Clinical Trials on Pharmacokinetic Profile

Total 833 results

Astellas Pharma Europe B.V.

Completed

A Study to Assess the Safety, Tolerability and Effects of Single and Multiple Ascending Doses of ASP1707 in Healthy Male and Pre-menopausal Female Subjects, Including a Comparison of the Effects Under Fasted and Fed Conditions in Healthy Young Male Subjects

Pharmacokinetics of ASP1707 | Pharmacodynamics of ASP1707

France
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How a Drug That Alters Liver Enzymes (Rifampin) Affects the Metabolism of Enzalutamide in Men

Healthy Subjects | Drug-Drug Interaction (DDI) | Pharmacokinetics of Enzalutamide

Germany
Central South University

Completed

Pharmacokinetics of a Standard Paracetamol Tablet and Oral Solution After Oral Administration in Chinese Healthy Volunteers

Focus of Study: Pharmacokinetics Analysis, in Vivo Dissolution Studies
Astellas Pharma Global Development, Inc.

Completed

A Dose Escalation Study to Assess the Safety, Tolerability, and Pharmacokinetics of ASP4058 Following Single Oral Doses

Healthy Subjects | Pharmacokinetics of ASP4058 | Food Effect of ASP4058

United States
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Safety, Tolerability and Effects of Single Ascending Doses of ASP3652 in Healthy Subjects

Healthy Subjects | Pharmacokinetics | Pharmacodynamics | Safety

Netherlands
Inje University

Completed

The Effect of CYP3A Genetic Polymorphism on the Pharmacokinetics of Phosphodiesterase type5 Inhibitors in Male Subjects (CYP3APDE5I)

Healthy Subjects | Pharmacokinetics of Three PDE5Is | Genetic Polymorphic CYP3A5
Lykos Therapeutics

Not yet recruiting

MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function

Pharmacokinetics | Hepatic Impairment

United States
University Hospital, Ghent
University Hospital, Antwerp; Queen Fabiola Children's University Hospital,...

Recruiting

Antibiotic Dosing in Pediatric Intensive Care (ADIC)

Pharmacokinetics | Vancomycin | Amoxicillin-clavulanate | Piperacillin-tazobactam | Teicoplanin | Meropenem | Ciprofloxacin | Amikacin

Belgium
Guangdong Raynovent Biotech Co., Ltd

Completed

Pharmacokinetics of ZSP1273 in Participants With Hepatic Impairment

Pharmacokinetics | Hepatic Impairment

China
Biota Pharmaceuticals, Inc.

Completed

Safety and Pharmacokinetics Study of Multiple Ascending Doses of BTA-C585 in Healthy Volunteers

Healthy Volunteers | Pharmacokinetics

United States
St George's, University of London

Unknown

Neonatal and Paediatric Pharmacokinetics of Antimicrobials Study (NAPPA)

Paediatric Antimicrobial Pharmacokinetics

United Kingdom
University of Hohenheim
German Federal Ministry of Education and Research

Completed

Improved Oral Bioavailability of Curcumin Incorporated Into Micelles

Pharmacokinetics of New Curcumin Formulations | Safety of New Curcumin Formulations

Germany
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Study of the Pharmacokinetics of Isavuconazole in Healthy Non-Elderly and Elderly Male and Female Subjects

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Safety and Tolerability in Elderly

United States
Johns Hopkins University

Completed

Polymorphic Effects of Cytochrome P450 3A5 on Pharmacokinetics of Maraviroc and Its Metabolites

Healthy Subjects | Cytochrome P450 CYP3A5 Enzyme Polymorphism | Pharmacokinetics of Maraviroc

United States
Astellas Pharma Inc

Completed

A Study to Find Out How Much Mirabegron Gets Into the Body After Dosing With a Tablet Formulation

Healthy Subjects | Bioavailability | Pharmacokinetics of Mirabegron

Netherlands
Turku University Hospital

Completed

Effects of Posaconazole and Voriconazole on the Pharmacokinetics and Pharmacodynamics of Sublingual Buprenorphine (PosaBupre)

Pharmacokinetics and Pharmacodynamics of Sublingual Buprenorphine

Finland
Astellas Pharma Inc

Completed

Relative Bioavailability Study of Solifenacin Succinate Liquid Suspension (Fed and Fasting) Versus VESIcare Tablet (Fasting) in Healthy Volunteers

Healthy Volunteers | Pharmacokinetics of Solifenacin Succinate | Bioavailability of Solifenacin Succinate

United States
Chung Shan Medical University

Not yet recruiting

Pharmacokinetic Effect of AstraGin on Whey Protein Absorption and Muscle Function in Healthy Subjects

Pharmacokinetic Effect of AstraGin on Whey Protein Absorption and Muscle Function in Healthy Subjects

Taiwan
Jazz Pharmaceuticals

Completed

Study to Evaluate the Effect of Rifampicin, Ketoconazole, and Omeprazole on the Pharmacokinetics of Sativex

Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Known Inducer of CYP3A4 | Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a Potent Inhibitor of CYP3A4 | Evaluation of Pharmacokinetics of Sativex in the Absence and Presence of a CYP2C19...

