Clinical Trials on PIK3CA Mutation in United States
Total 803 results
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Faeth TherapeuticsActive, not recruitingAdvanced Solid Tumor | PIK3CA Mutation | PTEN Loss of Function MutationUnited States
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Pamela MunsterNovartisWithdrawnLocally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Solid Tumors, Adult | HPV-Related Squamous Cell Carcinoma | Human Papillomavirus-Related Carcinoma | PIK3CA Mutation-Related Tumors | PIK3CA Mutation | Human Papillomavirus-Related Squamous Cell CarcinomaUnited States
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Novartis PharmaceuticalsActive, not recruitingPIK3CA-related Overgrowth Spectrum (PROS)Spain, France, Ireland, United States
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Novartis PharmaceuticalsCompletedPIK3CA-Related Overgrowth Spectrum (PROS)Spain, France, Australia, United States, Ireland
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AstraZenecaCompletedAdvanced Solid Malignancies | Breast Cancer - ER+, HER2 - | Breast Cancer - ER+, HER2-, PIK3CA Gene MutationUnited States, United Kingdom
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Novartis PharmaceuticalsRecruitingPIK3CA-related Overgrowth Spectrum (PROS)United States, Canada, Spain, Switzerland, France, United Kingdom, Germany, Italy, China, Hong Kong, Netherlands, Norway
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Novartis PharmaceuticalsRecruitingPIK3CA-related Overgrowth SpectrumUnited States
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National Human Genome Research Institute (NHGRI)CompletedGenetics | Growth Disorder | PIK3CA-Related Overgrowth Spectrum (PROS)United States
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Relay Therapeutics, Inc.RecruitingBreast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Solid Tumor, Adult | HER2-negative Breast Cancer | Unresectable Solid Tumor | PIK3CA MutationUnited States, Spain, France, Italy
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Relay Therapeutics, Inc.Active, not recruitingBreast Cancer | Advanced Breast Cancer | Metastatic Breast Cancer | Solid Tumor, Adult | HER2-negative Breast Cancer | Hormone Receptor Positive Tumor | Unresectable Solid Tumor | PIK3CA MutationUnited States
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Marc Dall'Era, MDNational Cancer Institute (NCI); Janssen, LPRecruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Prostate Carcinoma | RAD51C Gene Mutation | BRIP1 Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | CDK12 Gene Mutation | CHEK1 Gene Mutation | DNA Damage Response Gene Mutation | DNA Repair Gene Mutation | FANCA Gene Mutation and other conditionsUnited States
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Sidney Kimmel Comprehensive Cancer Center at Johns...Bristol-Myers Squibb; Vanderbilt University; Avon Breast Health Access FundActive, not recruitingMetastatic Solid Tumor | SF3B1 Gene Mutation | Spliceosome Mutation | U2AF1 Gene Mutation | SRSF2 Gene MutationUnited States
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University of California, San FranciscoGlaxoSmithKlineRecruitingMetastatic Solid Tumor | BRCA1 Mutation | BRCA2 Mutation | PALB2 Gene Mutation | ATM Gene MutationUnited States
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Pamela MunsterNational Cancer Institute (NCI)RecruitingBRCA1 Mutation | BRCA2 Mutation | PALB2 Gene Mutation | ATM Gene Mutation | BRCA Mutation | Checkpoint Kinase 2 Gene MutationUnited States
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Novartis PharmaceuticalsNantCell, Inc.TerminatedPIK3CA Mutated Advanced Solid Tumors | PIK3CA Amplified Advanced Solid TumorsSpain, Belgium, United States, Canada
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)RecruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Estrogen Receptor Negative | HER2/Neu Negative | Progesterone Receptor Negative | Triple-Negative Breast Carcinoma | MLH1 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | BARD1 Gene Mutation | MSH2 Gene Mutation | MSH6... and other conditionsUnited States
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University of PennsylvaniaRecruiting
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University of California, San FranciscoAmerican Cancer Society, Inc.CompletedBRCA1 Gene Mutation | BRCA2 Gene MutationUnited States
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Mayo ClinicNational Cancer Institute (NCI)TerminatedSecondary Acute Myeloid Leukemia | Untreated Adult Acute Myeloid Leukemia | Acute Myeloid Leukemia With FLT3/ITD Mutation | Acute Myeloid Leukemia With Gene Mutations | FLT3 Tyrosine Kinase Domain Point MutationUnited States
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Memorial Sloan Kettering Cancer CenterUniversity of Pennsylvania; University of California, Los Angeles; Dana-Farber... and other collaboratorsActive, not recruiting
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Weill Medical College of Cornell UniversityBasser Research Center for BRCARecruiting
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Memorial Sloan Kettering Cancer CenterRecruitingBRCA1 Mutation | BRCA2 Mutation | APC Gene Mutation | MLH1 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene Mutation | PALB2 Gene Mutation | PTEN Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | BARD1 Gene Mutation | MSH2 Gene Mutation | MSH6 Gene Mutation | PMS2 Gene Mutation | POLD1 Gene... and other conditionsUnited States
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Ohio State University Comprehensive Cancer CenterRecruitingBRCA1 Gene Mutation | BRCA2 Gene MutationUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingAdvanced Malignant Solid Neoplasm | Refractory Malignant Solid Neoplasm | KRAS Gene Mutation | Metastatic Malignant Solid Neoplasm | EGFR Gene Mutation | ERBB2 Gene Amplification | ERBB2 Gene Mutation | EGFR Gene Amplification | ERBB3 Gene Mutation | ERBB4 Gene MutationUnited States
