Clinical Trials on Undifferentiated Connective Tissue Diseases

Total 57758 results

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Nivolumab With and Without Ipilimumab and Radiation Therapy in Treating Patients With Recurrent or Resectable Undifferentiated Pleomorphic Sarcoma or Dedifferentiated Liposarcoma Before Surgery

Undifferentiated Pleomorphic Sarcoma | Recurrent Undifferentiated Pleomorphic Sarcoma | Dedifferentiated Liposarcoma | Resectable Dedifferentiated Liposarcoma | Resectable Undifferentiated Pleomorphic Sarcoma | Recurrent Dedifferentiated Liposarcoma

United States
Memorial Sloan Kettering Cancer Center
Incyte Corporation

Recruiting

Palbociclib and INCMGA00012 in People With Advanced Liposarcoma

Well-differentiated/Dedifferentiated Liposarcoma

United States
CHU de Quebec-Universite Laval

Not yet recruiting

Impact of Capillaroscopy on the Management of Undifferentiated Connective Tissue Disease

Undifferentiated Connective Tissue Diseases
Hospital for Special Surgery, New York

Recruiting

Undifferentiated Connective Tissue Disease Registry (UCTD Registry)

Undifferentiated Connective Tissue Disease

United States
Assaf-Harofeh Medical Center

Unknown

A Study Assessing Efficacy & Safety of Ribociclib in Patients With Advanced Well/Dedifferentiated Liposarcoma

Soft-Tissue Sarcoma | Liposarcomas, Dedifferentiated | Liposarcoma - Well Differentiated | Liposarcoma; Mixed Type

Israel
Memorial Sloan Kettering Cancer Center
ENABLE MEDICINE

Active, not recruiting

Study of DCC-3014 in Combination With Avelumab in Patients With Advanced or Metastatic Sarcomas

Sarcoma | Leiomyosarcoma | High Grade Sarcoma | Undifferentiated Pleomorphic Sarcoma | Advanced Sarcoma | Myxofibrosarcoma | Dedifferentiated Liposarcoma

United States
RenJi Hospital
The First Affiliated Hospital with Nanjing Medical University; The First Affiliated... and other collaborators

Recruiting

Immunosuppressant Regimens for Living Fetuses Study

Recurrent Pregnancy Loss | Undifferentiated Connective Tissue Disease

China
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Sintilimab for the Treatment of Locally Advanced, Metastatic, Recurrent, or Unresectable Undifferentiated Pleomorphic Sarcoma, SiARa Cancer Study

Metastatic Undifferentiated Pleomorphic Sarcoma | Recurrent Undifferentiated Pleomorphic Sarcoma | Locally Advanced Undifferentiated Pleomorphic Sarcoma | Unresectable Undifferentiated Pleomorphic Sarcoma

United States
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Etrumadenant and Zimberelimab in People With Dedifferentiated Liposarcoma

Sarcoma | Soft Tissue Sarcoma | Sarcoma,Soft Tissue | Dedifferentiated Liposarcoma | Recurrent Dedifferentiated Liposarcoma | Metastatic Dedifferentiated Liposarcoma | Unresectable Dedifferentiated Liposarcoma

United States
National Cancer Institute (NCI)

Terminated

CUDC-907 Treatment in People With Metastatic and Locally Advanced Thyroid Cancer

Thyroid Neoplasms | Differentiated Thyroid Cancer | Poorly Differentiated and Undifferentiated Thyroid Cancer

United States
Boehringer Ingelheim

Not yet recruiting

Brightline-3: A Study to Find Out Whether Brigimadlin in Combination With Ezabenlimab Helps People With Advanced Soft Tissue Sarcoma

Advanced Soft Tissue Sarcoma | Undifferentiated Pleomorphic Sarcoma (UPS) | Myxofibrosarcoma (MFS)
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Recruiting

Oleclumab and Durvalumab for the Treatment of Recurrent, Refractory, or Metastatic Sarcoma (DOSa)

