Clinical Trials on Preclinical Alzheimer's Disease

Total 379292 results

University of Southern California
National Institute on Aging (NIA); Alzheimer's Therapeutic Research Institute; Alzheimer's Clinical Trials Consortium (ACTC)

Enrolling by invitation

Alzheimer's Plasma Extension (APEX)

Preclinical Alzheimer's Disease | Early Preclinical Alzheimer's Disease

United States
Eisai Inc.
National Institute on Aging (NIA); Biogen; Alzheimer's Clinical Trials Consortium

Recruiting

AHEAD 3-45 Study: A Study to Evaluate Efficacy and Safety of Treatment With Lecanemab in Participants With Preclinical Alzheimer's Disease and Elevated Amyloid and Also in Participants With Early Preclinical Alzheimer's Disease and Intermediate Amyloid

Preclinical Alzheimer's Disease | Early Preclinical Alzheimer's Disease

United States, Singapore, Canada, Spain, Australia, Japan, United Kingdom, Sweden, Netherlands
University of Southern California
Alzheimer's Therapeutic Research Institute; American Heart Association; Schaeffer...

Recruiting

Financial Incentives and Recruitment to the APT Webstudy (FIND-AD)

Dementia | Alzheimer Disease | Prodromal Alzheimer's Disease | Preclinical Alzheimer's Disease

United States
University of Southern California
National Institute on Aging (NIA); Alzheimer's Therapeutic Research Institute; Brigham and Women's Hospital and other collaborators

Active, not recruiting

TRC-PAD Program: In-Clinic Trial-Ready Cohort (TRC-PAD)

Dementia | Alzheimer Disease | Prodromal Alzheimer's Disease | Preclinical Alzheimer's Disease

United States
University of Minnesota

Completed

Concurrent Aerobic Exercise and Virtual Reality Cognitive Training (VRCT)

Preclinical Alzheimer's Disease

United States
Gregory Jicha, 323-5550

Completed

Modulation of Micro-RNA Pathways by Gemfibrozil in Predementia Alzheimer Disease

Preclinical Alzheimer's Disease

United States
Novoic Limited

Recruiting

Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - FUTURE Extension (AMYPRED-FUTURE)

Alzheimer Disease | Mild Cognitive Impairment | Prodromal Alzheimer's Disease | Alzheimer's Disease (Incl Subtypes) | Preclinical Alzheimer's Disease

United Kingdom
Novoic Limited

Recruiting

Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - FUTURE Extension (FUTURE-US)

Alzheimer Disease | Mild Cognitive Impairment | Prodromal Alzheimer's Disease | Alzheimer's Disease (Incl Subtypes) | Preclinical Alzheimer's Disease

United States
Novoic Limited

Recruiting

Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech - PAST Extension (AMYPRED-PAST)

Alzheimer Disease | Mild Cognitive Impairment | Prodromal Alzheimer's Disease | Alzheimer's Disease (Incl Subtypes) | Preclinical Alzheimer's Disease

United Kingdom
Novoic Limited

Completed

Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping (AMYPRED-US)

Alzheimer Disease | Mild Cognitive Impairment | Prodromal Alzheimer's Disease | Alzheimer's Disease (Incl Subtypes) | Preclinical Alzheimer's Disease

United States
Novoic Limited

Completed

Amyloid Prediction in Early Stage Alzheimer's Disease From Acoustic and Linguistic Patterns of Speech (AMYPRED)

Alzheimer Disease | Mild Cognitive Impairment | Prodromal Alzheimer's Disease | Alzheimer's Disease (Incl Subtypes) | Preclinical Alzheimer's Disease

United Kingdom
XuanwuH 2

Completed

Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD

Subjective Cognitive Decline | Preclinical Alzheimer's Disease

China
Novoic Limited

Recruiting

Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - PAST Extension (PAST-US)

Alzheimer Disease | Mild Cognitive Impairment | Prodromal Alzheimer's Disease | Alzheimer's Disease (Incl Subtypes) | Preclinical Alzheimer's Disease | Normal Cognition

United States
Barcelonabeta Brain Research Center, Pasqual Maragall...

Recruiting

β-AARC: Cohort Study for the Identification of Blood-based Biomarkers in a Population With Subjective Cognitive Decline (β-AARC)

Alzheimer Disease | Mild Cognitive Impairment | Preclinical Alzheimer

Spain
Washington University School of Medicine
Eli Lilly and Company; Hoffmann-La Roche; Avid Radiopharmaceuticals; National Institute... and other collaborators

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. Master Protocol DIAN-TU-001 (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, France, Ireland, Mexico, Netherlands, Puerto Rico, Spain, United Kingdom, Brazil, Japan, Germany
Washington University School of Medicine
Hoffmann-La Roche; National Institute on Aging (NIA); Alzheimer's Association

Terminated

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, France, Spain, Ireland, Canada, Australia, Puerto Rico, United Kingdom
Washington University School of Medicine
Eli Lilly and Company; Hoffmann-La Roche; Avid Radiopharmaceuticals; National Institute... and other collaborators

Completed

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation. (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, France, Spain, Ireland, Australia, Puerto Rico, United Kingdom
Washington University School of Medicine
National Institute on Aging (NIA); Alzheimer's Association; Eisai Inc.; Accelerating...