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National Cancer Institute (NCI)CompletedAdult Solid Neoplasm | BRCA1 Mutation Carrier | BRCA2 Mutation CarrierUnited States
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University of VirginiaActive, not recruitingReal-Time Monitoring of Symptoms in Lung Cancer Patients Receiving Oral Targeted Therapies (Lung001)Lung Cancer | ALK Gene Mutation | MET Gene Mutation | KRAS Mutation-Related Tumors | RET Gene Mutation | EGFR Gene Mutation | EGFR | ROS1 Gene Mutation | BRAFUnited States
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Mayo ClinicRecruitingCancer | Cancer Gene Mutation | PAN Gene MutationUnited States
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nVision MedicalCompletedBRCA1 Mutation | BRCA2 Mutation | Atypia Suspicious for MalignancyUnited States
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Abramson Cancer Center at Penn MedicineRecruiting
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Johns Hopkins UniversityMuscular Dystrophy Association; Actio Biosciences, IncRecruiting
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Columbia UniversityRecruitingCancer | Insulin Resistance | MTOR Gene Mutation | PI3K Gene Mutation | AKT Gene MutationUnited States
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Anita TurkEli Lilly and CompanyTerminatedCancer | Cancer Metastatic | BRAF V600E | MEK1 Gene Mutation | MEK2 Gene Mutation | ERK Mutation | RAF1 Gene MutationUnited States
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Beth Israel Deaconess Medical CenterJohns Hopkins University; Dana-Farber Cancer Institute; AstraZenecaActive, not recruitingMetastatic Breast Cancer | Invasive Breast Cancer | BRIP1 Gene Mutation | PALB2 Gene Mutation | ATM Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | Somatic Mutation Breast Cancer (BRCA1) | Somatic Mutation Breast Cancer (BRCA2)United States
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Pathway GenomicsCompletedNeoplasms | MutationUnited States
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Pasithea Therapeutics Corp.RecruitingAdvanced Solid Tumors | RAS Mutation | NF1 Mutation | RAF MutationUnited States
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University of PennsylvaniaInovio PharmaceuticalsRecruiting
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Deciphera Pharmaceuticals LLCRecruitingMelanoma | Non-Small Cell Lung Cancer | Advanced Solid Tumor | Pancreatic Ductal Adenocarcinoma | BRAF Gene Mutation | RAS Mutation | NF1 Mutation | RAF Mutation | CRAF Gene MutationUnited States
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Weill Medical College of Cornell UniversityCompletedBreast Cancer | Gynecologic Cancer | BRCA1 Mutation | BRCA2 MutationUnited States
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University of ChicagoRecruitingMyeloproliferative Neoplasm | Blood Cancer | IDH2 Gene Mutation | IDH1 Mutation | IDH MutationUnited States
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University of California, San FranciscoThe Bluefield Project to Cure Frontotemporal DementiaCompletedProgranulin Mutation CarriersUnited States
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University of California, Los AngelesBoston Children's Hospital; Duke University; Children's Hospital Medical Center...RecruitingBohring-Opitz Syndrome | ASXL1 Gene Mutation | Shashi-Pena Syndrome | ASXL2 Gene Mutation | Bainbridge-Ropers Syndrome | ASXL3 Gene MutationUnited States
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Southwest Oncology GroupNational Cancer Institute (NCI)CompletedBRCA1 Gene Mutation | BRCA2 Gene Mutation | Recurrent Squamous Cell Lung Carcinoma | Stage IV Squamous Cell Lung Carcinoma AJCC v7 | BRIP1 Gene Mutation | PALB2 Gene Mutation | ATM Gene Mutation | ATR Gene Mutation | CHEK2 Gene Mutation | NBN Gene Mutation | RAD51 Gene Mutation | CHEK1 Gene Mutation | FANCA Gene... and other conditionsUnited States, Canada
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National Human Genome Research Institute (NHGRI)Children's National Research Institute; Uniformed Services University of the...RecruitingProteus Syndrome | PIK3CA Related Overgrowth SpectrumUnited States
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Prisma Health-UpstateIpsenRecruitingSolid Tumor | ARID1A Gene MutationUnited States
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Nested Therapeutics, IncRecruitingGlioma | Melanoma | NSCLC | Oncology | Solid Tumor, Adult | MEK Mutation | RAF Gene Mutation | Ras (KRAS or NRAS) Gene Mutation | MAPK Pathway Gene MutationUnited States, Australia
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BioMed Valley Discoveries, IncTerminatedAdvanced Solid Tumor | MAP2K1 Gene Mutation | BRAF Gene Mutation | MEK Mutation | BRAF Gene Alteration | MEK Alteration | MAP2K1 Gene Alteration | MAP2K2 Gene Mutation | MAP2K2 Gene AlterationUnited States
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University Medical Center NijmegenRecruitingOvarian Cancer | BRCA1 Gene Mutation | BRCA2 Gene Mutation | RAD51C Gene Mutation | RAD51D Gene Mutation | BRIP1 Gene MutationNetherlands, United States, Belgium, Norway, Poland, Italy, Australia, Mexico, Brazil, Sweden, Uruguay
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Irina A AnselmNo longer availableCitrate Transporter Deficiency | SLC13A5 Gene MutationUnited States
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Active, not recruitingBRCA1 Gene Mutation | BRCA2 Gene Mutation | Metastatic Malignant Neoplasm | Advanced Malignant Neoplasm | Recurrent Malignant Neoplasm | Refractory Malignant Neoplasm | PALB2 Gene Mutation | ATM Gene MutationUnited States
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Sidney Kimmel Comprehensive Cancer Center at Johns...Merck Sharp & Dohme LLCActive, not recruitingHigh Tumor Mutation Burden | High TMB (Tumor Mutation Burden) | MSS (Microsatellite Stable)United States