Clinical Trials on Pharmacologic Action

Total 2878 results

AstraZeneca

Completed

A Phase I Study in Healthy Volunteers to Assess the Effect of Cytochrome3A4 (CYP3A4) Inhibitors (Diltiazem and Itraconazole) on the Pharmacokinetics (PK) of AZD3293 and the Effects of AZD3293 on the Pharmacokinetics of Midazolam, a Cytochrome 3A4 and Cytochrome 3A5 (CYP3A4/CYP3A5) Substrate (AZD3293DDI)

Healthy Volunteers | Pharmacologic Action

United States
Vivoryon Therapeutics N.V.
Covance

Completed

Effects of PQ912 on the Pharmacokinetics of Midazolam and Omeprazole

Healthy Volunteers | Pharmacologic Action

United Kingdom
Universidad Nacional de Salta
Fundacion Mundo Sano

Not yet recruiting

Pharmacokinetics and Excretion of Albendazole and Its Metabolites in Saliva

Pharmacological Action
Federal State Budgetary Scientific Institution,...
The League of Clinical Research, Russia; Institute of Biomedical Chemistry,...

Completed

"Corticoid-16" in Long Term When Administered Systemically in Patients in Routine Medical Practice

Pharmacological Action
National Aeronautics and Space Administration (NASA)

Completed

Optimize Astronaut Sleep Medication Efficacy and Individual Effects

Sleep | Cognition | Pharmacologic Actions
Masaryk Hospital Usti nad Labem

Unknown

PARADOX - the Incidence of Paradoxical Reactions in Pediatric Patients Premedicated With Midazolam (PARADOX)

Pharmacological Action

Czechia
Ervin Taso
University of Belgrade

Completed

Dental Restorations Effect on Oxidative Status of the Gingival Crevicular Fluid

Pharmacological Action

Serbia
Tianjin Medical University General Hospital

Recruiting

Efficacy and Safety of Liposomal Bupivacaine Under ERAS Concept for Postoperative Analgesia of Ultrasound-Guided QLB in Gynecologic Laparoscopic Patients: A Randomized, Single-blind, Active-Controlled Clinical Study

Pharmacological Action

China
Qin Zhang

Recruiting

Ulinastatin Improves and Prevents Cardiac Dysfunction Induced by Cardiopulmonary Bypass

Pharmacological Action

China
Food and Nutrition Research Institute, Philippines
Ateneo de Manila University; De La Salle Medical and Health Sciences Institute

Active, not recruiting

Exploratory Pharmacokinetic Study of Virgin Coconut Oil (VCO)

Pharmacological Action

Philippines
Fudan University
Shanghai First Maternity and Infant Hospital; Women and children's hospital...

Unknown

Comparison of Epidural Labor Analgesia With Dexmedetomidine or Sufentanil

Pharmacological Action

China
Kolding Sygehus

Unknown

Pharmacokinetic Study of Paracetamol. (Para1523)

Pharmacological Action

Denmark
Walter Reed Army Institute of Research (WRAIR)

Completed

Genetic Variability in CYP2D6 in U.S Active Duty Population

Pharmacologic Action

United States
AstraZeneca

Completed

Relative Bioavailability Study to Assess Two Solid Formulations Compared to an Oral Solution of AZD3293 in Healthy Male and Non-Fertile Female Subjects (BA)

Healthy Volunteers | Pharmacologic Action

United States
CardioDex
Sheba Medical Center

Withdrawn

Hemostatic Closure of Femoral Artery Access Site, Using the QuickClose Design 9 System

Coagulation | Therapeutic Uses | Pharmacologic Actions

Israel
University of Malaya
Ministry of Health, Malaysia

Unknown

Pharmacometabolomics of Andrographis Paniculata And Metformin In Healthy Volunteers Under Fasting Condition

Pharmacokinetics | Molecular Mechanisms of Pharmacological Action

Malaysia
Balance Therapeutics

Completed

A Study to Investigate the Mass Balance of BTD-001 (HV103)

Molecular Mechanisms of Pharmacological Action

United Kingdom
Zealand University Hospital
University of Copenhagen

Unknown

Test of a New Gel-based Colon Cleansing Agent Compared to Moviprep

Pharmacological Action

Denmark
Emad Abdel Aal Saliem

Completed

Intravitreal Triamcinolone and Moxifloxacin Injection After Cataract Surgery

Pharmacological Action

Egypt
Karen Hoejmark Hansen

Completed

The Effect of Tranexamic Acid. A Randomised Study of Patients Undergoing Elective Lumbar Spine Surgery.

Pharmacological Action

Denmark
Johns Hopkins University

Completed

Pilot Study: Effects of Psilocybin on Behavior, Psychology and Brain Function in Long-term Meditators

Psilocybin | Therapeutic Uses | Psychotropic Drugs | Hallucinogens | Pharmacologic Actions | Central Nervous System Agents

United States
National Liver Institute, Egypt
Pharco Pharmaceuticals

Unknown

Safety and Efficacy of Gratisovir (Sofosbuvir)- Ribavirin Therapy in Pediatric Patients

Pharmacological Action

Egypt
Ain Shams University

Not yet recruiting

Assessment of Rituximab Therapeutic Response Versus Conventional Treatment

Pharmacological Action
Rambam Health Care Campus

Completed

The Effect Methylphenidate Hydrochloride on Pain and Auditory Sensitivity in Healthy Subjects

Pharmacological Action (PA)

Israel
Jaseng Medical Foundation

Recruiting

Ultrasound Guiding Pharmacopuncture Therapy for Supraspinatus Tendinopathy

Pharmacological Action

Korea, Republic of
Washington University School of Medicine
Centers for Disease Control and Prevention

Completed

Probiotics to Promote Intestinal Health

Communicable Diseases | Infection | Therapeutic Uses | Anti-Infective Agents | Pharmacologic Actions

United States
Profil Institut für Stoffwechselforschung GmbH
Merck Sharp & Dohme LLC

Completed

Sitagliptin and the Risk for Hypoglycaemia in Type 2 Diabetes Patients

Pharmacological Action

Germany
University of Oxford

Completed

Effects of Seven Day Prucalopride Administration in Healthy Volunteers

Mental Disorders | Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Cognition | Antidepressive Agents

United Kingdom
Dr. Lutfi Kirdar Kartal Training and Research Hospital

Not yet recruiting

Postoperative Pain in Laparoscopic Radical Prostatectomy Surgery With Tranexamic Acid: Analgesia? Hiperalgesia?

