Clinical Trials on Rendu Osler Weber Disease

Total 105 results

National Human Genome Research Institute (NHGRI)

Completed

Screening Behavior in Adults With Hereditary Hemorrhagic Telangiectasia

Telangiectasia, Hereditary Hemorrhagic | Osler-Rendu-Weber Disease | Osler-Rendu Disease

United States
Fundacion para la Investigacion Biomedica del Hospital...
Sociedad Española De Medicina Interna

Active, not recruiting

Genotype-phenotype Association in Hereditary Hemorrhagic Telangiectasia (Generate-HHT)

Hereditary Hemorrhagic Telangiectasia | HHT | Rendu Osler Weber Disease

Spain
Medical University of Vienna

Recruiting

Vienna Vascular Liver Disease Study (VALID)

Portal Vein Thrombosis | Budd-Chiari Syndrome | Non-Cirrhotic Portal Hypertension | Vascular Liver Disease | Rendu Osler Weber | Cardiac Cirrhosis | Porto-sinusoidal Vascular Disorder

Austria
University Hospital, Bordeaux
AMRO-HHT-France - Association Maladie de Rendu-Osler

Completed

Propranolol for Epistaxis in Hereditary Hemorrhagic Telangiectasia Patients (EPERO)

Hereditary Hemorrhagic Telangiectasia | Osler Weber Rendu Disease

France
Hospices Civils de Lyon

Recruiting

Stress-Echography in Hereditary Haemorrhagic Telangiectasia Patient With Hepatic Involvement (ROSE)

Hereditary Hemorrhagic Telangiectasia | Rendu Osler Disease

France
Hospices Civils de Lyon

Completed

BABH Study: Efficacy and Safety of Bevacizumab on Severe Bleedings Associated With Hemorrhagic Hereditary Telangiectasia (HHT). (BABH)

Telangiectasia, Hereditary Hemorrhagic | Rendu Osler Disease

France
University Hospital, Strasbourg, France

Recruiting

Calcium-phosphate Complications Induced by IV Iron Supplementation in Patients With Rendu-Osler Disease (OS-LERETRO)

Rendu Osler Disease

France
Hospices Civils de Lyon

Completed

Evaluation of Obstetrical and Neonatal Complications in Hereditary Haemorrhagic Telangiectasia (HHT) (CONCERTO)

Hereditary Hemorrhagic Telangiectasia | Osler Rendu Disease

France
Hospices Civils de Lyon

Completed

Diagnostic Value of Ultra-low Dose Thoracic Scanner for the Pulmonary Arteriovenous Malformation Detection in HHT Patient (ULD OSLER)

Telangiectasia, Hereditary Hemorrhagic | Rendu Osler Disease

France
University Hospital, Clermont-Ferrand

Recruiting

Prospective Study of Antiplatelet and Anticoagulation Therapy in Hereditary Haemorrhagic Telangiectasia (PROPLACO-Tel)

Hereditary Hemorrhagic Telangiectasia | Rendu Osler Disease

France
Hospices Civils de Lyon

Completed

Efficacy of Nintedanib Per os as a Treatment for Epistaxis in HHT Disease. (EPICURE)

Telangiectasia, Hereditary Hemorrhagic | Rendu Osler Disease

France
Hospices Civils de Lyon

Completed

ATERO : A Randomised Study With Tranexamic Acid in Epistaxis of Rendu Osler Syndrome

Telangiectasia, Hereditary Hemorrhagic | Osler-Rendu Disease

France
Hospices Civils de Lyon

Completed

Efficacy of a Timolol Nasal Spray as a Treatment for Epistaxis in Hereditary Hemorrhagic Telangiectasia (HHT) - (TEMPO) (TEMPO)

Telangiectasia, Hereditary Hemorrhagic | Osler Rendu Disease

France
Hospices Civils de Lyon

Completed

The ELLIPSE Study: A Phase-1 Study Evaluating the Tolerance of Bevacizumab Nasal Spray to Treat Epistaxis in Hereditary Hemorrhagic Telangiectasia (ELLIPSE)

Telangiectasia, Hereditary Hemorrhagic | Rendu Osler Disease
Johns Hopkins University
Vascular Birthmarks Foundation

Completed

Use of the Atkins Diet for Children With Sturge Weber Syndrome

Epilepsy | Sturge Weber Syndrome

United States
Clinica Universidad de Navarra, Universidad de...

Completed

Efficacy and Safety Study of Topical Rapamycin Associated With Pulsed Dye Laser in Patients With Sturge-Weber Syndrome (RSW)

Sturge- Weber Syndrome

Spain
Baylor College of Medicine
Novartis Pharmaceuticals

Withdrawn

Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS)

Sturge Weber Syndrome

United States
Wills Eye
University of Medicine and Dentistry of New Jersey

Terminated

Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol

Sturge Weber Syndrome | Port-wine Mark

United States
University of California, Irvine
Mainz University

Completed

Incidence of Ocular Antibodies in Patients With Sturge - Weber Syndrome (SWS)

Sturge - Weber Syndrome (SWS)

United States
University Hospital, Tours

Completed

French National Cohort of Children With Port Wine Stain (CONAPE)

Port Wine Stain | Parkes Weber Syndrome | Klippel Trenaunay Syndrome

France
Qlaris Bio, Inc.

Completed

A Study to Determine the Safety and Tolerability of 2 Concentrations of QLS-101

Ocular Hypertension | Glaucoma | Glaucoma Congenital | Sturge-Weber Syndrome (SWS)

United States
University of Illinois at Chicago
Wayne State University; Boston Children's Hospital; Duke University; University... and other collaborators

Recruiting

Longitudinal Studies to Identify Biomarkers for Sturge-Weber Syndrome

Sturge-Weber Syndrome

United States
Anne Comi, MD
Jazz Pharmaceuticals; Faneca 66 Foundation

Completed

Cannabidiol Expanded Access Study in Medically Refractory Sturge-Weber Syndrome

Sturge-Weber Syndrome

United States
Hugo W. Moser Research Institute at Kennedy Krieger...
Baylor College of Medicine; New York University; National Institute of Neurological... and other collaborators

Active, not recruiting

Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome

Sturge-Weber Syndrome

United States
Hugo W. Moser Research Institute at Kennedy Krieger...
National Institute of Neurological Disorders and Stroke (NINDS); National Institutes... and other collaborators

Completed

Biomarker Development in Sturge-Weber Syndrome (Pilot)

Sturge-Weber Syndrome

United States
Hospices Civils de Lyon

Not yet recruiting

Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study (COGRare5)

Arteriovenous Malformations | Marfan Syndrome | Osler Rendu Disease | Vascular Anomaly | Lymphedema Primary | Cerebrospinal; Disorder

France
Wayne State University
National Institutes of Health (NIH)

Recruiting

Longitudinal Neuroimaging in Sturge-Weber Syndrome

Sturge-Weber Syndrome

United States
Anne Comi, MD
Jazz Pharmaceuticals; Faneca 66 Foundation

Completed

Novel Cognitive Treatment Targets for Epidiolex in Sturge- Weber Syndrome

Sturge-Weber Syndrome

United States
Sohag University

Recruiting

Ahmed Valve Implantation Coated With Poly Lactic -Co-glycolic Acid (PLGA) Saturated With Mitomycin-C in the Management of Adult Onset Glaucoma in Sturge Weber Syndrome

Glaucoma

Egypt
Qlaris Bio, Inc.

Completed

Safety and Tolerability Study of QLS-101 in Adolescents With Sturge-Weber Syndrome (SWS)-Related Glaucoma Due to Elevated Episcleral Venous Pressure (EVP)

Ocular Hypertension | Glaucoma | Sturge-Weber Syndrome

United States
Anne Comi, MD
Pfizer; National Institute of Neurological Disorders and Stroke (NINDS); National... and other collaborators

Completed

Trial of Sirolimus for Cognitive Impairment in Sturge-Weber Syndrome

Sturge-Weber Syndrome

United States
University of Pennsylvania
National Eye Institute (NEI)

Active, not recruiting

Phase I Trial of Gene Vector to Patients With Retinal Disease Due to RPE65 Mutations (LCA)

Retinal Diseases | Amaurosis of Leber

United States
GenSight Biologics

No longer available

EAP_GS010_single Patient

Leber Hereditary Optic Neuropathy (Optic, Atrophy, Hereditary, Leber)
ProQR Therapeutics

Terminated

Extension Study to Study PQ-110-001 (NCT03140969) (INSIGHT)

Eye Diseases | Neurologic Manifestations | Eye Diseases, Hereditary | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Belgium
ProQR Therapeutics

Active, not recruiting

A Study to Evaluate Efficacy, Safety, Tolerability and Exposure After a Repeat-dose of Sepofarsen (QR-110) in LCA10 (ILLUMINATE) (ILLUMINATE)

Eye Diseases | Neurologic Manifestations | Eye Diseases, Hereditary | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Belgium, Brazil, Canada, France, Germany, Italy, Netherlands, United Kingdom
University of Campania "Luigi Vanvitelli"
Retina Italia Onlus

Completed

Natural History of Patients With Inherited Retinal Diseases Due to Mutations in RPE65 Gene (RPE65-NHS)

Leber Congenital Amaurosis 2 | Retinitis Pigmentosa 20

Italy
QLT Inc.

Completed

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

Leber Congenital Amaurosis (LCA) | Retinitis Pigmentosa (RP)

United States, Canada, Denmark, Germany, Netherlands, Switzerland, United Kingdom
MeiraGTx UK II Ltd
Syne Qua Non Limited

Completed

Long-Term Follow-Up Gene Therapy Study for Leber Congenital Amaurosis OPTIRPE65 (Retinal Dystrophy Associated With Defects in RPE65)

Eye Diseases | Retinal Diseases | Eye Diseases, Hereditary | Leber Congenital Amaurosis (LCA)

United States, United Kingdom
QLT Inc.

Completed

Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)

LCA (Leber Congenital Amaurosis) | RP (Retinitis Pigmentosa)

Canada, United States, Germany, Netherlands, United Kingdom
QLT Inc.

Completed

Safety/Proof of Concept Study of Oral QLT091001 in Subjects With Leber Congenital Amaurosis (LCA) or Retinitis Pigmentosa (RP) Due to Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) Mutations

LCA (Leber Congenital Amaurosis) | RP (Retinitis Pigmentosa)

United States, Canada, Germany, Netherlands, United Kingdom
Eyecure Therapeutics Inc.
Beijing Tongren Hospital

Unknown

Treatment of RP and LCA by Primary RPE Transplantation

Leber Congenital Amaurosis, Retinitis Pigmentosa

China
ProQR Therapeutics

Recruiting

An Open-label, Dose Escalation and Double-masked, Randomized, Controlled Trial Evaluating Safety and Tolerability of Sepofarsen in Children (<8 Years of Age) With LCA10 Caused by Mutations in the CEP290 Gene. (BRIGHTEN)

Eye Diseases | Neurologic Manifestations | Retinal Degeneration | Retinal Dystrophies | Sensation Disorders | Vision Disorders | Blindness | Leber Congenital Amaurosis | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

Belgium, Brazil, Canada, Germany, Italy, Netherlands, United Kingdom
Editas Medicine, Inc.

Completed

Natural History Study of CEP290-Related Retinal Degeneration

Eye Diseases | Retinal Degeneration | Eye Diseases, Hereditary | Vision Disorders | Blindness | Leber Congenital Amaurosis 10 | Retinal Disease | Eye Disorders Congenital

United States, Netherlands, France, Germany
University College, London
Moorfields Eye Hospital NHS Foundation Trust; Targeted Genetics Corporation

Completed

Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis

Retinal Degeneration

United Kingdom
University of California, Los Angeles
Université de Montréal

Withdrawn

Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery

Stroke | Epilepsy | Tuberous Sclerosis | Sturge-Weber Syndrome | Focal Cortical Dysplasia | Hemimegalencephaly | Polymicrogyria | Rasmussen Encephalitis | Gliosis | Tumor, Brain

United States, Canada
Editas Medicine, Inc.

Active, not recruiting

Single Ascending Dose Study in Participants With LCA10

Retinal Degeneration | Eye Diseases, Hereditary | Vision Disorders | Leber Congenital Amaurosis 10 | Inherited Retinal Dystrophies | Retinal Disease | Eye Disorders Congenital

United States
Neurophth Therapeutics Inc

Recruiting

Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND1 Mutations

Leber Hereditary Optic Neuropathy (LHON)

China, United States
University Hospital, Angers

Unknown

Trial of Cyclosporine in the Acute Phase of Leber Hereditary Optic Neuropathy (CICLO-NOHL)

Leber Hereditary Optic Neuropathy

France
GenSight Biologics

Completed

RESCUE and REVERSE Long-term Follow-up (RESTORE)

Leber Hereditary Optic Neuropathy

United States, France, Italy, United Kingdom, Germany
GenSight Biologics

Active, not recruiting

Efficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

Leber Hereditary Optic Neuropathy

Belgium, Spain, United States, France, United Kingdom, Taiwan, Italy

Clinical Trials on Rendu Osler Weber Disease

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