Clinical Trials on Mitochondrial Toxicity

Total 1078 results

University of Aarhus
Aarhus University Hospital

Not yet recruiting

Functional and Metabolic Effects of Ketone Bodies on Human Atrial Tissue in Patients With and Without Heart Failure

Heart Failure | Ischemia Reperfusion Injury | Mitochondrial Pathology

Denmark
Columbia University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Recruiting

Natural History Study - Mitochondrial Disease

MELAS or m.3243 A>G Mitochondrial DNA Mutation Carrier

United States
University of Maryland, Baltimore
National Institute of Nursing Research (NINR)

Completed

Biologic Mechanisms for Pain Variation After Physical Activity in Osteoarthritis

Pain | Physical Activity | Osteoarthritis, Knee | Mitochondrial Pathology

United States
University of Thessaly

Recruiting

Aminoglycoside Administration in Septic Patients (AMASEP)

Sepsis | Septic Shock | Renal Replacement Therapy | Aminoglycoside Toxicity

Greece
CNAO National Center of Oncological Hadrontherapy

Recruiting

Longitudinal Registry Including Patients Treated With Heavy Particles

Cancer | Radiation Toxicity | Oncology | Radiotherapy Side Effect | Radiation Exposure | Rare Disease

Italy
Sunnybrook Health Sciences Centre
Queen's University; The Leukemia and Lymphoma Society

Recruiting

Clonal Hematopoiesis is a Risk Factor for Chemotherapy-Related Complications

Lymphoma | Chemotherapeutic Toxicity

Canada
François Lellouche

Unknown

Influence of FreeO2 on Percentage of Time Within Oxygen Saturation Target Using Noninvasive Ventilation (NIV) and Continuous Positive Airway Pressure (CPAP) for Patients Admitted for AECOPD or Bariatric Surgery

Surgery | COPD Exacerbation | Abdominal Obesity | Oxygen Toxicity

Canada
Laval University

Unknown

Closed-Loop Oxygen to Verify That Healthcare Workers Interventions Decrease During SARS-CoV-2 Pneumonia (COVID-19)

Pneumonia | Coronavirus | Oxygen Toxicity

Canada
Centre Leon Berard

Recruiting

Cicaderma Efficacy vs Standard Care of Sites in Preventing Radiodermatitis in Non-metastatic Breast Cancer Patients (CICA-RT)

Radiation Toxicity | Radiation Dermatitis | Breast Adenocarcinoma

France
University of Alabama at Birmingham

Completed

Pharmacogenomic Profiling of Pediatric Patients

Mental Disorders | Metabolism Medication Toxicity | Pediatric Disorder

United States
University of Sao Paulo General Hospital

Completed

Neurovascular Changes Induced by Chemotherapy

Breast Cancer | Chemotherapeutic Toxicity

Brazil
Fundación Centro Nacional de Investigaciones Cardiovasculares...
European Commission

Recruiting

REmote iSchemic condItioning in Lymphoma PatIents REceiving ANthraCyclinEs (RESILIENCE)

Lymphoma | Anthracycline-induced Cardiac Toxicity

Netherlands, Spain, Denmark, Germany, France, Portugal
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Completed

Treatment of Acute Lymphoblastic Leukemia in Children

Leukemia | Drug/Agent Toxicity by Tissue/Organ

United States, Canada
Indiana University
Indiana University Melvin and Bren Simon Cancer Center

Completed

Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors

Brain and Central Nervous System Tumors | Drug/Agent Toxicity by Tissue/Organ | Bone Marrow Suppression

United States
The University of Texas Health Science Center at...
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Study of Dapagliflozin on Mitochondrial Dysfunction and Impaired Insulin Signaling/Action (DAPA MITO)

Insulin Sensitivity | Multiple Mitochondrial Dysfunctions Syndrome

United States
Queen Mary University of London

Completed

Bleomycin, Etoposide, and Cisplatin in Treating Patients With Metastatic Germ Cell Cancer of the Testicles

Testicular Germ Cell Tumor | Drug/Agent Toxicity by Tissue/Organ

United Kingdom
Ligand Pharmaceuticals

Completed

Dexamethasone Followed by Denileukin Diftitox in Treating Patients With Persistent or Recurrent T-Cell Lymphoma

Lymphoma | Drug/Agent Toxicity by Tissue/Organ

United States
Wellstat Therapeutics

Completed

Triacetyluridine and Fluorouracil Compared With Gemcitabine in Treating Patients With Unresectable Locally Advanced, or Metastatic Pancreatic Cancer

Pancreatic Cancer | Drug/Agent Toxicity by Tissue/Organ

United States, Canada
Cliniques universitaires Saint-Luc- Université...