Recurrent Osteosarcoma | Refractory Osteosarcoma | Metastatic Osteosarcoma | Metastatic Angiosarcoma | Recurrent Dedifferentiated Liposarcoma | Metastatic Dedifferentiated Liposarcoma | Recurrent Angiosarcoma | Refractory Dedifferentiated Liposarcoma

United States
National Cancer Institute (NCI)

Suspended

Testing Ipilimumab and Nivolumab Combination With or Without Cabozantinib in People >= 18 Years Old With Advanced Soft Tissue Sarcoma

Locally Advanced Leiomyosarcoma | Metastatic Undifferentiated Pleomorphic Sarcoma | Locally Advanced Liposarcoma | Locally Advanced Undifferentiated Pleomorphic Sarcoma | Locally Advanced Extraskeletal Myxoid Chondrosarcoma | Locally Advanced Unresectable Soft Tissue Sarcoma

United States, Canada
National Cancer Institute (NCI)

Completed

Nivolumab With or Without Ipilimumab in Treating Patients With Metastatic Sarcoma That Cannot Be Removed by Surgery

Stage III Soft Tissue Sarcoma AJCC v7 | Stage IV Soft Tissue Sarcoma AJCC v7 | Pleomorphic Liposarcoma | Metastatic Undifferentiated Pleomorphic Sarcoma | Metastatic Unresectable Sarcoma | Unresectable Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma | Locally Advanced Soft Tissue Sarcoma | Metastatic... and other conditions

United States
Maria Sklodowska-Curie National Research Institute...

Unknown

Hypofractionated Radiotherapy With Sequential Chemotherapy in Marginally Resectable Soft Tissue Sarcomas of Extremities or Trunk Wall (UN-RESARC)

Sarcoma | Leiomyosarcoma | Fibrosarcoma | Liposarcoma | Myxoid Liposarcoma | Myosarcoma | Histiocytic Sarcoma | Pleomorphic Liposarcoma | Synovial Sarcoma | Undifferentiated Pleomorphic Sarcoma | Myxofibrosarcoma | Dedifferentiated Liposarcoma | Malignant Peripheral Nerve Sheath Tumors | Malignant Triton Tumor | Pleomorphic... and other conditions

Poland
Sarcoma Alliance for Research through Collaboration
Eli Lilly and Company

Recruiting

SARC041: Study of Abemaciclib Versus Placebo in Patients With Advanced Dedifferentiated Liposarcoma

Advanced Dedifferentiated Liposarcoma

United States
IP Santé Domicile

Unknown

Initiation of Non- Invasive Ventilation at Home Versus Hospital Among Patients With Overlap Syndrome (OVNI-Dom)

Overlap Syndrome

France
Patrick Durez

Completed

A 6-Months Infliximab Or Placebo Study In UA At High Risk Of RA:Clinical,Radiological And Synovial Benefit (UA-IFX)

Undifferentiated Arthritis

Belgium
Children's Oncology Group
National Cancer Institute (NCI)

Completed

Biomarker Differences in Samples From Patients With Undifferentiated Sarcomas

Soft Tissue Sarcoma

United States
Bristol-Myers Squibb
Ono Pharmaceutical Co. Ltd

Completed

Study of the Safety of Orencia in Japanese Children and Adolescents With Active Juvenile Arthritis of Unknown Origin

Undifferentiated Arthritis

Japan
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

Testing the Addition of Cemiplimab to Palbociclib for the Treatment of Advanced Dedifferentiated Liposarcoma

Stage III Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage IV Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Advanced Dedifferentiated Liposarcoma | Metastatic Dedifferentiated Liposarcoma | Locally Advanced Dedifferentiated Liposarcoma | Unresectable Dedifferentiated...

United States
Mohammed Milhem

Recruiting

Palbociclib and Pembrolizumab in Undifferentiated Pleomorphic Sarcoma (UPS)

Undifferentiated Pleomorphic Sarcoma

United States
Matthew Bucknor
Focused Ultrasound Foundation; InSightec-TxSonics

Recruiting

Focused Ultrasound to Promote Immune Responses for Undifferentiated Pleomorphic Sarcoma (HIFU-UPS)

Undifferentiated Pleomorphic Sarcoma

United States
University Hospital, Strasbourg, France

Recruiting

Metabolomic Analysis of Systemic Sclerosis (SCLEROMICS)

Vascular Disease | Raynaud Disease | Healthy Control Subjects | Undifferentiated Connective Tissue Disease | Scleroderma (Limited and Diffuse)

France
BioAtla, Inc.

