Clinical Trials on Refractory Depression

Total 11949 results

Tulane University School of Medicine
BioMarin Pharmaceutical

Completed

Evaluation of Behavior, Executive Function, Neurotransmitter Function and Genomic Expression Kuvan Nonresponders (IST)

Phenylketonuria | Behavior and Behavior Mechanisms | PAH Gene Expression

United States
University of Houston
National Institute on Drug Abuse (NIDA)

Completed

Project PRIDE (Promoting Resilience In Discriminatory Environments)

Depression | Anxiety | Substance Use Disorders | Sexually Transmitted Infections | Human Immunodeficiency Virus

United States
Karolinska Institutet
Region Stockholm

Completed

Internet-based Cognitive Behavioral Therapy for Adolescents With Sleep Problems- a Feasibility Trial

Depressive Disorder | Inflammation | Anxiety Disorders | Pain, Chronic | Insomnia Disorder

Sweden
Center Trials & Treatment

No longer available

Expanded Access for Pembrolizumab (MK-3475)

Glioblastoma Multiforme | Melanoma (Skin) | Melanoma Recurrent | Glioma of Brain | Glioblastoma by Gene Expression Profile

Hong Kong, Belarus, Tajikistan, Uzbekistan
Fondation Ophtalmologique Adolphe de Rothschild

Recruiting

Genetic and Electrophysiologic Study in Focal Drug-resistant Epilepsies (GENEPHY)

Tuberous Sclerosis | Focal Cortical Dysplasia | Hemimegalencephaly | Refractory Focal Epilepsy | Mild Malformation of Cortical Development With Oligodendroglial Hyperplasia in Epilepsy (MOGHE)

France
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome | Chronic Myelomonocytic Leukemia | Secondary Acute Myeloid Leukemia | Myelodysplastic Syndrome | Recurrent Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Therapy-Related Acute Myeloid Leukemia | Acute Bilineal Leukemia and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability

Metastatic Malignant Solid Neoplasm | Stage IV Colon Cancer AJCC v8 | Stage IV Rectal Cancer AJCC v8 | Stage IVA Colon Cancer AJCC v8 | Stage IVA Rectal Cancer AJCC v8 | Stage IVB Colon Cancer AJCC v8 | Stage IVB Rectal Cancer AJCC v8 | Rectal Adenocarcinoma | Colon Adenocarcinoma | High-Frequency Microsatellite... and other conditions

United States
Jennifer Crombie, MD
Merck Sharp & Dohme LLC

Recruiting

Pembro Plus CAR T-cell Therapy in R/R in PMBCL

Primary Mediastinal Large B-cell Lymphoma (PMBCL) | Primary Mediastinal Large B Cell Lymphoma | T-Cell/Histiocyte-Rich Large B-Cell Lymphoma | Primary Mediastinal Large B-Cell Lymphoma Refractory | Primary Mediastinal Large B-Cell Lymphoma Recurrent | Epstein-Barr Virus Positive Diffuse Large...

United States
Qilu Puget Sound Biotherapeutics (dba Sound Biologics)

Recruiting

PSB202 in Patients With Previously Treated-, Relapsed-, Indolent B-Cell Malignancies

Follicular Lymphoma | Waldenstrom Macroglobulinemia | Mantle Cell Lymphoma | Marginal Zone Lymphoma | MALT Lymphoma | Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma | Indolent Lymphoma | Refractory B-Cell Lymphoma

United States, Australia, China
Huazhong University of Science and Technology
Shanghai IASO Biotechnology Co., Ltd

Not yet recruiting

Safety and Efficacy of CT125A Cells for Treatment of Relapsed/Refractory CD5+ Hematopoietic Malignancies

Chronic Lymphocytic Leukemia (CLL) | Peripheral T-cell Lymphomas (PTCL) | CD5+ Relapsed/Refractory Hematopoietic Malignancies | Mantle Cell Lymphoma (MCL) | Diffuse Large B-cell Lymphoma (DLBCL) | Follicular Lymphoma (FL)
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of an Experimental Medication MK-3475 (Pembrolizumab) to Usual Anti-Retroviral Medications in Patients With HIV and Cancer

HIV Infection | Hepatocellular Carcinoma | Non-Hodgkin Lymphoma | Metastatic Lung Non-Small Cell Carcinoma | Metastatic Melanoma | Kaposi Sarcoma | Stage III Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | Unresectable... and other conditions

United States
Karolinska Institutet
Region Stockholm; Forte; Stiftelsen Frimurarna Barnhuset

Active, not recruiting

Internet-delivered ACT (I-Navigator ACT) for Parents of Children With Disabilities

Depression | Stress, Psychological | Intellectual Disability | Anxiety | Neurodevelopmental Disorders | Traumatic Brain Injury | Autism Spectrum Disorder | Parents | Attention Deficit Hyperactivity Disorder | Physical Disability

Sweden
Norwegian University of Science and Technology

Completed

Subjective Memory Complaints, Objective Memory Performance and Cognitive Training

Depressive Disorder | Chronic Pain | Anxiety Disorders | Fatigue Syndrome, Chronic | Sleep Disorders

Norway
NexImmune Inc.

Not yet recruiting

Autologous T Cells Targeting HPV16 HPV18 & Survivin in Patients With R/R HPV-related Oropharyngeal Cancers

Head and Neck Cancer | Head and Neck Squamous Cell Carcinoma | Oropharyngeal Squamous Cell Carcinoma | Oropharyngeal Cancer | Human Papilloma Virus | Head and Neck Cancer Metastatic | HPV-Related Squamous Cell Carcinoma | Oropharyngeal Cancer, Metastatic | HPV-Related Mucosal Head and Neck Squamous... and other conditions
SWOG Cancer Research Network
National Cancer Institute (NCI)

Active, not recruiting

S1702 Isatuximab in Treating Patients With Relapsed or Refractory Primary Amyloidosis

Nausea | Constipation | Diarrhea | Purpura | Lymphadenopathy | Gastrointestinal Hemorrhage | Hepatomegaly | Primary Systemic Amyloidosis | Amorphous, Eosinophilic, and Acellular Deposit | Early Satiety | Macroglossia | Recurrent Primary Amyloidosis | Refractory Primary Amyloidosis

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab With or Without Elbasvir/Grazoprevir and Ribavirin in Treating Patients With Advanced Refractory Liver Cancer

Stage IIIB Hepatocellular Carcinoma AJCC v7 | Stage IIIC Hepatocellular Carcinoma AJCC v7 | BCLC Stage B Hepatocellular Carcinoma | BCLC Stage C Hepatocellular Carcinoma | Hepatitis C Infection | Stage IV Hepatocellular Carcinoma AJCC v7 | Stage III Hepatocellular Carcinoma AJCC v7 | Stage IIIA Hepatocellular... and other conditions

United States
Pediatric Brain Tumor Consortium
National Cancer Institute (NCI)

Completed

Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors

Malignant Glioma | Recurrent Childhood Ependymoma | Recurrent Medulloblastoma | Recurrent Diffuse Intrinsic Pontine Glioma | Recurrent Atypical Teratoid/Rhabdoid Tumor | Refractory Diffuse Intrinsic Pontine Glioma | CNS Embryonal Tumor, Not Otherwise Specified

United States
Amgen

Completed

Study of AMG 162 in Subjects With Advanced Cancer Currently Being Treated With Intravenous (IV) Bisphosphonates

Bone Metastases in Men With Hormone-Refractory Prostate Cancer | Bone Metastases in Subjects With Advanced Breast Cancer | Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma
Daniel Serrani Azcurra
Zarebski Graciela, Kabanchik Alicia, Marconi Araceli

Recruiting

Multifactorial Approach to Dementia, Multicentric Study

Depression | Dementia of Alzheimer Type | Dementia Frontotemporal | Narcissistic Personality Disorder | Personality Change

Argentina
Centro Universitário de Anapolis

Recruiting

Post COVID-19 Pulmonary Rehabilitation Program (COVID19REHAB)

Lung Diseases | Covid19 | Muscle Weakness | Respiratory Insufficiency | COVID-19 Respiratory Infection | Anxiety Disorder; Mixed With Depression (Mild)

Brazil
Columbia University
National Institute of Mental Health (NIMH); Yale University

Completed

Building Mobile HIV Prevention and Mental Health Support in Low-resource Settings

Depression, Anxiety | Human Immunodeficiency Virus | Risk Reduction | Alcohol Abuse | Behavior, Sex

Romania
VA Office of Research and Development

Completed

Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop (STEP-Home)

Depression | Pain | Anxiety Disorders | Suicide | Traumatic Brain Injury | Substance Related Disorders | Post-traumatic Stress Disorder

United States
D'Or Institute for Research and Education
Conselho Nacional de Desenvolvimento Científico e Tecnológico

Active, not recruiting

Mental Health of Professionals Working in Pediatric Intensive Care Units During the COVID-19 Pandemic

Depression | Covid19 | Burnout, Professional | Stress Disorders, Post-Traumatic | Compassion Fatigue | Anxiety

Brazil
Southwest Oncology Group
National Cancer Institute (NCI)

Completed

S1008: Exercise, Diet, & Counseling in Improving Weight Loss in Overweight Female Breast or Colorectal Cancer Survivors

Depression | Pain | Breast Cancer | Fatigue | Colorectal Cancer | Cognitive/Functional Effects | Anxiety Disorder | Psychosocial Effects of Cancer and Its Treatment | Weight Changes

United States
Centre for Addiction and Mental Health

Active, not recruiting

Neuroinflammation in COVID-19 and Depression

Covid19 | Major Depressive Episode

Canada
Sameek Roychowdhury
National Cancer Institute (NCI)

Withdrawn

Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers

Locally Advanced Malignant Solid Neoplasm | Metastatic Malignant Solid Neoplasm | ALK Gene Mutation | Metastatic Malignant Neoplasm in the Brain | Advanced Malignant Neoplasm | ALK Fusion Protein Expression | Metastatic Malignant Neoplasm in the Central Nervous System | ROS1 Gene Mutation | ALK Gene... and other conditions

United States
National Institute of Mental Health (NIMH)

Completed

Glucocorticoid Effects on Cellular Cytokine Release

Depressive Disorder | Inflammation | Healthy | Fibromyalgia | Fatigue Syndrome, Chronic

United States
University of Missouri-Columbia

Recruiting

Baker Gordon Syndrome Natural History Study (BAGOS)

Epilepsy, Generalized | Sleep Disorder | Rare Diseases | Development Delay | Motor Delay | Autism or Autistic Traits | SYT-SSX Fusion Protein Expression

United States
The Center for Mind-Body Medicine
U.S. Army Medical Research and Development Command; Southeast Louisiana Veterans...

Completed

Mind-Body Skills Groups for the Treatment of War Zone Stress in Military and Veteran Populations

Anger | Depressive Disorder | Brain Injuries | Anxiety Disorders | Stress Disorders, Post Traumatic

United States
Centre Hospitalier de Valence

Not yet recruiting

Evaluation of the Medical Service by Socio-aesthetics in Oncology (RCT-SE)

Anxiety Depression | Cancer, Breast | Cancer Pain | Cancer of Colon | Cancer, Lung | Cancer Prostate
University of Texas at Austin
Way West Wellness; SunFlora.Inc

Suspended

CBD Oil for Reducing Emotional Impact of COVID-19 (CBDOIL)

Anger | Sleep Disturbance | Anxiety Depression | Substance Abuse | Alcohol Abuse | Stress Reaction

United States
Charite University, Berlin, Germany

Completed

Evaluation of an Integrated Care Project (ediva)

Depression | Migraine | Asthma | Allergic Rhinitis | Headache | Atopic Eczema

Germany
Brigham and Women's Hospital
CVS Caremark

Completed

Robust Evaluation to Measure Improvements in Nonadherence From Low-cost Devices (REMIND)

Depression | Epilepsy | Cardiovascular Disease | Diabetes | Breast Cancer | Parkinson's Disease | Mental Health Disorder | Prostatic Hypertrophy, Benign

United States
Federal University of Minas Gerais
Harvard Medical School (HMS and HSDM)

Active, not recruiting

Assessment of Sleep Quality and Mental Health After Using Meditation

Depressive Disorder | Quality of Life | Sleep Disorder | Anxiety Disorders | Insomnia | Spirituality | Stress Disorder | Insomnia Chronic | Insomnia Disorder | Complementary Therapy

Brazil
Peking University Cancer Hospital & Institute

Completed

Gene Expression Profiling of Breast Cancer Cells Predict the Response of Malignant Pleural Effusion (GMPE)

Breast Neoplasms | Neoplasm Metastasis | Immunotherapy | Gene Expression Profiling

China
National Cancer Institute (NCI)

Terminated

Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane Hydrochloride in Treating Young Patients With Relapsed or Refractory Solid Tumors, Lymphoma, or Leukemia

Unspecified Childhood Solid Tumor, Protocol Specific | Peripheral T-cell Lymphoma | Angioimmunoblastic T-cell Lymphoma | Childhood Chronic Myelogenous Leukemia | Cutaneous B-cell Non-Hodgkin Lymphoma | Hepatosplenic T-cell Lymphoma | Intraocular Lymphoma | Recurrent Childhood Acute Lymphoblastic... and other conditions

United States, Canada
Fred Hutchinson Cancer Center
National Cancer Institute (NCI); National Heart, Lung, and Blood Institute...

Completed

Mycophenolate Mofetil and Cyclosporine in Reducing Graft-Versus-Host Disease in Patients With Hematologic Malignancies or Metastatic Kidney Cancer Undergoing Donor Stem Cell Transplant

Clear Cell Renal Cell Carcinoma | Chronic Myelomonocytic Leukemia | Recurrent Adult Acute Myeloid Leukemia | Juvenile Myelomonocytic Leukemia | Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue | Nodal Marginal Zone B-cell Lymphoma | Recurrent Adult Burkitt Lymphoma | Recurrent... and other conditions

United States, Germany, Italy
Johns Hopkins University
Department of Defense Congressionally Directed Medical Research Program

Recruiting

CBT-I vs. MBTI for Traumatic Brain Injury (TBI)-Related Insomnia and Post-Traumatic Stress Symptoms

Depression | Insomnia | Sleep | Traumatic Brain Injury | Memory Impairment | Head Injury | Cognitive Behavioral Therapy | Concussion, Brain | Post-traumatic Stress | Brain Injury Traumatic Mild

United States
Lisa Gallagher
The Cleveland Clinic; National Endowment for the Arts, United States; Cuyahoga...

Terminated

Arts & Health Education to Improve Health, Resilience, and Well-Being

Depression | Heart Diseases | Stroke | Multiple Sclerosis | Hypertension | Obesity | Diabetes | Chronic Pain | Asthma | Anxiety | COPD | CHF | High Cholesterol

United States
University of New Hampshire
National Institute on Alcohol Abuse and Alcoholism (NIAAA); University of South... and other collaborators

Completed

Development and Pilot Trial of an Intervention to Reduce Disclosure Recipients Negative Social Reactions and Victims Psychological Distress and Problem Drinking

Depression | Alcohol Drinking | Alcohol; Harmful Use | Social Skills | Coping Behavior | Post-traumatic Stress Disorder | Coping Skills | Social Behavior | Alcohol Abuse | Drinking, College | Social Stigma | Empathy | Self-Criticism | Social Norms | Social Responsibility

United States
The University of Texas Health Science Center at...
South Texas Veterans Health Care System

Completed

Establishing Efficacy of a Functional-Restoration Based CAM Pain Management Program in Post-9/11 Veterans

Depression | Chronic Pain | Traumatic Brain Injury | Opioid Use Disorder | Posttraumatic Stress Disorder

United States
Albert Einstein College of Medicine
National Cancer Institute (NCI)

Terminated

Meditation-Based Breathing Training in Improving Target Motion Management and Reducing Distress in Patients With Abdominal or Lung Cancer Undergoing Radiation Therapy

Depression | Pain | Anxiety | Digestive System Neoplasm | Post-Traumatic Stress Disorder | Lung Neoplasm | Psychological Impact of Cancer

United States
Regina Elena Cancer Institute
University of California, San Diego; Lega Italiana per la Lotta contro i Tumori

Recruiting

New Prognostic and Predictive Biomarkers for HPV-associated Oropharyngeal Cancer

PREDICTIVE BIOMARKERS | Evaluation of HPV-specific E5 Transcript Expression in a Cohort of Patients With HPV-associated OPC | HPV 16 Positive Oropharyngeal Tumors (OPC)

Italy
Universite de Moncton
Movember Foundation; New Brunswick Health Research Foundation

Unknown

Comorbid Mental Disease and Heart Disease in Men (MindTheHeart)

Depressive Disorder | Anxiety Disorders | Stress Disorders, Post-Traumatic | Acute Coronary Syndrome
National Center for Complementary and Integrative...

Completed

Women's Use of Alternative Medicine: A Multiethnic Study

Depression | Arthritis | Urinary Tract Infection | Osteoporosis | Heart Disease | Uterine Fibroids | High Blood Pressure | Headaches
Genelux Corporation
GOG Foundation

Recruiting

Efficacy & Safety of Olvi-Vec and Platinum-doublet + Bevacizumab Compared to Physician's Choice of Chemotherapy and Bevacizumab in Platinum-Resistant/Refractory Ovarian Cancer (PRROC) (OnPrime, GOG-3076)

Fallopian Tube Cancer | Platinum-resistant Ovarian Cancer | Platinum-refractory Ovarian Cancer | Primary Peritoneal Cancer | High-grade Serous Ovarian Cancer | Endometrioid Ovarian Cancer | Ovarian Clear Cell Carcinoma

United States
NiKang Therapeutics, Inc.

Recruiting

A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Kidney Cancer | Kidney Neoplasms | Renal Cell Carcinoma | Clear Cell Renal Cell Carcinoma | Hypoxia | Metastatic Renal Cell Carcinoma | Recurrent Renal Cell Carcinoma | Renal Cancer | Advanced Renal Cell Carcinoma | Renal Neoplasms | ccRCC | Refractory Renal Cell Carcinoma | Hypoxia Inducible Factor (HIF) | HIF2α... and other conditions

United States
University College London Hospitals

Completed

CAR T Cell Therapy Related Cardiovascular Outcomes (CARTCO)

Cardiovascular Diseases | Diffuse Large B Cell Lymphoma | Cardiotoxicity | B-cell Acute Lymphoblastic Leukemia | Primary Mediastinal Large B-cell Lymphoma (PMBCL) | B-cell Lymphoma Refractory | Cardiovascular Complication | B-cell Lymphoma Recurrent

United Kingdom
Ohio State University Comprehensive Cancer Center
MorphoSys AG

Active, not recruiting

Phase II MOR00208 in Combination With Lenalidomide for Patients With Relapsed or Refractory CLL, SLL or PLL or Older Patients With Untreated CLL, SLL or PLL

Recurrent Small Lymphocytic Lymphoma | Prolymphocytic Leukemia | Refractory Chronic Lymphocytic Leukemia | Stage III Small Lymphocytic Lymphoma | Stage IV Small Lymphocytic Lymphoma | Stage I Chronic Lymphocytic Leukemia | Stage II Chronic Lymphocytic Leukemia | Contiguous Stage II Small Lymphocytic... and other conditions

United States
Stanford University
California Breast Cancer Research Program

Completed

Phase I: At-Home Support for Rural Women Using Group Video Calling

Depression | Post-traumatic Stress Disorder | Stage IV Breast Cancer | Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Stage IA Breast Cancer | Stage IB Breast Cancer | Stage IIIC Breast Cancer | Recurrent Breast Cancer

United States

Clinical Trials on Refractory Depression

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Mongolia

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations