Clinical Trials on Multi-System Atrophy in South Africa

Total 9518 results

Antiva Biosciences

Completed

Study of Topical ABI-1968 in Subjects With Precancerous Cervical Lesions From Human Papillomavirus (HPV) Infection.

Cervical Cancer | Human Papilloma Virus | HSIL, High Grade Squamous Intraepithelial Lesions | Cervical Dysplasia | HSIL of Cervix | High-Grade Cervical Intraepithelial Neoplasia | HIV Negative | CIN - Cervical Intraepithelial Neoplasia | Cervical Neoplasm

South Africa
Novartis Pharmaceuticals

Completed

Safety and Efficacy of Intravenous OAV101 (AVXS-101) in Pediatric Patients With Spinal Muscular Atrophy (SMA) (SMART)

Spinal Muscular Atrophy

Taiwan, Belgium, Canada, United States, Australia, France, Italy, Portugal, United Kingdom
ApoPharma

Completed

Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects

Asymptomatic HIV Infection

South Africa
Boehringer Ingelheim

Completed

Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naïve Pediatric Patients

HIV Infections

South Africa
University of Stellenbosch
Thrasher Research Fund

Unknown

The Effect of Bacille Calmette Guerin (BCG) Vaccination on Immune Responses in HIV-Exposed and Unexposed Infants

HIV Infections

South Africa
International Agency for Research on Cancer
World Health Organization; Cheikh Anta Diop University, Senegal; Walter Sisulu... and other collaborators

Active, not recruiting

The Study for the "Cervical Cancer Screening and Treatment Algorithms Study Using HPV Testing in Africa" (CESTA)

HPV Infection

Senegal, South Africa
Barbara Ensoli, MD
Italian Ministry of Foreign Affairs - Dir. Gen. for Cooperation and Development

Completed

Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients (ISS OBS T-004)

HIV Infection

South Africa
Royal North Shore Hospital

Unknown

Laser Therapy for Vulvovaginal Symptoms in Breast Cancer Patients (LAAVA2)

Vulvovaginal Atrophy | Genitourinary Symptoms and Ill-Defined Conditions

Australia
Global Alliance for TB Drug Development

Completed

Shortening Treatment by Advancing Novel Drugs (STAND)

Tuberculosis, Pulmonary, Drug Sensitive | Tuberculosis, Pulmonary, Multi Drug-resistant

South Africa, Zambia, Georgia, Philippines, Kenya, Malaysia, Tanzania, Uganda
University of Washington
Bill and Melinda Gates Foundation

Completed

Delivery Optimization for Antiretroviral Therapy (The DO ART Study) (DO ART)

HIV | ART

South Africa, Uganda
University of Liverpool
Radboud University Medical Center; University of Cape Town; UNITAID; Liverpool... and other collaborators

Completed

Dolutegravir in Pregnant HIV Mothers and Their Neonates (DolPHIN-2)

Pregnancy Related | HIV-1-infection

Uganda, South Africa
Microbicide Trials Network
National Institute of Allergy and Infectious Diseases (NIAID); Eunice Kennedy... and other collaborators

Completed

Microbicide/PrEP Acceptability Among Mothers and Male Partners in Africa (MAMMA)

HIV Prevention

Malawi, Zimbabwe, South Africa, Uganda
University of Washington
Harvard Medical School (HMS and HSDM); National Institute of Mental Health... and other collaborators

Completed

The Prevention Options for Women Evaluation Research (POWER) Cohort

HIV/AIDS

Kenya, South Africa
Biogen

Active, not recruiting

A Study of Multiple Doses of Nusinersen (ISIS 396443) Delivered to Infants With Genetically Diagnosed and Presymptomatic Spinal Muscular Atrophy (NURTURE)

Spinal Muscular Atrophy

United States, Taiwan, Israel, Australia, Qatar, United Kingdom, Turkey, Italy, Germany, Argentina, Canada
Population Council
United States Agency for International Development (USAID); Bill and Melinda...

Completed

Efficacy Study of the Vaginal Gel Carraguard to Prevent HIV Transmission

HIV Infections | Sexually Transmitted Diseases | AIDS | HIV Seroconversion

South Africa
Hoffmann-La Roche

Completed

An Observational Study of Avastin (Bevacizumab) in First Line in Patients With Metastatic Colorectal Cancer (AVANiS)

Colorectal Cancer

South Africa
Massachusetts General Hospital
National Institute of Mental Health (NIMH); Match Research

Completed

Support for Perinatal Adherence and Depression (INSPireD)

Depression | Human Immunodeficiency Virus

United States, South Africa
University of Liverpool
University of Cape Town; Desmond Tutu HIV Foundation; Infectious Diseases Institute... and other collaborators

Completed

Pharmacokinetics of Atazanavir in Special Populations (VirTUAL WP5)

HIV/AIDS | Tuberculosis

Uganda, South Africa
London School of Hygiene and Tropical Medicine
Imperial College London; University of Sheffield; London School of Economics... and other collaborators

Unknown

TB Reduction Through ART and TB Screening Project (TREATS)

HIV/AIDS | Tuberculosis

South Africa, Zambia
Biogen

Completed

A Study for Participants With Spinal Muscular Atrophy (SMA) Who Previously Participated in Nusinersen (ISIS 396443) Investigational Studies (SHINE)

Spinal Muscular Atrophy

United States, Spain, Germany, United Kingdom, Australia, Japan, Canada, Belgium, France, Hong Kong, Italy, Korea, Republic of, Sweden, Turkey
Aeras
Statens Serum Institut

Completed

A Phase I Study of Safety & Immunogenicity of AERAS-456 in HIV-Neg. Adults Treated for Drug-susceptible Pulmonary TB (C-037-456)

Tuberculosis

South Africa
University of Cape Town

Completed

Linezolid, Aspirin and Enhanced Dose Rifampicin in HIV-TBM (LASER-TBM)

HIV-1-infection | Tuberculosis Meningitis

South Africa
Ionis Pharmaceuticals, Inc.

Withdrawn

Safety and Efficacy of IONIS-FB-Lrx in up to 120 Patients 55 and Older With Geographic Atrophy (GA) Secondary to Age-Related Macular Degeneration (AMD)

Geographic Atrophy | Age Related Macular Degeneration

Australia, United States, New Zealand
University of Cape Town

Completed

the PrEsentation, Rationale and Impact of reperFUSION for Acute Coronary Syndromes in Cape Town and the Garden Route Health District - the PERFUSION Registry (PERFUSION)

Acute Coronary Syndrome | Unstable Angina | ST Elevated Myocardial Infarction | Non ST Elevation Myocardial Infarction

South Africa
University of KwaZulu
King's College London; University of Oxford; University of East Anglia; University... and other collaborators

Recruiting

ENHANCE-EvideNce Led Co-created HeAlth Systems interventioNs for MLTCs CarE (ENHANCE)

Depression | Myocardial Infarction | HIV Infections | Stroke | Hypertension | Diabetes Mellitus | Asthma

South Africa
ONL Therapeutics

Completed

ONL1204 Ophthalmic Solution in Patients With Geographic Atrophy Associated With Age-related Macular Degeneration

Geographic Atrophy

New Zealand, Australia
Allergan

Completed

Safety and Efficacy of Brimonidine Intravitreal Implant in Patients With Geographic Atrophy Due to Age-related Macular Degeneration (AMD)

Macular Degeneration

Korea, Republic of, Australia, Portugal, Germany, United States, Philippines, Italy
Medtronic BRC

Terminated

Model 20105 Lead Study

Sick Sinus Node Syndrome

South Africa, Netherlands, Canada, Singapore
University of Cape Town
Uppsala University; Liverpool School of Tropical Medicine; University of North...

Completed

Optimal Dosing of 1st Line Antituberculosis and Antiretroviral Drugs in Children (a Pharmacokinetic Study) (DATiC)

HIV | Tuberculosis

South Africa, Malawi
Biogen

Terminated

A Study to Assess the Efficacy and Safety of Nusinersen (ISIS 396443) in Infants With Spinal Muscular Atrophy (ENDEAR)

Spinal Muscular Atrophy

Korea, Republic of, United States, Spain, Canada, Germany, Australia, Japan, Sweden, Belgium, France, Italy, Turkey, United Kingdom
Eastern Virginia Medical School
University of Pittsburgh; United States Agency for International Development... and other collaborators

Recruiting

Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert

Safety Issues

United States, Kenya, South Africa
Prosidion Ltd.

Completed

A PK-PD Study of PSN821 in Type 2 Diabetes Patients (T2DM)

Type 2 Diabetes Mellitus

South Africa
Prasco LLC

Completed

Study to Evaluate the Equivalence of Estradiol Vaginal Cream to Reference Standard in the Treatment of Vaginal Atrophy

Vulvar and Vaginal Atrophy

United States
Novartis

Completed

Safety and Tolerability of Omalizumab in Patients With Mild to Moderate Asthma

Asthma

Germany, South Africa
Pfizer

Completed

A Safety and Efficacy Study of Two Dose Levels of Taliglucerase Alfa in Pediatric Subjects With Gaucher Disease

Gaucher Disease

Israel, South Africa, Paraguay
Janssen Infectious Diseases BVBA

Withdrawn

A Study to Evaluate the Efficacy and Safety of TMC207 in Patients With Pulmonary Infection With Multi-drug Resistant Mycobacterium Tuberculosis

Multi-drug Resistant Tuberculosis

China, Ukraine, Taiwan, Korea, Republic of, Peru, Brazil, Estonia, Latvia, Philippines, Russian Federation, South Africa, Thailand, Turkey, Georgia, Mexico, Cambodia, Ethiopia
AveXis, Inc.
United BioSource, LLC

Recruiting

Registry of Patients With a Diagnosis of Spinal Muscular Atrophy (SMA)

Spinal Muscular Atrophy (SMA)

Japan, United States, Korea, Republic of, Israel, Greece, Ireland, Portugal, Russian Federation, Taiwan
Michael Hoelscher
Radboud University Medical Center; University College, London; University of...

Recruiting

BTZ-043 Dose Evaluation in Combination and Selection (DECISION)

Tuberculosis, Pulmonary | Other Specified Pulmonary Tuberculosis

South Africa, Tanzania
DS Biopharma

Completed

Efficacy and Safety Study of Orally Administered DS107 in Moderate to Severe Atopic Dermatitis Patients

Atopic Dermatitis

United States, South Africa
FHI 360
United States Agency for International Development (USAID); Makerere University and other collaborators

Completed

Interactions Between Antiretrovirals (ARVs) and Combined Oral Contraceptives (COCs)

HIV Infections | HIV/AIDS

South Africa, Uganda
Emory University

Completed

Comprehensive HIV Prevention Package for MSM in Southern Africa: Pilot Study (Sibanye Health Project)

HIV

United States, South Africa
AstraZeneca

Completed

Efficacy and Safety of Roflumilast Taken in the Morning or Evening in Patients With Stable Asthma (12 to 70 y) (BY217/M2-015)

Asthma

France, South Africa, Spain, Australia, Belgium
Boehringer Ingelheim

Completed

A Study of Single Dose Nevirapine (NVP) Combined With Combivir® for the Prevention of Mother to Child Transmission (pMTCT) - Treatment Options Preservation Study (TOPS)

Acquired Immunodeficiency Syndrome

South Africa
Aeras
National Institute of Allergy and Infectious Diseases (NIAID); Sanofi Pasteur... and other collaborators

Completed

Phase 1/II, Safety and Immunogenicity Study of AERAS-404 in BCG-Primed Infants (C-015-404)

Tuberculosis

South Africa
HIV Vaccine Trials Network

Completed

Safety of and Immune Response to Vaccination With 2 Experimental HIV Vaccines in Healthy Adults (HVTN 097)

HIV Infection

South Africa
AIDS Malignancy Consortium
National Cancer Institute (NCI); University of Arkansas; The Emmes Company, LLC; University of Stellenbosch

Withdrawn

Testing the Addition of Paclitaxel and Carboplatin Given After Standard Chemotherapy and Radiation for Cervical Cancer in HIV-positive Women

HIV Infection | Cervical Adenocarcinoma | Cervical Adenosquamous Carcinoma | Cervical Squamous Cell Carcinoma, Not Otherwise Specified | FIGO Stage IIB Cervix Carcinoma | FIGO Stage III Cervix Carcinoma | FIGO Stage IVA Cervix Carcinoma

South Africa, Zimbabwe
Massachusetts General Hospital
Bill and Melinda Gates Foundation; Mbarara University of Science and Technology and other collaborators

Completed

Examining HIV Treatment Adherence During Early Disease (META)

HIV | Medication Adherence

South Africa, Uganda
National Institute of Allergy and Infectious Diseases...

Completed

Safety, Tolerability and Acceptability of Long-Acting Cabotegravir (CAB LA) for the Prevention of HIV Among Adolescent Females - A Sub-study of HPTN 084

HIV Infections

Zimbabwe, South Africa, Uganda
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

PanACEA Sutezolid Dose-finding and Combination Evaluation (SUDOCU)

Pulmonary Tuberculosis | Other Specified Pulmonary Tuberculosis

South Africa, Tanzania
Medical University of Graz
Lagos State University; Walter Sisulu University; Management Sciences for Health and other collaborators

Enrolling by invitation

Effects of COVID-19 on Endothelium in HIV-Positive Patients in Sub-Saharan Africa (ENDOCOVID)

Covid19 | Hiv | ART

Nigeria, South Africa

Clinical Trials on Multi-System Atrophy in South Africa

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mali

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations