Clinical Trials on Primary Immunodeficiency Diseases in South Africa

Total 19011 results

ApoPharma

Completed

Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects

Asymptomatic HIV Infection

South Africa
University of Johannesburg

Completed

The Efficacy of OrasaltsTM in the Treatment of Gingivitis

Gingivitis

South Africa
University of Limpopo

Unknown

Effect of Vitamin D Supplementation on the Control of Asthma in Children at a South African Academic Hospital

Persistent Asthma

South Africa
Boehringer Ingelheim

Completed

Trial to Evaluate Steady State Pharmacokinetic Parameters, Efficacy and Safety of Nevirapine in Antiretroviral Drug naïve Pediatric Patients

HIV Infections

South Africa
University of Stellenbosch

Completed

Probiotics in the Management of Necrotizing Enterocolitis in HIV-exposed Premature Infants

Necrotizing Enterocolitis

South Africa
The Aurum Institute NPC
Johns Hopkins University

Recruiting

Rifapentine and Isoniazid TB Preventive Therapy (3HP) for Children Taking Dolutegravir-based Antiretroviral Treatment (DOLPHIN KIDS) (DOLPHIN KIDS)

HIV | Tuberculosis

South Africa
Neurotune AG
Cross Research S.A.; Triclinium clinical trial project managment LTD

Completed

Safety and Preliminary Evidence of Efficacy of Escalating Doses of Dimiracetam in AIDS Patients With Painful Neuropathy

Neuropathy | AIDS

South Africa
PowerVision

Completed

Clinical Evaluation of the FluidVision Accommodation Intraocular Lens (AIOL) (CLEAR)

Cataract

South Africa
GlaxoSmithKline

Completed

Study to Identify and Characterize Bacteria Causing Acute Otitis Media in South African Children

Acute Otitis Media

South Africa
Gilead Sciences

Terminated

Two Part Study to Evaluate Pharmacokinetics, Safety, and Antiviral Activity of Elvitegravir Administered With a PI/r Background Regimen for ARV Treatment-Experienced Pediatric Participants

HIV Infections | Acquired Immune Deficiency Syndrome (AIDS)

United States, Thailand, Spain, Uganda, South Africa, Italy
BioGaia AB

Completed

Evaluation and Comparison of 2 Cosmetic Investigational Products in Adults With Atopic Dermatitis

Atopic Dermatitis

South Africa
Chris Hani Baragwanath Academic Hospital

Terminated

High Flow Oxygen Therapy vs Standard Care in Infants With Viral Bronchiolitis

Bronchiolitis, Viral

South Africa
University of Witwatersrand, South Africa

Completed

Habitual Physical Activity and Sedentary Behavior Following Total Knee Arthroplasty

Knee Osteoarthritis

South Africa
University of Johannesburg

Completed

The Effect of a Homoeopathic Complex on Blood Pressure in Refractory Hypertension

Essential Hypertension

South Africa
University of Johannesburg

Completed

The Efficacy of Venavine Intensive® on the Quality of Life in Females With Chronic Venous Insufficiency

Venous Insufficiency

South Africa
University of Cape Town
London School of Hygiene and Tropical Medicine

Completed

Artemether/Lumefantrine and Nevirapine Interaction Study in HIV-infected Adults

HIV | Malaria

South Africa
University of Massachusetts, Worcester
National Institute of Allergy and Infectious Diseases (NIAID); Aurum Institute and other collaborators

Recruiting

Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV) (METHOD)

Tuberculosis | Pulmonary Tuberculosis | HIV Coinfection

South Africa
Novartis

Completed

A Quality of Life and Safety Study With Pimecrolimus Cream, 1% in Children (Age 2-12 Years) With Atopic Dermatitis

Atopic Eczema

South Africa
Swiss Federal Institute of Technology
University of Stellenbosch

Completed

Stable Iron Isotope Method in HIV+ and HIV- Children

Iron-deficiency

South Africa
Boston University
Vanderbilt University; University of Witwatersrand, South Africa

Completed

A Pilot Voucher Incentive for Improving Retention in Postpartum HIV Care in South Africa

HIV

South Africa
Barbara Ensoli, MD
Italian Ministry of Foreign Affairs - Dir. Gen. for Cooperation and Development

Completed

Study to Assess the Seroprevalence of Anti-Tat Antibodies in HIV-infected Patients (ISS OBS T-004)

HIV Infection

South Africa
University of Pretoria
South African Sugar Association

Completed

Nutrition Education Intervention for Adults With Type 2 Diabetes

Type 2 Diabetes Mellitus

South Africa
Sanofi

Completed

Antibody Persistence in Healthy Children After Primary and Booster DTaP-IPV-Hep B-PRP-T Vaccine or Control Vaccine

Hepatitis B | Whooping Cough | Tetanus | Diphtheria | Poliomyelitis

South Africa
Medicines for Malaria Venture
University of Cape Town

Completed

Phase I Study of Ascending Doses of MMV390048 in Healthy Adult Volunteers

Malaria

South Africa
University of Johannesburg

Completed

The Efficacy of Sodium Shale Oil Sulponate 1% Shampoo in the Treatment of Pityriasis Capitis

Dandruff

South Africa
Medicines for Malaria Venture
University of Cape Town

Terminated

Safety, Tolerability & Pharmacokinetics (PK) of Co-administered Single Doses of OZ439 and Mefloquine (MQ) in Healthy Volunteers

Malaria

South Africa
Eastern Virginia Medical School
University of Pittsburgh; United States Agency for International Development... and other collaborators

