Clinical Trials on Older Adults at High Risk for MCI in United States

Total 421 results

Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Lithium Carbonate in Treating Patients With Acute Intestinal Graft-Versus-Host-Disease (GVHD) After Donor Stem Cell Transplant (GVHD)

Primary Myelofibrosis | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Tacrolimus and Mycophenolate Mofetil in Preventing Graft-Versus-Host Disease in Patients Who Have Undergone Total-Body Irradiation With or Without Fludarabine Phosphate Followed by Donor Peripheral Blood Stem Cell Transplant for Hematologic Cancer

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell... and other conditions

United States, Italy
University of Virginia

Unknown

Continuous Exhaled Breath Condensate pH in Mechanically Ventilated Patients

Pneumonia | Respiratory Syncytial Virus Infections | Acute Lung Injury | Respiratory Distress Syndrome, Adult

United States
Zoll Medical Corporation

Enrolling by invitation

Pre-hospital Ventilation Clinical Study

Heart Failure | Sepsis | Hemorrhage | Cardiac Arrest | Respiratory Distress Syndrome, Adult | Altered Mental Status

United States
University of Michigan Rogel Cancer Center

Completed

Study of Enbrel (Etanercept) for the Treatment Sub-Acute Pulmonary Dysfunction After Allogeneic Stem Cell Transplant

Bronchiolitis Obliterans | Respiratory Distress Syndrome, Adult | Lung Injury, Acute

United States
NewAmsterdam Pharma

Active, not recruiting

Randomized Study to Evaluate the Effect of Obicetrapib on Top of Maximum Tolerated Lipid-Modifying Therapies (BROADWAY)

Dyslipidemias | Hypercholesterolemia | Familial Hypercholesterolemia | Atherosclerotic Cardiovascular Disease | High Cholesterol

United States, Poland, Denmark, Czechia, China, Netherlands, Japan, Georgia
Albert Einstein College of Medicine
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Early Insulin and Development of ARDS

Hyperglycemia | Sepsis | Respiratory Distress Syndrome, Adult

United States
Stony Brook University
FDA Office of Orphan Products Development; State University of New York

Completed

Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and Sepsis

Sepsis | Respiratory Distress Syndrome | Respiratory Distress Syndrome, Adult

United States
Versartis Inc.
Premier Research Group plc

Completed

Versartis International Trial in Adults With Long-Acting Growth Hormone (VITAL)

Adult Growth Hormone Deficiency

United States, Australia, Germany, United Kingdom
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Comparison of Two Methods of High Frequency Oscillatory Ventilation in Individuals With Acute Respiratory Distress Syndrome

Respiratory Distress Syndrome, Adult

United States
The Christie NHS Foundation Trust

Terminated

Effect of Pegvisomant on GH/IGF-I Relationship in GHD

Severe Adult Growth Hormone Deficiency

United Kingdom
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Fludarabine and Total-Body Irradiation Followed By Donor Stem Cell Transplant and Cyclosporine and Mycophenolate Mofetil in Treating HIV-Positive Patients With or Without Cancer

HIV Infection | Unspecified Childhood Solid Tumor, Protocol Specific | Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Stage I Multiple Myeloma | Stage II Multiple Myeloma | Stage III Multiple Myeloma | Chronic Myelomonocytic Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal... and other conditions

United States
BioMarck Pharmaceuticals, Ltd.

Completed

Evaluation of Safety & Efficacy of BIO-11006 Inhalation Solution in Patients With ARDS

Respiratory Distress Syndrome, Adult

United States
University of California, San Francisco
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Activated Protein C to Treat Acute Lung Injuries

Respiratory Distress Syndrome, Adult

United States
University of Washington
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Hypertonic Saline With Dextran for Treating Hypovolemic Shock and Severe Brain Injury

Shock | Head Injuries, Closed | Respiratory Distress Syndrome, Adult | Shock, Traumatic

United States
University of California, San Diego

Enrolling by invitation

Ventilation and Perfusion in the Respiratory System

Critical Illness | Respiratory Failure | Pulmonary Disease | Ventilator-Induced Lung Injury | Respiratory Distress Syndrome, Adult

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Terminated

Laboratory-Treated T Cells in Treating Patients With High-Risk Relapsed Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia Previously Treated With Donor Stem Cell Transplant

Recurrent Adult Acute Myeloid Leukemia | Secondary Acute Myeloid Leukemia | Recurrent Acute Myeloid Leukemia | Recurrent Childhood Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Donor | Hematopoietic Cell Transplant Recipient | HLA-A*0201 Positive Cells Present

United States
Tufts Medical Center

Active, not recruiting

Enhancing Utilization of Non-Invasive Positive Pressure Ventilation in Critical Care

Pneumonia | Asthma | COPD | Respiratory Distress Syndrome, Adult | Congestive Heart Failure

United States
Pure Biologics S.A.
Presage Biosciences

Recruiting

A Study of the Intratumoral Microdose Administration of PBA-0405 in Patients With Solid Tumors

Triple Negative Breast Cancer | Head and Neck Squamous Cell Carcinoma | Soft Tissue Sarcoma Adult

United States
Case Comprehensive Cancer Center

Completed

Donor Umbilical Cord Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell... and other conditions

United States
VA Office of Research and Development

Not yet recruiting

Growth Hormone Replacement Therapy in Veterans With Mild Traumatic Brain Injury (mTBI) and Adult Growth Hormone Deficiency (AGHD) (GRIT)

Mild Traumatic Brain Injury | Adult Growth Hormone Deficiency

United States
University of Maryland, Baltimore

Withdrawn

Pilot RCT of Therapeutic Hypothermia Plus Neuromuscular Blockade in COVID-19 Patients With ARDS (CHILL-pilot)

Respiratory Distress Syndrome, Adult | Sars-CoV2

United States
Children's Hospital Los Angeles

Recruiting

Long Term Follow up of Children Enrolled in the REDvent Study

Quality of Life | Respiration Disorders | Ventilator-Induced Lung Injury | Respiratory Distress Syndrome, Adult | Neurocognitive Dysfunction

United States
OHSU Knight Cancer Institute
National Cancer Institute (NCI)

Completed

Tissue Sample Collection From Patients With Fanconi Anemia

Unspecified Childhood Solid Tumor, Protocol Specific | Unspecified Adult Solid Tumor, Protocol Specific | Fanconi Anemia

United States
University of Chicago
National Cancer Institute (NCI)

Completed

Donor T Cells After Donor Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma | Recurrent... and other conditions

United States
National Cancer Institute (NCI)

Terminated

Monoclonal Antibody Therapy in Treating Patients With Ovarian Epithelial Cancer, Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Non-Small Cell Lung Cancer

Recurrent Adult Acute Myeloid Leukemia | Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities | Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) | Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) | Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) | Previously Treated Myelodysplastic... and other conditions

United States
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant

Clear Cell Renal Cell Carcinoma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent... and other conditions

United States, Germany, Italy
Masonic Cancer Center, University of Minnesota

Recruiting

Myeloablative Allo HSCT With Related or Unrelated Donor for Heme Disorders

Lymphoma | Follicular Lymphoma | Acute Myeloid Leukemia | Multiple Myeloma | Myelofibrosis | Juvenile Myelomonocytic Leukemia | Burkitt Lymphoma | Acute Lymphoblastic Leukemia | Lymphoblastic Lymphoma | Chronic Lymphocytic Leukemia | Lymphoplasmacytic Lymphoma | Acute Leukemia | Mantle-Cell Lymphoma | Chronic Myelogenous... and other conditions

United States
Michael A. Matthay
The University of Texas Health Science Center, Houston; United States Department... and other collaborators

Completed

Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (STAT)

Respiratory Distress Syndrome, Adult

United States
Michael A. Matthay
Massachusetts General Hospital; National Heart, Lung, and Blood Institute (NHLBI) and other collaborators

Completed

Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START) (START)

Respiratory Distress Syndrome, Adult

United States
Novo Nordisk A/S

Enrolling by invitation

A Study to Follow Patients With Adult Growth Hormone Deficiency (AGHD) Treated With Sogroya® for Long Term Safety Information

Adult Growth Hormone Deficiency

United States, Saudi Arabia, Germany, Slovenia
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Fludarabine and Busulfan Followed by Allogeneic Stem Cell Transplant in Treating Older Patients With Acute Myeloid Leukemia in First Complete Remission

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Adult Acute Myeloid Leukemia in Remission

United States
Roswell Park Cancer Institute
National Cancer Institute (NCI)

Completed

High-Dose Chemotherapy With or Without Total-Body Irradiation Followed by Autologous Stem Cell Transplant in Treating Patients With Hematologic Cancer or Solid Tumors

Unspecified Childhood Solid Tumor, Protocol Specific | Recurrent Adult Acute Myeloid Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent Adult Diffuse Large Cell Lymphoma | Recurrent Adult Diffuse Mixed Cell Lymphoma and other conditions

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...

Completed

A Two-Step Approach to Reduced Intensity Bone Marrow Transplant for Patients With Hematological Malignancies

Primary Myelofibrosis | Polycythemia Vera | Essential Thrombocythemia | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent... and other conditions

United States
University of Texas at Austin

Unknown

Peer Support for Post Intensive Care Syndrome Self-Management (PS-PICS)

Sepsis | Shock | Critical Illness | Shock, Septic | Respiratory Failure | Chronic Disease | Respiratory Distress Syndrome, Adult | Shock, Hypovolemic

United States
Roswell Park Cancer Institute

Completed

Fludarabine Phosphate, Melphalan, and Low-Dose Total-Body Irradiation Followed by Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Hematologic Malignancies

Primary Myelofibrosis | Polycythemia Vera | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma and other conditions

United States
LeMaitre Vascular
Factory CRO for Medical Devices B.V.

