Clinical Trials on Neuroinflammatory Response

Total 3808 results

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Recruiting

Radiomics Markers to Predict Sepsis Induced Acute Respiratory Distress Syndrome

Early Prediction for Sepsis Induced Acute Lung Injury

China
AstraZeneca

Active, not recruiting

Safety, Tolerability & Potential Anti-cancer Activity of Increasing Doses of AZD5363 in Different Treatment Schedules

Cervical Cancer | Ovarian Cancer | Pharmacokinetics | Endometrial Cancer | Pharmacodynamics | Safety and Tolerability | Advanced Solid Malignancy | Tumour Response | Advanced or Metastatic Breast Cancer | PIK3CA | AKT1 | PTEN | ER Positive | HER2 Positive

United States, Italy, Canada, France, Japan, United Kingdom, Spain, Netherlands, Denmark, Singapore
University Hospital, Clermont-Ferrand

Completed

Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients

Septic Shock | Acute Respiratory Distress Syndrome | Acute Lung Injury | Severe Sepsis | Mechanical Ventilation

France
Indian Council of Medical Research
King George's Medical University; Lady Hardinge Medical College; King Edward... and other collaborators

Not yet recruiting

Selective Antibiotics When Symptoms Develop Versus Universal Antibiotics for Preterm Neonates (SAUNA)

Sepsis | Preterm Birth | Preterm Premature Rupture of Membrane | PROM, Preterm (Pregnancy) | Early-Onset Neonatal Sepsis

India
MEDSI Clinical Hospital 1, ICU

Recruiting

Efficacy and Safety of Selective Digestive Decontamination in the ICU With High Rates of Antibiotic-resistant Bacteria

Respiratory Tract Infections | Pneumonia | Sepsis | Critical Illness | Respiratory Distress Syndrome | Pneumonia, Ventilator-Associated | Bloodstream Infection

Russian Federation
Uppsala University
Uppsala University Hospital

Recruiting

Follow-up of Critical COVID-19 Patients (FUP-COVID)

Inflammatory Response | AKI | Coagulation Disorder | ARDS | COVID19 | Circulatory Failure

Sweden
Unity Health Toronto
Boston University; Centre for Addiction and Mental Health; University of Toronto and other collaborators

Completed

Digital Interventions to Understand and Mitigate Stress Response

Distress, Emotional | Stress Reaction; Acute | Stress Response Among Nursing Professionals During the COVID-19

Canada
Christian Hassager

Completed

Steroid Treatment After Resuscitated Out-of-Hospital Cardiac Arrest (STEROHCA)

Systemic Inflammatory Response Syndrome | Cardiac Arrest | Out-Of-Hospital Cardiac Arrest | Neurological Injury | Cardiac Arrest With Successful Resuscitation | Post Cardiac Arrest Syndrome

Denmark
Xinhua Hospital, Shanghai Jiao Tong University...

Unknown

Effect of R-spondin3 on Sepsis Induced Endothelial Dysfunction

Acute Respiratory Distress Syndrome (ARDS) | Acute Lung Injury (ALI)

China
Tehran University of Medical Sciences
RojanPharma Pharmaceutical Company

Completed

Sofosbuvir and Daclatasvir for Treating Hepatitis C in 200 Patients Co-infected With Human Immunodeficiency Virus (HIV200)

Human Immunodeficiency Virus | Hepatitis C Virus Infection, Response to Therapy of

Iran, Islamic Republic of
Jack Khouri

Not yet recruiting

Siltuximab for Cytokine Release Syndrome Prophylaxis Prior to tx w/ Teclistamab in RRMM

Multiple Myeloma | Refractory Multiple Myeloma | Cytokine Release Syndrome | Immune Effector Cell Associated Neurotoxicity Syndrome

United States
Rempex (a wholly owned subsidiary of Melinta Therapeutics...

Completed

Study of Cases of Serious Infections Due to Carbapenem-Resistant Enterobacteriaceae

Bacteremia | Acute Pyelonephritis | Ventilator-associated Bacterial Pneumonia | Hospital Acquired Bacterial Pneumonia | Urinary Tract Infection, Complicated

Italy, United States, Greece, United Kingdom
National Taiwan University Hospital

Completed

Generic VEL/SOF With or Without RBV for HIV/HCV Coinfected Patients

Human Immunodeficiency Virus | Hepatitis C Virus Infection, Response to Therapy of

