Clinical Trials on Primary Agammaglobulinemia

Total 59345 results

Bio Products Laboratory

Completed

Pharmacokinetics (PK) and Safety of Subgam-VF in Primary Immunodeficiency Diseases (SCIG03)

Common Variable Immunodeficiency | Primary Immune Deficiency Disorders | X-linked Agammaglobulinaemia | Hyperimmunoglobulin M Syndrome

United States
Bio Products Laboratory

Completed

Bioequivalence Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Gammaplex® 10 and Gammaplex® 5% in Primary Immunodeficiency Diseases (GMX07)

Common Variable Immunodeficiency | Primary Immune Deficiency Disorders | Hyper-IgM Syndrome | X-linked Agammaglobulinaemia

United States, United Kingdom, Hungary
Shanghai Children's Medical Center

Unknown

Mutation of the BTK Gene and Genotype-phenotype Correlation of Chinese Patients With X-Linked Agammaglobulinemia

Agammaglobulinemia, BTK

China
CSL Behring

Completed

Study of Subcutaneous Immune Globulin in Patients Requiring IgG Replacement Therapy

Common Variable Immunodeficiency | X-linked Agammaglobulinemia | Autosomal Recessive Agammaglobulinemia

Germany, United Kingdom, France, Italy, Poland, Romania, Spain, Sweden, Switzerland
Duke University
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

COVID-19 Vaccine Responses in PIDD Subjects

Common Variable Immunodeficiency | X-linked Agammaglobulinemia | Primary Immune Deficiency | Primary Antibody Deficiencies | CVID | XLA | Secondary Hypogammaglobulinemia

United States
University of South Florida
Merck Sharp & Dohme LLC

Terminated

Assessment of Immunogenicity of Zostavax® in Patients With Antibody Deficiency 60 Years of Age and Older

X-linked Agammaglobulinemia | Specific Antibody Deficiency | Common Variable Immune Deficiency

United States
Bio Products Laboratory

Completed

A Study to Find Out How Safe and Effective Gammaplex® is in Young People With Primary Immunodeficiency

Common Variable Immunodeficiency | Wiskott-Aldrich Syndrome | X-linked Agammaglobulinemia | Primary Immune Deficiency Disorders | Hyper-IgM Syndrome

United States, Chile, Israel
Eunice Kennedy Shriver National Institute of Child...
University of Washington

Unknown

Study of Genetic and Molecular Defects in Primary Immunodeficiency Disorders

Wiskott-Aldrich Syndrome | Leukocyte Adhesion Deficiency Syndrome | X-Linked Agammaglobulinemia | X-Linked Hyper IgM Syndrome

United States
University Health Network, Toronto
CSL Behring

Completed

Subcutaneous Ig in Allogeneic Stem Cell Transplant Recipients (ScIGalloHCT)

Hypogammaglobulinemia

Canada
Baxalta now part of Shire

Completed

Safety, Pharmacokinetic and Efficacy Study of a 10% Triple Virally Reduced Intravenous Immune Globulin Solution in Patients With Primary Immunodeficiency (Hypo- or Agammaglobulinemia)

Primary Immunodeficiency Diseases (PID) | Hypogammaglobulinemia | Agammaglobulinemia

Finland, Sweden
Kedrion S.p.A.

Completed

Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID)

Primary Immunodeficiency | Hypogammaglobulinemia | Agammaglobulinemia | Antibody Deficiency

United States, Canada
CSL Behring

Completed

Efficacy and Safety of Vivaglobin® in Previously Untreated Patients With Primary Immunodeficiency

Common Variable Immunodeficiency | Agammaglobulinemia

Canada, Germany, Italy, Spain
CSL Behring

Completed

Safety and Efficacy of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency

United States
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
Prothya Biosolutions

Completed

Kinetics, Efficacy and Safety of IVIG-L in Hypogammaglobulinemia Patients

Hypogammaglobulinemia

Netherlands
Turku University Hospital

Unknown

Clinical and Virological Efficacy of Pegylated Interferon Alpha in the Treatment of Rhinovirus Infection in Patients With Primary Hypogammaglobulinemia: Randomized Controlled Trial (Hypogamma Int1)

Rhinovirus Infection

Finland
Columbia University
Grifols Therapeutics LLC

Completed

Intravenous Immunoglobulin (IVIG) in Lung Transplantation

Lung Transplantation | Hypogammaglobulinemia

United States
Federal University of São Paulo
CSL Behring

Completed

Specific IgG Antibody in Patients With Primary Antibody Deficiencies Treated With Subcutaneous Immunoglobulin