Recruiting

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation (DIAN-TU) (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, Argentina, Australia, Colombia, Netherlands, Puerto Rico, Spain, United Kingdom, France, Ireland, Mexico, Brazil, Japan, Germany
University of North Carolina, Chapel Hill
National Institute on Aging (NIA)

Completed

Telephone-delivered Mindfulness Intervention for African American Dementia Caregivers

Alzheimer Dementia | Dementia Alzheimers | Caregiver

United States
Massachusetts General Hospital
National Institutes of Health (NIH); National Institute on Aging (NIA)

Active, not recruiting

MASC: Reducing Stress for Caregivers (MASC)

Dementia Alzheimers | Alzheimer Disease and Related Dementias

United States
Washington University School of Medicine
Hoffmann-La Roche; Genentech, Inc.; National Institute on Aging (NIA); Alzheimer...

Suspended

A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset AD Caused by a Genetic Mutation (DIAN-TU)

Dementia | Alzheimers Disease | Alzheimers Disease, Familial

United States, Canada, Italy, France, Spain, Ireland, Argentina, Australia, Colombia, Germany, Mexico, Netherlands, Puerto Rico, United Kingdom
University of North Carolina, Chapel Hill
National Institute on Aging (NIA)

Enrolling by invitation

The Nightlight Falls Prevention Study

Alzheimer Disease | Aging | Fall Injury | Dementia Alzheimers | Dementia of Alzheimer Type

United States
Biogen

Terminated

An Observational Study of Aducanumab-avwa in Participants With Alzheimer's Disease in the US

Alzheimers Disease

United States
Hoffmann-La Roche

Recruiting

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

Alzheimers Disease

Korea, Republic of, United States, Canada, Poland, Spain, Australia, Japan, Chile, United Kingdom
Hoffmann-La Roche

Terminated

A Study to Evaluate the Efficacy and Safety of Gantenerumab in Participants at Risk for or at the Earliest Stages of Alzheimer's Disease (AD) (SKYLINE)

Alzheimers Disease

United States, United Kingdom, Korea, Republic of, Poland, Canada, Australia, Argentina, Spain, Sweden, Italy
Oslo University Hospital
Sykehuset Innlandet HF; Sykehuset i Vestfold HF

Unknown

Cognitive Behavioural Therapy for Persons With MCI or Mild Dementia

Alzheimers' Disease

Norway
Hoffmann-La Roche

Completed

A Single Ascending Dose Study to Investigate the Safety, Tolerability, Immunogenicity and Pharmacokinetics of Intravenously Administered RO7126209 in Healthy Participants

Alzheimers Disease

United States
Avid Radiopharmaceuticals

Completed

The Feasibility of Florbetapir Quantitation

Alzheimers Disease

United States
Avid Radiopharmaceuticals

Terminated

A Phase 0, Open Label, Multi-Center, Exploratory and Safety Study of [F-18]T808 (T808)

Alzheimers Disease

United States
University of Aarhus

Completed

Identifying Potential Effects of Liraglutide on Degenerative Changes

Alzheimers Disease

Denmark
Elizabeth K Rhodus
National Institute on Aging (NIA)

Recruiting

Person-Environment Fit for Persons With Dementia

Alzheimer Disease | Dementia Alzheimers

United States
Bijan Najafi, PhD
BioSensics

Recruiting

Care Coordination System for People With Dementia

Dementia | Alzheimer Disease | Dementia Alzheimers

United States
Baycrest

Completed

Low Dose Ionizing Radiation Using CT Scans as a Potential Therapy for Alzheimer's Dementia: A Pilot Study (LDIR-CT-AD)

Dementia Alzheimers

Canada
Avid Radiopharmaceuticals

Terminated

A Phase 0, Open Label, Multi-center Exploratory and Safety Study of [F-18]T807

Alzheimers Disease | AD

United States
Alzinova AB
CRST Oy

Recruiting

A Study on the Safety, Tolerability and Immunogenicity of ALZ-101 in Participants With Early Alzheimer's Disease

Alzheimer Disease | Dementia Alzheimers | Dementia, Mild

Finland
Molecular NeuroImaging
Institute for Neurodegenerative Disorders

Completed

Evaluation of [123I] AV83 and SPECT in Patients With Alzheimer Disease in Comparison to Healthy Controls