Pharmacological Action
Washington State University
Providence Medical Research Center

Unknown

Medication-taking Preferences & Practices of Patients With Chronic Conditions

Adult Disease | Pharmacological Action | Any Condition in N73.0 Specified as Chronic

United States
University of Oxford

Completed

Effects of Acute Prucalopride Administration in Healthy Volunteers

Depressive Disorder | Depression | Mood Disorders | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
University of Oxford
University of Bath

Unknown

Citalopram and Self Emotional Processing

Depressive Disorder | Depression | Molecular Mechanisms of Pharmacological Action | Mental Disorder | Cognition | Antidepressive Agents

United Kingdom
Universidad de Antioquia
Hospital Pablo Tobón Uribe

Unknown

Pharmacogenomic in Colombian Patients With Rheumatoid Arthritis

Pharmacological Action

Colombia
Fudan University

Not yet recruiting

The Maintenance Treatment of Apatinib/Capecitabine Versus Observation in Advanced Gastric Cancer

Neoplasms | Stomach Neoplasms | Gastrointestinal Neoplasms | Digestive System Neoplasms | Stomach Diseases | Molecular Mechanisms of Pharmacological Action | Capecitabine | Apatinib
Hanmi Pharmaceutical Company Limited

Completed

Single Ascending Dose Study to Assess Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of HM15912 in Healthy Korean Subjects

Pharmacology

Korea, Republic of
Janssen Research & Development, LLC

Completed

A Study to Assess the Effect of Timing of Food Intake on the Pharmacokinetics of Abiraterone Following Single-Dose Administration of Abiraterone Acetate Tablets in Healthy Caucasian and Japanese Men

Pharmacology

United States
Trakya University

Completed

The Effects of Different Anesthetic Techniques on QT, Corrected QT (QTc), and P Wave Dispersions in Cesarean Section

Caesarean Section | Anesthesia; Reaction
Bayer

Completed

Study to Investigate the Natriuretic Effects, Safety, Tolerability and Pharmacokinetics of BAY94-8862

Clinical Pharmacology

Germany
Bayer
Janssen Research & Development, LLC

Completed

Study to Compare the Effect of the Formulations (Orally Disintegrating Tablet and Film-coated Tablet) on Bioequivalence of Drug Rivaroxaban (Xarelto) at Dose of 10 mg in Japanese Healthy Male Adult Subjects

Clinical Pharmacology

Japan
Takeda

Completed

TAK-114 Single- and Multiple-Dose Phase 1 Study

Clinical Pharmacology

Japan
Second Affiliated Hospital of Wenzhou Medical University

Unknown

Acceptable Hemodynamic Changes in Dexmedetomidine for Single Intravenous Bolus Injection

Mental Disorders | Pathologic Processes | Postoperative Complications | Delirium | Neurocognitive Disorders | Dexmedetomidine | Molecular Mechanisms of Pharmacological Action | Physiological Effects of Drugs | Analgesics | Hypnotics and Sedatives

China
University Hospital, Basel, Switzerland
Obstetric Anaesthetists' Association United Kingdom

Completed

Carbetocin Trial: Carbetocin Appropriate Rate Better Equilibrium Between Tonus (TOnus) and CIrculatioN (CARBETOCIN)

Anesthesia; Reaction | Complications; Cesarean Section

Switzerland
Hanmi Pharmaceutical Company Limited

Completed

A First-in-Human, Study to Assess Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of HM15136 in Healthy Subjects

Pharmacology

Korea, Republic of
National Institute of Allergy and Infectious Diseases...

Completed

Voriconazole Blood Levels and Toxicity

Pharmacology

United States
INSYS Therapeutics Inc

Completed

Fentanyl Sublingual Spray in Opioid Naive Participants

Pharmacology

United States
U.S. Army Medical Research and Development Command
Walter Reed Army Institute of Research (WRAIR)

Completed

Evaluation of Three Potential Central Nervous System (CNS) Pretreatments for Soman Exposure on Human Performance

Biomarkers, Pharmacological

United States
Tiva Group

Completed

Morphine Consumption in the Obese Patients

Anesthesia Morbidity | Obesity, Morbid | Opioid Use | Post Operative Pain | Pharmacological Action

Spain
Mongi Slim Hospital

Completed

Comparaison of 3 Protocols of Ocytocin Administration in C Section

Cesarean Section Complications | Oxytocin Adverse Reaction

Tunisia
Guangzhou Lupeng Pharmaceutical Company LTD.

Completed

The Mass Balance Study of LP-168 in Healthy Subjects

Clinical Pharmacology

China
Bayer
Janssen Research & Development, LLC

Completed

Study to Compare the Effect of the Formulations (Orally Disintegrating Tablet and Film-coated Tablet) on the Bioequivalence of Drug Rivaroxaban (Xarelto) at Dose of 15 mg in Japanese Healthy Male Adult Subjects

Clinical Pharmacology

Japan

Clinical Trials on Pharmacologic Action

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