Recruiting

Prospective and Non-randomized Registry of CardioCel 3D

Intracardiac and Septal Defects | Valve and Anulus Repair | Great Vessel Reconstruction | Peripheral Vessel Reconstruction | Suture Line Buttressing

Germany, Italy, Spain, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
University of Nottingham; University of Warwick

Completed

Personalised Simulation Technologies for Optimising Treatment in the Intensive Care Unit (PSTOTICU)

Respiratory Insufficiency | Respiratory Distress Syndrome, Adult

United Kingdom
University of Washington
National Heart, Lung, and Blood Institute (NHLBI); American Thoracic Society; American Society for Parenteral and Enteral Nutrition and other collaborators

Completed

A Phase II Randomized Trial of Fish Oil in Patients With Acute Lung Injury (ALI)

Acute Respiratory Distress Syndrome | Acute Lung Injury | Respiratory Distress Syndrome, Adult

United States, Canada
Case Comprehensive Cancer Center
National Cancer Institute (NCI)

Completed

Quality of Life in Younger Leukemia and Lymphoma Survivors

Pain | Lymphoma | Leukemia | Fatigue | Small Intestine Cancer | Cancer Survivor | Anxiety Disorder | Psychosocial Effects of Cancer and Its Treatment | Lymphoproliferative Disorder | Long-term Effects Secondary to Cancer Therapy in Adults

United States
Roswell Park Cancer Institute

Completed

Combination Chemotherapy and Donor Stem Cell Transplant in Treating Patients With Aplastic Anemia or Hematologic Cancer

Lymphoma | Unspecified Childhood Solid Tumor, Protocol Specific | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Unspecified Adult Solid Tumor, Protocol Specific | Myelodysplastic/Myeloproliferative Diseases | Nonmalignant Neoplasm

United States
National Human Genome Research Institute (NHGRI)

Completed

Inherited Diseases, Caregiving, and Social Networks

Undiagnosed Disease | Healthy Volunteer (Adult With Typically Developing Child) | Inherited Neurodegenerative Disorders | Inherited Metabolic Disorders (Inborn Errors of Metabolism) | Alzheimer's Disease and Related Dementias

United States
Merck KGaA, Darmstadt, Germany

Completed

An Open-label Phase 4 Study to Explore Immunogenicity of the Liquid Formulation of Saizen® in Subjects With Adult Growth Hormone Deficiency (AGHD)

Adult Growth Hormone Deficiency

United Kingdom, Germany, Australia, Sweden
University of Maryland, Baltimore
United States Department of Defense; US Department of Veterans Affairs Cooperative... and other collaborators

Recruiting

Trial of Therapeutic Hypothermia in Patients With ARDS (CHILL)

Respiratory Distress Syndrome, Adult

United States
National Cancer Institute (NCI)

Completed

Ixabepilone in Treating Young Patients With Refractory Solid Tumors

Recurrent Neuroblastoma | Recurrent Osteosarcoma | Recurrent Childhood Rhabdomyosarcoma | Recurrent Adult Soft Tissue Sarcoma | Recurrent Wilms Tumor and Other Childhood Kidney Tumors | Previously Treated Childhood Rhabdomyosarcoma | Recurrent Childhood Soft Tissue Sarcoma | Recurrent Ewing Sarcoma... and other conditions

United States
Ascendis Pharma Endocrinology Division A/S

Active, not recruiting

A Trial to Investigate Long Term Efficacy and Safety of Lonapegsomatropin in Adults With Growth Hormone Deficiency

Endocrine System Diseases | Adult Growth Hormone Deficiency | Hormone Deficiency

United States, Armenia, Georgia, Greece, Ukraine, Australia, Canada, France, Israel, Italy, Japan, Malaysia, Poland, Romania, Serbia, Slovakia, Spain, Turkey, United Kingdom, Germany, Korea, Republic of
Extremity Medical

Recruiting

The KinematX Midcarpal Total Wrist Arthroplasty Registry

Osteoarthritis | Inflammatory Arthritis | Carpal Tunnel Syndrome (CTS) | Post Traumatic Arthritis | Scapholunate Advanced Collapse (SLAC) | Scapholunate Crystalline Advanced Collapse (SCAC) | Scaphoid, Trapezium, and Trapezoid Advanced Collapse (STTAC) | Kienbock's Disease of Adults | Radial Malunion | Ulnar Translocation and other conditions

United States
Hugo W. Moser Research Institute at Kennedy Krieger...

Recruiting

Home Exercise for Individuals With Neurodegenerative Disease

Neurodegenerative Diseases | Ataxia | Cerebellar Ataxia | Leukodystrophy | Adrenomyeloneuropathy | LBSL | Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation | Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder)

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Drug Study of Albuterol to Treat Acute Lung Injury (ALTA)

Respiratory Distress Syndrome, Adult

United States
University of Colorado, Denver

Terminated

INR-Triggered Transfusion In GI Bleeders From ER (I-TRIGER)

Liver Diseases | Respiratory Distress Syndrome, Adult | Gastrointestinal Hemorrhage | Transfusion Related Lung Injury

United States

Clinical Trials on Older Adults at High Risk for MCI in United States

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