Clinical Trials on PD-1 Inhibitors in Brazil

Total 114 results

Novartis Pharmaceuticals

Active, not recruiting

Study of Efficacy and Safety of JDQ443 Single-agent as First-line Treatment for Patients With Locally Advanced or Metastatic KRAS G12C- Mutated Non-small Cell Lung Cancer With a PD-L1 Expression < 1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation.

Locally Advanced or Metastatic KRAS G12C-mutated NSCLC With a PD-L1 Expression <1% or a PD-L1 Expression ≥ 1% and an STK11 Co-mutation

Spain, Italy, Austria, Netherlands, United Kingdom, Germany, Thailand, France, Belgium, China, Argentina, Greece, Turkey, Malaysia, Portugal, Hungary, Brazil, United States, India
Novo Nordisk A/S

Completed

To Quantify the Range of Main Psychosocial Factors Affecting Patients and Caregivers in Their Daily Lives (HERO)

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors | Haemophilia A | Haemophilia B | Relatives to/Carers of Patients

Brazil
Universidade Federal do Rio de Janeiro

Completed

Glucose Variability in Patients With Type 1 Diabetes With a Sucrose-added Diet

Type 1 Diabetes Mellitus

Brazil
Pedreira, Érika, M.D.

Completed

Sensorimotor Exercises in Virtual Reality Platform in Individuals With Human T-lymphotropic Virus

HTLV-1

Brazil
Hospital de Clinicas de Porto Alegre

Completed

High-Intensity Exercise and Endothelial Function in Type 1 Diabetes(HIIT-T1D) (HIIT-T1D)

Type 1 Diabetes Mellitus | Endothelial Dysfunction

Brazil
São Paulo State University

Completed

Muscular Resistance Test in the Elastic Tube: Reliability and Training of the Proposed Method

Muscle Strength Quantitative Trait Locus 1

Brazil
University of Sao Paulo
Northwestern University; Genzyme, a Sanofi Company

Completed

Safety and Efficacy Study of Autologous Stem Cell Transplantation for Early Onset Type I Diabetes Mellitus

Type 1 Diabetes Mellitus

Brazil
Federal University of Rio Grande do Sul
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.; University of...

Completed

Effects of Dance on the Turning Characteristics of Patients With Parkinson's Disease

Parkinson Disease(PD)

Brazil, United Kingdom
Universidade Federal do Rio de Janeiro

Completed

Mesenchymal Stem Cells in Patients With Type 1 Diabetes Mellitus

Type 1 Diabetes Mellitus

Brazil
Hospital de Clinicas de Porto Alegre

Unknown

Effect of Acute Exercise on Endothelial Function in Patients With Type 1 Diabetes. (EAEEFD)

Type 1 Diabetes Mellitus

Brazil
Universidade Federal do Rio de Janeiro
Rio de Janeiro State Research Supporting Foundation (FAPERJ)

Completed

Fructose and Glucose and TAS1R2 in Type 1 Diabetes (TAS1R2)

Type 1 Diabetes

Brazil
Federal University of São Paulo
Novartis

Unknown

Evaluation of Vildagliptin (Galvus®) as add-on to Insulin in New-onset Type 1 Diabetes Mellitus

Type 1 Diabetes | Autoimmune Diabetes | Insulin Dependent Diabetes | Juvenile Onset Diabetes Mellitus

Brazil
University of Sao Paulo

Active, not recruiting

Evaluation of Theta-burst Stimulation Efficacy, Safety and Tolerability in Major Depressive Episodes of Bipolar I Disorder

Bipolar Disorder, Type 1

Brazil
Sanofi

Completed

Comparison of Glucose Values and Variability Between TOUJEO and TRESIBA During Continuous Glucose Monitoring in Type 1 Diabetes Patients (inRange)

Type 1 Diabetes Mellitus

Turkey, Netherlands, Brazil, United States, Germany, Hungary, United Kingdom
Universidade Metodista de Piracicaba
Universidade do Estado do Pará

Recruiting

Rehabilitation in Patients With Human Lymphotropic Virus Type I

Human T-Lymphotropic Virus Type 1 Associated Myelopathy

Brazil
Universidade Estadual Paulista Júlio de Mesquita...
University of Sao Paulo

Completed

Influence of Diabetes on Tramadol Pharmacokinetics

Type 2 Diabetes Mellitus | Type 1 Diabetes Mellitus | Neuropathic Pain

Brazil
Rio de Janeiro State University
Laboratory for Clinical and Experimental Research on Vascular Biology

Completed

Acute and Short-term Chronic Effects of Galvus (Vildagliptin) in Diabetes Type 2 Obese Women

1- Microvascular Function | 2-oxidative Stress | 3-inflammation

Brazil
University of Sao Paulo

Completed

Treatment of Major Depressive Disorder Post Stroke With Transcranial Direct Current Stimulation

