Clinical Trials on Transfusion Dependent Beta-Thalassaemia

Total 308 results

Bioray Laboratories
PLA 923 Hospital

Terminated

β-globin Restored Autologous HSC in β-thalassemia Major Patients

β-thalassemia Major

China
bluebird bio

Completed

A Study Evaluating the Safety and Efficacy of the LentiGlobin BB305 Drug Product in β-Thalassemia Major Participants

β-thalassemia Major

United States, Australia, Thailand
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI); Thalassemia Clinical Research...

Completed

Thalassemia (Cooley's Anemia) Clinical Research Network (TCRN)

Hematologic Diseases | Iron Overload | Hypertension, Pulmonary | Osteoporosis | Thalassemia | Beta-Thalassemia | Anemia, Cooley's

United States, Canada
Prothya Biosolutions

Terminated

Apotransferrin in Patients With β-thalassemia

β-thalassemia Intermedia

Netherlands
Novartis Pharmaceuticals

Withdrawn

An Open Label Study to Evaluate the Pharmacokinetics, Safety, Tolerability and Efficacy of Deferasirox Administered to Chinese Patients With β-thalassemia Major Aged From 2 to Less Than 6 Years Old (MACS2163)

β-thalassemia Major
Assiut University

Completed

Erythrocyte Glutamine Level Relation to Pulmonary Hypertension Risk in Beta Thalassemia Major Children

Hemolysis | Pulmonary Hypertension | Thalassemia in Children

Egypt
Assiut University

Unknown

Red Cell Distribution Width Index Versus Red Cell Distribution Width as Discriminating Guide for Iron Deficiency Anaemia and Beta Thalassemia Trait .

Microcytic Hypochromic Anemia
Aghia Sophia Children's Hospital of Athens

Unknown

B Memory Cell Response to Vaccination With the 13-valent Pneumococcal Conjugate Vaccine in Asplenic Individuals

Asplenia | β-thalassemia Major

Greece
Cairo University

Recruiting

Correlation Between Pulmonary Functions and Physical Fitness in Children With β-thalassemia

Pulmonary Function | Physical Fitness | β-Thalassemia

Egypt
Assiut University

Not yet recruiting

Study on the Effect of Different Risk Factors on the Growth Parameters of Thalassemic Patients in Assiut (AUCH)

Thalassemia Major
Università degli Studi di Ferrara

Completed

Impact of the Preparation Method of Red Cell Concentrates on Transfusion Indices in Thalassemic Patients

Thalassemia Major

Italy
HaEmek Medical Center, Israel

Completed

Endocrine and Nutritional Assessment in B Thalassemia Major

Thalassemia

Israel
Cerus Corporation

Completed

Study to Evaluate Efficacy and Safety of S303 Treated Red Blood Cells (RBCs)in Subjects With Thalassemia Major Requiring Chronic RBC Transfusion

Thalassemia Major

Turkey, Italy
Memorial Sloan Kettering Cancer Center

Active, not recruiting

ß-Thalassemia Major With Autologous CD34+ Hematopoietic Progenitor Cells Transduced With TNS9.3.55 a Lentiviral Vector Encoding the Normal Human ß-Globin Gene

Confirmed Diagnosis of ß-thalassemia Major

United States
Protagonist Therapeutics, Inc.

Completed

Study of PTG-300 in Non-Transfusion Dependent and Transfusion-Dependent Beta-Thalassemia Subjects With Chronic Anemia (TRANSCEND)

Chronic Anemia | β-thalassemia | Ineffective Erythropoiesis

United States, Malaysia, Turkey, Thailand, United Kingdom, Italy, Lebanon, Tunisia, Greece
Assiut University

Unknown

Sexual Maturation in β-Thalassemia Major Patients in Assiut University Hospital

β-Thalassemia Major Patients Receiving Chelation Therapy
First Affiliated Hospital of Guangxi Medical University
Peking University People's Hospital; Ruijin Hospital; The Affiliated Hospital... and other collaborators

Recruiting

Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major: A Multicenter, Prospective Clinical Study

Thalassemia Major

China
Bioray Laboratories
First Affiliated Hospital of Guangxi Medical University

Suspended

Safety and Efficacy Evaluation of γ-globin Reactivated Autologous Hematopoietic Stem Cells

Thalassemia Major

China
Allife Medical Science and Technology Co., Ltd.

Unknown

iHSCs With the Gene Correction of HBB Intervent Subjests With β-thalassemia Mutations

Thalassemia
Assiut University

Not yet recruiting

Thyroid Function , HbA1c in Relation to Ferritin Level in Adullt Patient e B Thalassemia

B Thalassemia
Shanghai BDgene Co., Ltd.
920th Hospital of Joint Logistics Support Force of People's Liberation Army...

Recruiting

A Study Evaluating the Safety and Efficacy of the BD211 Drug Product in β-Thalassemia Major Participants

Hematologic Diseases

China
National Taiwan University Hospital

Recruiting

Observing the Changes of Endocrine and Metabolism in Patients With Thalassemia Major

Thalassemia Major

Taiwan
DisperSol Technologies, LLC

Completed

Pilot Study to Assess the Safety, PK and Iron Chelating Activity of DST-0509 (Deferasirox) in Thalassemia Patients Refractory to Chelation

Thalassemia Major

Thailand, United States
Assiut University

Completed

Evaluation of Nutritional Status in Thalassemia Major Patients in Assiut Children Hospital

Thalassemia Major

Egypt
National Human Genome Research Institute (NHGRI)

Completed

Perceptions of Thalassemia Major in Singapore: An Exploratory Study of Stigma

Thalassemia Major

Singapore
Novartis Pharmaceuticals

Completed

Study of Efficacy and Safety of INC424 in Regularly Transfused Patients With Thalassemia.

Thalassemia Major

Thailand, Turkey, Italy, Lebanon, Greece
First Affiliated Hospital of Guangxi Medical University

Unknown

Haploidentical Hematopoietic Stem Cell Transplantation for Patients With Thalassemia Major

Thalassemia Major

China
Nanfang Hospital of Southern Medical University

Unknown

Unrelated Umbilical Cord Blood Following HLA-haploidentical Hematopoietic Stem Cell Transplantation in Patients With β-thalassemia Major

Thalassemia Major

China
Ann & Robert H Lurie Children's Hospital of Chicago

Unknown

Long Term Outcomes in β Thalassemia Major

Thalassemia Major

United States
HealthCore-NERI
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Evaluating the Safety and Effectiveness of Decitabine in People With Thalassemia Intermedia

Thalassemia

United States, Canada
Mahidol University

Completed

The Change of Coagulation Markers in Children With β-thalassemia Disease After Stem Cell Transplantation

Thalassemia

Thailand
Ain Shams University

Unknown

Therapeutic Effect and Safety of Combined Hydroxyurea With Recombinant Human Erythropoietin.

Thalassemia Intermedia

Egypt
Dana-Farber Cancer Institute
Tehran University of Medical Sciences

Completed

Monitoring of Erythroid Lineage Specific Chimerism Following Allogeneic Hematopoietic Transplantation for Thalassemia Major

Thalassemia Major

United States, Iran, Islamic Republic of
Weill Medical College of Cornell University

Unknown

The Effect of Vitamin D Supplementation on Calcium Excretion in Thalassemia: a Dose Response Study

Thalassemia Major

United States
Masonic Cancer Center, University of Minnesota

Recruiting

Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

Sickle Cell Disease | Severe Congenital Neutropenia | Paroxysmal Nocturnal Hemoglobinuria | Glanzmann Thrombasthenia | Shwachman-Diamond Syndrome | Diamond Blackfan Anemia | Transfusion Dependent Alpha- or Beta- Thalassemia | Non-Malignant Hematologic Disorders

United States
Sherief Abd-Elsalam

Recruiting

L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension

Thalassemia

Egypt
Assiut University

Not yet recruiting

Assessment of Cognitive Functions, Psychological Symptoms, and Quality of Life Among B Thalassemia Patients and Their Clinical Correlates.

B Thalassemia
Assiut University

Unknown

Quality of Life and Treatment Satisfaction in β-Thalassemia Patients Receiving Deferasirox

β-thalassemia

Egypt
Fakultas Kedokteran Universitas Indonesia

Completed

Zinc Supplementation on Cellular Immunity in Thalassemia Major

Thalassemia | Immunosuppression | Splenectomy; Status

Indonesia
Columbia University

Completed

High-Tc Susceptometer to Monitor Transfusional Iron Overload

Myelodysplastic Syndromes | Sickle Cell Disease | Aplastic Anemia | Transfusional Iron Overload | Thalassemia Major

United States
Johann Wolfgang Goethe University Hospital
Wuerzburg University Hospital

Recruiting

Liberal Transfusion Strategy in Elderly Patients (LIBERAL)

Anemia | Surgery | Transfusion-dependent Anemia

Germany
Hematology department of the 920th hospital

Recruiting

Clinical Observation of Luspatercept in Treatment of Chinese Adult β-thalassaemia Patients With TD β-thalassemia

Effect of Drug

China
Assiut University

Completed

Adiponectin, IL-6 and hsC-RP in Relation to Carotid Intima-media Thickness in B-thalassemia Patients

Thalassemia

Egypt
Ain Shams University

Unknown

Role of Vitamin C to Augment Iron Chelation With DFP or DFX

Thalassemia Major | Iron Chelation | Vitamin c

Egypt
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

Not yet recruiting

Longitudinal Study on the QoL of Pediatric Patients After HSCT and Its Influencing Factors

Acute Leukemia | Thalassemia Major

China
National Institute of Allergy and Infectious Diseases...

Terminated

Stem Cell Transplantation After Reduced-Dose Chemotherapy for Patients With Sickle Cell Disease or Thalassemia

Anemia, Sickle Cell | Hemoglobinopathies | Thalassemia | Hemoglobin SC Disease | Thalassemia Major

United States
Timothy Olson

Active, not recruiting

Pilot Study PBSCT With TCRab Depletion For Hemoglobinopathies

Sickle Cell Disease | Thalassemia Major

United States
University of California, San Francisco
California Institute for Regenerative Medicine (CIRM)

Enrolling by invitation

In Utero Hematopoietic Stem Cell Transplantation for Alpha-thalassemia Major (ATM)

Hemoglobinopathies | Alpha Thalassemia Major | Thalassemia Major | Fetal Hydrops | Hemoglobinopathy; With Thalassemia | Fetal Anemia | Alpha; Thalassemia | Thalassemia Alpha | A-Thalassemia

United States
Ente Ospedaliero Ospedali Galliera
University of Campania "Luigi Vanvitelli"; Reggio Calabria; Ospedale Maggiore... and other collaborators

Completed

Efficacy and Safety of Neridronate (Nerixia®)to Treat Osteoporosis in Patients With TM and TI (Nerixia)

Osteoporosis | Thalassemia Major | Thalassemia Intermedia

Italy
Novartis Pharmaceuticals

Completed

Study to Evaluate Treatment Compliance, Efficacy and Safety of an Improved Deferasirox Formulation (Granules) in Pediatric Patients (2-<18 Years Old) With Iron Overload

Transfusion-dependent Anemia

Egypt, Hungary, Turkey, United States, Bulgaria, Italy, Belgium, Russian Federation, Philippines, France, Malaysia, India, Oman, Panama, Lebanon, Thailand, Tunisia

Clinical Trials on Transfusion Dependent Beta-Thalassaemia

Sponsors and Collaborators

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Drug Interventions

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CROs in Belarus

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