Alzheimers Disease

United States
Novartis Pharmaceuticals
Amgen; Banner Alzheimer's Institute

Terminated

A Study of CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease (GS2)

Alzheimers Disease

Spain, United States, Belgium, Italy, Germany, Australia, Israel, Taiwan, Japan, Canada, Korea, Republic of, United Kingdom, France, China, Argentina, Finland, Singapore, Portugal, Chile, Mexico, Switzerland, Netherlands, Iceland, Puerto... and more
Novartis Pharmaceuticals
National Institute on Aging (NIA); Amgen; Banner Alzheimer's Institute

Terminated

A Study of CAD106 and CNP520 Versus Placebo in Participants at Risk for the Onset of Clinical Symptoms of Alzheimer's Disease (GS1)

Alzheimers Disease

United States, Belgium, United Kingdom, Germany, Australia, Canada, Spain, Finland, Switzerland, Netherlands
Molecular NeuroImaging
Institute for Neurodegenerative Disorders

Completed

Use of [123I] AV39 and SPECT Imaging as a Marker of Protein Disposition in Subjects With Alzheimer Disease Compared to Healthy Subjects

Alzheimers Disease

United States
Cognito Therapeutics, Inc.

Recruiting

A Pivotal Study of Sensory Stimulation in Alzheimer's Disease (Hope Study, CA-0011) (Hope)

Cognitive Impairment | Dementia | Alzheimer Disease | Mild Cognitive Impairment | Cognitive Decline | Alzheimer Disease, Early Onset | Alzheimer Disease, Late Onset | MCI | Dementia Alzheimers | Mild Dementia | Dementia of Alzheimer Type | Cognitive Impairment, Mild | Alzheimer Disease 1 | Dementia, Mild | Alzheimer... and other conditions

United States
Novo Nordisk A/S

Active, not recruiting

A Research Study Looking at the Effect of Semaglutide on the Immune System and Other Biological Processes in People With Alzheimer's Disease

Alzheimers Disease

United States, Canada, Italy, Sweden, Denmark, Switzerland
Institute for Neurodegenerative Disorders
Molecular NeuroImaging

Completed

Evaluation of [123I] MNI-187 and SPECT in Patients With Alzheimers Disease in Comparison to Healthy Subjects

Alzheimers Disease

United States
University Hospital, Clermont-Ferrand

Not yet recruiting

Interest of the Reborn® Doll as a TO in the Care of Residents With Alzheimer's Disease or a Related Disorder (PROTMA)

Dementia Alzheimers

France
Barcelonabeta Brain Research Center, Pasqual Maragall...

Completed

Experimental Study of the Impact of a Group Therapy Psychological Intervention for Caregivers of Alzheimer's Disease Patients (EMOCUIDA)

Psychological Support to Caregivers of Azlheimer's Patients

Spain
Cognito Therapeutics, Inc.

Active, not recruiting

Multi-Center Study of Sensory Stimulation to Improve Brain Function (Overture)

Cognitive Impairment | Dementia | Alzheimer Disease | Mild Cognitive Impairment | Cognitive Decline | Dementia, Alzheimer Type | Dementia Alzheimers | Dementia of Alzheimer Type | Cognitive Impairment, Mild | Dementia, Mild

United States
Cognito Therapeutics, Inc.

Enrolling by invitation

Extension to a Pivotal Study of Sensory Stimulation in Alzheimer's Disease (OLE Hope Study, CA-0015)

Cognitive Impairment | Alzheimer Disease | Mild Cognitive Impairment | Dementia Alzheimers | Dementia of Alzheimer Type | AD | Dementia, Mild | Dementia Moderate

United States
Oslo University Hospital
South Eastern Area Health Service

Unknown

Multiple Nutritional Deficiencies Causing Dementia of the Alzheimer Type (ALZ-vit)

Mild Cognitive Impairment | Alzheimers Disease

Norway
Ascentys Ltd

Not yet recruiting

Feasibility Study of Game Technology in the Early Diagnosis of Mild Cognitive Impairment and Alzheimer's Disease (G:DATA)

Dementia Alzheimers

United Kingdom
University Hospital, Basel, Switzerland

Recruiting

Validation of a Novel Self-Administered Cognitive Assessment Tool (CogCheck) in Patients With Mild and Major Neurocognitive Disorder Predominantly Due to Alzheimer's Disease (CogCheck-MC)

Neurocognitive Disorders | Cognition Disorders | Mild Cognitive Impairment | Dementia Alzheimers

Switzerland
Stemedica Cell Technologies, Inc.
Stemedica International SA

Recruiting

Allogeneic Human Mesenchymal Stem Cells for Alzheimer's Disease

Alzheimer Dementia

United States

Clinical Trials on Preclinical Alzheimer's Disease

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CROs in Kazakhstan

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