Clinical Trials on PrEP and ART in United Kingdom

Total 161174 results

Ultragenyx Pharmaceutical Inc

Completed

An Open-Label Phase 1/2 Study to Assess the Safety, Efficacy and Dose of Study Drug UX003 Recombinant Human Beta-glucuronidase (rhGUS) Enzyme Replacement Therapy in Patients With Mucopolysaccharidosis Type 7 (MPS 7)

Mucopolysaccharidosis Type 7

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Withdrawn

Renal Function in Adults With Congenital Heart Disease.

Cardiovascular Abnormalities | Kidney Failure

United Kingdom
Imperial College London
Sarepta Therapeutics, Inc.; Department of Health, United Kingdom

Completed

Safety and Efficacy Study of Antisense Oligonucleotides in Duchenne Muscular Dystrophy

Duchenne Muscular Dystrophy

United Kingdom
Cardiff University
National Institute for Social Care and Health Research

Completed

Prostaglandin F2-alpha Eye Drops in Thyroid Eye Disease (Bima Study) (BIMA)

Graves' Ophthalmopathy

United Kingdom
Liverpool Heart and Chest Hospital NHS Foundation...

Withdrawn

Development of Diabetes in Adults With Cystic Fibrosis (CF) (CF-DIABETES)

Cystic Fibrosis

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Completed

Comparing Laboratory Blood Glucose Results With HemoCue Glucose 201 RT (CFRD)

Cystic Fibrosis

United Kingdom
Ohio State University

Completed

Improving Beta Cell Function in Mexican American Women With Prediabetes

Pre-Diabetes

United States
University of Leicester

Active, not recruiting

A Study to Evaluate the Feasibility of Screening Relatives of Patients Affected by Non-Syndromic Thoracic Aortic Diseases (ReST)

Genetic Disease | Screening | Aortic Aneurysm and Dissection

United Kingdom
Eli Lilly and Company
Daiichi Sankyo Co., Ltd.

Completed

An Assessment of Prasugrel on Healthy Adults and Sickle Cell Adults

Anemia, Sickle Cell

United Kingdom
Greater Manchester Mental Health NHS Foundation...
University of Manchester; National Institute for Health Research, United Kingdom and other collaborators

Recruiting

Cardiac Rehabilitation for Young People (CardioActive)

Heart Failure | Heart Valve Diseases | Cardiomyopathies | Congenital Heart Disease | Cardiac Arrythmias | Cerebrovascular Event

United Kingdom
University of Leicester

Recruiting

Paediatric Brain Injury Following Cardiac Interventions (BICI2Kids)

Congenital Heart Disease

United Kingdom
St. George's Hospital, London

Active, not recruiting

Distribution of Cell-cell Junction Proteins in Arrhythmic Disorders

Brugada Syndrome | Arrhythmogenic Right Ventricular Dysplasia | Cardiac Channelopathy

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Efficacy and Safety of the Cryopreserved Formulation of OTL-101 in Subjects With ADA-SCID

Severe Combined Immunodeficiency Due to ADA Deficiency

United Kingdom
Cell Therapy Catapult
University College, London; Videregen Limited

Suspended

A Study to Assess the Safety, Tolerability and Potential Efficacy of a Tracheal Replacement Consisting of a Tissue-engineered Tracheal Scaffold With Seeded Mesenchymal Cells

Tracheal Stenosis | Tracheomalacia

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...

Unknown

Gene Therapy for Netherton Syndrome

Netherton Syndrome

United Kingdom
University of Hull
University of Dundee

Terminated

Three Dimensional Facial Growth Analysis

Cleft Lip and Palate

United Kingdom
University Hospital Birmingham NHS Foundation Trust
British Heart Foundation

Completed

Metabolic Manipulation in Chronic Heart Failure

Chronic Heart Failure

United Kingdom
University of Manchester
University College, London; Manchester University NHS Foundation Trust; Orchard... and other collaborators

Active, not recruiting

Gene Therapy With Modified Autologous Hematopoietic Stem Cells for Patients With Mucopolysaccharidosis Type IIIA

Mucopolysaccharidosis Type IIIA

United Kingdom
The Leeds Teaching Hospitals NHS Trust

Unknown

Cubital Tunnel Syndrome and Diffusion MRI: A Proof of Concept Study

Cubital Tunnel Syndrome

United Kingdom
Nemours Children's Clinic

Withdrawn

Effect of Dexmedetomidine Versus Midazolam Versus a Combination of the Two as a Premedication for Children Undergoing Bilateral Myringotomy Tube Insertion

Pre Operative Sedation | Mask Acceptance | Post Operative Delerium

United States
University College, London

Recruiting

Hereditary Sensory Neuropathy Serine Trial (SENSE)

Hereditary Sensory Neuropathy Type I

United Kingdom
APR Applied Pharma Research s.a.

Recruiting

Evaluation of Phe Fluctuation in PKU Pts Treated With PKU GOLIKE Versus Standard Amino Acid Protein Substitute.

Phenylketonurias

United Kingdom
Nutricia UK Ltd

Completed

GMP Case Studies of Tolerance, Safety and Acceptability in PKU and TYR

PKU | Tyrosinemias

United Kingdom
Bayer

Completed

Effects of Angeliq and Prempro on Blood Pressure and Sodium Sensitivity in Postmenopausal Women With Prehypertension

Hypertension | Postmenopause | Pre-Hypertension

United States
Great Ormond Street Hospital for Children NHS Foundation...
GOSHCC

Completed

Measuring Normal and Impaired Walking in Children Using the GAITRite Walkway

Typically Developing Children | Talipes Equino Varus | Paediatric Orthopaedic | Paediatric Neurological

United Kingdom
Sheffield Hallam University
Medical Research Council

Completed

Virtual Reality Distraction From Procedural Pain in Children

Upper Extremity Fracture | Burn; Arm | Exostosis of Elbow | Burn Scald

United Kingdom
Birmingham Women's and Children's NHS Foundation...
Children's Cancer and Leukaemia Group

Not yet recruiting

Nephrogreen. Appearances of Exvivo Renal Tumours Under Near-infrared (Nephrogreen)

Renal Cancer | Wilms Tumor

United Kingdom
Imperial College London
University College, London

Recruiting

Electrophysiological Phenotyping Of Patients at Risk of Ventricular Arrhythmia and Sudden Cardiac Death (EPORVA)

Inflammation | Obesity | Arrhythmia | Cardiomyopathy, Dilated | Sudden Cardiac Death

United Kingdom
Cambridge University Hospitals NHS Foundation Trust

Completed

The Role of Circuit Flow During Mechanical Ventilation of Neonates (E-Flow)

Respiratory Distress Syndrome in Premature Infant

United Kingdom
University of Liverpool

Unknown

Suitability of Nitisinone in Alkaptonuria 2 (SONIA 2)

Alkaptonuria

United Kingdom
University of Liverpool
Liverpool University Hospitals NHS Foundation Trust

Completed

Dose Response Study of Nitisinone in Alkaptonuria (SONIA1)

Alkaptonuria

United Kingdom
LEO Pharma

Completed

LEO 29102 Single and Multiple Dose Study by Dermal Application

Atopic Dermatitis

United Kingdom
Imperial College London

Recruiting

The SMARTER Cardiomyopathy Study (SMARTER-CM)

Cardiomyopathies | Dilated Cardiomyopathy | Hypertrophic Cardiomyopathy

United Kingdom
University College, London

Recruiting

Liver Biopsy In Haemophilia Gene Therapy

Hemophilia A, Severe | Hemophilia B, Severe

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...
Orchard Therapeutics

Completed

Lentiviral (LV) Gene Therapy for Adenosine Deaminase (ADA) Deficiency

Adenosine Deaminase Deficiency | Severe Combined Immunodeficiencies (SCID)

United Kingdom
University College, London

Unknown

Atherosclerosis in Familial Hypercholesterolemia

Familial Hypercholesterolemia

United Kingdom
Royal Brompton & Harefield NHS Foundation Trust

Unknown

Assessment of Heart and Heart-Lung Transplant Patient Outcomes Following Pulmonary Rehabilitation

Lung Diseases | Bronchiectasis | Emphysema | Cystic Fibrosis | Alveolitis, Fibrosing

United Kingdom
University College, London
Medical Research Council

Withdrawn

Clinical Trial of Stem Cell Based Tissue Engineered Laryngeal Implants (RegenVOX)

Tracheal Stenosis | Laryngostenosis | Disorder of Upper Respiratory System

United Kingdom
Alexion Pharmaceuticals

Completed

Evaluation of Blood Brain Barrier Integrity and Structural Abnormalities in MPS IIIB Patients Using Multimodal Magnetic Resonance Imaging

MPS IIIB (Sanfilippo B Syndrome)

United Kingdom
Alder Hey Children's NHS Foundation Trust

Recruiting

Long-term Qualitative and Quantitative Outcomes of Children With Hirschsprung's Disease and Anorectal Malformations (ALOHA)

Anorectal Malformations | Hirschsprung Disease

United Kingdom
Cambridge University Hospitals NHS Foundation Trust

Recruiting

Low Energy Diet and Familial Partial Lipodystrophy

Diabetes | Diet Modification | Lipodystrophy

United Kingdom
University of Leicester
University Hospitals, Leicester; British Heart Foundation; Heart Link Children...

Completed

Markers of Inflammation and Lung Recovery in ECMO Patients for PPHN (Mi-ECMO)

Persistent Pulmonary Hypertension of the Newborn

United Kingdom
Massachusetts General Hospital
Hartford Hospital; Allina Health System

Completed

DAYLIGHT: Vitamin D Therapy in Individuals at High Risk of Hypertension (DAYLIGHT)

Hypertension | Vitamin D Deficiency | Pre-Hypertension

United States
Queen's University, Belfast
University of Warwick; University of Birmingham

Completed

Parents Resources for Decreasing the Incidence of Change Triggered Temper Outbursts (PREDICTORS)

Child Behavior

United Kingdom
Guy's and St Thomas' NHS Foundation Trust

Unknown

A Study Into the Future Cardiovascular Disease (CVD) Risk of Phenylketonuria (PKU) Patients on a Low Phenylalanine Treatment Diet (LPD).

Cardiovascular Diseases | Phenylketonurias

United Kingdom
Haemnet
BioMarin Pharmaceutical

Completed

Learning to Live With Non-severe Haemophilia

Hemophilia

United Kingdom
Institute of Cancer Research, United Kingdom
Cancer Research UK; National Institute for Health Research, United Kingdom

Completed

Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome (SIGNIFY)

Li-Fraumeni Syndrome

United Kingdom
University of Southampton
Imperial College London; University of Manchester; Royal Berkshire NHS Foundation... and other collaborators

Completed

Optimisation of Hearing Aid Fitting

Hearing Loss | Hearing Abnormality

United Kingdom
Indiana University

Completed

Assessment of a New "Boosting" Strategy for HIV Pre-exposure Prophylaxis in Healthy Volunteers

Pre-Exposure Prophylaxis

United States
Lenstec Incorporated

Completed

Clinical Evaluation of the Lenstec Softec HP1 Intraocular Lens

Aphakia

United Kingdom

Clinical Trials on PrEP and ART in United Kingdom

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