Recruiting

Safety and PK Multi-dose Study of TAF/EVG Vaginal Insert

Safety Issues

United States, Kenya, South Africa
Janssen R&D Ireland

Completed

A Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Etravirine Administered in Combination With Other Antiretroviral Agents in Antiretroviral Treatment-Experienced HIV-1 Infected Patients

Human Immunodeficiency Virus (HIV) Infection

France, Ukraine, United States, Mexico, Romania, South Africa, Peru, Argentina, Puerto Rico, Russian Federation, Guatemala
IDinsight
Reach Digital Health (formerly Praekelt.org)

Recruiting

Testing Content Delivery Models for MomConnect (MQR)

Hematological Diseases | Breastfeeding | Immunization Coverage

South Africa
Beth Israel Deaconess Medical Center
University of Stellenbosch

Recruiting

Testing Health Workers At Risk to Advance Our Understanding of TB Infection (THWART-TB)

Tuberculosis | Tuberculosis Infection

South Africa
Code Pharma

Recruiting

Phase IIa Randomized Placebo Controlled Clinical Study of Codivir in Hospitalized Patients With Moderate COVID-19

COVID-19

South Africa
University of Witwatersrand, South Africa

Terminated

Differences Between Stavudine and Tenofovir Each Combined With Lamivudine and Efavirenz in SA HIV-infected Patients (CHRU01)

Metabolic Complications | Mitochondrial Toxicity

South Africa
Wits Health Consortium (Pty) Ltd
Discovery Vitality

Active, not recruiting

Testing the Effectiveness of Different Messaging Approaches to Increase Doctor Visits Amongst Individuals With Risk Factors for Diabetes

Type 2 Diabetes | Pre-diabetes

South Africa
Convergence Pharmaceuticals

Completed

Efficacy and Safety of CNV2197944 Versus Placebo in Patients With Post-herpetic Neuralgia

Post-herpetic Neuralgia

South Africa
University of Witwatersrand, South Africa
University of Colorado, Denver; Emory University; Bill and Melinda Gates Foundation

Completed

Influenza Vaccine Trial in HIV Uninfected Pregnant Women (MatfluHIVneg)

Influenza

South Africa
University of Liverpool
Radboud University Medical Center; University of Cape Town; UNITAID; Liverpool... and other collaborators

Completed

Dolutegravir in Pregnant HIV Mothers and Their Neonates (DolPHIN-2)

Pregnancy Related | HIV-1-infection

Uganda, South Africa
Zimmer Biomet
University of Cape Town

Completed

Sternal Closure With SternaLock 360: First in Man Study (SL360)

Sternal Fracture

South Africa
Council for Scientific and Industrial Research,...
Royal College of Surgeons, Ireland; European Union

Completed

Solar Disinfection of Drinking Water (SODISWATER)

Diarrhea | Dysentery (Bloody Diarrhea)

South Africa
University of Witwatersrand, South Africa

Unknown

Safety and Immunogenicity of Measles Vaccine, Varicella Vaccine and Hepatitis-A Vaccine (MV/VV/Hep-AV)

Measles | Hepatitis A | Varicella

South Africa
Microbiome Health Research Institute
University of Cape Town

Terminated

Transfer of Healthy Gut Flora for Restoration of Intestinal Microbiota Via Enema for Patients in the Rehabilitative Phase of Malnutrition (THRIVE)

Moderate Acute Malnutrition | Severe Acute Malnutrition

South Africa
University of Witwatersrand, South Africa
SynaVir

Completed

Study of Oral Administration of Ribavirin and Nitazoxamide Versus Placebo in COVID-19 (DuACT)

Covid19 | SARS-CoV Infection

South Africa
Peter Siesjö
University of Stellenbosch

Completed

Effect of Antisecretory Factor, Given as a Food Supplement to Adult Patients With Severe Traumatic Brain Injury (SASAT)

Brain Trauma

South Africa
Boston University
Bill and Melinda Gates Foundation; University of Witwatersrand, South Africa

Withdrawn

Evaluation of Six-month HIV Treatment Dispensing in South Africa

HIV

South Africa
University of Witwatersrand, South Africa

Completed

Efficacy of Influenza Vaccine in HIV Infected Adults

HIV Infections | HIV | Influenza | Vaccination

South Africa
University of Witwatersrand, South Africa

Completed

Influenza Vaccine in HIV Infected Children

Influenza With Pneumonia, Influenza Virus Identified

South Africa
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)

Pulmonary Tuberculoses | Other Specified Pulmonary Tuberculosis

South Africa
University of Witwatersrand, South Africa

Completed

Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults (TIV_HIV_TB)

HIV | Tuberculosis | Influenza

South Africa
University of Witwatersrand, South Africa
UNITAID

Completed

CHARACTERISE - A Cross-sectional, Observational Study to Characterise the Transition to Dolutegravir-based Regimens in South Africa in Terms of the Emergence of Obesity, Viral Re-suppression and Integration Into Routine Programme Care (CHARACTERISE)

Dolutegravir

South Africa
GlaxoSmithKline

Completed

An Early Bactericidal Activity, Safety and Tolerability of GSK3036656 in Subjects With Drug-sensitive Pulmonary Tuberculosis

Tuberculosis

South Africa
Find
University of Cape Town; Universidad Peruana Cayetano Heredia

Unknown

Performance Evaluation of TB Breath- and Cough-testing Platforms

Diagnoses Diseases | Pulmonary TB

South Africa

Clinical Trials on Primary Immunodeficiency Diseases in South Africa

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