Clinical Trials on Severe Hepatic Impairment in Czechia

Total 125 results

Mitsubishi Tanabe Pharma Corporation

Completed

PK Study in Subjects With Severe Hepatic Impairment (MCI-186-E05 HP)

Healthy | Severe Hepatic Impairment

Czechia, Hungary, Slovakia
Hoffmann-La Roche

Completed

Effect of Hepatic Impairment on the Pharmacokinetics of Alectinib

Hepatic Impairment

Czechia, Slovakia
Takeda

Completed

A Study to Evaluate the Effect of Hepatic Impairment on the Single Dose Pharmacokinetics (PK) of Intravenous TAK-954

Healthy Volunteers | Hepatic Impairment

Czechia, Slovakia
Idorsia Pharmaceuticals Ltd.

Completed

A Study to Evaluate ACT-132577 in Healthy Subjects and in People With Severe Kidney Disease

Healthy Subjects | Severe Renal Impairment

Czechia
Pfizer

Completed

Study of PF-05221304 in Subjects With Varying Degrees of Hepatic Impairment

Hepatic Impairment

United States, Belgium, Czechia, Slovakia
Pfizer

Completed

A STUDY TO COMPARE THE PHARMACOKINETICS OF PF-06835919 IN PARTICIPANTS WITH AND WITHOUT HEPATIC IMPAIRMENT

Hepatic Impairment | Healthy Participants

Czechia, Slovakia, Belgium
AstraZeneca
PRA Health Sciences

Completed

Pharmacokinetics, Safety & Tolerability of ZD4054 (Zibotentan) in Subjects With Normal, Mild, Moderate and Severe Hepatic Impairment

Hepatic Impairment

Czech Republic
Vertex Pharmaceuticals Incorporated

Completed

Study of Lumacaftor in Combination With Ivacaftor in Subjects With Moderate Hepatic Impairment and Healthy Subjects

Healthy | Hepatic Impairment

Slovakia, Czech Republic
Janssen Infectious Diseases BVBA

Completed

A Study to Assess Safety and Pharmacokinetics of Telaprevir in Patients With Hepatic Impairment

Hepatic Impairment

Germany, Czech Republic
GlaxoSmithKline

Completed

A Study to Assess the Effects of Fluticasone Furoate and GW642444M Combination in Healthy Subjects and in Subjects With Mild, Moderate or Severe Hepatic Impairment.

Asthma

Czechia, Slovakia
FORUM Pharmaceuticals Inc
PRA Health Sciences

Completed

EVP-6124 Hepatic Impairment Study

Hepatic Impairment

Czech Republic, Poland, Slovakia
Brno University Hospital

Unknown

Early Identification of Sepsis in Children

Sepsis | Shock, Septic | SIRS | Sepsis, Severe

Czechia
University Hospital Ostrava

Completed

Control of Fever in Septic Patients (COVERSEP)

Sepsis | Septic Shock | Severe Sepsis

Czechia
Institute for Clinical and Experimental Medicine

Completed

Monitoring of Hepatic Fat Metabolism Using Magnetic Resonance Methods

Hepatic Fat Content

Czechia
Pierre Fabre Medicament

Withdrawn

Hepatic Impairment Study of Encorafenib in Combination With Binimetinib in BRAF Melanoma

Hepatic Impairment | Metastatic Melanoma | Unresectable Melanoma | BRAF V600 Mutation

Spain, Czechia, Italy
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Impaired Hepatic Function on the Pharmacokinetics of Entrectinib in Volunteers With Different Levels of Hepatic Function

Hepatic Insufficiency

Hungary, Czechia, Slovakia
Charles University, Czech Republic

Recruiting

PAPSY - Memory in Psychiatry (PAPSY)

Cognitive Impairment

Czechia
Masaryk University
St. Anne's University Hospital Brno, Czech Republic

Completed

The Effect of Transcranial Direct Current Stimulation on Visual Attention in Mild Cognitive Impairment

Mild Cognitive Impairment

Czechia
Masaryk University
Swiss Federal Institute of Technology

Recruiting

Novel, Individualized Brain Stimulation, Network-based Approaches to Improve Cognition (NiBS-iCog)

Healthy Aging | Mild Cognitive Impairment

Czechia
Charles University, Czech Republic

Unknown

Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination (FRIEND)

Septic Shock | Vein Collapsibility | Intravascular Doppler | Volume Responsiveness in Septic Shock

Czechia
University Hospital Hradec Kralove
University Hospital Pilsen

Completed

Effect of Fluid Challenge on Glycocalyx

Sepsis | Septic Shock | Surgery | Endothelial Dysfunction | Anesthesia

Czechia
Allecra

Completed

Pharmacokinetics of Cefepime and AAI101 in Subjects With Renal Insufficiency and Healthy Subjects

PK in Patients With Various Degrees of Renal Impairment

Czechia, Hungary
Charles University, Czech Republic

Recruiting

PAMNEU - Memory in Neurology

Cognitive Impairment

Czechia
National Institute of Mental Health, Czech Republic

Completed

Ecologically Valid Virtual Tasks vs Paper-pencil Methods in Cognitive Rehabilitation in Patients With Schizophrenia and Depression

Depression | Schizophrenia | Cognitive Impairment

Czechia
AstraZeneca

Completed

A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFab™) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock

Septic Shock | Severe Sepsis

Czech Republic, France, Spain, Finland, Canada, Australia, Belgium
Charles University, Czech Republic
University Hospital Vinohrady; Faculty of Physical Education and Sport

Recruiting

The Effect of Tai Chi and Therapy by Dance and Movement on Blood Irisin Levels in Older Adults Over 65 Years of Age.

Physical Activity | Cognitive Impairment | Aging | Mood Change | Memory Deficits

Czechia
University Hospital Ostrava

Completed

Bioelectrical Impedance in Monitoring Hyperhydration and Polyneuromyopathy in Critically Ill Patients

Septic Shock | Respiratory Insufficiency | Hypoxemia | Chronic Obstructive Pulmonary Disease Exacerbation | Lung Ventilator | Hyperhydration | Respiratory Distress Syndrome, Acute

Czechia
University Hospital Ostrava

Recruiting

MAnual Lymphatic DrAinage to iMprove the outcomE of Patients After Septic Shock (MADAME)

Sepsis | Septic Shock | Inflammatory Response | Multiorgan Failure

Czechia
University Hospital Hradec Kralove

Completed

The Effect of Blood Pressure on the Postoperative Cognitive Dysfunction

Mild Cognitive Impairment

Czechia
Brno University Hospital

Recruiting

Corticosteroids in Severe COVID-19(ASAP-C Study) (ASAP-C)

Severe COVID-19

Czechia
Masaryk University
St. Anne's University Hospital Brno, Czech Republic

Unknown

Modulation of Cognition and Brain Connectivity by Noninvasive Brain Stimulation in Patients With Mild Cognitive Impairment Due to Alzheimer's Disease (LUSTR)

Mild Cognitive Impairment

Czechia
University Hospital Hradec Kralove

Terminated

The Effect of Nimodipine on the Postoperative Cognitive Dysfunction

Mild Cognitive Impairment

Czechia
Novartis Pharmaceuticals

Completed

Pharmacokinetic Study of Buparlisib in Subjects With Renal Impairment.

Renal Impairment

Czechia, Germany, Romania, Bulgaria
Takeda

Completed

A Study to Evaluate the Effect of Renal Impairment and Dialysis Treatment on the Pharmacokinetics (PK) of a Single Intravenous (IV) TAK-954

Renal Impairment | Healthy Volunteers

Czechia, Hungary
Charles University, Czech Republic

Completed

Propafenone Versus Amiodarone in Septic Shock (PRASE)

Septic Shock | Supraventricular Arrhythmia

Czechia
Charles University, Czech Republic

Recruiting

Immune Homeostasis in Sepsis and Septic Shock (IMHOTEP)

Sepsis | Immune Deficiency | Immunologic Paralysis | Immunologic Suppression

Czechia
University Hospital Ostrava
University Hospital Olomouc; University of Ostrava; Palacky University; Technical...

Completed

Specific miRNAs in Sepsis and Nephrotoxic Antibiotic Treatment

Sepsis | Septic Shock | Acute Kidney Injury

Czechia
Masaryk University
St. Anne's University Hospital Brno, Czech Republic

Not yet recruiting

Noninvasive Temporal Interference Stimulation: Modulating Associative Memory by Targeting Deep-brain Targets (Deep-HiPs)

Alzheimer Disease | Healthy Aging | Mild Cognitive Impairment | Memory Disorders in Old Age

Czechia
Brno University Hospital
European Society of Intensive Care Medicine; European Society of Anaesthesiology...

Completed

Corticosteroids in Severe COVID-19 (ASAP-ESICM/ESAIC Study) (ASAPESICMESAIC)

Severe COVID-19

Czechia
GlaxoSmithKline

Completed

Study to Assess the Safety and PK of GSK573719 and GSK573719/GW642444(VI) Combination in Healthy Subjects and Subjects With Severe Renal Impairment

Pulmonary Disease, Chronic Obstructive

Czechia, Hungary
Fondazione IRCCS Ca' Granda, Ospedale Maggiore...
Charles University, Czech Republic

Unknown

Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients (ENTERPRISE)

Sepsis | Critical Illness | Septic Shock | Acid-Base Imbalance | Respiratory Acidosis | Respiratory Alkalosis

Italy, Czechia
Bristol-Myers Squibb

Completed

A Study to Assess the Safety of Experimental Medication BMS986165 in Participants With Normal Kidney Function and Participants With Mild to End-Stage Kidney Disease.

Renal Impairment | Healthy Volunteer

United States, Czechia, Hungary, Poland
Novartis

Completed

Effect of Severe Renal Impairment on Pharmacokinetics and Metabolism of a Single Administration of Licarbazepine

Healthy

Czech Republic
Johan Sanmartin Berglund
Andaluz Health Service; Universidad Politecnica de Madrid; Anglia Ruskin University and other collaborators

Unknown

Support Monitoring and Reminder Technology (SMART4MD)

Mild Dementia | Cognitive Impairment, Mild

Belgium, Czechia, Spain, Sweden
Boehringer Ingelheim

Completed

Treatment of Patients Undergoing Primary Unilateral Elective Total Knee or Hip Replacement With Dabigatran Etexilate

Arthroplasty, Replacement | Prevention of Venous Thromboembolism | Moderate Renal Impairment (CrCl 30-50 mL/Min)

Austria, Canada, Czechia, Finland, Netherlands, Sweden
Astellas Pharma Inc

Completed

Renal Impairment Study With ASP1941

Type 2 Diabetes Mellitus

Hungary, Poland, Czechia, Slovakia
Alnylam Pharmaceuticals

Completed

EXPLORE: A Natural History Study of Acute Hepatic Porphyria (AHP)

Acute Hepatic Porphyria

United States, Belgium, Bulgaria, France, Italy, Mexico, Spain, Taiwan, United Kingdom, Netherlands, Korea, Republic of, Switzerland, Czechia, Poland, Finland, Australia, Germany, Israel, Norway, South Africa
Brno University Hospital
Masaryk University

Completed

Malignant Hyperthermia in Czech Republic: Description of the Biggest Slavonic Group of Patients Investigated for Risk of Malignant Hyperthermia (MHCZECH)

Malignant Hyperthermia

Czechia
Ipsen

Completed

A Study on the Use of Tanakan® for Recovery of Neurological Impairment Following Ischaemic Stroke

Stroke, Acute | Neurological Impairment

Czechia, Poland, Romania, Russian Federation
Ocera Therapeutics, Inc.

Completed

Phase 2B Efficacy/Safety of Ornithine Phenylacetate in Hospitalized Cirrhotic Patients With Hepatic Encephalopathy (STOP-HE) (STOP-HE)

Hepatic Encephalopathy | Acute Episode of Overt Hepatic Encephalopathy

Belgium, Germany, Italy, Spain, United States, France, Austria, Russian Federation, Czechia, Australia, Hungary, Israel, Netherlands, Bulgaria, Estonia, Denmark, New Zealand

Clinical Trials on Severe Hepatic Impairment in Czechia

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