Clinical Trials on Primary Progressive Multiple Sclerosis

Total 4581 results

Sanford Health
National Ataxia Foundation; Beyond Batten Disease Foundation; Pitt Hopkins Research... and other collaborators

Recruiting

Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford (CoRDS)

Mitochondrial Diseases | Retinitis Pigmentosa | Myasthenia Gravis | Eosinophilic Gastroenteritis | Multiple System Atrophy | Leiomyosarcoma | Leukodystrophy | Anal Fistula | Spinocerebellar Ataxia Type 3 | Friedreich Ataxia | Kennedy Disease | Lyme Disease | Hemophagocytic Lymphohistiocytosis | Spinocerebellar Ataxia... and other conditions

United States, Australia
Jonsson Comprehensive Cancer Center
Upjohn

Completed

Dalteparin to Prevent Complications in Cancer Patients Receiving Chemotherapy Through a Catheter

Lymphoma | Cervical Cancer | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Unspecified Adult Solid Tumor, Protocol Specific | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous/Nonmalignant Condition | Veno-occlusive Disease

United States
Assistance Publique - Hôpitaux de Paris

Not yet recruiting

Metabolic Reprogramming in Renal Tubular Cells in Acute Kidney Injury Following Severe Trauma (METAKIT)

Multi-organ Failure After Severe Trauma

France
Washington University School of Medicine
Sanofi

Terminated

Isatuximab, Velcade, and Dexamethasone in Patients With Multiple Myeloma and Severe KIDNEY Disease

Multiple Myeloma

United States
Galapagos NV

Terminated

A Study to Evaluate the Effects of GLPG2737 in Participants With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Autosomal Dominant Polycystic Kidney Disease

Belgium, Netherlands, Italy, Spain, Czechia, Germany, Poland
Palladio Biosciences

Completed

The ELiSA Study - Evaluation of Lixivaptan in Subjects With Autosomal Dominant Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease

United States
University of Colorado, Denver
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Completed

Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults With Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney, Autosomal Dominant

United States
Otsuka Pharmaceutical Development & Commercialization...

Completed

Tolvaptan Extension Study in Participants With ADPKD (TEMPO 4/4)

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

United States, Australia, Belgium, Germany, Italy, Poland, Romania, United Kingdom, Argentina, Canada, France, Netherlands, Russian Federation
National Cancer Institute (NCI)

Terminated

Von Hippel-Lindau Disease Genetic Epidemiology Study

Kidney Neoplasms | Von Hippel Lindau Disease

United States
Otsuka Pharmaceutical Co., Ltd.

Completed

A Study to Investigate the Long-term Safety and Efficacy of Tolvaptan in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) [Extension of Trial 156-04-251 in Japan]

Autosomal Dominant Polycystic Kidney Disease （ADPKD)

Japan
Otsuka Pharmaceutical Development & Commercialization...

Completed

8-Week Study of Tolvaptan Dose Forms in Autosomal Dominant Polycystic Kidney Disease (ADPKD) (NOCTURNE)

Autosomal Dominant Polycystic Kidney Disease

United States
Otsuka Pharmaceutical Co., Ltd.

Completed

A Long-term Administration Study of OPC-41061 in Patients With Autosomal Dominant Polycystic Kidney Disease (ADPKD) (2) [Extension of Study 156-05-002]

Autosomal Dominant Polycystic Kidney Disease

Japan
Clinique Ovo

Terminated

Detecting Early Onset Pre-eclampsia and Use of Placental Growth Factor (PlGF) for Marker of Trisomy 21 (PlGF)

Pregnancy

Canada
Shanghai Changzheng Hospital

Unknown

Triptolide-Containing Formulation as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

China
Yale University

Terminated

Rapamycin as Treatment for Autosomal Dominant Polycystic Kidney Disease (ADPKD): The Role of Biomarkers in Predicting a Response to Therapy

Autosomal Dominant Polycystic Kidney Disease

United States
Assistance Publique - Hôpitaux de Paris

Completed

Assessment of the Prevalence of Genes AHI1, NPHP1 and CEP290 in Joubert Syndrome (JSCORS)

Joubert Syndrome | Cerebello-oculo-renal Syndromes

France
University of Bern

Recruiting

Swiss Primary Ciliary Dyskinesia Registry (CH-PCD)

Primary Ciliary Dyskinesia | Kartagener Syndrome

Switzerland
CND Life Sciences

Completed

Synuclein-One Study

Parkinson Disease | Multiple System Atrophy | Pure Autonomic Failure | Dementia With Lewy Bodies

United States
University of North Carolina, Chapel Hill
National Heart, Lung, and Blood Institute (NHLBI); National Institutes of Health... and other collaborators

Completed

Genetics of Primary Ciliary Dyskinesia

Primary Ciliary Dyskinesia | Kartagener Syndrome

United States, Canada
University of Utah

Terminated

Allogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis

Primary Myelofibrosis | Anemia | Thrombocytopenia | Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma | IDH2 Gene Mutation | IDH1 Gene Mutation | Secondary Myelofibrosis | ASXL1 Gene Mutation | EZH2 Gene Mutation

United States
National Institute of Neurological Disorders and...

Completed

Diagnosis and Natural History Study of Patients With Neurological Conditions

Parkinson's Disease | Dementia | Multiple System Atrophy | Alzheimer's Disease | Movement Disorder

United States
Vertex Pharmaceuticals Incorporated

Recruiting

A Phase 1 Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of VX-407 in Healthy Participants

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

United States
University of California, San Francisco

Recruiting

Genetic Testing in Autosomal Dominant Polycystic Kidney Disease

ADPKD

United States
Peking Union Medical College Hospital
Bellco Hoxen Medical (Shanghai) Co., Ltd

Not yet recruiting

Effect of HFR-SUPRA in the Treatment of Multiple Myeloma-related Acute Kidney Injury

Multiple Myeloma | Acute Kidney Injury | Hemodiafiltration With Ultrafiltrate Regeneration (HFR)
The University of Queensland

Recruiting

Implementation of Metformin theraPy to Ease Decline of Kidney Function in Polycystic Kidney Disease (IMPEDE-PKD)

Autosomal Dominant Polycystic Kidney Disease

Australia
Mayo Clinic
Polycystic Kidney Disease Foundation

Recruiting

NOX4 and Related Biomarkers in ADPKD

Autosomal Dominant Polycystic Kidney Disease

United States
University of Cologne

Recruiting

The German ADPKD Tolvaptan Treatment Registry (AD(H)PKD)

ADPKD (Autosomal Dominant Polycystic Kidney Disease)

Germany
Regulus Therapeutics Inc.

Completed

A Study of RGLS4326 in Patients With Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Autosomal Dominant

United States
Jose Alberola-Rubio

Completed

Electromyographic Study for the Help and Guidance of BoNTA Administration in the Treatment of Chronic Pelvic Floor Pain (SEMG)

Pelvic Pain | Pelvic Floor Disorders | Pelvic Pain Syndrome | Electromyography | EMG Syndrome | EMG: Myopathy | ElectroPhys: Myopathy

Spain
Massachusetts General Hospital

Completed

Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)

Multiple Myeloma | End Stage Renal Disease

United States
Asan Medical Center

Completed

Evaluation of Nephrectomy Specimen for Intracranial Aneurysm Development in ADPKD

Polycystic Kidney Diseases | Kidney Transplant; Complications | Aneurysm, Brain
University Hospital of Split

Completed

Indicators of Growth, Nutritional Status and Comorbide Disorders of Newborns With Down Syndrome (DownSy)

Down Syndrome,Auxological Indexes, Auxological Parametars, Intrauterine Growth Restriction

Croatia
Otsuka Pharmaceutical Development & Commercialization...
Otsuka Pharmaceutical Co., Ltd.

Completed

Tolvaptan Phase 3 Efficacy and Safety Study in Autosomal Dominant Polycystic Kidney Disease (ADPKD) (TEMPO3:4)

Polycystic Kidney Disease, Autosomal Dominant

United States, Belgium, United Kingdom, Russian Federation, France, Australia, Netherlands, Italy, Japan, Denmark, Romania, Poland, Canada, Argentina, Germany
ThermoFisher Scientific Brahms Biomarkers France

Completed

Biomarkers Correlation With Volemia (ENVOL)

Renal Insufficiency | Cerebral Hemorrhage | Head Injury | Non Traumatic Post Surgery | Poly Trauma Patients Without Heart Failure

France
University of Zurich

Completed

Sirolimus (Rapamune®) for Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Switzerland
Istanbul University

Completed

Adrenal Functions in Autosomal Dominant Polycystic Kidney Disease

Autosomal Dominant Polycystic Kidney Disease

Turkey
City of Hope Medical Center
National Cancer Institute (NCI)

Completed

Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Small Intestine Cancer | Infection | Multiple Myeloma and Plasma Cell Neoplasm | Precancerous Condition | Graft Versus Host Disease | Myelodysplastic/Myeloproliferative Neoplasms | Secondary Myelofibrosis

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Completed

Zoledronic Acid in Treating Patients With Metastatic Breast Cancer, Metastatic Prostate Cancer, or Multiple Myeloma With Bone Involvement

Pain | Urinary Complications | Breast Adenocarcinoma | DS Stage I Plasma Cell Myeloma | DS Stage II Plasma Cell Myeloma | Metastatic Malignant Neoplasm to the Bone | Musculoskeletal Complication

United States, Puerto Rico
University Health Network, Toronto

Recruiting

Liquid Biopsy Evaluation and Repository Development at Princess Margaret (LIBERATE)

Melanoma | Lymphoma | Kidney Cancer | Leukemia | Cancer | Breast Cancer | Head and Neck Cancer | Ovarian Cancer | Lynch Syndrome | Lung Cancer | Colon Cancer | Meningioma | BRCA1 Mutation | BRCA2 Mutation | Myeloma | Mutation | Uterine Cancer | Cowden Syndrome

Canada
Massachusetts General Hospital

Recruiting

PET Imaging Evaluation of [11C]SY08

Parkinson's Disease | Multiple System Atrophy | Dementia With Lewy Bodies | Healthy Controls

United States
University of North Carolina, Chapel Hill
The Hospital for Sick Children; Washington University School of Medicine; McGill... and other collaborators

Recruiting

Longitudinal Characterization of Respiratory Tract Exacerbations and Treatment Responses in Primary Ciliary Dyskinesia

Primary Ciliary Dyskinesia | Kartagener Syndrome

United States, Canada
University of Bern
Centre Hospitalier Intercommunal Creteil; Hacettepe University; Universitaire... and other collaborators

Recruiting

The Ear-Nose-Throat (ENT) Prospective International Cohort of PCD Patients (EPIC-PCD) (EPIC-PCD)

Primary Ciliary Dyskinesia | Kartagener Syndrome

Switzerland
Assistance Publique - Hôpitaux de Paris

Completed

Diagnosis of Primary Ciliary Dyskinesia (DCP)

Primary Ciliary Dyskinesia | Kartagener Syndrome

France
IntraBio Inc

Completed

N-Acetyl-L-Leucine for Niemann-Pick Disease, Type C (NPC)

Niemann-Pick Disease, Type C

United States, United Kingdom, Germany, Slovakia, Spain
Eunice Kennedy Shriver National Institute of Child...

Terminated

Combined Intrathecal and Intravenous VTS-270 Therapy for Liver and Neurological Disease Associated With Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C1

United States
Cyclo Therapeutics, Inc.

Completed

Safety and Efficacy of Intravenous Trappsol Cyclo (HPBCD) in Niemann-Pick Type C Patients

Niemann-Pick Disease, Type C1

Israel, Sweden, United Kingdom
Vtesse, LLC, a Mallinckrodt Pharmaceuticals Company

Completed

Hydroxypropyl Beta Cyclodextrin for Niemann-Pick Type C1 Disease

Niemann-Pick Disease, Type C1

United States
Cyclo Therapeutics, Inc.

Active, not recruiting

Open-Label Study of Long-Term Safety and Efficacy of Intravenous Trappsol Cyclo (HPβCD) in Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C1

United States
CENTOGENE GmbH Rostock

Completed

Induced Pluripotent Stem Cells for Niemann Pick Disease (IPSNPABC)

Niemann-Pick Diseases

Pakistan
KemPharm Denmark A/S

Completed

A Prospective Non-therapeutic Study in Patients Diagnosed With Niemann-Pick Disease Type C

Niemann-Pick Disease, Type C

Spain, France, United Kingdom, Switzerland, Denmark, Poland, Italy, Germany

Clinical Trials on Primary Progressive Multiple Sclerosis

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CROs in Jordan

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Rare Diseases

Drug Interventions

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