Multifactorial Approach to Dementia, Multicentric Study

Multifactorial Approach to Dementia. Multicentric Study

The goal of this observational study is to assess the role of narcisistic personality disorder and life stressful events in conversion rate to dementia, using a three tier approach along three research lines employing subjects with dementia in retrospective assessment, and normal subjects no yet developing demetia in prospective follow up. The main question[s] it aims to answer are:

• narcisistic personality disorder as risk factor for conversion to dementia
• life stressful events as risk factor for conversion to dementia Participants will be assessed with a complete neurocognitive battery, brain images studies, laboratory analysis, and sociodemographic profile, including depression and comorbidities.

Study Overview

• Status: Recruiting
• Conditions: Depression; Dementia of Alzheimer Type; Dementia Frontotemporal; Narcissistic Personality Disorder; Personality Change

Detailed Description

Previous studies have identified multiple risk factors for dementia in a variety of settings. However personality traits have received less attention as a contributing or mediating factor. The identification of potentially modifiable risk factors has been critical in the development of effective multifactorial intervention programmes for people at risk of dementia. Studies that examined the role of personality traits as risk factor for dementia recruited participants with mild cognitive impairment or mild to moderate dementia living in institutional or community settings. In this 3 tiered study, 3 lines of research will be pursued. In lines 1 and 2 retrospective analysis of patients with dementia will be performed searching for the mediating or predisposing role of narcissistic personality disorder as a risk factor for the development of dementia. in the 3rd line of research normal participants will complete a multifactorial baseline assessment of putative predictors of mild cognitive impairment or dementia and then will complete prospective cognitive, affective and personality diaries for a period of 12 months, in order to detect association of personality traits to dementia conversion.

Methods Ethics statement This study will be submitted to Ethics Committee of INICIEN Research Authority, and participants will be requested to give written informed consent in accordance with the declaration of Helsinki.

Design Longitudinal prospective and retrospective cohort study. Participant recruitment 3 lines of research. In line 1 and 2 patients with dementia will be assessed in a retrospective approach and in the line 3 healthy cases without cognitive impairment will be recruited to determine if narcisistic personality play a role in the risk of dementia onset (AD, frontotemporal dementia). Patients files and subjects will be recruited from multicenter Neurology, Old Age Psychiatry and Geriatric Medical secondary care outpatient clinics. Cases should be referred to these clinics for assessment, diagnosis and management by their primary care physician, or referred to a Psychiatrist by their clinical physician.

Inclusion and exclusion criteria All participants should be over 50 years of age in research line 1, and no age limit will be assumed for cases in reesarch lines 1 and 2. All diagnoses of dementia will be made according to DSM V criteria. Significant medical causes of dementia should be excluded during diagnostic investigations. Diagnoses will be made by operationalised criteria for dementia validated against neuropathological diagnosis Participants were excluded if they declined participation, died or withdrew from the study before commencing follow up period, unable to perform the assessments due to other co-morbid conditions, or were too visually impaired to complete cognitive assessments. Baseline Clinical Assessment All participants received a detailed baseline assessment to quantify putative risk factors for dementia. The factors included were selected on the basis of their previous identification as risk factors in more than one high quality study in older people, and/or their relevance to clinical features of dementia postulated to be causative of neurocognive disorder conversion.

Assessments included medical history (residence, history of life stressful events, affective state, sociodemographic factors). Objective assessments included the cognitive battery, personality assessment with narcisistic personality disorder, Yesavage depression scale. Participants were assessed at baseline and during follow up period of one year.

Dementia specific scales were used to assess specific staging level and dementia specific type, depression, and behavioural and psychological symptoms of dementia.

Outcome Measures The primary outcome measure will be dementia conversion occurring during the 12 month follow up period. Secondary outcome measures will be proportional hazard ratios for time to dementia conversion, according to diagnosis and status of personality disorder narcisistic type as putative clinical predictor. If the participants did not show off at previously assigned points, they will be reminded by telephone after 2 weeks. The caregiver will be asked to assist in the completion of diaries when dementia is present.

Statistics Differences in baseline characteristics across groups will be compared using Fisher's Exact test for categorical data, ANOVA for normally distributed data and Kruskal-Wallis for non-normally distributed data. Differences between individual groups will be compared using the Chi squared test for categorical data, Student's t test for normally distributed data and Mann-Whitney U test for non-normally distributed data.

In case of censoring of data from some participants (as a result of death or withdrawal from the study), Cox regression (adjusted for age and sex) will be used to obtain a proportional hazard ratio for personality disorder as risk factor to dementia conversion. Loglinear Poisson regression models (adjusted for age and sex) will be used to obtain an incidence density ratio for dementia and its subtypes in comparison with healthy controls. without personality disorders In order to examine the associations between exposure to narcisitic personality disorder as risk factors for dementia conversion in those participants with dementia, Cox regression will be used to obtain univariate proportional hazard ratios for each risk factor, adjusted for age and sex, using time to the occurrence of at least mild cognitive impairment as the dependent variable. Hazard ratios will be given according to presence or absence of the risk factor, or per point on quantitative scales as appropriate. Analyses will be performed initially for all participants with or without dementia, and then repeated stratified by diagnosis.

Following identification in univariate models, significant and potentially modifiable risk factors will be entered into a multivariate forward stepwise Cox regression model, p 0.05 for entry, p 0.1 for removal. Age and sex will be included even if not significant. Where similar clinical features coould be described by more than one significant risk factor the factor with the higher level of significance in univariate analyses will be entered into multivariate analyses, in order to avoid co-aggregation of predictors.

• Study Type: Observational
• Enrollment (Estimated): 450

Contacts and Locations

Study Locations

• Argentina
  • Outside U.S. And Canada
    • Buenos Aires, Outside U.S. And Canada, Argentina, 1405
      • Recruiting
      • universidad Atlantida
      • Contact: daniel joge serrani, MD; Phone Number: 01168087072; Email: danielserraniazcurra@gmail.com
      • Contact: daniel jorge serrani, MD; Phone Number: +541168087072; Email: danielserraniazcurra@gmail.com
      • Principal Investigator: grciela zarebski, MD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

individuals eligible to participate were diagnosed with dementia, or had inconclusive results living at the community or residential institutions invited to attend a follow-up, cognitively healthy or minimally impaired, or had mild cognitive impairment (MCI), or dementia

Description

Inclusion Criteria:

research line 3

• healthy subjects over 50 years of age.
• diagnosis of dementia should be made according to DSM V criteria.
• Diagnoses made by operationalised criteria for dementia

Exclusion Criteria:

• Participants excluded if declined participation, died or withdrew from the study
• unable to perform the assessments due to other co-morbid conditions
• were too visually impaired to complete cognitive assessments.

in research lines 1 and 2 inclusion criteria subjects with confirmed diagnosis of dementia

• putative narcisistic personality disorder
• no age limit

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
new onset of dementia during the follow-up period	dementia diagnosed according to the Diagnostic and Statistical Manual of Mental Disorders V, considered affected by dementia when agreement on this diagnosis was reached between a psychologist and a geriatrician. If the physicians failed to agree, the diagnosis had to be confirmed by a second geriatrician.	1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
univariate proportional hazard ratios for narcissistic personality as risk factor, adjusted for age and sex	Hazard ratios are given according to presence or absence of the risk factor, or per point on quantitative scales as appropriate.	1 year

Collaborators and Investigators

• Sponsor: Daniel Serrani Azcurra
• Collaborators: Zarebski Graciela, Kabanchik Alicia, Marconi Araceli

Publications and helpful links

General Publications

• Fiest KM, Jette N, Roberts JI, Maxwell CJ, Smith EE, Black SE, Blaikie L, Cohen A, Day L, Holroyd-Leduc J, Kirk A, Pearson D, Pringsheim T, Venegas-Torres A, Hogan DB. The Prevalence and Incidence of Dementia: a Systematic Review and Meta-analysis. Can J Neurol Sci. 2016 Apr;43 Suppl 1:S3-S50. doi: 10.1017/cjn.2016.18.
• Ganguli M, Dodge HH, Chen P, Belle S, DeKosky ST. Ten-year incidence of dementia in a rural elderly US community population: the MoVIES Project. Neurology. 2000 Mar 14;54(5):1109-16. doi: 10.1212/wnl.54.5.1109.
• serrani daniel Narcissism Vulnerability as Risk Factor for Alzheimer´s Disease- A Prospective Study Austin J Clin Neurol 2015;2(7): 1057.
• Chatterjee A, Strauss ME, Smyth KA, Whitehouse PJ. Personality changes in Alzheimer's disease. Arch Neurol. 1992 May;49(5):486-91. doi: 10.1001/archneur.1992.00530290070014.
• Wilson RS, Schneider JA, Arnold SE, Bienias JL, Bennett DA. Conscientiousness and the incidence of Alzheimer disease and mild cognitive impairment. Arch Gen Psychiatry. 2007 Oct;64(10):1204-12. doi: 10.1001/archpsyc.64.10.1204.

Study record dates

Study Major Dates

• Study Start (Actual): May 20, 2023
• Primary Completion (Estimated): April 20, 2024
• Study Completion (Estimated): September 20, 2024

Study Registration Dates

• First Submitted: June 19, 2023
• First Submitted That Met QC Criteria: June 19, 2023
• First Posted (Actual): June 28, 2023

Study Record Updates

• Last Update Posted (Actual): July 6, 2023
• Last Update Submitted That Met QC Criteria: July 3, 2023
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mental Disorders; Metabolic Diseases; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neurologic Manifestations; Neurobehavioral Manifestations; Neurocognitive Disorders; Neurodegenerative Diseases; TDP-43 Proteinopathies; Proteostasis Deficiencies; Tauopathies; Language Disorders; Communication Disorders; Speech Disorders; Frontotemporal Lobar Degeneration; Aphasia; Personality Disorders; Dementia; Alzheimer Disease; Frontotemporal Dementia; Aphasia, Primary Progressive; Pick Disease of the Brain
• Other Study ID Numbers: 01569

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No