Taiwan
Chang Gung Memorial Hospital

Unknown

EVLWI Exhibits Pulmonary and Systemic Permeability in Sepsis Related ALI/ARDS

Sepsis Related Acute Lung Injury/Acute Respiratory Distress Syndrome

Taiwan
Mahidol University

Completed

Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)

Septic Shock | Acute Respiratory Distress Syndrome | Acute Lung Injury | Severe Sepsis

Thailand
University of California, Los Angeles

Unknown

Cysteine Supplementation in Critically Ill Neonates

Sepsis | Systemic Inflammatory Response Syndrome | Necrotizing Enterocolitis | Retinopathy of Prematurity | Bronchopulmonary Dysplasia

United States
Duke University
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Active, not recruiting

Vestibulodynia: Understanding Pathophysiology and Determining Appropriate Treatments

Back Pain | Irritable Bowel Syndrome | Endometriosis | Interstitial Cystitis | Chronic Fatigue Syndrome | Temporomandibular Disorder | Fibromyalgia Syndrome | Vestibulodynia | Migraines | Tension Headache

United States
Tongji Hospital
Nanjing IASO Biotechnology Co., Ltd.

Recruiting

Safety and Efficacy of CT103A Cells for Relapsed/Refractory Antibody-associated Inflammatory Diseases of the Nervous System (CARTinNS)

Multiple Sclerosis | Autoimmune Diseases of the Nervous System | Autoimmune Diseases | Myasthenia Gravis | Neuromyelitis Optica Spectrum Disorder | Autoimmune Encephalitis | Idiopathic Inflammatory Myopathies | Chronic Inflammatory Demyelinating Polyradiculoneuropathy | Myelin Oligodendrocyte Glycoprotein... and other conditions

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Cytotoxic T Lymphocytes in Treating Patients With Malignancies With BK and/or JC Virus

Acquired Immunodeficiency Syndrome | BK Virus Infection | Merkel Cell Carcinoma | Human Immunodeficiency Virus | Malignant Neoplasm | JC Virus Infection | Merkel Cell Polyomavirus Infection | Viral Encephalitis

United States
Cook County Health
Centers for Disease Control and Prevention; Sage Products, Inc.

Completed

Skin Cleansing With Chlorhexidine to Decrease Hospital Acquired Infections

Pneumonia | Sepsis | Bacteremia | Urinary Tract Infection | Nosocomial Infection | Clostridium Infection

United States
University of Pecs

Completed

Presepsin:Gelsolin Ratio in Sepsis-related Organ Dysfunction

Sepsis | Septic Shock | Acute Respiratory Distress Syndrome | Acute Kidney Injury Due to Sepsis

Hungary
Shionogi

Completed

Study of Cefiderocol (S-649266) or Best Available Therapy for the Treatment of Severe Infections Caused by Carbapenem-resistant Gram-negative Pathogens (CREDIBLE - CR)

Sepsis | Bloodstream Infections (BSI) | Hospital Acquired Pneumonia (HAP) | Complicated Urinary Tract Infection (cUTI) | Healthcare-associated Pneumonia (HCAP) | Ventilator Associated Pneumonia (VAP)

United States, Brazil, Croatia, France, Germany, Greece, Guatemala, Israel, Italy, Japan, Korea, Republic of, Spain, Taiwan, Thailand, Turkey, United Kingdom
Hellenic Institute for the Study of Sepsis
European Commission

Completed

Benefit of Clarithromycin in Patients With Severe Infections Through Modulation of the Immune System (INCLASS)

Pneumonia | Sepsis | Mortality | Biomarkers | Respiratory Distress Syndrome | Multiple Organ Failure | Gram-Negative Bacteria Infection

Greece, Belgium
Wake Forest University Health Sciences

Withdrawn

Telemedicine for Early Detection of Cytokine Release Syndrome and Neurotoxicity

Follicular Lymphoma | Diffuse Large B Cell Lymphoma | High-grade B-cell Lymphoma | Primary Mediastinal Large B Cell Lymphoma | Large B-cell Lymphoma
Central Hospital, Nancy, France

Unknown

Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery (RELASTANCE)

Shock, Septic | Aortic Stenosis | Oliguria | Aortic Aneurysm, Abdominal | Hyperlactatemia | Aortic Aneurysm, Ruptured

France
Ain Shams University

Recruiting

Assessment Of Dose-Dependent Immunomodulatory Effect Of Alveofact With or Without Steroisd In Neonatal RDS

Inflammatory Response | Preterm Birth | Premature Lungs | Neonatal Respiratory Distress Syndrome | Neutrophil Extracellular Trap Formation

Egypt
Croatian Society for Organ Support
Clinical Hospital Centre Zagreb

Recruiting

European Registry for Hemadsorption in Sepsis With the Seraph Filter

Sepsis | Systemic Inflammatory Response Syndrome | Disease | Critical Illness | Acute Respiratory Distress Syndrome | Multi Organ Failure | Infections - Pathogen Unspecified

Croatia
Marc Dall'Era, MD
National Cancer Institute (NCI); Janssen, LP

Recruiting

Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects

BRCA1 Gene Mutation | BRCA2 Gene Mutation | Prostate Carcinoma | RAD51C Gene Mutation | BRIP1 Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | CDK12 Gene Mutation | CHEK1 Gene Mutation | DNA Damage Response Gene Mutation | DNA Repair Gene Mutation | FANCA Gene Mutation and other conditions

United States
University of Ulm

Recruiting

Monocyte Profiles in Critically Ill Patients With Pseudomonas Aeruginosa Sepsis (MIPSA)

Sepsis | Critically Ill | Pseudomonas Infections | Sepsis, Severe | Pseudomonas Septicemia | Pseudomonas; Pneumonia | Pseudomonal Bacteraemia | Pseudomonas Urinary Tract Infection | Pseudomonas Gastrointestinal Tract Infection

Germany
Onze Lieve Vrouwe Gasthuis
Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Active, not recruiting

Parental Participation on the Neonatal Ward - the neoPARTNER Study (neoPARTNER)

Infant, Premature, Diseases | Premature Birth | Parent-Child Relations | Parents | Infant, Newborn, Disease | Prematurity | Neonatal Hyperbilirubinemia | Infant Development | Neonatal Infection | Premature | Neonatal Sepsis | Infant, Small for Gestational Age | Maternal Distress | Perinatal Problems | Small for Gestational...

Netherlands
Karolinska Institutet
University of California, San Diego; The Swedish Research Council; University... and other collaborators

Terminated

Safety and Efficacy of Hyperbaric Oxygen for ARDS in Patients With COVID-19 (COVID-19-HBO)

COVID-19 | Cytokine Storm | SARS (Severe Acute Respiratory Syndrome) | Acute Respiratory Failure | ARDS, Human | Sars-CoV2

Sweden, Germany
Indiana University
National Heart, Lung, and Blood Institute (NHLBI); University of California... and other collaborators

Enrolling by invitation

SHADES Mechanistic Trial (SHADES)

Heart Diseases | Cardiovascular Diseases | Coronary Artery Disease | Stroke | Sleep Disorder | Insomnia | Sleep Disturbance | Metabolic Disease | Autonomic Dysfunction | Insomnia Chronic | Systemic Inflammatory Response | Insomnia, Primary

United States
Washington University School of Medicine
National Cancer Institute (NCI); Incyte Corporation; American Society of Hematology

Active, not recruiting

Study of Itacitinib for the Prophylaxis of Graft-Versus-Host Disease and Cytokine Release Syndrome After T-cell Replete Haploidentical Peripheral Blood Hematopoietic Cell Transplantation

Myelodysplastic Syndromes | Hodgkin Disease | Non-Hodgkin Lymphoma | Acute Lymphocytic Leukemia | Acute Myelogenous Leukemia

United States
Aga Khan University
The International Federation of Red Cross and Red Crescent Societies

Completed

Strengthening Maternal Neonatal and Child Health Services in a Rural District of Pakistan (SRC)

Pneumonia | Anemia | Eclampsia | Postpartum Hemorrhage | Diarrhoea | Neonatal Sepsis | Birth Asphyxia | Antepartum Hemorrhage
Rempex (a wholly owned subsidiary of Melinta Therapeutics...
Department of Health and Human Services

Completed

Efficacy, Safety, Tolerability of Vabomere Compared to Best Available Therapy in Treating Serious Infections in Adults

Bacteremia | Acute Pyelonephritis | Ventilator-associated Bacterial Pneumonia | Urinary Tract Infection Complicated | Hospital Acquired Bacterial Pneumonia | Abdominal Infection

Italy, United States, Colombia, Greece, Israel, Brazil, Argentina, United Kingdom
Centre Hospitalier Universitaire de Nīmes

Completed

Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds (ORISA)

Diabetic Foot | Foot Ulcer | Leg Ulcer | Bacteremia | Infection

France
Beth Israel Medical Center

Terminated

The Role of Synbiotics in Reducing Post-Operative Infections in Patients Undergoing Cardiac Surgery: A Pilot Study

Pneumonia | Cystitis | Bacteremia | Surgical Wound Infection | Enterocolitis, Pseudomembranous

United States
University of California, Los Angeles
Université de Montréal

Withdrawn

Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery

Stroke | Epilepsy | Tuberous Sclerosis | Sturge-Weber Syndrome | Focal Cortical Dysplasia | Hemimegalencephaly | Polymicrogyria | Rasmussen Encephalitis | Gliosis | Tumor, Brain

United States, Canada
Medical University of Warsaw

Recruiting

Possible Differences in HCC Course Depending on DAA Treatment

Liver Cirrhosis | Carcinoma, Hepatocellular | Hepatitis C, Chronic | Drug Effect | Hepatitis C Virus Infection, Response to Therapy of | Drug Side Effect

Poland
AstraZeneca
Merck Sharp & Dohme LLC; European Network of Gynaecological Oncological Trial... and other collaborators

Active, not recruiting

Olaparib Treatment in BRCA Mutated Ovarian Cancer Patients After Complete or Partial Response to Platinum Chemotherapy

Relapsed Ovarian Cancer | Following Complete or Partial Response to Platinum Based Chemotherapy | Platinum Sensitive | BRCA Mutated

Korea, Republic of, France, China, Italy, United States, Israel, United Kingdom, Canada, Japan, Germany, Brazil, Netherlands, Belgium, Poland, Australia, Russian Federation, Spain
Hospital do Coracao
Hospital Israelita Albert Einstein; Hospital Moinhos de Vento; Hospital Sirio-Libanes and other collaborators

Active, not recruiting

Daily Chlorexidine Bath for Health Care Associated Infection Prevention (CLEAN-IT)

Ventilator Associated Pneumonia | Health Care Associated Infection | Catheter-Associated Urinary Tract Infection | Central Line-associated Bloodstream Infection (CLABSI)

Brazil
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Response to the SHINGRIX Varicella Zoster Virus (VZV) Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's Tyrosine Kinase Inhibitor (BTK-I)

Chronic Lymphocytic Leukemia (CLL) | Small Lymphocytic Lymphoma (SLL) | Safety and Tolerability | Compare SHINGRIX Vaccine Response Rates

United States
University of Texas at Austin

Unknown

Peer Support for Post Intensive Care Syndrome Self-Management (PS-PICS)

Sepsis | Shock | Critical Illness | Shock, Septic | Respiratory Failure | Chronic Disease | Respiratory Distress Syndrome, Adult | Shock, Hypovolemic

United States
University of Illinois at Chicago
Rush University Medical Center; American Society for Parenteral and Enteral...

Completed

Feeding the Critically Ill During Phases of Altered Redox Status (FEDOX)

Systemic Inflammatory Response Syndrome | Oxidative Stress | Acute Respiratory Distress Syndrome | Euthyroid Sick Syndromes

United States
Hospital de Santa Maria, Portugal

Completed

Antibiotic Prophylaxis in Prelabor Rupture of Membranes at Term

Chorioamnionitis | Neonatal Meningitis | Puerperal Endometritis | Neonatal Early Onset Sepsis | Neonatal Pneumonia

Portugal
Hospital General Universitario Gregorio Marañon
Instituto de Salud Carlos III

Recruiting

Cell Therapy With Treg Cells Obtained From Thymic Tissue (thyTreg) to Control the Immune Hyperactivation Associated With COVID-19 and/or Acute Respiratory Distress Syndrome (THYTECH2) (THYTECH2)

Systemic Inflammatory Response Syndrome

Spain
St. Jude Children's Research Hospital

Recruiting

Cardiovascular Magnetic Resonance Prognosticators in Pediatric Oncology Patients With Sepsis

Sepsis | Acute Respiratory Distress Syndrome | Cardiovascular Shock

United States
University of Alabama at Birmingham

Recruiting

Study to Evaluate the Role of Siltuximab in Treatment of Cytokine Release Syndrome (CRS) and Immune Effector Cell Associated Neurotoxicity (ICANS) Related to CAR-T Cell Therapy

Lymphoma, Non-Hodgkin | Multiple Myeloma | Acute Lymphoblastic Leukemia | Cytokine Release Syndrome | ICANS

United States
Aveni Foundation

Withdrawn

CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19 (CORONA)

COVID-19 | Acute Respiratory Distress Syndrome | Cytokine Storm
Biocon Limited

Completed

Efficacy and Safety of Itolizumab in COVID-19 Complications

Covid19 | Acute Respiratory Distress Syndrome | Cytokine Release Syndrome

India

Clinical Trials on Neuroinflammatory Response

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Ethiopia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations