Clinical Trials on Oral Cavity Leukoplakia in Canada

Total 103 results

National Cancer Institute (NCI)

Active, not recruiting

Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion

Hyperplasia | Oral Cavity Carcinoma | Oral Leukoplakia | Erythroplakia

United States, Canada
University of Arizona
National Cancer Institute (NCI)

Recruiting

Metformin for the Prevention of Oral Cancer in Patients With Oral Leukoplakia or Erythroplakia

Oral Leukoplakia | Erythroplakia

United States, Canada
National Cancer Institute (NCI)

Terminated

Pioglitazone for Oral Premalignant Lesions

Oral Leukoplakia

United States, Italy, Canada
University Health Network, Toronto

Completed

A Comparative Study of Ultrasound Versus CT Measurement of Tongue and Oral Cavity Size

Ultrasound Airway Imaging in Determining the Oral Cavity and Tongue Size

Canada
National Cancer Institute (NCI)

Terminated

Cisplatin With or Without WEE1 Inhibitor MK-1775 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Recurrent Hypopharyngeal Squamous Cell Carcinoma | Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Recurrent Lip and Oral Cavity Squamous Cell Carcinoma | Recurrent Laryngeal Verrucous Carcinoma | Recurrent Metastatic Squamous Cell Carcinoma in... and other conditions

Canada
University of British Columbia

Recruiting

Mandibular Reconstruction Preplanning (ViPMR) (ViPMR)

Oral Cancer | Oral Cavity Cancer

Canada
University of British Columbia

Recruiting

Radial Forearm Donor Site Closure

Oral Cancer | Oral Cavity Cancer | Donor Site Complication

Canada
University of Calgary

Completed

Does the Harmonic Scalpel Reduce Blood Loss and OR Time in Major Head and Neck Cancer Surgery Undergoing Major Surgery for Oral Cavity Squamous Cell Carcinoma? (HS2)

Oral Cavity Squamous Cell Carcinoma, Treated With Surgery

Canada
University Health Network, Toronto
Pfizer

Completed

Study to Assess Biomarkers in Patients With Resectable Oral Cavity Cancer Randomized to Receive Preoperative Treatment

Oral Cavity Cancer

Canada
University Health Network, Toronto
AstraZeneca; Mirati Therapeutics Inc.

Withdrawn

Pre-operative Mocetinostat (MGCD0103) and Durvalumab (MEDI4736) (PRIMED) for Squamous Cell Carcinoma of the Oral Cavity (PRIMED-001)

Squamous Cell Carcinoma, Head And Neck | Squamous Cell Carcinoma Mouth | Resectable Squamous Cell Carcinoma of Oral Cavity

Canada
University Health Network, Toronto
Mirati Therapeutics Inc.

Completed

Sitravatinib (MGCD516) and Nivolumab in Oral Cavity Cancer Window Opportunity Study (SNOW)

Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma, Head And Neck | Squamous Cell Carcinoma Mouth

Canada
National Cancer Institute (NCI)

Completed

Vorinostat in Treating Patients With Locally Advanced, Recurrent, or Metastatic Adenoid Cystic Carcinoma

Recurrent Salivary Gland Carcinoma | Stage IVA Major Salivary Gland Cancer AJCC v7 | Stage IVB Major Salivary Gland Cancer AJCC v7 | Stage IVC Major Salivary Gland Cancer AJCC v7 | Tongue Carcinoma | Salivary Gland Adenoid Cystic Carcinoma | Recurrent Oral Cavity Adenoid Cystic Carcinoma | Stage... and other conditions

United States, Canada
National Cancer Institute (NCI)

Terminated

Capecitabine and Vorinostat in Treating Patients With Recurrent and/or Metastatic Head and Neck Cancer

Recurrent Hypopharyngeal Squamous Cell Carcinoma | Recurrent Laryngeal Squamous Cell Carcinoma | Recurrent Oral Cavity Squamous Cell Carcinoma | Recurrent Oropharyngeal Squamous Cell Carcinoma | Stage IVA Oral Cavity Squamous Cell Carcinoma | Stage IVA Laryngeal Squamous Cell Carcinoma | Stage... and other conditions

Canada, United States
NRG Oncology
National Cancer Institute (NCI)

Recruiting

Comparing Sentinel Lymph Node (SLN) Biopsy With Standard Neck Dissection for Patients With Early-Stage Oral Cavity Cancer

Oral Cavity Squamous Cell Carcinoma | Stage I Lip and Oral Cavity Cancer AJCC v8 | Stage II Lip and Oral Cavity Cancer AJCC v8 | Buccal Mucosa Squamous Cell Carcinoma | Floor of Mouth Squamous Cell Carcinoma | Gingival Squamous Cell Carcinoma | Hard Palate Squamous Cell Carcinoma | Lip Squamous Cell... and other conditions

United States, Canada
National Cancer Institute (NCI)

Active, not recruiting

Onalespib in Treating Patients With Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck Receiving Radiation Therapy and Cisplatin

Stage IVA Hypopharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVA Laryngeal Squamous Cell Carcinoma AJCC v7 | Stage IVA Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 | Stage IVA Oropharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVB Hypopharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IVB Laryngeal Squamous Cell Carcinoma AJCC... and other conditions

United States, Canada
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer

Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Hypopharyngeal Carcinoma AJCC v8 | Stage III Laryngeal Cancer AJCC v8 | Stage III Lip and Oral Cavity Cancer AJCC v8 | Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8 | Stage IVA Lip and Oral... and other conditions

United States, Canada
University Health Network, Toronto

Completed

Biofeedback Rehabilitation to Improve Speaking and Eating in Public (Biofeedback)

Oral Cavity Squamous Cell Carcinoma

Canada
National Cancer Institute (NCI)

Completed

SB-715992 in Treating Patients With Recurrent or Metastatic Head and Neck Cancer

Recurrent Metastatic Squamous Neck Cancer With Occult Primary | Recurrent Salivary Gland Cancer | Recurrent Squamous Cell Carcinoma of the Hypopharynx | Recurrent Squamous Cell Carcinoma of the Larynx | Recurrent Squamous Cell Carcinoma of the Lip and Oral Cavity | Recurrent Squamous Cell Carcinoma... and other conditions

Canada
Brooklyn ImmunoTherapeutics, LLC

Completed

IRX-2 Regimen in Patients With Newly Diagnosed Stage II, III, or IVA Squamous Cell Carcinoma of the Oral Cavity (INSPIRE)

Squamous Cell Carcinoma of the Oral Cavity

United States, Brazil, United Kingdom, Canada
McGill University
Rossy Cancer Network

Completed

Oncology - Bolstering Oral Agent Reporting Related to Distress (ON-BOARD)

Oral Chemotherapy

Canada
University of Toronto

Recruiting

Oral Contraceptive vs Menstrual Cycle Ex Vivo Model (OCEV)

Contraceptives, Oral | Sex Hormone

Canada
Western University, Canada

Recruiting

The Effect of Menstrual Cycle and Oral Contraceptive Pill Phase on Aspects of Exercise Physiology

Menstrual Cycle | Oral Contraceptives

Canada
GlaxoSmithKline

Completed

Study to Investigate the Stain Control of Two Stannous Fluoride Dentifrices

Oral Hygiene | Extrinsic Dental Stain

Canada
National Cancer Institute (NCI)
NRG Oncology; Canadian Cancer Trials Group

Active, not recruiting

Radiation Therapy With Durvalumab or Cetuximab in Treating Patients With Locoregionally Advanced Head and Neck Cancer Who Cannot Take Cisplatin

Head and Neck Squamous Cell Carcinoma | Oropharyngeal Squamous Cell Carcinoma | Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Stage III Hypopharyngeal Carcinoma AJCC v8 | Stage III Laryngeal Cancer AJCC v8 | Stage III Lip and Oral Cavity Cancer AJCC v8 | Stage... and other conditions

United States, Canada
Lawson Health Research Institute

Recruiting

Preservation of Swallowing in Respected Oral Cavity Squamous Cell Carcinoma: Examining Radiation Volume Effects (PRESERVE): A Randomized Trial

Head and Neck Cancer

Canada, United States, Ireland, United Kingdom
National Cancer Institute (NCI)

Completed

Sunitinib Malate in Treating Patients With Recurrent Ovarian Epithelial, Fallopian Tube, or Primary Peritoneal Cancer

Stage IV Ovarian Epithelial Cancer | Recurrent Ovarian Epithelial Cancer | Recurrent Primary Peritoneal Cavity Cancer | Stage IV Primary Peritoneal Cavity Cancer | Recurrent Fallopian Tube Cancer | Stage IIIA Fallopian Tube Cancer | Stage IIIB Fallopian Tube Cancer | Stage IIIC Fallopian Tube Cancer and other conditions

Canada
National Cancer Institute (NCI)
NRG Oncology

Recruiting

Testing Docetaxel-Cetuximab or the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy and Radiation Therapy in High-Risk Head and Neck Cancer

Stage IV Hypopharyngeal Squamous Cell Carcinoma AJCC v7 | Stage IV Laryngeal Squamous Cell Carcinoma AJCC v7 | Stage IV Oral Cavity Squamous Cell Carcinoma AJCC v6 and v7 | Stage IV Oropharyngeal Squamous Cell Carcinoma AJCC v7 | Oropharyngeal p16INK4a-Negative Squamous Cell Carcinoma | Stage... and other conditions

United States, Canada, China
Sunnybrook Health Sciences Centre
Celgene; Sunnybrook Research Institute

Withdrawn

Apremilast - Oral Lichen Planus Trial (APOLP)

Oral Lichen Planus

Canada
University of Calgary
Terry Fox Research Institute

Completed

Fluorescent Visualization in Early Oral Cancer

Oral Squamous Cell Carcinoma or Severe Dysplasia

Canada
CEL-SCI Corporation
Teva Branded Pharmaceutical Products R&D, Inc.; Orient Europharma Co., Ltd.

