Clinical Trials on Pharmacological Action (PA)

Total 2827 results

Rambam Health Care Campus

Completed

The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects

Pharmacological Action (PA)

Israel
Universidad Nacional de Salta
Fundacion Mundo Sano

Not yet recruiting

Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva

Pharmacological Action
Federal State Budgetary Scientific Institution,...
The League of Clinical Research, Russia; Institute of Biomedical Chemistry,...

Completed

"Corticoid-16" in Long Term When Administered Systemically in Patients in Routine Medical Practice

Pharmacological Action
Masaryk Hospital Usti nad Labem

Unknown

PARADOX - the Incidence of Paradoxical Reactions in Pediatric Patients Premedicated With Midazolam (PARADOX)

Pharmacological Action

Czechia
Ervin Taso
University of Belgrade

Completed

Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid

Pharmacological Action

Serbia
Tianjin Medical University General Hospital

Recruiting

Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study

Pharmacological Action

China
Qin Zhang

Recruiting

Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary Bypass

Pharmacological Action

China
Food and Nutrition Research Institute, Philippines
Ateneo de Manila University; De La Salle Medical and Health Sciences Institute

Active, not recruiting

Exploratory Pharmacokinetic Study of Virgin Coconut Oil (VCO)

Pharmacological Action

Philippines
Fudan University
Shanghai First Maternity and Infant Hospital; Women and children's hospital...

Unknown

Comparison of Epidural Labor Analgesia With Dexmedetomidine or Sufentanil

Pharmacological Action

China
Kolding Sygehus

Unknown

Pharmacokinetic Study of Paracetamol. (Para1523)

Pharmacological Action

Denmark
University of Malaya
Ministry of Health, Malaysia

Unknown

Pharmacometabolomics of Andrographis Paniculata And Metformin In Healthy Volunteers Under Fasting Condition

Pharmacokinetics | Molecular Mechanisms of Pharmacological Action

Malaysia
Balance Therapeutics

Completed

A Study to Investigate the Mass Balance of BTD-001 (HV103)

Molecular Mechanisms of Pharmacological Action

United Kingdom
Zealand University Hospital
University of Copenhagen

Unknown

Test of a New Gel-based Colon Cleansing Agent Compared to Moviprep

Pharmacological Action

Denmark
Emad Abdel Aal Saliem

Completed

Intravitreal Triamcinolone and Moxifloxacin Injection After Cataract Surgery

Pharmacological Action

Egypt
AstraZeneca

Completed

A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate (AZD3293DDI)

Healthy Volunteers | Pharmacologic Action

United States
Karen Hoejmark Hansen

Completed

The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.

Pharmacological Action

Denmark
Vivoryon Therapeutics N.V.
Covance

Completed

Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole

Healthy Volunteers | Pharmacologic Action

United Kingdom
National Aeronautics and Space Administration (NASA)

Completed

Optimize Astronaut Sleep Medication Efficacy and Individual Effects

Sleep | Cognition | Pharmacologic Actions
Walter Reed Army Institute of Research (WRAIR)

Completed

Genetic Variability in CYP2D6 in U.S Active Duty Population

Pharmacologic Action

United States
National Liver Institute, Egypt
Pharco Pharmaceuticals

Unknown

Safety and Efficacy of Gratisovir (Sofosbuvir)- Ribavirin Therapy in Pediatric Patients

Pharmacological Action

Egypt
AstraZeneca

Completed

Relative Bioavailability Study to Assess Two Solid Formulations Compared to an Oral Solution of AZD3293 in Healthy Male and Non-Fertile Female Subjects (BA)

Healthy Volunteers | Pharmacologic Action

United States
Ain Shams University

Not yet recruiting

Assessment of Rituximab Therapeutic Response Versus Conventional Treatment

Pharmacological Action
CardioDex
Sheba Medical Center

Withdrawn

Hemostatic Closure of Femoral Artery Access Site, Using the QuickClose Design 9 System

Coagulation | Therapeutic Uses | Pharmacologic Actions

Israel
Jaseng Medical Foundation

Recruiting

Ultrasound Guiding Pharmacopuncture Therapy for Supraspinatus Tendinopathy

Pharmacological Action

Korea, Republic of
Profil Institut für Stoffwechselforschung GmbH
Merck Sharp & Dohme LLC

Completed

Sitagliptin and the Risk for Hypoglycaemia in Type 2 Diabetes Patients

Pharmacological Action

Germany
Johns Hopkins University

Completed

Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Psilocybin | Therapeutic Uses | Psychotropic Drugs | Hallucinogens | Pharmacologic Actions | Central Nervous System Agents

United States
Dr. Lutfi Kirdar Kartal Training and Research Hospital

Not yet recruiting

Postoperative Pain in Laparoscopic Radical Prostatectomy Surgery With Tranexamic Acid: Analgesia? Hiperalgesia?