Recruiting

Intermittent Versus Continuous Surface O2 During HMP of DCD Kidneys (HMPO2)

Ischemia Reperfusion Injury | Kidney Transplant; Complications | Delayed Graft Function | Mitochondrial

Belgium
Oregon State University

Terminated

Insulin and Muscle Fat Metabolism

Sedentary Lifestyle | Insulin Resistance | Overweight and Obesity | Metabolic Disease | Mitochondrial Metabolism

United States
Oregon Health and Science University
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Oregon...

Terminated

Vitamin E Treatment for Long-Chain 3-Hydroxyacyl Coenzyme A (CoA) Dehydrogenase (LCHAD) Associated Neuropathy

Peripheral Neuropathy | Mitochondrial Trifunctional Protein Deficiency

United States
UMC Utrecht
The Netherlands Cancer Institute

Completed

The Effect of Hyperbaric OxygeN Therapy on brEast Cancer Patients With Late Radiation toxicitY - UMBRELLA HONEY Trial (HONEY)

Breast Cancer | Radiation Toxicity

Netherlands
Carol Davila University of Medicine and Pharmacy
S.C. Sanador S.R.L

Active, not recruiting

Acute Effects of Intravenous Iron on Oxidative Stress and Endothelial Dysfunction in Non-dialysis CKD

Endothelial Dysfunction | Oxidative Stress | Renal Anemia | Iron Toxicity

Romania
University of Padova

Completed

Effects of Ketogenic Diet in Divers Breathing Enriched Air Nitrox

Overweight and Obesity | Oxygen Toxicity | Exertion; Excess
University of Sao Paulo General Hospital
InCor Heart Institute; Hospital do Cancer, Sao Paulo

Suspended

Evaluation of Regional Anticoagulation With Citrate in Extended Hemodialysis

Hemodialysis Complication | Acute Kidney Injury | Anticoagulant Toxicity

Brazil
Johns Hopkins University

Completed

Impact of Exercise on Mitigating the Cardio-toxic Effects of Adriamycin Among Women Newly Diagnosed With Breast Cancer.

Breast Cancer Female | Adriamycin Toxicity

United States
Cardiocentro Ticino

Unknown

Anesthetic Neurotoxicity: the Association Between General Anesthesia and the Level of Plasma Neurofilament Light (ANESTOX-2019)

General Anesthetics Toxicity

Switzerland
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Capsaicin Lozenges in Treating Patients With Mucositis Caused by Radiation Therapy

Head and Neck Cancer | Radiation Toxicity

United States
University of Turin, Italy

Recruiting

Ropivacaine Plasma Concentrations After Fascial Blocks in Elective Cardio-thoracic and Abdominal Surgery

Postoperative Pain | Regional Anesthesia Morbidity | Local Anesthetic Toxicity

Italy
Duke University

Active, not recruiting

PaRTNer: Patient Reported Outcomes and Financial Toxicity in Head and Neck Cancer A Pilot, Survey Based Study (PaRTNer)

Head and Neck Cancer

United States
Rigshospitalet, Denmark
Danish Cancer Society

Completed

Electronic Patient Reporting of Side Effects to Chemotherapy: A Cluster Randomized Controlled Trial

Chemotherapeutic Toxicity | Cancer, Breast | Adverse Event | Patient Outcomes Assessments
The Affiliated Nanjing Drum Tower Hospital of Nanjing...

