Mitochondrial Remodeling After Exercise

February 12, 2024 updated by: Sean Newsom, Oregon State University
Regulation of mitochondrial health in overweight and obese individuals may be impaired. The purpose of this study is to identify impairments in regulation of mitochondrial health within skeletal muscle and to determine if short-term exercise training (2-weeks) can reverse such impairments. The investigator's hypothesis is that pathways that serve to degrade poorly functioning mitochondria in overweight and obese individuals are down-regulated, but that short-term exercise training can restore these pathways to improve skeletal muscle mitochondrial function.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

31

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • United States
    • Oregon
      • Corvallis, Oregon, United States, 97331
        • Oregon State University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years to 45 years (Adult)

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • Age 18-45 years
  • Body mass index (BMI) 18-45 kg/m2
  • Sedentary (<1 hour of planned exercise per week)

Exclusion Criteria:

  • Regular exercise (>1 hour of planned exercise per week)
  • Smoking, tobacco or nicotine use within the last 1-year
  • Fasting glucose >126mg/dL
  • Hypertension (systolic pressure >140 mmHg or diastolic pressure >90 mmHg)
  • Chronic metabolic or cardiovascular health conditions
  • Pregnant, nursing, irregular menses or post-menopausal
  • Lidocaine allergy
  • Certain medications
  • Physical limitations that prevent safe or successful exercise completion
  • Diminished capacity for consent

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Basic Science
  • Allocation: Non-Randomized
  • Interventional Model: Crossover Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
No Intervention: Pre-training Metabolic Study Visit
Participants will first complete a pre-training metabolic study visit.
Experimental: Post-training Metabolic Study Visit
Participants will complete a second, identical metabolic study visit following 2-weeks of exercise training.
Behavioral: Short-term Exercise Training
Participants will perform 2-weeks of supervised exercise training on a stationary bike.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change in skeletal muscle mitochondrial protein degradation peptide products
Time Frame: After 2-weeks of exercise training compared with before training.
Skeletal muscle mitochondrial protein degradation peptide products after 2-weeks of exercise training compared with before training.
After 2-weeks of exercise training compared with before training.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Oregon State University

Investigators

  • Principal Investigator: Sean Newsom, PhD, Oregon State University
  • Principal Investigator: Matthew Robinson, PhD, Oregon State University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

August 23, 2019

Primary Completion (Actual)

November 25, 2020

Study Completion (Actual)

December 3, 2022

Study Registration Dates

First Submitted

August 23, 2019

First Submitted That Met QC Criteria

September 23, 2019

First Posted (Actual)

September 25, 2019

Study Record Updates

Last Update Posted (Estimated)

February 13, 2024

Last Update Submitted That Met QC Criteria

February 12, 2024

Last Verified

February 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IRB-2019-0124

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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