Completed

Efficacy and Safety Study of Leukocyte Interleukin,Injection (LI) to Treat Cancer of the Oral Cavity (IT-MATTERS)

Squamous Cell Carcinoma of the Oral Cavity | Squamous Cell Carcinoma of the Soft Palate

Spain, Taiwan, United States, United Kingdom, Romania, India, Croatia, Belarus, Hungary, Bosnia and Herzegovina, Russian Federation, Austria, Canada, France, Israel, Italy, Malaysia, Poland, Serbia, Sri Lanka, Thailand, Turkey, Ukraine
British Columbia Cancer Agency
University of British Columbia; BC Cancer Foundation

Unknown

Innovative Approach to Triage Oral Precancer (iTOP)

Oral Cancer | Oral Premalignant Lesion

Canada
University of British Columbia

Completed

Lactose, Sucrose & Corn Syrup Tolerance

Focus of Study: Oral Tolerance Test With Glucose, Lactose, Sucrose

Canada
Johnson & Johnson Vision Care, Inc.

Completed

Clinical Performance Evaluation of Two Silicone Hydrogel Lenses

Visual Acuity

Canada
Johnson & Johnson Vision Care, Inc.

Completed

Clinical and Laboratory Study of Lysozyme Deposition on Daily Disposable Contact Lenses

Visual Acuity

Canada
Johnson & Johnson Vision Care, Inc.

Completed

Evaluation of Three Daily Disposable Contact Lenses

Visual Acuity

Canada
Proteocyte Diagnostics Inc.

Recruiting

Early Prediction of Oral Cancer by S100A7 Immunohistochemistry Signature-based Assessment

Oral Neoplasm

Canada
Johnson & Johnson Vision Care, Inc.

Completed

Evaluation of On-eye Optical Performances of the RMY-100 Lens

Visual Acuity

Canada
Menicon Co., Ltd.

Completed

Assessment of Comfort & Ocular Surface Parameters w Novel Designs of Daily Disposable Silicone Hydrogel Contact Lenses (BASS)

Visual Acuity | Contact Lens Comfort

Canada
NCIC Clinical Trials Group

Terminated

Pilocarpine in Treating Patients With Dry Mouth Caused by Opioids

Quality of Life | Oral Complications

Canada
Johnson & Johnson Vision Care, Inc.

Terminated

Characterizing Successful Myopic Multifocal Contact Lens Wearers

Visual Acuity

Canada
Ottawa Hospital Research Institute

Recruiting

Photobiomodulation for the Prevention of Radiation Induced Oral Mucositis

Head and Neck Cancer | Radiation Dermatitis | Mucositis Oral

Canada
Université de Sherbrooke

Unknown

Effect of Nasal Continuous Positive Airway Pressure (CPAP) on Oral Feeding in Human Neonates

Oral Feeding in Human Neonates During Nasal CPAP

Canada
University Health Network, Toronto

Completed

Sentinel Lymph Node Mapping of Oral Cancer Using Near-Infrared Fluorescence Imaging (SLN Mapping)

Head and Neck Neoplasms

Canada
Sanotize Research and Development corp.

Recruiting

Nitric Oxide Releasing Mouthwash (NORM) for the Management of Oropharyngeal Candidiasis

Candidiasis, Oral

Canada
British Columbia Cancer Agency
M.D. Anderson Cancer Center; University of Texas at Austin

Completed

Polarized Reflectance Spectroscopy for Oral Lesions (PolProbe)

Oral Cancer

Canada
Fundació Institut de Recerca de l'Hospital de la...

Terminated

Bemiparin Randomized Trial on Bridging Oral Anticoagulants in Invasive Procedures (BERTA Study) (BERTA)

Long-term Oral Anticoagulant Therapy

Spain
Mucosa Innovations, S.L.
Universidad de Granada

Active, not recruiting

Study on the Effects of a Toothpaste in the Microbiome and Clinical Parameters in Patients With Oral Dysbiosis

Oral Dysbiosis

Spain
McGill University Health Centre/Research Institute...

Unknown

Efficacy of Ranibizumab in Combination With Photodynamic Therapy for Wet Age-Related Macular Degeneration

Macular Degeneration | Visual Acuity

Canada
British Columbia Cancer Agency

Completed

A Randomized Placebo-Controlled Trial of Manuka Honey for Oral Mucositis Due to Radiation Therapy for Cancer

Head and Neck Cancer | Radiotherapy Induced Mucositis

Canada
University of Toronto
University Health Network, Toronto; Sunnybrook Health Sciences Centre; Unity... and other collaborators

Completed

De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL) (CHORAL)

Mortality | Oral Health | Pain, Orofacial | Dryness, Mouth

Canada

Clinical Trials on Oral Cavity Leukoplakia in Canada

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