Clinical Trials on Severe Haemophilia B in United Kingdom

Total 4154 results

Imperial College London

Terminated

Predicting Severity and Disease Progression in Influenza-like Illness (Including COVID-19) (PREDICT-ILI)

RNA Virus Infections | Respiratory Tract Infections | Covid19 | Influenza | Infection, Bacterial | SARS (Severe Acute Respiratory Syndrome) | Respiratory Viral Infection | Infection Viral

United Kingdom
Kythera Biopharmaceuticals
Bayer

Completed

Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat

Moderate or Severe Submental Fullness

Germany, France, Belgium, Spain, United Kingdom
Hull University Teaching Hospitals NHS Trust

Recruiting

Multi-centre Acute Severe Ulcerative Colitis Prospective Cohort Study (Elevate ASUC) (ELEVATE-ASUC)

Severe Ulcerative Colitis

United Kingdom
Kythera Biopharmaceuticals
Bayer

Completed

Evaluation of Safety and Efficacy of Deoxycholic Acid Injection (ATX-101) in the Reduction of Submental Fat

Moderate or Severe Submental Fullness

Belgium, France, Germany, Italy, Spain, United Kingdom
Kymera Therapeutics, Inc.

Suspended

Safety, PK/PD, and Clinical Activity of KT-413 in Adult Patients With Relapsed or Refractory B-cell NHL

Non Hodgkin Lymphoma | Diffuse Large B Cell Lymphoma | DLBCL | MYD88 Gene Mutation

United States, United Kingdom
University of Liverpool
Metabolic Health Solutions UK

Completed

Energy Expenditure From ECAL Indirect Calorimeter in a Multicomponent Weight Management Service (ECAL)

Obesity | Severe Obesity | Sleep Apnoea

United Kingdom
King's College London

Unknown

Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD)

Moderate to Severe Alzheimer's Disease

United Kingdom
Gustave Roussy, Cancer Campus, Grand Paris
Children's Oncology Group

Unknown

Intergroup Randomized Trial for Children or Adolescents With B-Cell Non Hodgkin Lymphoma or B-Acute Leukemia: Rituximab Evaluation in High Risk Patients

B-cell Non Hodgkin Lymphoma | Mature B-cell Leukemia Burkitt-type

Belgium, France, United Kingdom, Netherlands, Canada, Hungary, Italy, Poland, Spain, China
Leeds Cancer Centre at St. James's University Hospital

Completed

Alemtuzumab in Treating Patients With B-Cell Chronic Lymphocytic Leukemia in Partial Remission or Complete Remission

Leukemia

United Kingdom
Alexion Pharmaceuticals

Terminated

A Open Label Study in Previously Studied, SBC-103 Treatment Naïve MPS IIIB Subjects to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics/Efficacy of SBC-103 Administered Intravenously (CL01-T)

Mucopolysaccharidosis III, Type B (MPS IIIB) | Sanfilippo B

United Kingdom
Regeneron Pharmaceuticals

Completed

Real-World Clinical Outcomes in Adult Patients Who Initiate Systemic Treatment for Relapsed/Refractory Diffuse Large B-Cell Lymphoma (ORCHID)

Diffuse Large B-Cell Lymphoma

Austria, France, Germany, United Kingdom
Queen Mary University of London

Completed

Severe Head Injury Brain Analysis (SHIBA)

Brain Injury Traumatic Severe

United Kingdom
University of Surrey
American Society of Hematology

Recruiting

Investigating the Role of Energy Balance Modification on Health Responses in Chronic Lymphocytic Leukaemia (HIT-CLL)

Frailty | Chronic Lymphocytic Leukemia | Muscle Function | Immune Function | Lipid Cell; Tumor

United Kingdom
Bayer

Completed

Patient Functioning and Well-being, Economic, and Clinical Impact of Hemophilia A and Its Treatment (ECHO)

Hemophilia A

United States, Japan, United Kingdom, Spain
University of Oxford
University of Maryland; Imperial College London; Wellcome Trust

Completed

Understanding Typhoid Disease After Vaccination

Typhoid Fever | Typhoid | Enteric Fever

United Kingdom
The Royal Wolverhampton Hospitals NHS Trust
University of Wolverhampton

Active, not recruiting

COVID-19 Health Professional Impact Study (CHIP)

Severe Acute Respiratory Syndrome | Coronavirus Infection

United Kingdom
St George's, University of London
Assistance Publique - Hôpitaux de Paris; MRC/UVRI and LSHTM Uganda Research... and other collaborators

Recruiting

Serocorrelate of Protection Against GBS (PREPARE WP3)

Group B Streptococcus Carrier in Childbirth | Group B Streptococcal Infection, Late-Onset | Group B Streptococcal Infection, Early-Onset | Group B Streptococcus Neonatal Sepsis | Group B Strep Infection

France, Italy, Malawi, Netherlands, Uganda, United Kingdom
Royal Marsden NHS Foundation Trust
Cambridge University Hospitals NHS Foundation Trust; University Hospital Plymouth...

Unknown

Tissue Collection for Biomarkers Determining Resistance to Ibrutinib (CLARITY)

Mantle Cell Lymphoma | Chronic Lymphocytic Leukaemia

United Kingdom
GlaxoSmithKline

Completed

Ofatumumab With Fludarabine and Cyclophosphamide in B-CLL Patients (BIFROST)

Leukaemia, Lymphocytic, Chronic

United States, United Kingdom
Guy's and St Thomas' NHS Foundation Trust
King's College London

Not yet recruiting

Outcome Prediction in Patients With Aortic Stenosis After TAVI (PREDICT-TAVI)

Aortic Stenosis, Severe

United Kingdom
King's College London

Active, not recruiting

Psychosis and Type 2 Diabetes Study (PODS)

Type 2 Diabetes | Severe Mental Disorder

United Kingdom
Hoffmann-La Roche

Completed

An Observational Study on The Health Related Quality of Life in Patients With Chronic Lymphocytic Leukaemia

Lymphocytic Leukemia, Chronic

United Kingdom
Bayer
Ultragenix pharmaceutical

Active, not recruiting

Study to Test the Safety and How Well Patients With Severe Hemophilia A Respond to Treatment With BAY 2599023 (DTX 201), a Drug Therapy That Delivers a Healthy Version of the Defective Factor VIII Gene Into the Nucleus of Liver Cells Using an Altered, Non-infectious Virus (AAV) as a "Shuttle".

Hemophilia A

Netherlands, United States, Germany, United Kingdom, France, Bulgaria
Swedish Orphan Biovitrum
Bioverativ Therapeutics Inc.

Completed

Study of rFVIIIFc for Immune Tolerance Induction (ITI) in Haemophilia A Patients With Inhibitors Who Have Failed Previous ITI Therapies (ReITIrate)

Hemophilia A

Ireland, United Kingdom, Germany, United States, Canada, Slovenia, Sweden
University of West London

Completed

Supplementary Vitamin B12 Effects on Elevated Homocysteine Levels of Vegetarians - Clinical Trial

Vitamin B12 Deficiency

United Kingdom
King's College London
National Institute for Health Research, United Kingdom; South London and Maudsley...

Completed

Electronic Clinical Decision Support for Diabetes and Dysglycaemia in Secondary Mental Healthcare

Diabetes Mellitus | Dysglycemia | Severe Mental Disorder | Staff Attitude

United Kingdom
GlaxoSmithKline

Completed

A Mechanistic Study of GSK3228836 With Fine Needle Aspiration (FNA) in Participants With Chronic Hepatitis B (B-Fine)

Hepatitis B

United States, Netherlands, United Kingdom, Canada
University of York
University of Leeds; University of Southampton

Completed

Improving Diabetes Outcomes for People With Severe Mental Illness (SMI) (EMERALD)

Diabetes Mellitus, Type 2 | Severe Mental Disorder

United Kingdom
QIAGEN Gaithersburg, Inc

Recruiting

Clinical Performance Evaluation of the NeuMoDx™ FluA/FluB/RSV/Severe Acute Respiratory Syndrome-CoV-2 Assay

Respiratory Disease

United Kingdom
University of Oxford

Completed

Vaccines Against Salmonella Typhi (VAST)

Typhoid Fever | Enteric Fever

United Kingdom
Abbott Medical Devices

Withdrawn

Assessment of St Jude Medical Portico Re-sheathable Transapical Aortic Valve System (Portico TA EU)

Severe Symptomatic Aortic Stenosis

United Kingdom
Baxalta now part of Shire

No longer available

Expanded Access to B-Domain Deleted Recombinant Porcine Factor VIII (OBI-1) in the Treatment of Acquired Hemophilia A Due to Factor VIII Inhibitory Auto-antibodies

Acquired Hemophilia A

United States
BioMarin Pharmaceutical

Active, not recruiting

Gene Therapy Study in Severe Hemophilia A Patients With Antibodies Against AAV5 (GENEr8-AAV5+)

Hemophilia A | Gene Therapy | Blood Disorder | Clotting Disorders

Taiwan, Korea, Republic of, United Kingdom, South Africa
AstraZeneca

Recruiting

Patient Characteristics, Treatment Patterns and Outcomes of Patients Enrolled in the Tezepelumab Patient Access Programme; a Retrospective, Observational Medical Chart Review Conducted in UK Severe Asthma Centres (TPAP)

Severe Asthma

United Kingdom
Cancer Research UK
Aleta BioTherapeutics

Recruiting

A Phase I/II Trial of ALETA-001 for the Treatment of Participants With B-cell Malignancies

Lymphoma, Follicular | Lymphoma, B-Cell | Lymphoma, Large B-Cell, Diffuse | Lymphoma, Non-Hodgkin | Lymphoma, Mantle-Cell

United Kingdom
University of Oxford

Completed

Understanding Paratyphoid Infection

Enteric Fever Caused by Salmonella Enterica Serovar Paratyphi A

United Kingdom
Cambridge University Hospitals NHS Foundation Trust
Advanced Bionics AG

Completed

Bimodal, CROS and Severe Profound Hearing Loss Study

Hearing Loss, Bilateral | Cochlear Implant | Hearing Loss, Cochlear | Severe-Profound Hearing Loss

United Kingdom
Great Ormond Street Hospital for Children NHS Foundation...
Imperial College London; Barts & The London NHS Trust; Intensive Care National...

Completed

FIRST-line Support for Assistance in Breathing in Children (FIRST-ABC) Feasibility Study (FIRST-ABC)

Hypoxia | Respiratory Acidosis | Moderate/Severe Respiratory Distress

United Kingdom
University of Leicester
University of Edinburgh

Recruiting

MRI in Randomised Cohorts of Asymptomatic AS

Aortic Stenosis, Severe

United Kingdom
Lymphoma Study Association

Completed

R-ICE Versus R-DHAP in Patients Aged 18-65 With Relapse Diffuse Large B-cell Lymphoma

Lymphoma, Large-Cell, Diffuse

United States, Australia, Belgium, Czechia, Finland, Germany, Israel, Sweden, Switzerland, United Kingdom
Academisch Medisch Centrum - Universiteit van Amsterdam...

Unknown

The Dynamic Interplay Between Bleeding Phenotype and Baseline Factor Level in Moderate and Mild Hemophilia A and B (DYNAMO)

Hemophilia

Netherlands, Austria, Australia, Belgium, Canada, Finland, Germany, Italy, Spain, United Kingdom
GlaxoSmithKline

Terminated

A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of GSK2816126 in Subjects With Relapsed/Refractory Diffuse Large B Cell Lymphoma, Transformed Follicular Lymphoma, Other Non-Hodgkin's Lymphomas, Solid Tumors and Multiple Myeloma

Neoplasms | Cancer

United States, United Kingdom, France
Hoffmann-La Roche

Terminated

A Study of RO7239958 to Evaluate Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Healthy Volunteers and Participants With Chronic Hepatitis B Virus Infection

Hepatitis B Virus Infection

United Kingdom, Hong Kong, Korea, Republic of, Taiwan, Poland, Bulgaria, New Zealand
Gilead Sciences

Active, not recruiting

Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies

B-cell Malignancies

United States, United Kingdom, France
Telios Pharma, Inc.

Active, not recruiting

Phase I/II, FIH, Dose Escalation Trial of TL-895 and Expansion of TL-895 Monotherapy and Combination Therapy With Navtemadlin in Tx-Naïve and R/R CLL/SLL Subjects

Chronic Lymphocytic Leukemia | Small Lymphocytic Lymphoma | Relapsed/Refractory B Cell Malignancies | Mantle Cell Lymphoma and Diffuse Large B Cell Lymphoma | Treatment-Naive B Cell Malignancies

United States, Poland, Ukraine, Hungary, Italy, Russian Federation, United Kingdom
Portsmouth Hospitals NHS Trust

Completed

A Feasibility Study Using the CoronaCheck Device to Identify Incident Cases of SARS CoV-2 Covid-19

SARS-CoV Infection

United Kingdom
Prokarium Ltd
Simbec Research

Completed

Study to Evaluate the Safety, Tolerability and Immunogenicity of a Potential Enteric Fever Vaccine

Enteric Fever

United Kingdom
Cancer Research UK

Completed

A Phase I Study of the Chimeric Anti-CD40 Monoclonal Antibody ChiLob 7/4 to Treat Advanced Malignancies Refractory to Conventional Anti-cancer Treatment

Neoplasms | Lymphoma | Cancer | B-Cell | Non-Hodgkin

United Kingdom
Janssen Vaccines & Prevention B.V.
Institut National de la Santé Et de la Recherche Médicale, France; University...

Completed

A Study to Assess Safety, Tolerability, and Immunogenicity of Three Heterologus 2-dose Regimens of the Candidate Prophylactic Vaccines for Ebola in Healthy Adults

Ebola Viral Disease

France, United Kingdom
Wyeth is now a wholly owned subsidiary of Pfizer

Withdrawn

Study Comparing Blood Levels of ReFacto and Advante in Hemophilia A

Hemophilia A

Italy, United States, Netherlands, United Kingdom, Germany, New Zealand, Belgium, France

Clinical Trials on Severe Haemophilia B in United Kingdom

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