Clinical Trials on Targeted Alpha Therapy

Total 2840 results

FlowMedica, Inc.

Withdrawn

Post-Market Observational Study of Intra-Renal Drug Delivery (PROVIDE)

Targeted Renal Therapy

United States
The University of Hong Kong-Shenzhen Hospital
Tianjin Happy Life Technology Co., Ltd.

Not yet recruiting

a Prospective Registration Study for Patients With Advanced Refractory Solid Tumors

Feasibility | Safety | Targeted Molecular Therapy | Effectiveness
Xueqin Yang

Recruiting

RecistTM Criteria in Evaluating the Efficacy of Targeted Therapy for NSCLC

NSCLC | Targeted Therapy | Evaluation

China
Harbin Medical University

Recruiting

An Exploratory Trail of Camrelizumab Plus Apatinib Mesylate for Advanced Gastrointestinal

Gastrointestinal Cancer | Immunotherapy | Targeted Therapy

China
Beijing Friendship Hospital

Completed

Camrelizumab Combined With Apatinib and Capecitabine in Patients With Advanced Biliary Tract Cancer.

Biliary Tract Cancer | Capecitabine | Targeted Molecular Therapy | Anti-PD-1 Therapy

China
Napo Pharmaceuticals, Inc.

Active, not recruiting

Prophylaxis of Diarrhea in Adult Cancer Patients Receiving Targeted Cancer Therapy (OnTARGET)

Adult Solid Tumor | Cancer Therapy-Related Diarrhea | Chemotherapy-related Diarrhea | Prophylaxis of Diarrhea | Symptomatic Relief of Diarrhea | Targeted Therapy-related Diarrhea

United States, Taiwan, Georgia, Serbia, Argentina
David Moss

Recruiting

Novel Mental Health Therapies to Improve Military Readiness

Anxiety | Heart Rate Variability | Cognitive Behavioral Therapy | Alpha Stim | Cranial Electrotherapy Stimulation

United States
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Chidamide/Everolimus for PIK3CA Wild-type/Mutant HR+/HER2- Advanced Breast Cancer

Targeted Therapy | HR+/HER2- Advanced Breast Cancer

China
LiNanlin,Ph.D, Chief Physician,Clinical Professor
Roche Pharma AG

Unknown

Observational Studies of the Application of Bevacizumab in HER2-negative Breast Cancer Neoadjuvant Chemotherapy (BIBC)

Breast Cancer | Bevacizumab | Neoadjuvant Chemotherapy | Molecular Targeted Therapy

China
Oslo University Hospital
AstraZeneca

Active, not recruiting

AZD9291, an Irreversible EGFR-TKI, in Relapsed EGFR-mutated Non-small Cell Lung Cancer Patients Previously Treated With an EGFR-TKI, Coupled to Extensive Translational Studies (TREM)

Lung Cancer | Targeted Therapy

Sweden, Finland, Denmark, Lithuania, Norway
Hasselt University

Completed

Oxygenation of the Cerebrum and Cooling During TAVI - Part I (OCCTAVI-I)

TAVI | Neuroprotection | Targeted Brain Cooling

Belgium
RenJi Hospital

Completed

Lenvatinib Combined With Gefitinib in the Treatment of Lenvatinib-resistant Hepatocellular Carcinoma

Hepatocellular Carcinoma | Molecular Targeted Therapy

China
Shanghai Zhongshan Hospital

Recruiting

Camrelizumab Combined With Apatinib Mesylate for Perioperative Treatment of Resectable Hepatocellular Carcinoma

Hepatocellular Carcinoma | Immunotherapy | Molecular Targeted Therapy

China
University Hospital, Limoges

Recruiting

Onco-haematology Vigilance Card (THERANOVA-LIM)

Medical Oncology | Hematology | Molecular Targeted Therapies

France
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Shandong Cancer Hospital and Institute

Recruiting

Sintilimab Combined With Fruquintinib/Regorafenib ± Radiotherapy for Third-line Treatment of Advanced Metastatic Colorectal Cancer

Colorectal Cancer | Radiotherapy | Immunotherapy | Targeted Therapy

China
Grifols Therapeutics LLC

Recruiting

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of Two Different Doses of Alpha1-Proteinase Inhibitor Subcutaneous (Human) 15% in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

United States
Vertex Pharmaceuticals Incorporated

Completed

Evaluation of the Efficacy and Safety of VX-864 in Subjects With the PiZZ Genotype

Alpha1-Antitrypsin Deficiency

United States, Germany, Canada, Ireland, Sweden, United Kingdom
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Safety and Pharmacokinetics of Alpha-1 MP (Alpha1-proteinase Inhibitor (Human), Modified Process) in Participants With Alpha1-Antitrypsin Deficiency

Alpha1-Antitrypsin Deficiency

Japan
Baxalta now part of Shire

Completed

GLASSIA Safety, Immunogenicity, and Bronchoalveolar Lavage Study

Alpha1-antitrypsin Deficiency

United States, Canada
Baxalta now part of Shire

Terminated

Aralast alpha1-proteinase Inhibitor Surveillance Study

Alpha1-antitrypsin Deficiency

United States
Centre Hospitalier Universitaire, Amiens

Recruiting

Risk Factors for Postoperative Complications in Major Non-cardiac Surgery: Post-hoc Analysis of the OPHIQUE Multicentre Study (MULTIPAS)

Postoperative Morbidity | Goal Directed Therapy | Individualised Target | Postopera Mortality

France
Grifols Therapeutics LLC
Grifols Japan K.K.

Completed

Long-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)

Alpha1-Antitrypsin Deficiency

Japan
Baxalta now part of Shire
Arriva Pharmaceuticals, Inc.

Completed

Safety Study of an Aerosolized, Recombinant Alpha 1-Antitrypsin in Subjects With Alpha 1-Antitrypsin Deficiency

Alpha1-antitrypsin Deficiency

United States
Lebanese University
Haykel Hospital

Recruiting

Precision Therapy for Solid Tumors: Synergistic CDK4/6 Inhibition and Anti-VEGF Targeting LncRNA (PTST_PALBEVA)

Cancer | Breast Cancer | Colorectal Cancer | Ovarian Cancer | Lung Cancer | Chemotherapy | Solid Tumor | Immunotherapy | Targeted Therapy | Precision Therapy

Lebanon
Z Factor Limited
Hammersmith Medicines Research; Centessa Pharmaceuticals plc

Terminated

A Single Ascending and Repeated Dose Study of Oral ZF874 in Healthy Volunteers and PiXZ Subjects

Alpha1 Anti-Trypsin Deficiency

United Kingdom
Baxalta now part of Shire

Completed

GLASSIA Infusion Rate Study

Healthy Volunteers | Alpha1-antitrypsin Deficiency

United States
RWTH Aachen University

Unknown

Liver Disease in Patients With alpha1-antitrypsin Deficiency

alpha1-antitrypsin Deficiency

Germany
Takeda

Recruiting

Study to Learn About the Safety of Fazirsiran and if it Can Help People With Alpha-1 Antitrypsin Liver Disease With Mild Liver Scarring (Fibrosis)

Alpha1-Antitrypsin Deficiency

United States, Poland
Takeda
Takeda Development Center Americas, Inc.

Recruiting

Study to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin Protein

Alpha1-Antitrypsin Deficiency

United States, Belgium, Switzerland, Canada, Australia, Germany, United Kingdom, Austria, France, Spain, Portugal, Italy, Poland
Shanghai Chest Hospital

Recruiting

Association of Psychological Distress in Patients With Lung Cancer (Life-Score)

Lung Neoplasms | Psychological Distress | IMMUNOTHERAPY | Lifestyle, Healthy | Targeted Molecular Therapy | Prognosis Factors

China
UNICANCER
CAMI: Sport & Cancer

Active, not recruiting

QUALIOR Feasibility and Efficacy of a Supervised Home-based Standard Physical Exercise Program (QUALIOR)

Home Based Standardised Adapted Physical Activity Programme | Patients Taking Oral Targeted Therapy for Metastatic Cancer

France
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Chemoradiotherapy in Esophageal or Esophagogastric Junction Cancer

Chemoradiation | Chemotherapy Effect | Immunotherapy | Targeted Therapy | Esophagus Cancer | Esophagogastric Junction Cancer

China
Takeda

Enrolling by invitation

An Extension Study to Learn About the Long-Term Safety of Fazirsiran and if Fazirsiran Can Help People With Alpha-1 Antitrypsin Liver Disease

Alpha1-Antitrypsin Deficiency

United Kingdom, Germany, United States, Austria, Portugal
Alison Galbraith
National Institute on Aging (NIA); Massachusetts Institute of Technology; Harvard... and other collaborators

Completed

Analyzing the Impact of the Now iKnow Health Care Price Transparency Tool

no Specific Condition Targeted | Use of a Price Transparency Tool

United States
Peking Union Medical College Hospital

Completed

Lenvatinib in Patients With Previously Treated Advanced Biliary Tract Cancer (LENABC)

Cholangiocarcinoma | Biliary Tract Cancer | Targeted Therapy

China
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Neoadjuvant Treatment Modalities in Esophageal Cancer

Esophageal Cancer | Chemoradiation | Surgery | Chemotherapy Effect | Immunotherapy | Targeted Therapy | Esophagogastric Juction Cancer

China
Cancer Institute and Hospital, Chinese Academy...

Recruiting

Preoperative IMRT With Concurrent Apatinib for Localised Extremity or Trunk Sarcoma

Sarcoma,Soft Tissue | Trunk | Extremity | Intensity-modulated Radiotherapy | Major Wound Complications | Targetd Therapy

China
University of California, San Francisco

Recruiting

International Registry of Patients With Alpha Thalassemia (ATM Registry)

Alpha-Thalassemia | Alpha Thalassemia Major | Alpha Thalassemia Minor

United States
CSL Behring

Completed

Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.

Emphysema | Alpha 1-proteinase Inhibitor Deficiency

Australia, Canada, Czech Republic, Denmark, Estonia, Finland, Germany, Ireland, Poland, Romania, Sweden
Johns Hopkins University
National Institute on Drug Abuse (NIDA)

Recruiting

Behavioral Pharmacology of THC and Alpha-pinene

THC | Alpha-pinene

United States
Zhongnan Hospital

Recruiting

Surufatinib Alone or Combined With Anti-PD-1 mAb in the Treatment of Advanced Hepatocellular Carcinoma

Hepatocellular Carcinoma; Targeted Therapy; Progression-free Survival

China
Baxalta now part of Shire
Baxalta Innovations GmbH, now part of Shire

Terminated

Stage 1 Study of ARALAST NP and GLASSIA in A1PI Deficiency

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency

United States, Canada, Australia
Shire

Withdrawn

ARALAST NP Alpha-1 Lung Density Chronic Obstructive Pulmonary Disease-Emphysema (COPD-E) Study

Chronic Obstructive Pulmonary Disease | Alpha1-antitrypsin Deficiency
Accademia Italiana Medicina Osteopatica

Completed

Effect of Cranial Manipulation on ANS Activity

Manipulation, Osteopathic | Alpha Amylase

Italy
Lei Li

Completed

First-line Chemotherapy for Recurrent Cervical Cancer

Chemotherapy | Recurrent Cervical Carcinoma | Apatinib | Targeted Therapy | Persistent Advanced Cervical Carcinoma | Vascular Endothelial Growth Factor 2 Inhibitor

China
Dermatologic Cooperative Oncology Group

Unknown

Standard High-Dose Alpha Interferon Versus Intermittent High-Dose Alpha Interferon

Therapy | Adjuvant | Stage III Malignant Melanoma | Interferon Alpha

Germany
Sang Hoon Oh

Unknown

Multi-channel aEEG in Cardiac Arrest Patients With Targeted Temperature Management (MAEGIC)

Heart Arrest | Targeted Temperature Management

Korea, Republic of
Arkansas Tech University

Completed

Salivary Alpha Amylase as a Biomarker of Transdermal Vagus Nerve Stimulation

No Condition Salivary Alpha Amylase

United States
CENTOGENE GmbH Rostock

Withdrawn

Biomarker for Mannosidosis Disease (BioMannosidosis) (BioMannosido)

Alpha-Mannosidase B Deficiency | Lysosomal Alpha B Mannosidosis | Alpha-Mannosidase Deficiency

India, Sri Lanka, Germany

Clinical Trials on Targeted Alpha Therapy

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