Major Depressive Disorder 1

Brazil
Novo Nordisk A/S

Completed

A Survey on Hypoglycaemia Among Insulin-treated Patients With Diabetes

Diabetes Mellitus, Type 2 | Diabetes | Diabetes Mellitus, Type 1

Brazil
University of Sao Paulo

Unknown

Wound Healing After Tooth Extraction in Individuals With Type 1 Diabetes Mellitus

Diabetes Mellitus, Type 1

Brazil
Hospital Universitário Professor Edgard Santos

Unknown

A Randomized, Placebo-Controlled Study to Assess the Efficacy of Propantheline for the Treatment of Overactive Bladder

Overactive Bladder Associated With HTLV-1

Brazil
Pedreira, Érika, M.D.

Completed

Pilates Method in People With HAM/TSP

Balance | HAM/TSP | Functional Mobility | HTLV-1 Secondary Myelopathy | Gait Balance

Brazil
Universidade Estadual de Londrina

Completed

Educational Efficacy Assessment of a Serious Game to Teach Insulin Therapy to Primary Care Physicians

Diabetes Mellitus, Type 2 | Diabetes Mellitus, Type 1 | Knowledge, Attitudes, Practice

Brazil
University of Sao Paulo

Unknown

Safety and Efficacy of Mesenchymal Stem Cells in Newly-diagnosed Type 1 Diabetic Patients

Diabetes Mellitus, Insulin-Dependent

Brazil
Sigilon Therapeutics, Inc.

Withdrawn

Safety and Efficacy of Encapsulated Allogeneic MPS-1 Therapy

MPS I | MPS1-S | MPS1-HS

Brazil, United Kingdom
Hospital de Clinicas de Porto Alegre

Unknown

Telepsychoeducation for the Prevention of Emotional Distress in Professionals and Students From Essential Services in the Context of COVID-19

Depressive Symptoms | COVID | Irritability | Mental Health Wellness 1 | Anxiety Symptoms | Emotional Distress | Telepsychotherapy

Brazil
University of Sao Paulo

Completed

Periodontal and Salivary Evaluation of Type 1 Diabetes Mellitus Patients

Diabetes Mellitus, Type 1 | Periodontal Diseases

Brazil
Federal University of Rio Grande do Sul

Completed

Impact of Different Types of Exercise Training on Biochemical Markers of Insulin-dependent Patients

Diabetes Mellitus, Type 1

Brazil
Grifols Therapeutics LLC

Terminated

Study to Evaluate the Safety and Efficacy of Liquid Alpha1-Proteinase Inhibitor (Human) in Hospitalized Participants With Coronavirus Disease (COVID-19)

COVID-19

United States, Brazil, Chile, Colombia, Mexico
Chiltern Pesquisa Clinica Ltda

Completed

Immunogenicity, Safety, and Tolerability of MF59-Adjuvanted Versus Non-Adjuvanted Influenza Vaccines in Patients With HIV-1 Infection

H1N1 Influenza Virus | Human Immunodeficiency Virus Type 1 (HIV-1) Infection

Brazil
University of Sao Paulo

Terminated

Antimicrobial Photodynamic Therapy on Periodontal Treatment and Salivary Status of Type 1 Diabetes Mellitus Patients

Diabetes Mellitus, Type 1 | Periodontal Diseases | Periodontal Pocket

Brazil
AIDS Clinical Trials Group
National Cancer Institute (NCI); National Institute of Allergy and Infectious... and other collaborators

Completed

Three Chemo Regimens as an Adjunct to ART for Treatment of Advanced AIDS-KS

HIV-1 Infection

South Africa, Brazil, Zimbabwe, Kenya, Malawi, Uganda
AstraZeneca
Hutchinson MediPharma (HMP)

Active, not recruiting

Savolitinib vs. Sunitinib in MET-driven PRCC.

Kidney Neoplasms | Carcinoma, Renal Cell | Urologic Neoplasms | Neoplasms by Site | Kidney Diseases | Carcinoma | Enzyme Inhibitors | Protein Kinase Inhibitors

United States, Italy, France, Korea, Republic of, Brazil, Russian Federation, Ukraine
Roberto Léo da Silva

Completed

Preclinical Cardiomyopathy and Autonomic Function in Type 1 Diabetes

Diabetes Mellitus, Type 1 | Diabetic Cardiomyopathies | Autonomic Neuropathy, Diabetic

Brazil
Hospital Universitário Professor Edgard Santos

Completed

Use of Pentoxifylline in Human T-lymphotropic Virus Type-1 (HTLV-1) Diseases (Pentox)

Immune System Diseases | Physical Disability | Tropical Spastic Paraparesis | HTLV-1 | Pentoxifylline

Brazil
Novo Nordisk A/S

Completed

Safety and Efficacy of 3 Different Doses of Long Acting Factor VII in Haemophilia A or B Patients With Inhibitors

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors

France, United States, Sweden, Serbia, Turkey, United Kingdom, Malaysia, Brazil, Former Serbia and Montenegro, Japan, South Africa
Fundação Educacional Serra dos Órgãos

Completed

Use of Topical Liquid Diclofenac Following Laser Microporation of Cutaneous Neurofibromas in Patients With NF1

Neurofibromatosis 1 | Cutaneous Neurofibroma

Brazil
Hospital Universitário Professor Edgard Santos

Completed

Urological Physical Therapy in HTLV-1 With Urinary Symptoms (UROHTLV)

Tropical Spastic Paraparesis | HTLV-1

Brazil
ANRS, Emerging Infectious Diseases
MSD France

Not yet recruiting

DORAvirine Versus DOlutegravir Based Antiretroviral Regimens in Treatment-naïve People Living With HIV-1 Infection (ELDORADO)

HIV-1-infection

Brazil, Cambodia, Cameroon, Côte D'Ivoire, France, Mozambique
Universidade Federal Fluminense

Active, not recruiting

Gingival Health and Malocclusion Among Type 1 Diabetic Children and Adolescents

Diabetes | Diabetes Mellitus, Type 1 | Periodontal Diseases | Gingivitis | Malocclusion | Malocclusion in Children

Brazil
Baxalta now part of Shire

Completed

Efficacy and Safety Study of Prophylactic Versus On-Demand Treatment With Feiba NF in Subjects With Hemophilia A or B and a High Titer Inhibitor

Hemophilia A | Hemophilia B | Hemophilia A or B With Inhibitors

Poland, United States, Bulgaria, Romania, Japan, Russian Federation, New Zealand, Croatia, Ukraine, Brazil
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Study of Options for Second-Line Effective Combination Therapy (SELECT) (SELECT)

HIV-1 Infection

Peru, Kenya, Malawi, Brazil, South Africa, Zimbabwe, India, Thailand, Tanzania
Janssen Sciences Ireland UC

Completed

TMC114-TiDP29-C232 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir (Rtv) for Children Coming From Any of the Three Ongoing Tibotec Sponsored Pediatric Studies With DRV

HIV-1 Infections

France, Ukraine, South Africa, United Kingdom, Argentina, Brazil, India, Spain
Janssen Sciences Ireland UC

Completed

TMC114IFD3001 - Study Providing Continued Access to Treatment With Darunavir (DRV)/Ritonavir(Rtv) in HIV1 Infected Adults, Adolescents and Children Aged 3 Years or Above and Coming From Previous Company Sponsored Studies With DRV

HIV-1 Infections

Costa Rica, Panama, South Africa, Ukraine, Malaysia, Brazil, Thailand, Guatemala
Fundación Huésped
ViiV Healthcare; Federal University of Bahia

Recruiting

Dolutegravir-Lamivudine for naïve HIV-Infected Patients With ≤200 CD4/mm3 (DOLCE)

HIV-1-infection

Brazil, Argentina
Novo Nordisk A/S

Completed

Efficacy and Safety of NNC 0078-0000-0007 in Patients With Congenital Haemophilia and Inhibitors (adept™2)

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors

Taiwan, United Kingdom, Thailand, Serbia, Croatia, Italy, Poland, Romania, Hungary, Malaysia, United States, Austria, Brazil, Greece, Japan, Puerto Rico, Russian Federation, South Africa, Turkey
Novo Nordisk A/S

Completed

Efficacy of NovoSeven® in Bleeding Prophylaxis in Hemophilia

Congenital Bleeding Disorder | Haemophilia A With Inhibitors | Haemophilia B With Inhibitors

France, United States, Spain, Brazil, Philippines, South Africa, Poland, Turkey, Romania, Bulgaria, Russian Federation, Argentina
ANRS, Emerging Infectious Diseases
Merck Sharp & Dohme LLC; Ministry of Health, Brazil

Completed

Raltegravir Versus Efavirenz in Naive HIV-1-infected Patients Receiving Rifampin for Active Tuberculosis (REFLATE TB2)

Tuberculosis | HIV-1 Infection

France, Vietnam, Brazil, Côte D'Ivoire, Mozambique
University of Extremadura

Completed

Influence Physical Activity Psychological Responses COVID-19 Pandemic

Mental Health Wellness 1 | Sedentary Behavior

Brazil, Chile, Uruguay
National Institute of Allergy and Infectious Diseases...
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Recruiting

Study of Oral and Long-Acting Injectable Cabotegravir and Rilpivirine in Virologically Suppressed Children Living With HIV-1, Two to Less Than 12 Years of Age

HIV-1-infection

United States, Brazil, South Africa, Uganda, Botswana, Thailand

Clinical Trials on PD-1 Inhibitors in Brazil

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