Recruiting

CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients With Sarcoma

Undifferentiated Pleomorphic Sarcoma | Myxofibrosarcoma

United States, Hong Kong, Taiwan
Fred Hutchinson Cancer Center
Incyte Corporation

Terminated

Itacitinib in Treating Patients With Refractory Metastatic/Advanced Sarcomas

Refractory Soft Tissue Sarcoma | Metastatic Leiomyosarcoma | Metastatic Synovial Sarcoma | Metastatic Undifferentiated Pleomorphic Sarcoma | Advanced Soft Tissue Sarcoma | Metastatic Soft Tissue Sarcoma | Advanced Synovial Sarcoma | Metastatic Chondrosarcoma | Advanced Leiomyosarcoma | Metastatic Myxoid... and other conditions

United States
Istituto Ortopedico Rizzoli

Recruiting

Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project (GRACefUl)

Undifferentiated Round Cell Sarcoma

Italy
Tracon Pharmaceuticals Inc.

Recruiting

ENVASARC: Envafolimab And Envafolimab With Ipilimumab In Patients With Undifferentiated Pleomorphic Sarcoma Or Myxofibrosarcoma (ENVASARC)

Undifferentiated Pleomorphic Sarcoma | Myxofibrosarcoma

United States, United Kingdom
Sunshine Guojian Pharmaceutical (Shanghai) Co.,...

Not yet recruiting

A Phase II Study for 609A in the Treatment of Advanced Undifferentiated Pleomorphic Sarcoma

Sarcoma, Soft Tissue

China
Paul R Fortin
Canadian Institutes of Health Research (CIHR)

Recruiting

COvid-19 Vaccine Booster in Immunocompromised Rheumatic Diseases (COVBIRD)

Rheumatoid Arthritis | Systemic Lupus Erythematosus | Systemic Sclerosis | Systemic Vasculitis | Immunosuppression | Scleroderma | Autoimmune Rheumatologic Disease | Undifferentiated Connective Tissue Diseases | Overlap Connective Tissue Disease

Canada
Royal Marsden NHS Foundation Trust
Merck Sharp & Dohme LLC

Active, not recruiting

Pembrolizumab and Gemcitabine Chemotherapy in Leiomyosarcoma and Undifferentiated Pleomorphic Sarcoma (GEMMK)

Sarcoma

United Kingdom
Di Wu

Not yet recruiting

Study of Anlotinib Hydrochloride and Toripalimab in Subjects With Unresectable or Metastatic Undifferentiated Pleomorphic Sarcoma

Undifferentiated Pleomorphic Sarcoma | Soft Tissue Sarcomas

China
Institut Bergonié
Ministry of Health, France; PharmaMar

Terminated

Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial (APLIPO)

Adult Patients With Unresectable Locally Advanced or Metastatic, Relapsed/Refractory Dedifferentiated Liposarcoma

France
Nanjing Medical University

Completed

Auto-trilevel Ventilator for Patients With Overlap Syndrome

Overlap Syndrome

China
Dana-Farber Cancer Institute
Merck Sharp & Dohme LLC

Active, not recruiting

A Phase II Study of Eribulin and Pembrolizumab in Soft Tissue Sarcomas

Sarcoma | Leiomyosarcoma | Liposarcoma | Undifferentiated Pleomorphic Sarcoma

United States
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI); Highlight Therapeutics

Active, not recruiting

Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma

Leiomyosarcoma | Malignant Peripheral Nerve Sheath Tumor | Synovial Sarcoma | Undifferentiated Pleomorphic Sarcoma | Undifferentiated High Grade Pleomorphic Sarcoma of Bone | Myxofibrosarcoma | Stage II Soft Tissue Sarcoma of the Trunk and Extremities AJCC v8 | Stage III Soft Tissue Sarcoma of the... and other conditions

United States
Seoul National University Bundang Hospital

Completed

Overlap FGIDs and Genetic Polymorphism

Functional Gastrointestinal Disorders | Overlap Syndromes
Shanghai Pharma Biotherapeutics USA Inc.

Recruiting

Open-Label Study of the CDK4/6 Inhibitor SPH4336 in Subjects With Locally Advanced or Metastatic Liposarcomas

Liposarcoma, Dedifferentiated

United States
Boehringer Ingelheim

Active, not recruiting

Real-world Study of Dedifferentiated Liposarcoma Patients in China

Dedifferentiated Liposarcoma

China
Rain Oncology Inc

Terminated

Treatment of Milademetan Versus Trabectedin in Patient With Dedifferentiated Liposarcoma (MANTRA)

Dedifferentiated Liposarcoma

United States, Spain, France, Korea, Republic of, Taiwan, Canada, Hong Kong, Austria, Germany, Belgium, Georgia, Ireland, Italy, Poland, United Kingdom
Karyopharm Therapeutics Inc

Completed

Selinexor in Advanced Liposarcoma (SEAL)

Dedifferentiated Liposarcoma

United States, United Kingdom, Israel, France, Canada, Spain, Belgium, Sweden, Germany, Italy
Niels Junker
Karolinska University Hospital; Oslo University Hospital; Aarhus University Hospital

Recruiting

Propranolol and Pembrolizumab in Advanced Soft Tissue Sarcoma Patients (PROPANE)

Soft Tissue Sarcoma Adult | Angiosarcoma | Undifferentiated Pleomorphic Sarcoma

Norway, Sweden, Denmark
Memorial Sloan Kettering Cancer Center
Eli Lilly and Company

Active, not recruiting

Study of Abemaciclib in Dedifferentiated Liposarcoma

Sarcoma | Dedifferentiated Liposarcoma

United States
Infinity Pharmaceuticals, Inc.

Withdrawn

Study Evaluating the Efficacy and Safety of IPI 504 in Patients With Advanced Dedifferentiated Liposarcoma

Dedifferentiated Liposarcoma

United States
Lund University Hospital

Not yet recruiting

A Phase 2, Open Label Study of PEmigatinib and REtifanlimab in Advanced Dedifferentiated LIposarcoma (PERELI) (PERELI)

Dedifferentiated Liposarcoma

Sweden, Norway
Boehringer Ingelheim

Recruiting

Brightline-4: A Study to Test How Well Brigimadlin is Tolerated by People With a Type of Cancer Called Dedifferentiated Liposarcoma

Liposarcoma, Dedifferentiated

United States, Australia, Canada, United Kingdom, Japan
Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Not yet recruiting

TQB3616 Capsules in the Treatment of Dedifferentiated Liposarcoma

Dedifferentiated Liposarcoma

China
Boehringer Ingelheim

Active, not recruiting

Brightline-1: A Study to Compare Brigimadlin (BI 907828) With Doxorubicin in People With a Type of Cancer Called Dedifferentiated Liposarcoma

Liposarcoma, Dedifferentiated

United States, Spain, Canada, Taiwan, Belgium, Australia, China, Italy, Germany, Japan, Hong Kong, Finland, United Kingdom, Denmark, France, Sweden, Netherlands, Portugal, Czechia, Greece, Norway
European Organisation for Research and Treatment...
Sanofi

Completed

Ph II Cabazitaxel DD Liposarcoma

Dedifferentiated Liposarcoma

United Kingdom, Belgium, France, Italy
Memorial Sloan Kettering Cancer Center

Recruiting

A Study of Pembrolizumab Plus Local Chemotherapy Using Isolated Limb Infusion (ILI) for Patients With Sarcoma in the Arm or Leg

Sarcoma | Undifferentiated Pleomorphic Sarcoma | Alveolar Soft Part Sarcoma | Myxofibrosarcoma

United States

Clinical Trials on Undifferentiated Connective Tissue Diseases

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