Clinical Trials on Monoclonal

Total 95 results

RxCelerate Ltd
RxCelerate Limited

Unknown

Unravel MGUS (Monoclonal Gammopathy of Unknown Significance)

Monoclonal Gammopathy of Unknown Significance

United Kingdom
University of California, San Francisco

Recruiting

Efficacy of Montelukast in Reducing the Incidence and Severity of Monoclonal Antibodies Associated Infusion Reactions

Infusion Reaction | Monoclonal Antibody

United States
Rennes University Hospital

Completed

Prognostic Study of Markers of Angiogenesis and Coagulability in Patients With Monoclonal Gammopathy (PACMoG)

Myeloma | Monoclonal Gammopathy | Monoclonal Gammopathy of Undetermined Signification

France
University of Milano Bicocca

Completed

MGRS: Clinical-histological Features of a Multicenter Case Series

Monoclonal Gammopathy of Renal Significance

Italy
Emory University
The Leukemia and Lymphoma Society

Recruiting

Rifaximin in Patients With Monoclonal Gammopathy

Waldenstrom Macroglobulinemia | Light Chain Deposition Disease | IgA Monoclonal Gammopathy | IgG Monoclonal Gammopathy | IgM Monoclonal Gammopathy | Monoclonal Gammopathy | Smoldering Waldenstrom Macroglobulinemia | Gammopathy, Monoclonal | Gammopathy Igg

United States
University of Miami

Withdrawn

Antigen-Lipid-Driven Monoclonal Gammopathies Targeting Epicardial Fat

Obesity | Overweight | Monoclonal Gammopathies
Dartmouth-Hitchcock Medical Center
Celgene Corporation

Terminated

Study of Lenalidomide as a Treatment for Neuropathy Associated With Monoclonal Gammopathy of Undetermined Significance (MGUS)

Neuropathy | Nonmalignant Monoclonal Gammopathy of Undetermined Significance (MGUS)

United States
Academia Nacional de Medicina

Unknown

Diagnosis of MGRS in Patients With Paraproteinemias: Clinical, Anatomopathological and Pathophysiological Study (MGRS-CAPS)

Monoclonal Gammopathy of Renal Significance

Argentina
Columbia University
Genzyme, a Sanofi Company

Recruiting

Isatuximab in Patients With Monoclonal Gammopathy of Renal Significance

Monoclonal Gammopathy

United States
UMC Utrecht
BeiGene

Not yet recruiting

Zanubrutinib Treatment in Patients With IgM Monoclonal Gammopathy and Antri-MAG Related Polyneuropathy (MAGNAZ)

Monoclonal Gammopathy of Uncertain Significance

Netherlands
Zhujiang Hospital
National Natural Science Foundation of China

Recruiting

Screening and Therapeutic Monitoring of Multiple Myeloma by MALDI-TOF MS Analysis

Multiple Myeloma | Monoclonal Gammopathies | M-protein

China
Oxford University Hospitals NHS Trust

Recruiting

A Prospective Long-term Observational Study in Patients With Monoclonal Gammopathy of Undetermined Significance (SECURE)

MGUS

United Kingdom
Regeneron Pharmaceuticals

Not yet recruiting

A Proof-of-Concept Study to Learn Whether Linvoseltamab Can Eliminate Abnormal Plasma Cells That May Lead to Multiple Myeloma in Adult Patients With High-Risk Monoclonal Gammopathy of Undetermined Significance or Non-High-Risk Smoldering Multiple Myeloma (LINKER-MGUS1)

Monoclonal Gammopathy of Undetermined Significance (MGUS) | Smoldering Multiple Myeloma (SMM)
Peking University First Hospital

Recruiting

A Cohort Study of Plasma Cell Disorders (PCDs) in PKUFH

Multiple Myeloma | Amyloidosis | Smoldering Multiple Myeloma | Plasma Cell Leukemia | Cryoglobulinemia | Light Chain Deposition Disease | Castleman's Disease | Heavy Chain Deposition Disease | Polyneuropathy Organomegaly Endocrinopathy Monoclonal Gammopathy and Skin Changes | Monoclonal Gammopathy of Undetermined... and other conditions

China
Memorial Sloan Kettering Cancer Center
Janssen Pharmaceuticals

Recruiting

A Study of CyBorD (Cyclophosphamide, Bortezomib, Dexamethasone) Plus Daratumumab in People With Monoclonal Gammopathy of Renal Significance (MGRS)

Multiple Myeloma | Monoclonal Gammopathy of Renal Significance

United States
Assistance Publique - Hôpitaux de Paris
Hospices Civils de Lyon; University Hospital, Basel, Switzerland; University... and other collaborators

