
First Affiliated Hospital of Fujian Medical University

Recruiting

Treatment of Transcranial Alternating Current Stimulation（tACS）on Cerebellar Ataxia

Spinocerebellar Ataxia Type 3 | Multiple System Atrophy-cerebellar Type

China
University of Washington
Seattle Children's Hospital

Recruiting

Spinal Stimulation and Mobility Devices

Stroke | Cerebral Palsy | Premature Birth | Hypoxic-Ischemic Encephalopathy | Periventricular Leukomalacia

United States
St. Olavs Hospital
Norwegian University of Science and Technology; The Research Council of Norway and other collaborators

Recruiting

Early Psychological Intervention After Rape (EIR)

Sexual Dysfunctions, Psychological | Sleep Disturbance | Post Traumatic Stress Disorder | Depression, Anxiety | Activity, Motor | Pelvic Pain Syndrome | Rape Sexual Assault | Pelvic Floor Myalgia | Cortisol Deficiency

Norway
Capital Medical University

Recruiting

Integrated Diagnosis and Treatment of CKD on Outcomes

Hyperglycemia | Hypertension | Chronic Kidney Diseases | Anemia | Malnutrition | Hyperlipidemias | Chronic Kidney Disease-Mineral and Bone Disorder

China
Stanford University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Interventions in Mathematics and Cognitive Skills

Cognitive Dysfunction | Cognitive Change | Learning Disabilities | Individuality | Child Development | Developmental Disability | Behavior | Cognition | Learning Curve | Decision Making | Behavior and Behavior Mechanisms | Behavior, Child | Cognitive Impairment, Mild | Cognition Disorder | Neuroscience | Cognitive Orientation and other conditions

United States
RenJi Hospital
Shanghai 8th People's Hospital

Recruiting

Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients

Kidney Neoplasms | Fractures, Bone | Stomach Neoplasms | Prostatic Neoplasms | Urinary Bladder Neoplasms | Gynecologic Cancer | Liver Neoplasms | Rectal Neoplasms | Colonic Neoplasms | Sigmoid Neoplasms | Osteoarthropathy

China
Melbourne Health

Recruiting

Venetoclax in Combination With Non-myeloablative Conditioning Allogeneic Haematopoietic Stem Cell Transplantation (VICTORY)

Myelodysplastic Syndromes | Leukemia, Myeloid, Acute | Plasma Cell Myeloma | Non-hodgkin Lymphoma | Leukemia, Lymphoblastic, Acute, L1 | Leukemia, Lymphoblastic, Acute, L2

Australia
Massachusetts General Hospital
European Leukodystrophy Association

Recruiting

Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy

Restless Legs Syndrome | Adrenoleukodystrophy

United States, Netherlands
Viking Therapeutics, Inc.

Recruiting

A Study to Assess the Pharmacodynamics of VK0214 in Male Subjects With AMN

Adrenomyeloneuropathy Form (AMN) of X-linked Adrenoleukodystrophy (X-ALD)

United States, France, Germany, Italy, United Kingdom
University of North Carolina, Chapel Hill
The Hospital for Sick Children; Washington University School of Medicine; McGill... and other collaborators

Recruiting

Defining the Genetic Etiology of Suppurative Lung Disease in Children and Adults

Primary Ciliary Dyskinesia | Kartagener Syndrome | Primary Immune Deficiency

United States, Canada

Clinical Trials on Mitochondrial Pathology

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Medical Conditions

Drug Interventions

CROs by country

CROs in Kazakhstan

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Rare Diseases

Drug Interventions

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