Common Variable Immunodeficiency | Agammaglobulinemia

Brazil
The Cleveland Clinic

Completed

Cytomegalovirus Hyperimmune Globulin (CMV-Ig) Replacement in Hypogammaglobulinemic Lung Transplant Recipients

Hypogammaglobulinemia

United States
O & O Alpan LLC

Unknown

Investigation of Immune Disorders and Deficiencies

Autoimmune Diseases | Hypogammaglobulinemia | Inflammatory Diseases | Primary Immune Deficiencies | Common Variable Immune Deficiencies

United States
National Human Genome Research Institute (NHGRI)

Withdrawn

Quality of Life and Neuropsychiatric Sequelae in Patients Treated With Gene Therapy for ADA-SCID and in Their Parents

ADA-SCID
Monash University

Recruiting

Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Immunoglobulin Stopping or Extension (RATIONALISE)

Hypogammaglobulinemia | Haematological Malignancy

Australia
National Institute of Allergy and Infectious Diseases...

Completed

Plerixafor Versus G-CSF in the Treatment of People With WHIM Syndrome

Infections | Warts | Neutropenia | Myelokathexis | Hypogammaglobulinemia

United States
University of Alabama at Birmingham
Grifols Biologicals, LLC

Completed

Post-bypass Prophylactic IVIG in Infants and Neonates

Congenital Heart Disease | Hypogammaglobulinemia

United States
Bio Products Laboratory

Completed

Efficacy, Safety and Pharmacokinetics of Gammaplex in Primary Immunodeficiency Diseases.

Primary Immunodeficiency | Wiskott-Aldrich Syndrome | Hypogammaglobulinemia | Common Variable Hypogammaglobulinemia | X-linked Hypogammaglobulinemia | Immunodeficiency With Hyper-IgM

United States
Mazandaran University of Medical Sciences

Unknown

Rituximab-Induced Hypogammaglobulinemia in Multiple Sclerosis

Multiple Sclerosis | Hypogammaglobulinemia

Iran, Islamic Republic of
Advanced Neurosciences Institute
Novel Pharmaceutics Institute

Unknown

Immunodeficiency in MS

Multiple Sclerosis | Infection, Bacterial | Immunodeficiency | Hypogammaglobulinemia

United States
Brigham and Women's Hospital

Completed

Personalized Immunotherapeutic for Antibiotic-resistant Infection

Infection | Immune Deficiency | Hypogammaglobulinemia | Septic Arthritis | Mycoplasma Hominis

United States
Insel Gruppe AG, University Hospital Bern

Recruiting

Immunoglobulin Deficiency a Treatable Cause of Fatigue in Patients With Multiple Sclerosis (MS)? (FatIgG)

Multiple Sclerosis | Fatigue | Hypogammaglobulinemia

Switzerland
Octapharma

Recruiting

Double-blind, Randomized, Placebo-controlled, Prospective Phase III Study Evaluating Efficacy and Safety of Panzyga in Primary Infection Prophylaxis in Patients With Chronic Lymphocytic Leukemia ("PRO-SID" Study)

Chronic Lymphocytic Leukemia | Hypogammaglobulinemia

United States, Denmark, Germany, Hungary, Italy, Poland, Russian Federation, Spain, Czechia, Greece, Israel, Turkey
Grifols Therapeutics LLC

Completed

Rapid Infusion of Immune Globulin Intravenous (Human) In Primary Immunodeficiency Patients

Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Wiskott-Aldrich Syndrome | Agammaglobulinemia | Immunologic Deficiency Syndrome

Canada, United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Lenalidomide and Ofatumumab in Treating Participants With Previously Treated Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma

Fatigue | Thrombocytopenia | Fever | Chronic Lymphocytic Leukemia | Lymphadenopathy | Small Lymphocytic Lymphoma | Hypogammaglobulinemia | Lymphocytosis | Night Sweats | Paraproteinemia

United States
Washington University School of Medicine

Recruiting

Immune Disorder HSCT Protocol

Severe Combined Immunodeficiency | Chronic Granulomatous Disease | DiGeorge Syndrome | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | X-linked Lymphoproliferative Syndrome | X-linked Agammaglobulinemia | Chediak-Higashi Syndrome | IPEX | Autoimmune Lymphoproliferative Syndrome | Common Variable... and other conditions

United States
Fairview University Medical Center

Terminated

Allogeneic Bone Marrow Transplantation in Patients With Primary Immunodeficiencies