United Kingdom
Astellas Pharma Europe B.V.
Medivation, Inc.

Completed

A Study to Evaluate How Daily Dosing With Enzalutamide Affects the Metabolism of Caffeine and Dextromethorphan in Men With Prostate Cancer

Prostate Cancer | Pharmacokinetics of Dextromethorphan | Pharmacokinetics of Caffeine

Moldova, Republic of
Astellas Pharma Global Development, Inc.

Recruiting

A Study to Assess the Antitumor Activity, Safety, Pharmacokinetics and Biomarkers of Zolbetuximab (IMAB362) in Participants With Claudin (CLDN) 18.2 Positive, Metastatic or Advanced Unresectable Gastric and Gastroesophageal Junction (GEJ) Adenocarcinoma and Locoregional Gastric or GEJ Adenocarcinoma (ILUSTRO)

Gastric Cancer | Pharmacokinetics of Zolbetuximab | Gastro-esophageal Junction (GEJ) Cancer | Pharmacokinetics of Oxaliplatin | Pharmacokinetics of Fluorouracil Bolus (5-FU)

United States, Japan, Italy, Korea, Republic of, Taiwan, France
Centre Hospitalier Universitaire, Amiens
Université de Lille

Recruiting

Spectroscopic Analysis of Tongue Tumor Samples. (SpecTum)

Squamous Cell Carcinoma | Oral Cavity | Mass Spectroscopy | Molecular Profile | Surgical Margins | Tongue

France
University of Bergen
Helse Fonna

Unknown

Children With ADHD Symptoms: Comorbid Conditions, Cognitive and Social Performance (NF ADHD)

Comorbid Conditions | Social-demographic Profiles

Norway
Altor BioScience

Terminated

PK Sub-Study of QUILT-3.032 (CA ALT-803-01-16) and of QUILT-2.005 (CA ALT-803-01-14)

Pharmacokinetics

United States
University Medicine Greifswald

Completed

Pharmacokinetic and Pharmacodynamic Interactions Between the Cholesterol-lowering Ezetimibe and the Non-nucleoside Reverse Transcriptase Inhibitor Efavirenz During Chronic Treatment in Healthy Volunteers With Reference to Intestinal Expression of CYP3A4, UGT1A1, ABCB1 and ABCC2

Pharmacokinetics | Pharmacodynamics | Drug Interactions | Intestinal Transporter Expression

Germany
Seattle Institute for Biomedical and Clinical Research
Genomind, LLC

Completed

Medication Optimization Using Pharmacogenetic Testing and the G-DIG to Reduce Polypharmacy in a Mental Health Population (MedOPT)

Pharmacogenetic Testing

United States
Vrije Universiteit Brussel

Completed

Prognostic Factor Research of Sensory Profiles in Development of Central Sensitization

Low Back Pain | Central Sensitisation | Sensory Profiles | Nociplastic Pain

Belgium
University Hospital, Ghent

Recruiting

Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO) (PADECMO)

Pharmacokinetics | Vancomycin | Amoxicillin-clavulanate | Piperacillin-tazobactam | Teicoplanin | Meropenem | Ciprofloxacin | Amikacin | Cefazolin

Belgium
University of Hohenheim
Universität Tübingen

Completed

Oral Bioavailability and Bioactivity of Prenylflavonoids From Hops

Safety After Oral Intake | Pharmacokinetics After Oral Intake | Immune Cells Activity

Germany
Pfizer

Completed

A Study to Investigate the Effect of Administration of Ceftazidime-avibactam (CAZ-AVI) and Ceftaroline Fosamil -Avibactam (CXL) on the Intestinal Flora of Healthy Volunteers

Pharmacokinetics | Safety | Open Label | CAZ-AVI | CXL | Effect on Intestinal Flora

Sweden
AstraZeneca

Withdrawn

A Study to Compare the Pharmacokinetics of Different Formulations of AZD9977 and the Influence of Food in Healthy Male Subjects

Healthy Male Subjects | Pharmacokinetics | Safety | Food Effect

United Kingdom
Astellas Pharma Europe B.V.

Completed

A Study to Assess the Interaction Between ASP1707 and Itraconazole in Healthy Female Subjects

Healthy Subjects | Pharmacokinetics | DDI (Drug-Drug Interaction)

Germany
Mutual Pharmaceutical Company, Inc.

Completed

Drug-Drug Interaction Study Between Colchicine and Diltiazem ER

Healthy; Adult; Volunteer; Colchicine; Pharmacokinetics; Diltiazem; Cytochrome p450 3A4; P-glycoprotein

United States
University of Hohenheim
German Federal Ministry of Education and Research

Completed

Oral Bioavailability of Curcumin From Micronized Powder and Liquid Micelles in Healthy Young Women and Men

Pharmacokinetics of Novel Curcumin Formulations | Safety of Novel Curcumin Formulations

Germany
Clavis Pharma

Completed

Elacytarabine Mass Balance Study in Healthy Volunteers

Not Applicable as This is a Mass Balance/Pharmacokinetic Study Performed in Healthy Subjects

United Kingdom
Elina Brinck

Not yet recruiting

KetaMoHydBup: Pharmacokinetic Interaction of S-ketamine, Morphine, Hydromorphone and Buprenorphine (KetaMoHydBup)

The Effect of S-ketamine on Pharmacokinetics of Morphine, Hydromorphone, and Buprenorphine
Astellas Pharma Global Development, Inc.
Janssen Biotech, Inc.

Completed

A Study to Assess the Relative Bioavailability Between Two ASP015K Tablets and the Food Effect of a New Tablet in Healthy Adult Subjects

Healthy Subjects | Bioavailability of ASP015K | Pharmacokinetics of ASP015K | Food Effect of ASP015K

United States
Tibotec Pharmaceuticals, Ireland

Completed

TMC125-TiDP2-C188: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Effect of Multiple-dose TMC125 on Buprenorphine and Norbuprenorphine Administered in HIV-negative Patients on Stable Buprenorphine/Naloxone Maintenance Therapy.

HIV | Pharmacokinetics
Heidelberg University

Completed

Influence of Drug Transporter Expression on the Pharmacokinetics of the HIV Protease Inhibitor Kaletra

Healthy | Pharmacokinetics

Germany
National Taiwan University Hospital

Unknown

Immune Profiles and Circulating Tumor Cell Status Following Prostate Cryotherapy

Prostate Cancer | Immune Profile | Circulating Cancer Cells | Clinical Corelation

Taiwan
Guangzhou General Hospital of Guangzhou Military...

Unknown

Pharmacokinetics and Pharmacodynamics of Sugammadex in Reversal of Vecuronium-induced Neuromuscular Blockade

Pharmacokinetics | Pharmacodynamics

China
Mallinckrodt

Completed

Pharmacokinetic, Bioavailability, and Safety Study of COV155 Administered in Healthy Subjects Under Fed and Fasted Conditions

Pharmacokinetics
Takeda

Completed

TAK-875 Glimepiride Drug-Interaction Study

Pharmacokinetics

United States
Beijing Children's Hospital
Shandong University

Recruiting

Population Pharmacokinetics of Fluconazole in the Treatment of Neonatal Fungal Infectious Disease

Pharmacokinetics | Infection | Newborn | Fluconazole

China
AstraZeneca

Completed

Comparison of Two Formulations of AZD5363 and the Effect of Food on Pharmacokinetic Exposure, Safety and Tolerability (OAK)

Safety and Tolerability, | Advanced Solid Malignancy, | Pharmacokinetics, Pharmacodynamics, | Tumour Response,

United Kingdom, Netherlands
Columbia University
Organon

Completed

Comparison of Serum Contraceptive Hormone Levels Between Normal Weight and Obese Users of the NuvaRing®

Pharmacokinetics

United States
Vanda Pharmaceuticals

Completed

Evaluation of the Pharmacodynamic and Pharmacokinetic Interactions of Tasimelteon and Ethanol

Pharmacodyamics and Pharmacokinetics of Tasimelteon Alone and in Combination With Ethanol

Canada
University Medicine Greifswald
AWD.pharma GmbH & Co. KG

Completed

Pharmacokinetics, Metabolism and Analgesic Effects of Flupirtine

Pain | Pharmacokinetics | Flupirtine

Germany
Radboud University Medical Center
Sint Maartenskliniek

Not yet recruiting

Periarticular Penetration of Cefazolin and Clindamycin in Second Stage Revision Arthroplasty of the Hip (CONCENTRATE)

Pharmacokinetics | Bone and Joint Infection | PJI
Aquilon Pharmaceuticals S.A.

Completed

Single-dose AQ001S PK Study in Healthy Volunteers (BORA)

Pharmacokinetics

Bulgaria

Clinical Trials on Pharmacokinetic Profile

Sponsors and Collaborators

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Drug Interventions

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CROs in Mali

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Rare Diseases

Drug Interventions

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