Clinical Trials on Pulmonary Exacerbation

Total 8459 results

François Lellouche
Ottawa Hospital Research Institute; The Ottawa Hospital

Unknown

FreeO2 PreHospital - Automated Oxygen Titration vs Manual Titration According to the BLS-PCS

Trauma | COPD Exacerbation
Alung Technologies

Terminated

Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD (VENT-AVOID)

Acute Exacerbation of COPD

United States
Elpen Pharmaceutical Co. Inc.

Recruiting

Clinical Study for the Effectiveness of Roflumilast Treatment in COPD Greek Patients Based on Standard Clinical Practice. (ARGO)

Copd | COPD Exacerbation

Greece
Vastra Gotaland Region

Recruiting

Multidisciplinary Management of Severe COPD

Copd | COPD Exacerbation

Sweden
University of Milan
IRCCS Azienda Ospedaliero-Universitaria di Bologna; Valduce Hospital; Ente Ospedaliero... and other collaborators

Completed

Optimization of Ventilator Setting for Acute Exacerbations of Chronic Obstructive Pulmonary Disease (NIMV01AECB)

Acute Exacerbation of Chronic Obstructive Airways Disease

Italy, Switzerland
Northumbria Healthcare NHS Foundation Trust
Newcastle-upon-Tyne Hospitals NHS Trust; National Institute for Health Research... and other collaborators

Completed

Mortality and Symptom Burden Post Hospitalisation With COPD (MoSHCOPD)

Pulmonary Disease, Chronic Obstructive | Emphysema | Chronic Bronchitis | Pulmonary Disease, Obstructive | Chronic Bronchitis With Airways Obstruction | Chronic Bronchitis With Acute Exacerbation

United Kingdom
Hillel Yaffe Medical Center

Unknown

Prognostic Value of Prothrombin Fragments 1+2 for Pulmonary Embolism Incidence

Pulmonary Disease, Chronic Obstructive | Pulmonary Embolism | Disease Exacerbation | Prothrombin Fragments

Israel
AstraZeneca

Completed

Roflumilast in Chronic Obstructive Pulmonary Disease (COPD) Patients Treated With Fixed Dose Combinations of Long-acting β2-agonist (LABA) and Inhaled Corticosteroid (ICS)

Lung Diseases | Pulmonary Disease | COPD | COPD Exacerbation | Respiratory Disorders | Chronic Obstructive Airway Disease | Chronic Obstructive Lung Diseases

United States, Argentina, Canada, Chile, Colombia, Italy, Malaysia, Mexico, Peru, Philippines, Romania, Russian Federation, Serbia, Spain, Taiwan, Thailand, Ukraine
University Hospital, Montpellier
Fisher and Paykel Healthcare

Not yet recruiting

Nasal High Flow Versus Non-invasive Ventilation for Early Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease With Hypercapnic Acidosis (HiCOPD)

Acute Exacerbation of Chronic Obstructive Pulmonary Disease | Hypercapnic Acidosis | Respiratory Failure With Hypercapnia

France
IRCCS San Raffaele Roma

Not yet recruiting

Ultrasonographic Evaluation of Diaphragm and Quadriceps in Chronic Obstructive Pulmonary Disease (COPD) Patients (EDIFEB)

COPD | COPD Exacerbation
Chiesi Farmaceutici S.p.A.

Recruiting

A Study Comparing Efficacy, Safety and Tolerability of the Fixed Dose Triple Combination CHF 5993 With the Fixed Dose Dual Combination CHF 1535 in Subjects With COPD (TRITON)

COPD | COPD Exacerbation

United States, Bulgaria, Hungary, Poland, Argentina, Czechia, Mexico, Canada, Puerto Rico, Romania
University College, London

Unknown

Mechanisms of COPD Exacerbation Recurrence

Recurrence | Pulmonary Disease, Chronic Obstructive | COPD Exacerbation | Patient Readmission

United Kingdom
Saglik Bilimleri Universitesi
Gulhane Training and Research Hospital

Recruiting

The Effect of Airway and Chest Wall Oscillation on Respiratory Functions in COPD Patients in Acute Exacerbation

COPD Exacerbation Acute

Turkey
Centre Hospitalier Universitaire, Amiens

Terminated

Impact of Air Quality on Exacerbations of COPD in the Somme (PolluBPCO)

Acute Exacerbation Copd

France
Atlantic Health System

Not yet recruiting

Prevalence of OSA in COPD and the Clinical Impact of OSA Diagnosis and Treatment

Prevalence of OSA in Patients Hospitalized With COPD Exacerbation
Rijnstate Hospital

