Clinical Trials on Pre-motor Parkinson's Disease

Total 7071 results

UNC Lineberger Comprehensive Cancer Center
National Cancer Institute (NCI); Syndax Pharmaceuticals

Terminated

Window of Opportunity Trial of Entinostat in Patients With Newly Diagnosed Stage I-IIIC,TNBC

Breast Cancer | Invasive Breast Cancer | ER-Negative PR-Negative HER2-Negative Breast Cancer

United States
University Hospital, Bordeaux

Recruiting

Treatment Pause Versus Treatment Continuation in IMDC Good or Intermediate Risk With Only One Adverse Prognostic Factor in mRCC Patients With an Objective Response at 12 Months of Treatment With PD1/ PDL1 ICIs + VEGFR-Tyrosine Kinase Inhibitors (SPICI)

Metastatic Renal Cell Carcinoma | Good or Only One Adverse Prognostic Factor Intermediate Risk Per IMDC Score

France
Massachusetts General Hospital

Completed

Olfactory Deficits in Neurologic Disease

Amyotrophic Lateral Sclerosis | Alzheimer Disease | Traumatic Brain Injury | Mild Cognitive Impairment | Lewy Body Disease | Frontotemporal Dementia

United States
University of Massachusetts, Worcester

Enrolling by invitation

Genetic Study of Familial and Sporadic ALS/Motor Neuron Disease, Miyoshi Myopathy and Other Neuromuscular Disorders

Motor Neuron Disease | Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Frontotemporal Dementia | Miyoshi Myopathy | Amyotrophic Lateral Sclerosis, Sporadic | PLS | Lou Gehrigs Disease | Familial Disease | Amyotrophic Lateral Sclerosis With Dementia

United States
Institut Curie

Completed

COVID-19 Study of the Serological Response Against the Severe Acute Respiratory Syndrome (SARS) Coronavirus 2 (CoV-2) Virus in 2 Types of Employees, Hospital and Non-hospital, at Institute Curie and Institute Pasteur (Curie-O-SA)

Volunteers From the Institute Curie and Institute Pasteur Staff Who Are Not Showing Active SARS-CoV-2 Infection

France
Jules Bordet Institute
Hoffmann-La Roche; Breast International Group; Institut Curie; International Drug...

Suspended

De-escalation Adjuvant Chemo in HER2+/ER-/Node-neg Early BC Patients Who Achieved pCR After Neoadjuvant Chemo & Dual HER2 Blockade (Decrescendo)

HER2-positive Breast Cancer | ER-Negative Breast Cancer | PR-Negative Breast Cancer | Node-negative Breast Cancer

Korea, Republic of, France, Israel, Belgium, Switzerland, Australia
Jewish Hospital, Cincinnati, Ohio

Unknown

Incentive Spirometry in Non-critically Ill Hospitalized Patients With Acute Respiratory Failure

Pneumonia | COPD | Dyspnea | CHF | Pulmonary Complication | Atelectasis | PE

United States
Yonsei University

Completed

Prognostic Factors for Acute Pulmonary Embolism in Critically Ill Patients

Acute Pulmonary Embolism (PE)

Korea, Republic of
Parc de Salut Mar

Completed

High-density Activation Mapping of the Slow Pathwayto Guide Catheter Ablation in Patients With Typical Atrioventricular Nodal Reentrant Tachycardia

Supraventricular Tachycardia | Atrioventricular Nodal Re Entrant Tachycardia

Spain
Vanderbilt University
National Heart, Lung, and Blood Institute (NHLBI); National Center for Advancing...

Terminated

Water and Sudafed in Autonomic Failure

Multiple System Atrophy | Shy-Drager Syndrome

United States
Leigh R. Hochberg, MD, PhD.
National Institute of Neurological Disorders and Stroke (NINDS); US Department... and other collaborators

Recruiting

BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia (BrainGate2)

Amyotrophic Lateral Sclerosis | Muscular Dystrophy | Spinal Cord Injuries | Tetraplegia | Brain Stem Infarctions | Locked in Syndrome

United States
Gillette Children's Specialty Healthcare

Completed

Effects of Standing on Non-Ambulatory Children With Neuromuscular Conditions

Cerebral Palsy | Muscular Dystrophy | Osteopenia | Rett Syndrome | Spinal Muscular Atrophy | Spina Bifida

United States
Dana-Farber Cancer Institute
Novartis Pharmaceuticals

Completed

Everolimus for Cancer With TSC1 or TSC2 Mutation

Tuberous Sclerosis Complex | TSC1 | TSC2 | MTOR

United States
Stanford University
University of Alabama at Birmingham; University of Minnesota

Completed

Allo-HCT MUD for Non-malignant Red Blood Cell (RBC) Disorders: Sickle Cell, Thal, and DBA: Reduced Intensity Conditioning, Co-tx MSCs

Sickle Cell Disease | Thalassemia | Diamond-Blackfan Anemia

United States
Vanderbilt University
Forest Laboratories

Completed

Nebivolol in the Supine Hypertension of Autonomic Failure

Hypertension | Multiple System Atrophy | Pure Autonomic Failure

United States
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Hemodynamic Mechanisms of Abdominal Compression in the Treatment of Orthostatic Hypotension in Autonomic Failure

Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
Clionsky Neuro Systems Inc.

Completed

Concussion in Motor Vehicle Accidents: The Concussion Identification Index (CIDI)

Brain Injuries | TBI (Traumatic Brain Injury) | Motor Vehicle Accidents | Brain Concussion | Brain Contusion | Traumatic Brain Injury With Brief Loss of Consciousness | Cerebral Concussion | Accidents, Traffic | Traumatic Brain Injury With Loss of Consciousness | Traffic Accidents | Cortical Contusion | Concussion... and other conditions

United States
Ataturk University

Unknown

Comparison of Low-Molecular-Weight Heparin (LMWH) and Unfractionated Heparin (UFH) in Combination With Thrombolytic Treatment of Acute Massive Pulmonary Thromboembolism

This Study Will Provide Data Comparing Safety of LMWH Versus UFH in the Treatment of Acute PE Cases Who Require Thrombolytic Treatment.

Turkey
Children's & Women's Health Centre of British Columbia

Withdrawn

Intranasal Mometasone in Children With Obstructive Sleep Apnea Due to Adenotonsillar Hypertrophy (Nasonex OSA)

Obstructive Sleep Apnea (Mild, Moderate, Severe) as Per Polysomnography

Canada
Ian Law
The Hospital for Sick Children; Mayo Clinic; University of California, Los Angeles and other collaborators

Recruiting

ATrial Tachycardia PAcing Therapy in Congenital Heart (AT-PATCH)

Congenital Heart Disease | Atrial Tachycardia | Atrial Arrhythmia | Pacemaker Re-Entrant Tachycardia

United States, Canada
National institute of Siddha

Completed

Evaluation of Preclinical Toxicity andTherapeutic Efficacy of Kandhaga Rasayanam in Padarthamarai (KR)

Tinea Infections Such as Tinea Corporis, Tinea Cruris, Tinea Pedis, Tinea Mannum, Tinea Barbae, Tinea Capitis Are Studied

India
University of Chicago

Completed

Parkinsonism in Spinocerebellar Ataxia Type 6

Spinocerebellar Ataxia Type 6

United States
St. Jude Children's Research Hospital

Completed

Partially Matched Stem Cell Transplantation for Patients With Refractory Severe Aplastic Anemia or Refractory Cytopenias

Anemia, Aplastic | Diamond-Blackfan Anemia | Amegakaryocytic Thrombocytopenia | Kostmann Syndrome

United States
Diagnostica Stago R&D
Hopital Lariboisière; Hôpital Louis Mourier

Completed

Evaluation of Soluble Fibrin in Thrombosis Exclusion (FSET)

Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE)

France
Vanderbilt University Medical Center
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Automated Abdominal Binder for Orthostatic Hypotension

Multiple System Atrophy | Orthostatic Hypotension | Pure Autonomic Failure | Autonomic Failure

United States
UCSF Benioff Children's Hospital Oakland
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Medical... and other collaborators

Completed

Multi-Center Study of Iron Overload: Pilot Study (MCSIO)

Sickle Cell Disease | Thalassemia | Diamond-Blackfan Anemia

United Kingdom, United States, Germany
Motric Bio

Recruiting

Single and Multiple Ascending Dose Study of MTR-601 in Healthy Individuals

Stroke | Multiple Sclerosis | Cerebral Palsy | Spinal Cord Injuries | Dystonia | Muscle Spasticity | Hereditary Spastic Paraplegia | Hypertonia, Muscle

United States
University Hospital, Ghent

Completed

A Feasibility Study on Adaptive 18F-FDG-guided Radiotherapy for Recurrent and Second Primary Head and Neck Cancer in the Previously Irradiated Territory.