Pharmacological Action
Washington State University
Providence Medical Research Center

Unknown

Medication-taking Preferences & Practices of Patients With Chronic Conditions

Adult Disease | Pharmacological Action | Any Condition in N73.0 Specified as Chronic

United States
University of Oxford

Completed

Effects of Seven Day Prucalopride Administration in Healthy Volunteers

Mental Disorders | Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Cognition | Antidepressive Agents

United Kingdom
University of Oxford

Completed

Effects of Acute Prucalopride Administration in Healthy Volunteers

Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
Takeda

Completed

A Phase 1 Positron Emission Tomography Study to Measure Cholesterol 24S-Hydroxylase Target Occupancy of TAK-935

Epilepsy, Molecular Mechanisms of Pharmalogical Action, Protective Agents

United States
University of Oxford
University of Bath

Unknown

Citalopram and Self Emotional Processing

Depressive Disorder | Depression | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
Universidad de Antioquia
Hospital Pablo Tobón Uribe

Unknown

Pharmacogenomic in Colombian Patients With Rheumatoid Arthritis

Pharmacological Action

Colombia
Washington University School of Medicine
Centers for Disease Control and Prevention

Completed

Probiotics to Promote Intestinal Health

Communicable Diseases | Infection | Therapeutic Uses | Anti-Infective Agents | Pharmacologic Actions

United States
Fudan University

Not yet recruiting

The Maintenance Treatment of Apatinib/Capecitabine Versus Observation in Advanced Gastric Cancer

Neoplasms | Stomach Neoplasms | Gastrointestinal Neoplasms | Digestive System Neoplasms | Stomach Diseases | Molecular Mechanisms of Pharmacological Action | Capecitabine | Apatinib
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR)

Completed

Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance

Biomarkers, Pharmacological

United States
Second Affiliated Hospital of Wenzhou Medical University

Unknown

Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection

Mental Disorders | Pathologic Processes | Postoperative Complications | Delirium | Neurocognitive Disorders | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Analgesics | Hypnotics and Sedatives

China
University of Pennsylvania
Bayer; National Institutes of Health (NIH)

Completed

Mechanism Based Resistance to Aspirin

Aspirin Resistance | Pharmacological Aspirin Non-responsiveness
Tiva Group

Completed

Morphine Consumption in the Obese Patients

Anesthesia Morbidity | Obesity, Morbid | Opioid Use | Post Operative Pain | Pharmacological Action

Spain
Hui-Sheng Chen

Terminated

Argatroban Plus r-tPA for Posterior Circulation Infarction（AR-PCI）

Argatroban, Rt-PA

China
Hospital of Prato

Unknown

Baricitinib in Symptomatic Patients Infected by COVID-19: an Open-label, Pilot Study. (BARI-COVID)

Pharmacological Action

Italy
Centre for Addiction and Mental Health

Completed

Using Non-invasive Brain Stimulation (tDCS) With Varenicline for Treating Tobacco Dependence

Smoking Cessation | Tobacco Smoking | Tobacco Use Disorder | Substance Use Disorders | Molecular Mechanisms of Pharmacological Action | Tobacco Dependence | Physiological Effects of Drugs

Canada
Lawson Health Research Institute

Not yet recruiting

Personalized Pharmacotherapy Using Pharmacogenetics in Veterans (PGx)

Pharmacogenetic Testing to Determine Pharmacological Treatment in PTSD
Trakya University

Completed

The Effects of Different Anesthetic Techniques on QT, Corrected QT (QTc), and P Wave Dispersions in Cesarean Section

Caesarean Section | Anesthesia; Reaction
Luye Pharma Group Ltd.

Completed

Study to Evaluate the PK Profiles of LY03010 in Patients With Schizophrenia or Schizoaffective Disorder

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Neurotransmitter Agents | Central...

United States
University Hospital, Basel, Switzerland
Obstetric Anaesthetists' Association United Kingdom

Completed

Carbetocin Trial: Carbetocin Appropriate Rate Better Equilibrium Between Tonus (TOnus) and CIrculatioN (CARBETOCIN)

Anesthesia; Reaction | Complications; Cesarean Section

Switzerland
Luye Pharma Group Ltd.

Completed

Relative Bioavailability of LY03010 Compared to Listed Drug

Mental Disorders | Psychotic Disorders | Mood Disorders | Schizophrenia | Molecular Mechanisms of Pharmacological Action | Tranquilizing Agents | Physiological Effects of Drugs | Psychotropic Drugs | Antipsychotic Agents | Central Nervous System Depressants | Neurotransmitter Agents | Schizophrenia Spectrum

United States
Mongi Slim Hospital

Completed

Comparaison of 3 Protocols of Ocytocin Administration in C Section

Cesarean Section Complications | Oxytocin Adverse Reaction

Tunisia
Mayo Clinic
National Institute on Aging (NIA)

Completed

Pain Management Intervention Preparatory to a Future Pragmatic Trial

Non-Pharmacological Pain Management

United States
Sichuan Cancer Hospital and Research Institute

Recruiting

TACE, Sorafenib and PD-1 Monoclonal Antibody in the Treatment of HCC

Liver Diseases | Digestive System Neoplasms | Liver Neoplasms | Hepatocellular Carcinoma | Antineoplastic Agents | Molecular Mechanisms of Pharmacological Action | Protein Kinase Inhibitors | Sorafenib

China

Clinical Trials on Pharmacological Action (PA)

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