Unknown

Individualized Intraperitoneal and System Chemotherapy Versus System Chemotherapy as First-line Chemotherapy for AGC

Stomach Neoplasms | Chemotherapy Effect | Chemotherapeutic Toxicity

China
National Taiwan University Hospital
National Cheng-Kung University Hospital

Unknown

Mitochondrial nt3243 A>G Mutation in Taiwan

MELAS Syndrome | Noninsulin-dependent Diabetes Mellitus With Deafness

Taiwan
University of California, San Francisco
National Institute on Drug Abuse (NIDA)

Recruiting

Pharmacokinetics and Pharmacodynamics of Nicotine With Use of Standardized Research Electronic Cigarette (SREC) (SREC22)

Nicotine Dependence | Cardiovascular Risk Factors | Tobacco Toxicity

United States
University Hospital Hradec Kralove

Recruiting

The Role of Neurofilament Light (NfL) in Patients With Hydrocephalus

Brain Damage | Hydrocephalus | General Anesthetics Toxicity

Czechia
Pontificia Universidad Catolica de Chile

Unknown

PK/PD Levobupivacaine With and Without Epinephrine After Ultrasound Guided ESP Block

Surgery | Nerve Block | Anesthetic Toxicity | Anesthetics Complications | Bupivacaine Overdose

Chile
Amsterdam UMC, location VUmc

Terminated

Safety Study of Bevacizumab (Avastin) With Thoracic Radiation in Non-small Cell Cell Lung Cancer

Toxicity

Netherlands
Washington University School of Medicine
American Academy of Clinical Toxicology

Not yet recruiting

Rivastigmine for Antimuscarinic Delirium (RIVA-AM)

Anticholinergic Toxicity

United States
Brigham and Women's Hospital

Recruiting

First in Human Phase 1 Ascending Dose Study of PanChol in Healthy Volunteers

Cholera | Cholera Vaccine Toxicity

United States
Taipei Medical University WanFang Hospital
Asia University

Recruiting

Oligo-Fucoidan Decrease Lung Radiation Damage (FIRILI)

Radiation Toxicity

Taiwan
Kwang Dong Pharmaceutical co., ltd.

Completed

Phase I Clinical Trial to Investigate the Safety, Tolerability, Pharmacokinetics of KD101 in Healthy Male Subjects

Drug Toxicity

Korea, Republic of
NHS Greater Glasgow and Clyde
Pneumowave Ltd

Completed

ARM-ED: Advanced Respiratory Monitoring Events in Drug Toxicity (ARM-ED)

Respiratory Insufficiency | Overdose of Opiate | Sedative Overdose | Sedative Toxicity

United Kingdom
Azienda Ospedaliera Città della Salute e della...

Completed

Subclinical Cardio-toxicities Evaluation With Strain Rate Echocardiography After Chemotherapy and/or Mediastinal Radiotherapy in Patient With Lymphoma (Cardiocare)

Lymphoma, Non-Hodgkin | Hodgkin Lymphoma | Toxicity, Cardiac

Italy
Children's Hospital Los Angeles
National Cancer Institute (NCI)

Completed

N2003-01: Irinotecan, Temozolomide, and Cefixime in Treating Young Patients With Recurrent or Resistant Neuroblastoma

Diarrhea | Neuroblastoma | Drug/Agent Toxicity by Tissue/Organ

United States
Oregon State University

Completed

Mitochondrial Remodeling After Exercise

Sedentary Lifestyle | Insulin Resistance | Overweight and Obesity | Metabolic Disease | Mitochondrial Metabolism

United States
Peking University People's Hospital

Enrolling by invitation

Automitochondrial Transplantation Improves Live Birth in Elderly Patients With Low Prognosis After Repeated IVF Failure (ACTILB)

Elderly | Infertility, Female | Mitochondrial | Assisted Reproductive Technique

China
Academisch Medisch Centrum - Universiteit van Amsterdam...

Recruiting

Medical Checklists in the Emergency Department

Emergencies | Tricyclic Antidepressant Poisoning | Tricyclic Antidepressant Toxicity

Netherlands
Central Hospital, Nancy, France
PAPE Elise

Not yet recruiting

Peritoneal Diffusion and Efficacy of Antibiotic Therapy in Pediatric Peritonitis (DIFFUPERPED)

Appendicitis | Peritonitis | Children, Only | Antibiotic Toxicity
Washington University School of Medicine
National Cancer Institute (NCI)

Completed

Patient-Centered Intervention to Reduce Cancer Patients' Financial Toxicity

Gynecologic Cancer | Colorectal Cancer | Lung Cancer

United States
Association Tunisienne d'Etude & de Recherche sur...
Faculty of Medicine of Tunis; Rabta University Hospital

Completed

Vitamin D Supplementation in Intensive Care Unit Patients

Vitamin D Deficiency | Intensive Care Unit | Dietary Supplements | Vitamin D Toxicity

Clinical Trials on Mitochondrial Toxicity

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Zambia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations