Clinical Trials on Multiple Chronic Conditions

Total 439766 results

Nantes University Hospital

Not yet recruiting

Premorbid Personality Profile of Patients With Cognitive and Behavioral Disorders

Bipolar Disorder | Behavioral Variant of Frontotemporal Disorder (bvFTD) | Phenocopy Frontotemporal Dementia (phFTD) | Frontal Variant of Alzheimer Disease
Chongqing Precision Biotech Co., Ltd
Zhejiang University

Recruiting

A Clinical Trial Targeting CEA Chimeric Antigen Receptor T (CAR-T) for CEA Positive Advanced Malignant Solid Tumors

Breast Cancer | Gastric Cancer | Colorectal Cancer | Bile Duct Cancer | Non-small Cell Lung Cancer | Pancreas Cancer | Esophagus Cancer

China
Fred Hutchinson Cancer Center
Affini-T Therapeutics, Inc.

Recruiting

Autologous CD8+ and CD4+ Transgenic T Cells Expressing High Affinity KRASG12V Mutation-Specific T Cell Receptors (FH-A11KRASG12V-TCR) in Treating Patients With Metastatic Pancreatic, Colorectal and Non-Small Cell Lung Cancers With KRAS G12V Mutations

Metastatic Lung Non-Small Cell Carcinoma | Stage IV Pancreatic Cancer AJCC v8 | Metastatic Pancreatic Adenocarcinoma | Metastatic Colorectal Adenocarcinoma | Stage IV Lung Cancer AJCC v8 | Stage IV Colorectal Cancer AJCC v8

United States
Phio Pharmaceuticals Inc.
Prosoft Clinical

Recruiting

Intratumoral PH-762 for Cutaneous Carcinoma

Squamous Cell Carcinoma of the Skin | Malignant Melanoma of Skin | Merkel Cell Carcinoma of Skin

United States
First Affiliated Hospital Xi'an Jiaotong University
General Hospital of Ningxia Medical University; Second Affiliated Hospital... and other collaborators

Not yet recruiting

Prognosis Prediction System of Patients With Cardiovascular and Cerebrovascular Diseases Based on Multi-omics (PROSPECT)

Coronary Artery Disease | Hypertension | Arrhythmias, Cardiac | Heart Valve Diseases | Brain Neoplasms | Myocarditis | Cardiomyopathies | Aortic Dissection | Structural Heart Disease | Heart Neoplasms | Ischemic Cerebrovascular Disease | Hemorrhagic Cerebrovascular Disease

China
Johns Hopkins Bloomberg School of Public Health
Massachusetts General Hospital; Mayo Clinic; National Institute of Diabetes and... and other collaborators

Not yet recruiting

Gastroparesis Registry 4 (GpR4)

Gastroparesis | Gastro-Intestinal Disorder | Gastroparesis Due to Diabetes Mellitus Type I | Gastroparesis Nondiabetic | Gastroparesis Due to Diabetes Mellitus Type II | Functional Disorder of Gastrointestinal Tract

United States
Medical University of South Carolina
National Cancer Institute (NCI)

Recruiting

Multi-Site Trial of Navigation vs Treatment as Usual for Delays in Starting Adjuvant Therapy (ENDURE)

Head and Neck Cancer | Head and Neck Squamous Cell Carcinoma | Oropharynx Cancer | Oral Cavity Cancer | Larynx Cancer

United States
Medical University of South Carolina

Recruiting

Hypothermia's Effect on Hepatitis B Vaccination

Hepatitis B Vaccination | Hypoxic-Ischemic Encephalopathy | Hypothermia, Newborn

United States
University Hospital Inselspital, Berne

Recruiting

MRI-markers to Monitor Small Vessel Disease Dynamics in the Prognosis of Small Vessel Disease-associated, Cerebrovascular Events (MRI-PRO-SVD)

Cerebral Small Vessel Diseases | Intracerebral Hemorrhage | CAA - Cerebral Amyloid Angiopathy

Switzerland
Seattle Children's Hospital

Recruiting

Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma | Refractory Primary Malignant Central Nervous System Neoplasm | Recurrent CNS Tumor, Adult | Recurrent, CNS Tumor, Childhood

United States
University of Texas at Austin
Hospital Clinic of Barcelona; Fundació Institut de Recerca de l'Hospital de...

Recruiting

Cognitive Reserve and Response to Speech-Language Intervention in Bilingual Speakers With Primary Progressive Aphasia

Neurocognitive Disorders | Neurodegenerative Diseases | Dementia | Alzheimer Disease | Language Disorders | Communication Disorders | Primary Progressive Aphasia | Aphasia | Speech Disorders | Frontotemporal Lobar Degeneration | Dysarthria | Apraxia, Motor | Dementia, Frontotemporal | Bilingual Aphasia

Spain, United States
Institut National de la Santé Et de la Recherche...
Centre Hospitalier Universitaire de Nice

Not yet recruiting

CHronic Hepatopathies Associated With ALcohol Consumption aNd metAbolic Syndrome (CHALNA2)

Hepatocellular Carcinoma | Cirrhosis, Liver | Non-Alcoholic Fatty Liver Disease | Non-Alcoholic Steatohepatitis | Alcohol-related Liver Disease
Molnlycke Health Care AB

Recruiting

A Clinical Investigation to Follow the Progress of Exuding Chronic Wounds Using Mepilex® Up as the Primary Dressing.

Diabetic Foot Ulcer | Wound; Foot | Venous Leg Ulcer | Wounds | Wound of Skin | Wound Leg

United States
ETOP IBCSG Partners Foundation
USZ Foundation

Recruiting

Immunotherapy or Targeted Therapy With or Without Stereotactic Radiosurgery for Patients With Brain Metastases From Melanoma or Non-small Cell Lung Cancer (USZ-STRIKE)

Melanoma | Non-Small Cell Lung Cancer

Switzerland, Netherlands, Italy, United Kingdom
Fondazione IRCCS Istituto Nazionale dei Tumori,...
Ministry of Health, Italy; European Union; Alleanza Contro il Cancro; Associazione...

Recruiting

The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)

Head and Neck Cancer | Nasopharynx Cancer | Salivary Gland Cancer | Nasal Cavity and Paranasal Sinus Cancer | Middle Ear Carcinoma

Italy, Germany, Czechia, France, Spain
University Hospital, Limoges

Recruiting

Acceptability of Simultaneous Screening for Viral Hepatitis B, C and HIV Among Drug Users in Non-conventional Structures (SCANVIR)

Hepatitis C | Hepatitis C Virus Infection, Response to Therapy of | Addiction, Alcohol | Addiction Opiate | Transmission, Intravenous Drug Abuser

France
Iovance Biotherapeutics, Inc.

Recruiting

A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer

Metastatic Melanoma | Unresectable Melanoma | Stage IV Non-small Cell Lung Cancer | Stage III Non-small Cell Lung Cancer

United States
Medical University of Bialystok
University of Bialystok

Recruiting

Diffusion Weighted Magnetic Resonance Imaging and the Optic Nerve Neuropathy.

Optic Neuritis | Ischemic Optic Neuropathy | Traumatic Optic Neuropathy | Toxic Optic Neuropathy | Compressive Optic Neuropathy | Hereditary Optic Neuropathies

Poland
National Cancer Institute (NCI)

Recruiting

Testing of Tazemetostat in Combination With Topotecan and Pembrolizumab in Patients With Recurrent Small Cell Lung Cancer

Extensive Stage Lung Small Cell Carcinoma | Limited Stage Lung Small Cell Carcinoma | Platinum-Resistant Lung Small Cell Carcinoma | Platinum-Sensitive Lung Small Cell Carcinoma | Recurrent Lung Small Cell Carcinoma

United States
Seoul National University Hospital

Recruiting

SeOuL cOhort of Brain Tumor MONitoring Study (SOLOMON) (SOLOMON)

Pituitary Adenoma | Meningioma | Schwannoma | Brain Tumor, Primary | Gliomas Benign

Korea, Republic of
Instituto para el Desarrollo Biotecnológico y la...
Corporación de Fomento de la Producción, Chile

Recruiting

Cell Therapy for Diabetic Foot Ulcer

Wound Heal | Diabetic Foot Ulcer Associated With Type II Diabetes Mellitus

Chile
University of British Columbia
Vancouver Coastal Health Research Institute; Genome British Columbia

Recruiting

Advancing Cardiac Care Unit-based Rapid Assessment and Treatment of hypErcholesterolemia (ACCURATE)

Acute Coronary Syndrome | Familial Hypercholesterolemia | STEMI | NSTEMI - Non-ST Segment Elevation MI | Familial Hypercholesterolemia - Heterozygous | Familial Hypercholesterolemia Due to Genetic Defect of Apolipoprotein B | Familial Hypercholesterolemia Due to Heterozygous LDL Receptor Mutation and other conditions

Canada
Ohio State University Comprehensive Cancer Center
National Cancer Institute (NCI)

Recruiting

A Video Intervention to Improve Patient Understanding of Tumor Genomic Testing in Patients With Metastatic Cancer

Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Anatomic Stage IV Breast Cancer AJCC v8 | Prognostic Stage IV Breast Cancer AJCC v8 | Metastatic Lung Carcinoma | Stage IV Lung Cancer AJCC v8 | Metastatic Malignant Solid Neoplasm | Metastatic Breast Carcinoma

United States
Viracta Therapeutics, Inc.

Recruiting

Nanatinostat Plus Valganciclovir in Patients With Advanced EBV+ Solid Tumors, and in Combination With Pembrolizumab in EBV+ RM-NPC

Nasopharyngeal Carcinoma | EBV-Related Gastric Carcinoma | EBV-Related Leiomyosarcoma | EBV Related Carcinoma | EBV-Related Sarcoma

United States, Hong Kong, Taiwan, Korea, Republic of, Singapore, Australia, Canada, Malaysia
VA Office of Research and Development

Recruiting

OSA PAP Treatment for Veterans With SUD and PTSD on Residential Treatment Unit

Obstructive Sleep Apnea | Substance Use Disorder | Post Traumatic Stress Disorder | Residential Treatment Program

United States
Poxel SA

Not yet recruiting

Study to Assess PXL770 in Subjects With Adrenomyeloneuropathy (AMN) Form of X-linked Adrenoleukodystrophy (X-ALD or ALD)

Adrenomyeloneuropathy
Hadassah Medical Organization

Recruiting

A Study to Evaluate the Efficacy of Osimertinib With Early Intervention SRS Treatment Compared to the Continuation of Osimertinib Alone, in Patients With EGFR Mutated NSCLC and Asymptomatic Brain Metastases

NSCLC | Non-small Cell Lung Cancer | EGF-R Positive Non-Small Cell Lung Cancer | Brain Metastases | EGFR Gene Mutation

Israel
University of California, San Francisco
National Institute of Neurological Disorders and Stroke (NINDS); The Chad-Tough... and other collaborators

Recruiting

Combination Therapy for the Treatment of Diffuse Midline Gliomas

Diffuse Intrinsic Pontine Glioma | Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Diffuse Midline Glioma, H3 K27M-Mutant | Recurrent WHO Grade III Glioma | WHO Grade III Glioma

United States, Netherlands, Israel, Australia, New Zealand, Switzerland
Balt Extrusion

Recruiting

Safety, Performance and Usability of BALT Medical Devices: The EVIDENCE Post Marketing Clinical Follow-up Platform

Peripheral Vascular Diseases | Acute Ischemic Stroke | Intracranial Aneurysm | AVM | AVM - Cerebral Arteriovenous Malformation | Brain Arterial Disease

France, Spain
Baylor College of Medicine
Children's National Research Institute

Recruiting

Hepatic Histopathology in Urea Cycle Disorders

Ornithine Transcarbamylase Deficiency | Urea Cycle Disorder | Carbamyl Phosphate Synthetase Deficiency | Argininosuccinic Aciduria | Hyperargininemia | Citrullinemia 1 | ARGI Deficiency | ASL Deficiency | ASS Deficiency | NAGS Deficiency

United States
SWOG Cancer Research Network
National Cancer Institute (NCI)

Recruiting

A Study to Compare the Administration of Encorafenib + Binimetinib + Nivolumab Versus Ipilimumab + Nivolumab in BRAF-V600 Mutant Melanoma With Brain Metastases

Metastatic Melanoma | Metastatic Cutaneous Melanoma | Acral Lentiginous Melanoma | Clinical Stage IV Cutaneous Melanoma AJCC v8 | Pathologic Stage IV Cutaneous Melanoma AJCC v8 | Metastatic Malignant Neoplasm in the Brain | Metastatic Mucosal Melanoma

United States
Udai Kammula

Recruiting

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Sarcoma | Gastric Cancer | Colorectal Cancer | Pancreatic Cancer | Neuroendocrine Tumors | Mesothelioma | Merkel Cell Carcinoma | Microsatellite Instability | Squamous Cell Cancer | Mismatch Repair Deficiency

United States
Loxo Oncology, Inc.
Eli Lilly and Company

Recruiting

A Study of Oral LOXO-292 (Selpercatinib) in Pediatric Participants With Advanced Solid or Primary Central Nervous System (CNS) Tumors (LIBRETTO-121)

Soft Tissue Sarcoma | Medullary Thyroid Cancer | Papillary Thyroid Cancer | Infantile Fibrosarcoma | Infantile Myofibromatosis

United States, Australia, Japan, Canada, Germany, Korea, Republic of, France, Spain, United Kingdom, Denmark, Italy
Masonic Cancer Center, University of Minnesota

Recruiting

Adrenoleukodystrophy National Registry Study

Cerebral Adrenoleukodystrophy | Adrenoleukodystrophy | ALD (Adrenoleukodystrophy)

United States
Shanghai Mental Health Center

Recruiting

The China Longitudinal Aging Study of Cognitive Impairment

Depression | Anxiety | Alzheimer Disease | Mild Cognitive Impairment | Dementia, Vascular | Dementia With Lewy Bodies | Dementia Frontal

China
M.D. Anderson Cancer Center

Recruiting

Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pulmonary Nodules, the IMPRINT-Lung Study

Lung Non-Small Cell Carcinoma | Stage II Lung Cancer AJCC v8 | Stage IIA Lung Cancer AJCC v8 | Stage IIB Lung Cancer AJCC v8 | Stage I Lung Cancer AJCC v8 | Stage IA1 Lung Cancer AJCC v8 | Stage IA2 Lung Cancer AJCC v8 | Stage IA3 Lung Cancer AJCC v8 | Stage IB Lung Cancer AJCC v8

United States
Myotonic Dystrophy Foundation

Recruiting

Myotonic Dystrophy Family Registry (MDFR)

Myotonic Dystrophy | Myotonic Dystrophy 1 | Steinert's Disease | Congenital Myotonic Dystrophy | PROMM (Proximal Myotonic Myopathy) | Steinert Disease | Dystrophia Myotonica 1 | Myotonic Dystrophy 2 | Dystrophia Myotonica | Dystrophia Myotonica 2 | Myotonia Dystrophica | Myotonic Dystrophy, Congenital | Myotonic... and other conditions

United States
Barts & The London NHS Trust

Recruiting

Genetics of Endocrine Tumours - Familial Isolated Pituitary Adenoma - FIPA

Acromegaly | Gigantism | Familial Isolated Pituitary Adenoma | FIPA | Pituitary Adenoma Predisposition | PAP

United Kingdom
National Cancer Institute (NCI)

Active, not recruiting

Riluzole and Sorafenib Tosylate in Treating Patients With Advanced Solid Tumors or Melanoma

Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Advanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | Recurrent Melanoma | Stage IIIC Cutaneous Melanoma AJCC v7 | Stage IIIA Cutaneous Melanoma AJCC v7 | Stage IIIB Cutaneous Melanoma AJCC v7

United States
National Cancer Institute (NCI)

Completed

Transformation of Plexiform Neurofibromas to Malignant Peripheral Nerve Sheath Tumors in Neurofibromatosis Type 1

Neurofibromatosis | MPNST

United States
National Cancer Institute (NCI)

Active, not recruiting

Paclitaxel With or Without Cixutumumab as Second-Line Therapy in Treating Patients With Metastatic Esophageal Cancer or Gastroesophageal Junction Cancer

Recurrent Esophageal Carcinoma | Metastatic Gastroesophageal Junction Adenocarcinoma | Stage IV Esophageal Cancer AJCC v7 | Metastatic Esophageal Squamous Cell Carcinoma | Metastatic Esophageal Adenocarcinoma | Recurrent Gastroesophageal Junction Adenocarcinoma | Recurrent Esophageal Adenocarcinoma and other conditions

United States
National Cancer Institute (NCI)

Active, not recruiting

Veliparib With or Without Radiation Therapy, Carboplatin, and Paclitaxel in Patients With Stage III Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Lung Adenocarcinoma | Lung Large Cell Carcinoma | Stage IIIA Lung Non-Small Cell Cancer AJCC v7 | Minimally Invasive Lung Adenocarcinoma | Stage IIIB Lung Non-Small Cell Cancer AJCC v7 | Stage III Lung Non-Small Cell Cancer AJCC v7 | Lung Squamous Cell Carcinoma | Lung Adenocarcinoma, Mixed Subtype

United States
NRG Oncology
National Cancer Institute (NCI)

Active, not recruiting

Reduced-Dose Intensity-Modulated Radiation Therapy With or Without Cisplatin in Treating Patients With Advanced Oropharyngeal Cancer

Tongue Carcinoma | Stage IVA Oropharyngeal Squamous Cell Carcinoma | Stage IVB Oropharyngeal Squamous Cell Carcinoma | Stage IVC Oropharyngeal Squamous Cell Carcinoma | Stage III Oropharyngeal Squamous Cell Carcinoma

United States, Canada, Saudi Arabia, Ireland
National Heart, Lung, and Blood Institute (NHLBI)

Completed

CADASIL Disease Discovery

Cardiovascular Disease | Arterial Stiffness | Germline Mutation in the NOTCH 3 Gene | Pathogenesis of CADASIL | Clinical Phenotype of CADASIL

United States
Pfizer

Terminated

A FIH Study of PF-07284890 in Participants With BRAF V600 Mutant Solid Tumors With and Without Brain Involvement

Carcinoma, Non-Small-Cell Lung | Brain Neoplasms | Malignant Melanoma | Brain Neoplasms, Primary | Malignant Neoplasms

United States, Canada, Israel
National Cancer Institute (NCI)

Active, not recruiting

Berzosertib and Irinotecan in Treating Patients With Progressive, Metastatic, or Unresectable TP53 Mutant Gastric or Gastroesophageal Junction Cancer

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction... and other conditions

United States
Karolinska Institutet

Enrolling by invitation

Age Related Differences in Respiratory Immune Responses in Influenza Virus Infection (NPA-DC)

RSV Infection | SARS CoV 2 Infection | Influenza B Virus Infection | Influenza A Infection

Sweden
University of Southern Denmark
Odense University Hospital; University of Copenhagen; Region of Southern Denmark and other collaborators

Active, not recruiting

LIFE - Lung Cancer, Immunotherapy, Frailty, Effect

Quality of Life | Venous Thromboembolism | Non-small Cell Lung Cancer | Brain Metastases

Denmark
Shire

Completed

An Extension Study of HGT-HIT-045 Evaluating Long-Term Safety and Clinical Outcomes of Idursulfase-IT in Conjunction With Elaprase in Pediatric Participants With Hunter Syndrome and Cognitive Impairment

Hunter Syndrome

United States, United Kingdom, Canada
Michael M. Pham

Terminated

A Study to Evaluate the Safety and Tolerability of Oral Ixazomib in Scleroderma-related Lung Disease Patients

Systemic Sclerosis | Scleroderma, Systemic | Scleroderma, Diffuse | Diffuse Cutaneous Systemic Sclerosis | Interstitial Lung Disease | Scleroderma | Systemic Sclerosis, Diffuse | Diffuse Systemic Sclerosis | Pulmonary Fibrosis Interstitial | Diffuse Scleroderma | Diffuse Cutaneous Scleroderma | Progressive Systemic... and other conditions

United States

Clinical Trials on Multiple Chronic Conditions

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Medical Conditions

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CROs in Benin

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Rare Diseases

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