Immunologic Deficiency Syndromes | Common Variable Immunodeficiency | Severe Combined Immunodeficiency | Chronic Granulomatous Disease | Hemophagocytic Lymphohistiocytosis | Wiskott-Aldrich Syndrome | Graft Versus Host Disease | X-linked Agammaglobulinemia | Chediak-Higashi Syndrome | Virus-Associated... and other conditions

United States
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Efficacy, Safety, and Pharmacokinetics of XEMBIFY® Plus Standard Medical Treatment (SMT) Compared to Placebo Plus SMT to Prevent Infections in Participants With Hypogammaglobulinemia and Recurrent or Severe Infections Associated With B-cell Chronic Lymphocytic Leukemia

Bacterial Infections | B-cell Chronic Lymphocytic Leukemia | Hypogammaglobulinemia

United States, Bulgaria, Poland, Romania, Serbia
IVI Bilbao
University of the Basque Country (UPV/EHU)

Withdrawn

Analysis of Lipid Profiles in Samples Sperm and Seminal Plasma Under Artificial Insemination

Primary Infertility

Spain
Karadeniz Technical University

Completed

Endometrial Injury and Single Embryo Transfer

Primary Infertility
Amro M. Hetta, M.Sc.
Mansoura University; Al-Azhar University

Not yet recruiting

First Clinical Live-Donor Uterus Transplantation Trial In Egypt

Primary Uterine Infertility

Egypt
Sahlgrenska University Hospital, Sweden
The Swedish Research Council

Completed

Uterus Transplantation From Live Donor (utx)

Primary Uterine Infertility

Sweden
The Cleveland Clinic

Enrolling by invitation

Uterine Transplantation for the Treatment of Uterine Factor Infertility

Primary Uterine Infertility

United States
University of Rome Tor Vergata
University Of Perugia; University of L'Aquila

Completed

Intravesical Adjuvant Electromotive Mitomycin-C (EMDA/MMC)

Bladder Cancer TNM Staging Primary Tumor (T) Ta | Bladder Cancer TNM Staging Primary Tumor (T) T1 | Bladder Cancer Transitional Cell Grade

Italy
Bayer

Completed

Second Primary Cancers in Patients With Castration Resistant Prostate Cancer (BOCARP)

Prostatic Neoplasms

Germany
Taris Biomedical LLC
Bristol-Myers Squibb

Terminated

Safety and Tolerability of TAR-200 and Nivolumab in Subjects With Muscle-Invasive Bladder Cancer

Bladder Cancer TNM Staging Primary Tumor (T) T2 | Bladder Cancer TNM Staging Primary Tumor (T) T2A | Bladder Cancer TNM Staging Primary Tumor (T) T2B | Bladder Cancer TNM Staging Primary Tumor (T) T3 | Bladder Cancer TNM Staging Primary Tumor (T) T3A | Bladder Cancer TNM Staging Primary Tumor... and other conditions

United States
Ain Shams Maternity Hospital

Unknown

Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility

Infertility | Pregnancy | Ovarian Hyperstimulation | Primary Infertility Unspecified
MOHAMED BEHERY

Completed

AOA in Recurrent Fertilization Failure (AOA)

Infertility Primary

Egypt
Grand River Hospital

Unknown

Telemedicine Clinic for Prostate Cancer Patients

Cancer, Treatment-Related

Canada
Dicerna Pharmaceuticals, Inc.

Completed

A Study to Evaluate DCR-PHXC in Children and Adults With Primary Hyperoxaluria Type 1 and Primary Hyperoxaluria Type 2 (PHYOX2)

Kidney Diseases | Urologic Diseases | Genetic Disease | Primary Hyperoxaluria Type 1 (PH1) | Primary Hyperoxaluria Type 2 (PH2)

Poland, United Kingdom, New Zealand, United States, Australia, Canada, France, Germany, Israel, Italy, Japan, Lebanon, Netherlands, Romania, Spain
Johns Hopkins University
National Institute of Mental Health (NIMH); University of Michigan

Recruiting

Clinic-based HIV Identification and Prevention Project Using Electronic Resources (CHIPPER)

PrEP | HIV Prevention | Primary Care

United States
Alnylam Pharmaceuticals

Completed

Study of Lumasiran in Healthy Adults and Patients With Primary Hyperoxaluria Type 1

Primary Hyperoxaluria Type 1 (PH1)

France, United Kingdom, Netherlands, Israel, Germany

Clinical Trials on Primary Agammaglobulinemia

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