Clinical Trials on Severe Combined Immunodeficiency

Total 6080 results

ASIS Corporation

Unknown

ASIS for GAMMAGARD in Primary Immunodeficiency (ASISinPI)

Primary Immunodeficiency

United States
National Institute of Allergy and Infectious Diseases...

Completed

Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults

Human Immunodeficiency Virus (HIV) | Human Immunodeficiency Virus Prevention

United States
Federal Research Institute of Pediatric Hematology...

Recruiting

Evaluation of Subcutaneous Immunoglobulin Product Cutaquig in Terms of Safety and Efficacy in the Treatment of Patients With Primary Immunodeficiencies

Primary Immunodeficiency Diseases (PID)

Russian Federation
Baxalta now part of Shire

Completed

Comparison of Intravenous and Subcutaneous Administration of IGIV, 10% in Primary Immunodeficiency (PID) Subjects

Primary Immunodeficiency Diseases (PID)

United States
Baxalta now part of Shire

Completed

Study to Determine the Dose of Recombinant Human Hyaluronidase Needed to Infuse a Full Dose of IGIV Subcutaneously

Primary Immunodeficiency Diseases (PID)

United States
University of South Florida

Unknown

Evaluation of Efficacy and Tolerability of Hizentra®

Primary Immunodeficiency Disorders

United States
Pôle Saint Hélier
Clinique Mutualiste la Sagesse

Completed

Medico-economic Impact Evaluation in Telemedecine Follow-up in Complement of a Mobile Team in Patients With Neurological Disabilities (HANDI@CCESS) (HANDI@CCESS)

Severe Neurological Disabilities

France
Mahidol University
Ministry of Health, Thailand

Unknown

Treatment of Adult-Onset Immunodeficiency With Bortezomib

Adult-onset Immunodeficiency

Thailand
Centre de Recherche Médicale de Lambaréné
Institute of Tropical Medicine, University of Tuebingen

Not yet recruiting

A Crossover Bioavailability Clinical Trial of Parenteral Pyronaridine and Artesunate

Severe Malarial Treatment

Gabon
Ottawa Hospital Research Institute
Canadian Virtual Hospice

Enrolling by invitation

ICU BEREAVE: Feasibility of a Multi-component Bereavement Support Intervention to Prevent Severe Grief Reaction

Severe Grief Reaction

Canada
Johns Hopkins University
National Institute of Mental Health (NIMH)

Completed

Interpersonal Psychotherapy in Youth With Severe Mood Dysregulation-Pilot

Severe Mood Dysregulation

United States
Federal University of Rio Grande do Sul

Unknown

Pharmacological Treatment of Children and Adolescents With Severe Mood Dysregulation

Severe Mood Dysregulation

Brazil
Northwell Health
National Institute of Nursing Research (NINR)

Not yet recruiting

MOMs Chat and Care Study (MOMs-CC)

Severe Maternal Morbidity

United States
Universidad Miguel Hernandez de Elche
Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la...

Active, not recruiting

Gender Bias in the Overuse Studies Conducting in Primary Care (OVERGEND)

Severe Adverse Event

Spain
UNICEF
Save the Children

Completed

Effects of Cash Transfers on Severe Acute Malnutrition

Severe Malnutrition

Congo, The Democratic Republic of the
Centre d'Investigation Clinique et Technologique...

Completed

Upper Limb Botulinum Toxin Injection Combined With Self Rehabilitation (Armautotox)

Self Rehabilitation Combined With BTI on Upper Limb

France
Takeda

Recruiting

At-Home Subcutaneous Immunoglobulin Replacement Therapy Using Alexa Skill

Primary Immunodeficiency Diseases (PID)

United States
Takeda
Takeda Development Center Americas, Inc.

Recruiting

A Study About How TAK-881 is Processed by the Body and Side Effects in People With Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases (PID)

United States
Takeda

Completed

A Study of TAK-771 in Japanese People With Primary Immunodeficiency Diseases (PID)

Primary Immunodeficiency Diseases (PID)

Japan
Baxalta now part of Shire

Completed

Immune Globulin Subcutaenous (Human), 20%

Primary Immunodeficiency Diseases (PID)

Germany, Austria, Hungary, Sweden, United Kingdom
CSL Behring

Completed

Multicenter Study of Long-Term Clinical Outcomes of Subcutaneous Immune Globulin IgPro20 in Subjects With Primary Immunodeficiency (Japan Study)

Primary Immune Deficiency

Japan
International Centre for Diarrhoeal Disease Research...
UNICEF

Not yet recruiting

Effectiveness Trial of Locally Developed Ready to Use Therapeutic Food

Malnutrition Severe

Bangladesh
Aga Khan University
Action Contre la Faim

Completed

Evaluation of the Effectiveness and Impact of Community Case Management of Severe Acute Malnutrition

Severe Malnutrition

Pakistan
MacroGenics
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes... and other collaborators

Active, not recruiting

A Study of MGD020 Alone or Combined With MGD014 in Persons With HIV-1 on Antiretroviral Therapy

Human Immunodeficiency Virus I Infection | Immunodeficiency Virus Type 1, Human | Human Immunodeficiency Virus Type 1

United States
Yanbing Li

Not yet recruiting

Efficacy and Safety of Chiglitazar Added to Glargine in Patients With Type 2 Diabetes

Efficacy and Safety of Chiglitazar Sodium in the Treatment of T2DM Patients | Metformin Combined With Insulin Glargine in the Treatment of Type 2 Diabetes Patients Who Still Have Poor Hypoglycemic Effect | 128 Patients Were Randomly Assigned 1:1 | Metformin and Insulin Glargine Combined... and other conditions

China
University of Vermont
Medical University of South Carolina; University of Washington; University of...

