Clinical Trials on Severe Respiratory Disease

Total 381583 results

International Centre for Diarrhoeal Disease Research...

Completed

Randomized Controlled Trial (RCT) in Children With Severe Pneumonia

Severe Pneumonia

Bangladesh
Jeffrey Jenks, MD, MPH
Astellas Pharma Global Development, Inc.

Terminated

Isavuconazole for the Prevention of COVID-19-associated Pulmonary Aspergillosis (Isavu-CAPA)

Severe Acute Respiratory Syndrome Coronavirus 2 | Aspergillosis Invasive

United States
University of Liege
KCE Belgian Healthcare Knowledge Centre

Active, not recruiting

Efficacy of CONvalescent Plasma in Patients With COVID-19 Treated With Mechanical Ventilation (CONFIDENT)

Covid19 | Respiratory Failure | Corona Virus Infection | Mechanical Ventilation Complication | SARS (Severe Acute Respiratory Syndrome)

Belgium
Gérond'if

Completed

Personalized Dietary Advice 3 Months After Discharge From Hospitalization in Geriatrics: Effect on Nutritional Status According to Coronavirus Disease 2019 (COVID-19) Status (Positive or Negative) During Hospitalization (COVINUT)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

France
Nemechek Technologies

Completed

Vagus Nerve Stimulation ARDS Prevention Trial for COVID-19 Hospitalized Patients

Severe Acute Respiratory Syndrome Coronavirus 2

Argentina
NeuroActiva, Inc.
Biomed Industries, Inc.

Unknown

A Phase 3 Randomized Double Blind Efficacy and Safety Study of Oral Polio Vaccine and NA-831 for Covid-19 (OPV-NA831)

Covid19 | SARS-CoV-2 | SARS-CoV Infection | SARS (Severe Acute Respiratory Syndrome)

New Zealand, United States
University of Sao Paulo
Fundação de Amparo à Pesquisa do Estado de São Paulo; Hospital das Clínicas...

Unknown

Adolescents With COVID-19/MIS-C at HCFMUSP

Covid19 | Corona Virus Infection | SARS-CoV Infection | SARS (Severe Acute Respiratory Syndrome)

Brazil
AUVA
Paracelsus Medical University

Completed

Antibody Seroprevalence and Rate of Asymptomatic Infections With SARS-CoV-2 in Austrian Hospital Personnel.

Coronavirus Infection | SARS-CoV 2 | Covid19 | Severe Acute Respiratory Syndrome Coronavirus 2

Austria
Hospices Civils de Lyon

Completed

Host-pathogen Interactions During SARS-CoV-2 Infection (HPI-COVID-19)

Severe Acute Respiratory Syndrome Coronavirus 2 | Infection, Coronavirus

France
Assistance Publique - Hôpitaux de Paris

Completed

EFFICACY and SAFETY OF BEVACIZUMAB (ZIRABEV®) IN PATIENTS WITH SEVERE HYPOXEMIC COVID-19 (BEVA)

Coronaviridae Infections | Nidovirales Infections | RNA Virus Infections | Virus Diseases | Respiratory Tract Infections | Respiratory Tract Diseases | Corona Virus Infection | SARS (Severe Acute Respiratory Syndrome)

France
Emory University
National Cancer Institute (NCI)

Terminated

Radiation Eliminates Storming Cytokines and Unchecked Edema as a 1-Day Treatment for COVID-19 (RESCUE 1-19)

Pneumonia | Coronavirus Infection in 2019 (COVID-19) | Severe Acute Respiratory Syndrome (SARS) Pneumonia

United States
Goethe University

Completed

Evaluation of Sedation in COVID-19 ARDS

Severe Acute Respiratory Syndrome Coronavirus 2 | Prone Position | Pulmonary Ventilation | Hypnotics and Sedatives

Germany
Asan Medical Center

Suspended

Fluvoxamine for Adults With Mild to Moderate COVID-19

Coronavirus Infection | Severe Acute Respiratory Syndrome Coronavirus 2 | Mild to Moderate COVID-19

Korea, Republic of
Hospices Civils de Lyon

Unknown

Senior-COVID-Rea Multicentric Survey (SeniorCOVIDRea)

COVID-19 Disease, Severe Form

France
University of Minnesota
National Institute of Allergy and Infectious Diseases (NIAID); National Institutes...

Recruiting

Respiratory Virus Hospitalization Study (FLU 003 Plus)

Influenza | Novel Respiratory Virus-1 Middle Eastern Respiratory Syndrome Coronavirus (MERS-CoV) | Novel Respiratory Virus-2 Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)

United States, Australia, Spain, Denmark, Greece, Argentina, United Kingdom, Belgium, Chile, Germany, Peru, Thailand
Rigel Pharmaceuticals

Completed

Double-Blind, Randomized, Placebo-Controlled, Multi-Center Phase 3 Study to Evaluate the Efficacy and Safety of Fostamatinib in COVID-19 Subjects

Pneumonia, Viral | Pneumonia | Covid19 | SARS (Severe Acute Respiratory Syndrome) | SARS-Associated Coronavirus as Cause of Disease Classified Elsewhere | SARS Pneumonia

United States, Argentina, Brazil, Mexico
Hospital Universitari Joan XXIII de Tarragona.
Sociedad Española de Medicina Intensiva,critica y unidades coronarias

Recruiting

Characteristics of Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection (COVID-19) (GETCOV-2)

SARS-CoV2 Infection

Spain
Gordon Bernard
AstraZeneca

Terminated

Ticagrelor in Severe Community Acquired Pneumonia (TCAP)

Community Acquired Pneumonia, Severe

United States
Ophirex, Inc.
Premier Research Group plc

Terminated

Study of Varespladib in Patients Hospitalized With Severe COVID-19 (STAIRS)

Coronavirus Disease 2019 | Disease Caused by Severe Acute Respiratory Syndrome Coronavirus 2

United States
University of Trieste

Completed

Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome (MP-C19)

Coronavirus Infections | ARDS, Human | Severe Acute Respiratory Syndrome (SARS) Pneumonia

Italy
UMC Utrecht
Dutch Health Care Insurance Board

Completed

Study on Costs and Safety of Early Conversion From Intravenous to Oral Antibiotic Treatment in Patients With Severe Community-Acquired Pneumonia

Severe Communtity-Acquired Pneumonia

Netherlands
Sanofi Pasteur, a Sanofi Company

Completed

Safety and Immunogenicity of a Tetravalent Dengue Vaccine in HIV-Positive Adults

Human Immunodeficiency Virus | Dengue Fever | Dengue Hemorrhagic Fever

Brazil
Ain Shams University
Misr International University

Completed

Effect of N-acetylcysteine on Oxidative Stress in COVID-19 Patients

Corona Virus Infection | Corona Virus Disease 19 (Covid19) | Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV2)

Egypt
Capital Medical University

Recruiting

Diagnosis and Treatment Strategy Optimization of Severe Pneumonia Based on Multi-omics Data Integration

Severe Community-acquired Pneumonia

China
CHU de Reims

Unknown

Prevalence of Long-term Respiratory Complications of Severe SARS-CoV-2 Pneumonia - COVID-19

Severe SARS-CoV2 Pneumonia

France
Tongji Hospital

Unknown

The Efficacy of Different Hormone Doses in 2019-nCoV Severe Pneumonia

2019-nCoV Severe Pneumonia

China
60P Australia Pty Ltd

Not yet recruiting

A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression

Infectious Disease | SARS-CoV-2 | Severe Acute Respiratory Syndrome Coronavirus 2 | COVID 19 Disease | Mild to Moderate COVID 19 Disease
European Society of Intensive Care Medicine

Completed

Intensive Care - GLObal Study on Severe Acute Respiratory Infection

Severe Acute Respiratory Failure

Belgium
Mexican Emerging Infectious Diseases Clinical Research...
National Institute of Allergy and Infectious Diseases (NIAID); Secretaria de...

Terminated

Evaluation of Culture Negative Severe Acute Respiratory Infection in Mexico (CNSARI)

Severe Acute Respiratory Infection (SARI)

Mexico
Yang I. Pachankis

Completed

Medicine-induced Cardiac Hemodialysis on COVID-19

Renal Dialysis | Vaccines | Infection Viral | Severe Acute Respiratory Syndrome-related Coronavirus | Myocarditis Allergic

China
Peking Union Medical College Hospital

Recruiting

The Efficacy and Safety of Corticosteroids in Combination With Ruxolitinib in the Management of Checkpoint Inhibitor Pneumonia

Severe Checkpoint Inhibitor Pneumonitis

China
King George's Medical University
United States Agency for International Development (USAID)

Completed

Indiaclen Short Course Amoxycillin Therapy for Pneumonia With Wheeze

Non-Severe Pneumonia With Wheeze

India
Maimónides Biomedical Research Institute of Córdoba
Dynamic Solutions; Faes Farma, S.A.; Junta de Andalucía - Consejería de Salud...

Completed

Prevention and Treatment With Calcifediol of COVID-19 Induced Acute Respiratory Syndrome (COVIDIOL)

SARS-CoV 2 | COVID19 | Cytokine Storm | Cytokine Release Syndrome | SARS (Severe Acute Respiratory Syndrome)

Spain
Pfizer

Withdrawn

A Study to Learn About the Medicine Called Nirmatrelvir Used in Combination With Ritonavir in People With Weakened Immune Systems or at Increased Risk for Poor Outcomes Who Are Hospitalized Due to Severe COVID-19 (EPIC-HOS)

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) | Coronavirus Disease 2019 (COVID-19) | Immunocompromised | Hospitalization | Child, Hospitalized

United States, Bulgaria
Instituto Nacional de Enfermedades Respiratorias

Terminated

Glycine Supplement for Severe COVID-19

COVID-19 | Pneumonia, Viral | SARS-CoV Infection | SARS (Severe Acute Respiratory Syndrome) | ARDS, Human | SARS Pneumonia

Mexico
Duke University
University of California, San Diego; University of Wisconsin, Madison

Completed

Eovist vs. Dotarem Healthy Volunteer MRI

Transient Severe Arterial Phase Motion

United States
Aga Khan University
Bill and Melinda Gates Foundation

Completed

Impact of Pulse Oximetry on Hospital Referral Acceptance in Children Under 5 With Severe Pneumonia

Hypoxemia | Severe Pneumonia

Pakistan
Universitair Ziekenhuis Brussel

Unknown

Predictive Value of Spirometric PIF to Produce PIF Rate Needed for the Use of Current DPI's.

COPD | Severe Asthma

Belgium
ANRS, Emerging Infectious Diseases
Institut National de la Santé Et de la Recherche Médicale, France; University... and other collaborators

Recruiting

Early Treatment of Vulnerable Individuals With Non-Severe SARS-CoV-2 Infection (COVERAGE-A)

Covid19 | SARS-CoV2 Infection | Severe Acute Respiratory Syndrome Coronavirus 2 | Covid19 Drug Treatment

Burkina Faso, Guinea
A.O. Ospedale Papa Giovanni XXIII

Completed

An Observational Study of the Use of Siltuximab (SYLVANT) in Patients Diagnosed With COVID-19 Infection Who Have Developed Serious Respiratory Complications (SISCO)

Severe Acute Respiratory Syndrome (ARDS) Secondary to SARS-COV-2 Infection

Italy
King George's Medical University
Indian Council of Medical Research; United States Agency for International...

Completed

ICMR-Indiaclen Trial on Amoxycillin vs Cotrimoxazole for Non-Severe Pneumonia

Children | Non-Severe Pneumonia | Under-Fives

India
Instituto Nacional de Enfermedades Respiratorias

Completed

Renal Biomarkers in AKI and COVID-19

Coronavirus Infection | Covid19 | AKI | SARS (Severe Acute Respiratory Syndrome)

Mexico
NYU Langone Health

Withdrawn

Mainstream Sleep Tracking Devices vs Polysomnography

Severe Sleep Apnea | Severe Insomnia | Epileptiform Activity

United States
Upstream Bio Inc.

Recruiting

A Study to Investigate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)

Severe Asthma

United States, United Kingdom, Canada
Royal Devon and Exeter NHS Foundation Trust
University of Plymouth; Plymouth Marjon University

Recruiting

Adapting Body Reprogramming for Severe Asthma: a Feasibility Study (BoBSA)

Severe Asthma

United Kingdom
Assistance Publique - Hôpitaux de Paris

Recruiting

Defining the Severe Paediatric Asthma Endotype (SevAsthma)

Severe Asthma

France
University of British Columbia
McGill University; University of Alberta; University of Toronto; University of... and other collaborators

Recruiting

International Severe Asthma Registry: Canadian Cohort (ISAR)

Severe Asthma

Canada
University of Thessaly

Completed

Impulse Oscillometry Measurements in Severe Eosinophilic Asthmatics Before and After Anti-IL-5 Factor Initiation (IMPOSE)

Severe Asthma

Greece
Hopital du Sacre-Coeur de Montreal
GlaxoSmithKline

Completed

Effectiveness of Anti-IL-5/IL5R Inhibitors

Severe Asthma

Canada
Makerere University

Completed

African Severe Asthma Program: A Research Network for Characterisation of Severe Asthma in Africans (ASAP) (ASAP)

Severe Asthma

Ethiopia, Kenya, Netherlands, Uganda

Clinical Trials on Severe Respiratory Disease

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