Completed

RIMAG Study: Trial of Rituximab Versus Placebo in Polyneuropathy Associated With Anti-MAG IgM Monoclonal Gammopathy

Polyneuropathy

France
Georgetown University
Janssen, LP

Recruiting

Daratumumab for Polyneuropathy Associated With MGUS (Dara-MGUS)

Monoclonal Gammopathy of Undetermined Significance | Peripheral Neuropathy

United States
Indiana University

Active, not recruiting

Observation of the Incidence and Natural History of MGUS in Patients Undergoing Weight Reduction Surgery

Monoclonal Gammopathy of Undetermined Significance

United States
University Hospital, Brest

Completed

Frequency and Characteristics of Pruritus in Patients With Monoclonal Gammopathy (PRURIGAMMA)

Pruritus | Monoclonal Gammopathy

France
Oxford University Hospitals NHS Trust
Amgen

Completed

The Development and Pilot Testing of a New MR Imaging Protocol to Quantify Myeloma Disease Burden and Bone Loss (LOOMIS)

Myeloma | Smouldering Myeloma | Monoclonal Gammopathy of Undetermined Significance (MGUS)

United Kingdom
Shanghai Zhongshan Hospital

Recruiting

The China M-protein Screening Project in First-degree Relatives of Myeloma Patient - The CHAPERONE Study (CHAPERONE)

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance

China
National Institute of Allergy and Infectious Diseases...

Completed

Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC-HIVMAB060-00-AB (VRC01), Administered Intravenously or Subcutaneously to Healthy Adults

HIV Infection | Monoclonal Antibody, Human | HIV Antibodies | VRC01 Monoclonal Antibody | Neutralizing Antibody

United States
Mayo Clinic
National Cancer Institute (NCI)

Recruiting

Dysregulation of Glutamine Activity in the Pathogenesis of Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Plasma Cell Myeloma

United States
Mayo Clinic
Genentech, Inc.; Biogen; National Center for Research Resources (NCRR)

Terminated

Rituximab in Treating Patients With Peripheral Neuropathy Caused by Monoclonal Gammopathy of Undetermined Significance

Precancerous Condition

United States
National Taiwan University Hospital

Unknown

Immunologic and Genetic Characteristics of Monoclonal Immunoglobulins in Patient With Tuberculosis

Tuberculosis | Monoclonal Gammopathy

Taiwan
National Cancer Institute (NCI)

Withdrawn

Imaging Studies and the Development of Multiple Myeloma

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma
National Cancer Institute (NCI)

Completed

Celecoxib in Preventing Multiple Myeloma in Patients With Monoclonal Gammopathy or Smoldering Myeloma

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
National Institute of Allergy and Infectious Diseases...

Completed

VRC 601: A Phase I, Open-Label, Dose-Escalation Study of the Safety and Pharmacokinetics of a Human Monoclonal Antibody, VRC HIVMAB060-00-AB (VRC01), With Broad HIV-1 Neutralizing Activity, Administered Intravenously or Subcutaneously to HIV-Infected...

HIV-1 Infection | HIV Antibodies | Neutralizing Antibody | Viral Load | Monoclonal Antibody

United States
University of Iceland
Memorial Sloan Kettering Cancer Center; Landspitali University Hospital; deCODE... and other collaborators

Active, not recruiting

Iceland Screens, Treats or Prevents Multiple Myeloma (iStopMM)

Monoclonal Gammopathy of Undetermined Significance

Iceland
Assistance Publique - Hôpitaux de Paris
INSERM UMR 1163

Not yet recruiting

Establishment of Genomic, Transcriptomic and Functional Characteristics of Tumor Cells in Hyperinflammatory Hemopathies (GEN-HEMO-INF)

Multiple Myeloma | Waldenstrom Macroglobulinemia | Monoclonal Gammopathy of Undetermined Significance

France
Dana-Farber Cancer Institute
The Leukemia and Lymphoma Society

Recruiting

Study of MGUS, Smoldering Myeloma, Early MDS and CLL to Assess Molecular Events of Progression and Clinical Outcome

Myelodysplastic-Myeloproliferative Diseases | Waldenstrom Macroglobulinemia | Smoldering Multiple Myeloma | Chronic Lymphocytic Leukemia (CLL) | Hematological Malignancies | Monoclonal Gammopathy of Undetermined Significance (MGUS) | B-cell Malignancy, Low-grade | Myelodysplastic Syndrome With Low-grade... and other conditions

United States
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S0120, Studying Blood and Bone Marrow Samples From Patients With Monoclonal Gammopathy of Undetermined Significance, Multiple Myeloma, or Plasmacytoma

Multiple Myeloma | Plasma Cell Myeloma | Precancerous Condition

United States
Dana-Farber Cancer Institute
National Cancer Institute (NCI)

Recruiting

Investigation of Metformin for the Prevention of Progression of Precursor Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Case Comprehensive Cancer Center

Withdrawn

Dendritic Cell DKK1 Vaccine for Monoclonal Gammopathy and Stable or Smoldering Myeloma

Myeloma | Smoldering Myeloma | Monoclonal Gammopathy

United States
National Cancer Institute (NCI)

Terminated

Natural History Study of Monoclonal Gammopathy of Undetermined Significance (MGUS) and Smoldering Myeloma (SMM)

Monoclonal Gammopathy of Undetermined Significance | Smoldering Myeloma

United States
Dana-Farber Cancer Institute

Completed

Genomic and Psychosocial Effects of the 3RP on Patients With MGUS and Smoldering Multiple Myeloma

Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Radboud University Medical Center
Novartis

Completed

Efficacy and Safety of Canakinumab in Schnitzler Syndrome

Schnitzler Syndrome

Netherlands
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Isatuximab in Type I Cryoglobulinemia (ICE)

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Cryoglobulinemic Vasculitis
R-Pharm Overseas, Inc.
Worldwide Clinical Trials

Not yet recruiting

Study of the Efficacy and Safety of RPH-104 in Adult Subjects With Schnitzler Syndrome

Schnitzler Syndrome | Urticarial Vasculitis With Monoclonal Immunoglobulin M Component, Schnitzler (Disorder)

United States
Case Comprehensive Cancer Center

Recruiting

Early Detection of Multiple Myeloma to Fight Cancer Disparities: A Screening and Patient Navigation Program

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Memorial Sloan Kettering Cancer Center
Paula and Rodger Riney Foundation; Plantable; M and M labs; VeggieDoctor; Sabinsa...

Recruiting

A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance

United States
University of Miami

Recruiting

Two Biologically and Clinically Distinct Entities: Progressive Versus Stable Multiple Myeloma (MM) Precursor Conditions (TRANSFORMM)

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma

United States
Dana-Farber Cancer Institute
Janssen Pharmaceuticals; The Leukemia and Lymphoma Society; Multiple Myeloma... and other collaborators

Active, not recruiting

Phase II Study of the CD38 Antibody Daratumumab in Patients With High-Risk MGUS and Low-Risk Smoldering Multiple Myeloma

Smoldering Multiple Myeloma | Monoclonal Gammopathy

United States
Rennes University Hospital
Intergroupe Francophone du Myelome

Terminated

Study of DNA Copy Numbers Variations and Gene Expression Profile of Bone Marrow Plasma Cells From MGUS and SMM. (GENOMGUS)

Monoclonal Gammopathy of Undetermined Significance | Smoldering Myeloma

France
Olatec Therapeutics LLC
Radboud University Medical Center

Terminated

Pilot Study of Dapansutrile Capsules in Schnitzler's Syndrome

Schnitzler Syndrome

Netherlands
Universitaire Ziekenhuizen KU Leuven

Completed

Ilaris (Canakinumab) in the Schnitzler Syndrome

Schnitzler Syndrome

Belgium
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; Sorbonne... and other collaborators

Not yet recruiting

Clonal Hematopoiesis of Immunological Significance (CHIS)

Immune System Diseases | Lymphoma | Lymphoproliferative Disorders | Autoimmune Diseases | Inflammation | Myelodysplastic Syndromes | Hematologic Diseases | Leukemia | Myeloproliferative Disorders | Myelodysplastic-Myeloproliferative Diseases | Monoclonal Gammopathy of Undetermined Significance | Autoinflammatory... and other conditions
HealthTree Foundation
GlaxoSmithKline

Recruiting

MGUS, SMM, and MM Patient Experience With Coronavirus 19 (COVID-19) Survey

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance | Smoldering Multiple Myeloma | Coronavirus

United States
Melissa Bates
Department of Health and Human Services

Recruiting

Sleep Apnea in Patients With MGUS and MM

Multiple Myeloma | Monoclonal Gammopathy of Undetermined Significance

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Observational Prospective Research Study In Monoclonal Gammopathies leadINg to Myeloma

Monoclonal Gammopathy of Undetermined Significance | Smoldering Plasma Cell Myeloma

United States

Clinical Trials on Monoclonal

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