Active, not recruiting

Communication During Hospitalization About Resuscitation Trial (CHART)

End Stage Renal Disease | Severe Life-limiting COPD | Severe Life-limiting Heart Failure | Severe Life-limiting Cirrhosis | Severe Life-limiting Malignancy | Severe Functional Impairment

United States
Sarepta Therapeutics, Inc.
United States Department of Defense

Withdrawn

A Study to Assess the Safety, Tolerability and Pharmacokinetics of AVI-7537 in Healthy Adult Volunteers

Ebola Hemorrhagic Fever

United States
Sarepta Therapeutics, Inc.
United States Department of Defense

Completed

Safety Study of Single Administration Post-Exposure Prophylaxis Treatment for Ebola Virus

Ebola Hemorrhagic Fever

United States
University Hospital, Montpellier

Recruiting

Systematic Screening for Primary Immunodeficiencies in Patients Hospitalized for Severe Infections in Intensive Care. (DIPREA)

Primary Immunodeficiency

France
Biotest
Syneos Health

Completed

Study to Investigate Efficacy, Safety and Pharmacokinetics of BT595 in Subjects With PID

Primary Immunodeficiency Disease

United States, Germany, Hungary, Russian Federation, Spain
Grifols Therapeutics LLC

Withdrawn

Study Evaluating IGSC 20% Flexible Dosing in Treatment-Experienced and Treatment-Naive Subjects With Primary Immunodeficiency

Primary Immunodeficiency

United States
Beijing Children's Hospital
Shenzhen Children's Hospital; Capital Institute of Pediatrics, China

Unknown

Pediatric Primary Immunodeficiency Disease (PID) in China

Primary Immunodeficiency Disease
Children's Hospital of Philadelphia
University of California, San Francisco

Recruiting

Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies

Immunodeficiencies | Immune Dysregulation Syndromes

United States
Indonesia University

Unknown

Resuscitation With Albumin 5% in Dengue Haemorrhagic Fever

Dengue Hemorrhagic

Indonesia
UConn Health

Completed

Vaccination Efficacy With Metformin in Older Adults (VEME)

Aging | Vaccine Response Impaired | Age-Related Immunodeficiency

United States
Gamaleya Research Institute of Epidemiology and...

Completed

Open Study of the Duration of Immunity After Vaccination With GamEvac-Combi

Ebola Hemorrhagic Fever

Russian Federation
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IgPro10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
CSL Behring

Completed

Efficacy and Safety of Intravenous Immunoglobulin IVIG-F10 in Patients With Primary Immunodeficiencies (PID)

Common Variable Immunodeficiency | Agammaglobulinemia | IgG Deficiency
Takeda
Takeda Development Center Americas, Inc.

Not yet recruiting

A Study About the Long-Term Safety of TAK-881 in People With Primary Immunodeficiency Diseases

Primary Immunodeficiency Diseases (PID)
Baxalta now part of Shire

Completed

A Study of Immune Globulin Subcutaneous (Human), 20% Solution (IGSC, 20%) in Japanese Participants With Primary Immunodeficiency Diseases (PID)

Primary Immunodeficiency Diseases (PID)

Japan
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

Post-Authorization Safety, Tolerability and Immunogenicity Evaluation of HyQvia in Pediatric PIDD Subjects

Primary Immunodeficiency Diseases (PID)

Denmark, United Kingdom, Czechia, France, Greece, Hungary, Slovakia, Sweden
Shire

Completed

Retrospective, Observational Chart Review Study Conducted in Poland to Document the Management and Clinical Outcome of CUVITRU and HYQVIA in Pediatric Participants (< 18 Years) With Primary Immunodeficiency (PID) (IG-TATRY)

Primary Immunodeficiencies (PID)

Poland
Baxalta now part of Shire

Completed

Phase 2/3 Study of IGSC, 20% in PIDD

Primary Immunodeficiency Diseases (PID)

United States, Canada
Baxalta now part of Shire

Completed

Tolerability and Safety of IGI, 10% With rHuPH20 in PIDD

Primary Immunodeficiency Diseases (PID)

United States
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Completed

Real-world CANadian CUvitru Non-Interventional Study in Subjects Transitioning From Subcutaneous Immunoglobulin (CANCUN)

Primary Immunodeficiency Diseases (PID)

Canada
Daewoong Pharmaceutical Co. LTD.

Completed

Evaluation Onset Time of DWP450-004 and Safety in Moderate-severe Glabellar Lines

Moderate-severe Glabellar Lines
United States Army Research Institute of Environmental...

Completed

Effect of Tyrosine on Behavioral, Physiological and Nutritional Status During Survive, Evade, Resist, Escape (SERE) School

Response to Severe Stress

United States
U.S. Army Medical Research and Development Command

Not yet recruiting

Treatment of Hemorrhagic Fever With Ribavirin

Hemorrhagic Fever
Janssen Sciences Ireland UC

Completed

A Study to Evaluate Efficacy and Safety of Darunavir/Cobicistat/Emtricitabine/Tenofovir Alafenamide (D/C/F/TAF) Fixed Dose Combination (FDC) Versus a Regimen Consisting of Darunavir/Cobicistat FDC With Emtricitabine/Tenofovir Disoproxil Fumarate FDC in Treatment-naive HIV Type 1 Infected Subjects

Immunodeficiency Virus Type 1, Human

United States, France, Poland, United Kingdom, Belgium, Germany, Spain, Canada, Russian Federation, Puerto Rico
Kahramanmaras Sutcu Imam University

Completed

Thiol/Disulfide and Oxidative Stress

Severe Early Childhood Caries

Turkey

Clinical Trials on Severe Combined Immunodeficiency

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