Re-irradiation in Recurrent and Second Primary Head and Neck Cancer

Belgium
Leigh R. Hochberg, MD, PhD.
National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruiting

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-02) (BG-Speech-02)

Amyotrophic Lateral Sclerosis | Muscular Dystrophies | Spinal Cord Injuries | Tetraplegia | Dysarthria | Brain Stem Infarctions | Locked-in Syndrome | Anarthria

United States
All Natural Medicine Clinic, LLC

Recruiting

Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 (sequelae)

Depression | Anxiety Disorders | Hepatitis | Insomnia | Gastro Esophageal Reflux | GERD | Glomerulonephritis | Depression, Anxiety | Depression, Bipolar | Sequelae of; Infection | Post Infection Glomerulonephritis | Post-Infectious Peripheral Neuralgia | Post-Infectious Disorder (Disorder) | Post-Infectious Arthritis and other conditions

United States
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Functional Modeling of the Pediatric Airway

Subglottic Stenosis (SGS) | Pierre Robin Sequence (PRS) | Micrognathia | Normal Controls From CT Scans of the Upper Airway

United States
Erasmus Medical Center

Recruiting

Self-testing for HCV Re-infection in MSM (SELFIE)

HIV-1-infection | Hepatitis C Recurrent

Netherlands
Bayer
Janssen Research & Development, LLC

Completed

Treatment of Venous Thromboembolism (VTE) With Either Rivaroxaban or Current Standard of Care Therapy (XALIA LEA)

Deep Vein Thrombosis (DVT) | Pulmonary Embolism (PE)

Turkey, Russian Federation, Korea, Republic of, Mexico, Indonesia, Malaysia, Philippines, Singapore, Taiwan, Egypt, Kazakhstan, Algeria, Lebanon, Saudi Arabia, Ukraine, Jordan, Kenya, Kuwait, Morocco, Qatar, United Arab Emirates
Washington University School of Medicine
Medical Compression Systems

Withdrawn

Outcomes Study in Patients Receiving Aspirin With Mechanical Compression Devices Versus Aspirin Alone Following Knee and Hip Arthroplasty (PDAS)

PE - Pulmonary Thromboembolism | DVT - Deep Vein Thrombosis
Synta Pharmaceuticals Corp.

Completed

An Open-Label Multicenter Phase 2 Window of Opportunity Study Evaluating Ganetespib in Women With Breast Cancer (Enchant)

Breast Cancer | Triple Negative Breast Cancer | HER-2 Positive Breast Cancer | ER/Progressive Response (PR) + Refractory to Prior Hormonal Treatment

Spain, United States, Argentina, Belgium, Brazil, Korea, Republic of, Peru, United Kingdom
Erasme University Hospital

Completed

Influenza A/H1N1/2009-adjuvanted Vaccine in Renal Disease Patients

Influenza | Rejection | Decreased Immunologic Activity [PE]

Belgium
Global Healthy Living Foundation
University of Alabama at Birmingham

Recruiting

PatientSpot Formerly Known as ArthritisPower (GHLF)

Heart Failure | Stroke | Epilepsy | Multiple Sclerosis | Obesity | Diabetes | Chronic Obstructive Pulmonary Disease | Osteoarthritis | Rheumatoid Arthritis | Parkinson Disease | Peripheral Arterial Disease | Inflammatory Bowel Diseases | Amyotrophic Lateral Sclerosis | Psoriasis | Asthma | Muscular Dystrophy | Fibromyalgia | Alzheimer... and other conditions

United States
University Health Network, Toronto

Unknown

Diagnosing Frontotemporal Lobar Degeneration

Progressive Supranuclear Palsy | Semantic Dementia | Corticobasal Syndrome | Progressive Nonfluent Aphasia | Behavioral Variant Frontotemporal Dementia | Amyotrophic Lateral Sclerosis and/or Frontotemporal Dementia

Canada
Vanderbilt University Medical Center

Recruiting

Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

Hypertension | Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure

United States
Vanderbilt University

Completed

Local Heat Stress in Autonomic Failure Patients With Supine Hypertension

Hypertension | Multiple System Atrophy | Pure Autonomic Failure | Autonomic Failure

United States
Vanderbilt University Medical Center

Terminated

Blood Pressure Lowering Effects of Angiotensin-(1-7) in Primary Autonomic Failure

Shy-Drager Syndrome | Pure Autonomic Failure | Orthostatic Hypotension, Dysautonomic | Autonomic Nervous System Disorders

United States
Nkarta Inc.

Recruiting

NKX019, Intravenous Allogeneic Chimeric Antigen Receptor Natural Killer Cells (CAR NK), in Adults With B-cell Cancers

Lymphoma, Non-Hodgkin | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Chronic Lymphocytic Leukemia | B-cell Acute Lymphoblastic Leukemia | Small Lymphocytic Lymphoma | Large B-cell Lymphoma | Indolent Lymphoma | Aggressive Lymphoma | Large-cell Lymphoma

United States, Australia
Oulu University Hospital
University of Oulu; Academy of Finland; Roche Diagnostics; PerkinElmer, Inc.; Sigrid... and other collaborators

Recruiting

PEPPI Study: Identification of Women at Risk for Placental Dysfunction

Cardiovascular Diseases | Polycystic Ovary Syndrome | Iron-deficiency | Pre-Eclampsia | Intrauterine Growth Restriction | Hypertensive Disorder of Pregnancy | Proteinuria in Pregnancy

Finland
Massachusetts General Hospital
Gilead Sciences

Recruiting

Sacituzumab Govitecan In TNBC (NeoSTAR)

Triple Negative Breast Cancer | Invasive Breast Cancer | HER2-negative Breast Cancer | ER-Negative Breast Cancer | PR-Negative Breast Cancer

United States
Masonic Cancer Center, University of Minnesota

Active, not recruiting

Assessment of Complete Pathologic Response After Neoadjuvant Chemotherapy for Breast Cancer

Triple Negative Breast Cancer | HER2-positive Breast Cancer | TN ER-/PR-/HER2- Breast Cancer | ERany/PRany/HER2+ Breast Cancer

United States
UCSF Benioff Children's Hospital Oakland
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Medical... and other collaborators

Completed

Multi-Center Study of Iron Overload: Survey Study (MCSIO) (MCSIO)

Sickle Cell Disease | Thalassemia | Diamond-Blackfan Anemia

United States, United Kingdom, Germany
MD Stem Cells

Recruiting

Neurologic Stem Cell Treatment Study (NEST)

Stroke | Nervous System Diseases | Diabetic Neuropathies | Neurodegenerative Diseases | Cognitive Impairment | Amyotrophic Lateral Sclerosis | Dementia | Neurological Disorders | Alzheimer Disease | ALS | Traumatic Brain Injury | Cerebral Infarction | Lewy Body Disease | Cerebral Hemorrhage | Frontotemporal Dementia | Progressive... and other conditions

United States, United Arab Emirates
Leigh R. Hochberg, MD, PhD.
National Institute on Deafness and Other Communication Disorders (NIDCD)

Recruiting

Feasibility of the BrainGate2 Neural Interface System in Persons With Tetraplegia (BG-Speech-01)

Amyotrophic Lateral Sclerosis | Muscular Dystrophies | Spinal Cord Injuries | Tetraplegia | Dysarthria | Brain Stem Infarctions | Locked in Syndrome | Anarthria

United States
AIO-Studien-gGmbH

No longer available

A Randomized, Open-label Phase III Trial of Mapisal® Versus an Urea Hand-foot Cream as Prophylaxis for Capecitabine-induced Hand-foot Syndrome in Patients With Gastrointestinal Tumors or Breast Cancer (PROCAPP)

the Treatment Hand-foot Syndrome Patients With Gastrointestinal Tumors or Breast Cancer, Who Are Treated With Capecitabine

Germany
Massachusetts General Hospital
Puma Biotechnology, Inc.; Celcuity, Inc.

Withdrawn

Fulvestrant + Neratinib In Breast Cancer (HER2-Signal)

Metastatic Breast Cancer | Invasive Breast Cancer | HER2-negative Breast Cancer | ER Positive Breast Cancer | PR-Positive Breast Cancer | Stage IV (Metastatic) Breast Cancer

United States

Clinical Trials on Pre-motor Parkinson's Disease

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Jordan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

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