Terminated

The Effects of Enoximone in Acute Exacerbation COPD

COPD Exacerbation | Enoximone | Phosphodiesterase Inhibitor

Netherlands
Lady Reading Hospital, Pakistan
Pakistan Chest Society, Pakistan

Recruiting

Clopidogrel for the Prevention of Exacerbations in Severe COPD (CLOPEX)

COPD | COPD Exacerbation Acute

Pakistan
Malmö University
Lund University

Completed

The Oral Microbiota as Reservoir for Systemic Opportunistic Pathogens

Pulmonary Disease, Chronic Obstructive | Dental Plaque | COPD Exacerbation

Sweden
Unity Health Toronto

Recruiting

High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease (HiFOLD)

Acute Hypercapnic Respiratory Failure | Acute Respiratory Distress | Exacerbation Copd

Canada
Synspira, Inc.

Terminated

A Study of the Safety and Tolerability of Inhaled SNSP113 in Healthy Subjects and Subjects With Stable Cystic Fibrosis

Lung Diseases | Cystic Fibrosis | Pulmonary Disease | Antibiotic Resistant Infection | Respiratory Tract Disease | Cystic Fibrosis Pulmonary Exacerbation | Lung Inflammation | Burkholderia Infections | Lung Infection | Multi-antibiotic Resistance | Pulmonary Inflammation | Lung Infection Pseudomonal | Cystic Fibrosis... and other conditions

United Kingdom
Assistance Publique - Hôpitaux de Paris
BioMérieux

Recruiting

Use of MULTIplex PCR, Procalcitonin, and Sputum Appearance to Reduce Duration of Antibiotic Therapy During Severe COPD EXAcerbation: A Controlled, Randomized, Open-label, Parallel-Group, Multicenter Trial (MULTI-EXA)

Acute Exacerbation of COPD

France
University of Zurich

Completed

Nurse-led Integrated Care in COPD Patients With a Pulmonary Exacerbation (NICCO)

COPD Exacerbation

Switzerland
Columbia University
Alpha-1 Foundation

Recruiting

COPD Exacerbation Blood and Urine Biomarkers Study

Chronic Obstructive Pulmonary Disease | Acute Exacerbation Copd | Alpha-1 Anti-trypsin Deficiency

United States
University of Colorado, Denver
Cystic Fibrosis Foundation

Terminated

Sensor Augmented Pump (SAP) Therapy for Inpatient CFRD Management

Cystic Fibrosis-related Diabetes | Cystic Fibrosis Pulmonary Exacerbation | Cystic Fibrosis in Children

United States
Joseph L. Kuti, PharmD
Cubist Pharmaceuticals LLC; Indiana University Health; University of North Carolina and other collaborators

Completed

Population Pharmacokinetics and Safety of Intravenous Ceftolozane/Tazobactam in Adult Cystic Fibrosis Patients

Cystic Fibrosis | Cystic Fibrosis Pulmonary Exacerbation | Pseudomonas Aeruginosa Infection

United States
University Hospital Ostrava

Completed

Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients

Septic Shock | Respiratory Insufficiency | Hypoxemia | Chronic Obstructive Pulmonary Disease Exacerbation | Lung Ventilator | Hyperhydration | Respiratory Distress Syndrome, Acute

Czechia
University of Milan

Completed

Ceftidoren Versus Levofloxacin in the Treatment of Patients With Acute Exacerbations of Chronic Bronchitis (AECB)

COPD Exacerbation

Italy
Ankara University

Completed

Are Comorbidities Related to Frequent Severe Exacerbations of AECOPD

Chronic Obstructive Lung Disease | Acute Exacerbation of COPD | Comorbidities and Coexisting Conditions

Turkey
Rochester General Hospital
Takeda

Recruiting

Prevalence of Humoral Dysfunction in Pts With Frequent Exacerbations of COPD, and the Effect of SCIgR for Prevention

COPD Exacerbation Acute

United States
University Hospital, Gentofte, Copenhagen
Philips Respironics

Unknown

Home Non Invasive Ventilation (NIV) Treatment for COPD-patients After a NIV-treated Exacerbation

Chronic Obstructive Pulmonary Disease | Chronic Hypercapnic Respiratory Failure | Acute Exacerbation of Chronic Obstructive Airways Disease

Denmark
Poznan University of Medical Sciences

Recruiting

Catheter-directed Thrombectomy in High and Intermediate-high Risk Pulmonary Embolism (CATH-PE)

Pulmonary Embolism With Acute Cor Pulmonale

Poland
Poznan University of Medical Sciences
Polish Cardiac Society

Recruiting

Polish Multicenter PERTs PE Outcomes Registry (PolPERTs)

Pulmonary Embolism With Acute Cor Pulmonale

Poland
Victor Tapson, MD
Bristol-Myers Squibb

Terminated

Standard-dose Apixaban AFtEr Very Low-dose ThromboLYSis for Acute Intermediate-high Risk Acute Pulmonary Embolism (SAFE-LYSE)

Pulmonary Embolism | Right Ventricular Dysfunction | Right Ventricular Failure | Pulmonary Embolism With Acute Cor Pulmonale | Pulmonary Embolism With Pulmonary Infarction | Pulmonary Embolism Subacute Massive

United States
Hospital Viamed Valvanera, Spain
Campus Bio-Medico University

Completed

Non-invasive Assessment of Pulmonary Vascular Resistance in Elderly Patients With Chronic Obstructive Pulmonary Disease (PVR-COPD)

Chronic Obstructive Pulmonary Disease | Pulmonary Hypertension | Cor Pulmonale

Italy
University of Ulm

Completed

NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE)

Pulmonary Embolism | Pulmonary Embolism Without Mention of Acute Cor Pulmonale

Germany
NuvoAir Medical PC
Optum, Inc.

Not yet recruiting

The COPD CARE Study: Evaluating the Impact of a Virtual-First COPD Service on Major Cardiac and Respiratory Events

COPD | COPD Exacerbation | Cardio/Pulm: Heart Failure
Prof. Dr. Jörg Leuppi
Kantonsspital Baselland Bruderholz; Institut für Hausarztmedizin Basel

Recruiting

Reduction of Corticosteroid Use in Outpatient Treatment of Exacerbated COPD (RECUT)

Pulmonary Disease, Chronic Obstructive | Disease Exacerbation | Adverse Effect of Glucocorticoids and Synthetic Analogues

Switzerland
University of California, San Francisco

Active, not recruiting

Innate Immunity in Ozone-induced Airway Inflammation in COPD (CO3PD)

Pulmonary Disease, Chronic Obstructive | COPD Exacerbation | Pollution; Exposure | Airway Disease | Pollution Related Respiratory Disorder

United States
Far Eastern Memorial Hospital

Completed

The Impact of Sarcopenia on COPD Exacerbation Admission Outcome and Further Exacerbation Risk

Sarcopenia | COPD Exacerbation

Taiwan
Sultan Abdulhamid Han Training and Research Hospital...

Recruiting

Evaluation of the Efficacy of Different Nebulization Techniques

COPD Exacerbation

Turkey
Albert Einstein Healthcare Network

Terminated

Health Literacy Activation RCT Among the COPD Patients and Designated Support Dyad

COPD Exacerbation

United States
AstraZeneca

Completed

Development of AECOPD Identification Tool (DETECT Study)

Acute Exacerbations of COPD

China
Assiut University

Not yet recruiting

Prediction of Outcome of Non Invasive Ventilation COPD Patients by Assessment of Diaphragmatic Performance

Acute Exacerbation COPD
Zhang Xiangyu

Completed

The Effect of External Diaphragmatic Pacemaker on the Patients With Chronic Cor Pulmonale

Chronic Cor Pulmonale

China
Centre Hospitalier de Saint-Denis

Completed

Extracorporeal CO2 Removal in Acute Exacerbation of COPD Not Responding to Non-Invasive Ventilation

COPD Exacerbation Acute
Parc de Salut Mar

Completed

Respiratory Therapy in COPD Exacerbations (TRESEPOCAS)

Obstructive Chronic Bronchitis With Acute Exacerbation

Spain
Assistance Publique - Hôpitaux de Paris
Ministry of Health, France; Xenios AG

Recruiting

CO2 Removal in Severe Acute exacerbatIons of Chronic Obstructive Lung Diseases (CORAIL)

COPD Acute Exacerbation

France
Institut für Pneumologie Hagen Ambrock eV

Active, not recruiting

Evaluation of the Multidimensional Dyspnea Profile (MDP)

OSA | COPD | COPD Exacerbation | CHF

Germany
Holbaek Sygehus
Aase and Ejnar Danielsens Foundation; Region Sjælland

Unknown

Procalcitonin as a Marker of Antibiotic Therapy in Patients With Lower Respiratory Tract Infections

Pneumonia | Acute Exacerbation of Chronic Obstructive Airways Disease

Denmark
National Jewish Health
Cystic Fibrosis Foundation

Completed

Cystic Fibrosis (CF) Leukocyte Genes as Biomarkers for Novel Therapies

Cystic Fibrosis | Pulmonary Exacerbation

United States

Clinical Trials on Pulmonary Exacerbation

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