Clinical Trials on Unresectable Solid Neoplasm in Italy

Total 6756 results

Pierre Fabre Medicament

Withdrawn

Hepatic Impairment Study of Encorafenib in Combination With Binimetinib in BRAF Melanoma

Hepatic Impairment | Metastatic Melanoma | Unresectable Melanoma | BRAF V600 Mutation

Spain, Czechia, Italy
Novartis Pharmaceuticals

Completed

An Open Label Multi-center Extension Study to Evaluate Long-term Safety/ Tolerability of Dovitinib in Patients With Solid Tumors Who Continue to Receive Treatment With Dovitinib (TKI258) in Novartis-sponsored Single Agent Dovitinib Studies Which Fulfilled the Requirements for the Primary Objective

Solid Tumors

Austria, Belgium, United States, Italy, Denmark, Spain, Japan
Azienda Ospedaliera Universitaria Integrata Verona

Completed

Non-hypovascular Solid Pancreatic Lesions: Role of EUS (LE-VASC)

Endoscopic Ultrasound | Solid Pancreatic Neoplasms

Italy
Novartis Pharmaceuticals

Terminated

An Open-label, Dose Escalation Study to Assess the Pharmacokinetics of of ASA404 in Adult Cancer Patients With Impaired Hepatic Function

Histologically-proven and Radiologically-confirmed Solid Tumors

Italy, New Zealand
CNAO National Center of Oncological Hadrontherapy
Foundation IRCCS San Matteo Hospital

Recruiting

Carbon Ions Radiation Therapy for Resectable or Borderline Resectable Pancreas Adenocarcinoma (PIOPPO)

Pancreas Adenocarcinoma | Resectable Pancreatic Cancer | Cancer of Pancreas

Italy
Hoffmann-La Roche

Completed

Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Participants With Previously Treated Solid Tumors (iMATRIXcobi)

Solid Tumors

United States, Spain, Germany, France, Israel, Italy, United Kingdom
Philogen S.p.A.

Terminated

Combination Therapy of F16IL2 and Doxorubicin in Solid Tumour Patients

Breast Cancer | Advanced Solid Tumor

Italy
Novartis Pharmaceuticals

Terminated

KAZ954 Alone and With PDR001, NZV930 and NIR178 in Advanced Solid Tumors

Solid Tumors

United States, Taiwan, Spain, Canada, Italy, Singapore, Japan, Hong Kong
Centro di Riferimento Oncologico - Aviano

Recruiting

A Study on the Prevalence of Clinically Useful Mutations in Solid Tumor Characterized by Next Generation Sequencing Methods on Liquid Biopsy Analysis (POPCORN) (POPCORN)

Melanoma | Cervical Cancer | Breast Cancer | Gastric Cancer | Pancreatic Cancer | Ovarian Cancer | Solid Tumor | Bile Duct Cancer | Advanced Solid Tumor | Endometrial Cancer | Hepatocarcinoma | Locally Advanced Solid Tumor | Colon Rectal Cancer | Vulva Cancer

Italy
Incyte Corporation

Completed

A Study Exploring the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB086550 in Participants With Advanced Solid Tumors

Solid Tumors

United States, Italy, United Kingdom, France, Belgium
IRCCS Policlinico S. Matteo
Norgine; Akern Srl

Completed

Whey Protein Supplementation in Cancer Patients

Solid Tumors

Italy
Istituto Scientifico Romagnolo per lo Studio e...

Recruiting

68 Gallium-Fibroblast Activating Protein Inhibitors-46 Positron Emission Tomography - Computerized Tomography for Molecular Assessment of Fibroblast Activation and Risk Assessment in Solid Tumors (FAPI)

Solid Tumor, Unspecified, Adult

Italy
Byondis B.V.

Active, not recruiting

A First-in-human Dose-escalation and Expansion Study With the Antibody-drug Conjugate BYON3521

Solid Tumor

Belgium, Italy, Netherlands, United Kingdom
Glycotope GmbH
Glycotope Biotechnology GmbH

Completed

TrasGEX™: Phase 1 Study in Cancer Patients

Solid Tumors

Austria, Germany, Italy, Switzerland
Hoffmann-La Roche

Completed

A Study of the Safety, Pharmacokinetics, and Therapeutic Activity of RO6958688 in Combination With Atezolizumab in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen (CEA)-Positive Solid Tumors

Solid Tumors

United States, Denmark, Spain, Canada, France, Italy, Netherlands
Terumo Europe N.V.

Recruiting

BioPearl™ Microspheres Loaded With Doxorubicin for the Treatment of Unresectable Hepatocellular Carcinoma (HCC) (BIOPEARL-ONE)

Hepatocellular Carcinoma Non-resectable

Belgium, Germany, Italy
Hoffmann-La Roche

Completed

A Study of RO6958688 in Participants With Locally Advanced and/or Metastatic Carcinoembryonic Antigen Positive Solid Tumors

Solid Tumors

United States, Denmark, Spain, Canada, France, Netherlands, Italy
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Study to Evaluate SHR-1210 in Combination With Apatinib as First-Line Therapy in Patients With Advanced HCC

Locally Advanced or Metastatic and Unresectable HCC

United States, Spain, China, Taiwan, Belgium, Korea, Republic of, Italy, Hong Kong, Russian Federation, Ukraine, Turkey, Poland, Germany
Novartis Pharmaceuticals

Completed

A Drug-drug Interaction (DDI) Study to Assess the Effect of INC280 on the Pharmacokinetics of Digoxin and Rosuvastatin in Patients With cMET-dysregulated Advanced Solid Tumors

cMET-dysregulated Advanced Solid Tumors

United States, Italy, Spain, United Kingdom, Greece, Belgium, Austria, Czechia
Rottapharm Biotech
Agenus Inc.

Active, not recruiting

A Phase Ib/IIa Study of CR6086 in Combination With Balstilimab in pMMR-MSS Metastatic Colorectal Cancer Patients

Solid Tumor | Metastatic Microsatellite-stable Colorectal Cancer | Mismatch Repair Protein Proficient | Refractory Metastatic Colorectal Cancer

Italy
Nerviano Medical Sciences

Active, not recruiting

Study on Safety and Efficacy of NMS-01940153E in Adult Patients With Unresectable Hepatocellular Carcinoma (HCC) Previously Treated With Systemic Therapy

Unresectable Hepatocellular Carcinoma (HCC)

Italy, Spain, United States
Novartis Pharmaceuticals

Completed

A DDI Study to Assess the Effect of INC280 on the PK of Midazolam and Caffeine in Patients With cMET-dysregulated Advanced Solid Tumors

cMET-dysregulated Advanced Solid Tumors

United States, Spain, Italy, Bulgaria, United Kingdom, France, Denmark
Phost'In Therapeutics

Recruiting

First-in-human Trial of PhOx430, a First-in-class Acetylglucosaminyltransferase V Inhibitor, in Advanced Solid Tumours (PhAST)

Glioblastoma Multiforme | Metastatic Cancer | Advanced Solid Tumor | Malignant Tumor

Italy, France
Azienda Ospedaliero, Universitaria Pisana

Completed

Observational Retrospective Study of Evaluation of Prognostic Factors in Advanced Pancreatic Cancer Patients Treated With FOLFIRINOX (HOPE)

Pancreatic Cancer Non-resectable

Italy
Taiho Oncology, Inc.

Completed

A Trial of TAS-114 in Combination With S-1

Advanced Solid Tumors

France, Belgium, Italy, Switzerland
Bayer

Recruiting

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery (REFINE-IO)

Unresectable Hepatocellular Carcinoma

Greece, Spain, Brazil, China, Colombia, Italy, Saudi Arabia, Taiwan, Thailand, United States, Korea, Republic of, Argentina, France, Mexico, Turkey
Hoffmann-La Roche

Completed

Study Evaluating the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD), and Therapeutic Activity of Selicrelumab (RO7009789) With Vanucizumab or Bevacizumab in Participants With Metastatic Solid Tumors

Advanced/Metastatic Solid Tumors

United States, Belgium, Denmark, Spain, Netherlands, Canada, Italy
Ethical Oncology Science

Completed

Phase I Study of the Proteosome Inhibitor CEP 18770 in Patients With Solid Tumours or Non-Hodgkin's Lymphomas

Lymphoma, Non-Hodgkin | Solid Tumors

Switzerland, Italy
Genentech, Inc.

Recruiting

An Open-Label Dose-Escalation Study to Evaluate XmAb24306 as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Solid Tumors

Solid Tumors

Korea, Republic of, Netherlands, Spain, United States, Brazil, Canada, Italy, Australia, Belgium
ArQule, Inc. (a wholly owned subsidiary of Merck...

Completed

Trial of ARQ 197 in Patients With Unresectable Hepatocellular Carcinoma (HCC) Who Have Failed One Prior Systemic Therapy

Unresectable Hepatocellular Carcinoma

Belgium, Italy, United States, Germany, Canada
Novartis Pharmaceuticals

Terminated

Study of the Safety and Efficacy of LHC165 Single Agent and in Combination With PDR001 in Patients With Advanced Malignancies

Solid Tumors

United States, Germany, Spain, Belgium, Korea, Republic of, Japan, Italy
Bristol-Myers Squibb

Completed

Phase II Study to Determine Predictive Markers of Response to BMS-734016 (MDX-010)

Unresectable Stage III or IV Malignant Melanoma

United States, Peru, Norway, Italy, Sweden, Denmark, Israel
PharmaMar

Completed

Clinical Trial of Lurbinectedin (PM01183) in Selected Advanced Solid Tumors

Advanced Solid Tumors

Spain, United States, Belgium, France, Italy, Switzerland, Germany, Sweden, United Kingdom
CatalYm GmbH

Recruiting

Neoadjuvant Immunotherapy in Combination With the Anti-GDF-15 Antibody Visugromab (CTL-002) for Treatment of Muscle Invasive Bladder Cancer

Adult Solid Tumor | Bladder Cancer

Italy
AstraZeneca

Recruiting

Investigating Safety, Tolerability, Efficacy and PK of Olaparib in Paediatric Patients With Solid Tumours

Solid Tumours

Australia, Korea, Republic of, Germany, United States, Spain, France, Canada, Italy, Austria, Israel, United Kingdom, Denmark, Hungary, Poland, Russian Federation, Ukraine, Brazil
Novartis Pharmaceuticals

Completed

Phase 1b Trial of BGJ398/BYL719 in Solid Tumors

Advanced Solid Tumors | Metastatic Solid Tumors

France, Netherlands, Spain, Canada, Singapore, Germany, Korea, Republic of, Australia, Belgium, Switzerland, Italy, United States
Bayer

Terminated

A Clinical Study of Anetumab Ravtansine in Adults With Solid Tumors Who Have Been Treated in Previous Bayer-sponsored Anetumab Ravtansine Studies

Solid Tumors

United States, Italy, France, Poland
Neuromed IRCCS

Recruiting

Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia (EpidemioPIT)

Hyperparathyroidism | Solid Tumor | Pituitary Tumor | Endocrine Neoplasia | Familial Tumor Syndrome

Italy
Novartis Pharmaceuticals

Terminated

A Study of BLZ945 Single Agent or BLZ945 in Combination With PDR001 in Advanced Solid Tumors

Advanced Solid Tumors

Spain, Japan, Taiwan, Italy, Switzerland, Israel, United States, Singapore
Gruppo Italiano per lo studio dei Carcinomi dell...
Regione Lombardia

Terminated

Low-Tox Vs Eox In Patients With Locally Advanced Unresectable Or Metastatic Gastric Cancer

Metastatic Gastric Cancer | Locally Advanced Unresectable Gastric Cancer

Italy
Bristol-Myers Squibb

Completed

An Efficacy Study in Gastric and Gastroesophageal Junction Cancer Comparing Ipilimumab Versus Standard of Care Immediately Following First Line Chemotherapy

Locally Advanced (Unresectable) or Metastatic Adenocarcinoma of the Gastric and Gastro-esophageal Junction

France, Poland, Russian Federation, Taiwan, United States, Hong Kong, Spain, Germany, Italy, Japan, Korea, Republic of, Singapore
Philogen S.p.A.

Completed

131I-L19SIP Radioimmunotherapy (RIT) in Combination With External Beam Radiation in Patients With Multiple Brain Metastases From Solid Tumors

Brain Metastases From Solid Tumors

Italy, United Kingdom
Sanofi

Terminated

A First-in-human Study of the Safety, Pharmacokinetics, Pharmacodynamics and Anti-tumor Activity of SAR439459 Monotherapy and Combination of SAR439459 and Cemiplimab in Patients With Advanced Solid Tumors

Malignant Solid Tumor

France, Spain, Australia, Belgium, Italy, United Kingdom, Taiwan, Estonia, Netherlands, Korea, Republic of, United States, Canada, Germany
Eli Lilly and Company

Active, not recruiting

A Study of LY3200882 in Participants With Solid Tumors

Solid Tumor

United States, Spain, Japan, France, Italy, Australia, Germany, Canada
Takeda

Completed

A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate, Midazolam, in Participants With ALK-Positive or ROS1-Positive Solid Tumors

Carcinoma, Advanced ALK+ or ROS1+Non-Small-Cell Lung, Neoplasm, Advanced ALK+ or ROS1+Solid Tumors

Spain, Italy, Netherlands, France
MedImmune LLC

Active, not recruiting

A Study to Evaluate MEDI5752 in Subjects With Advanced Solid Tumors

Selected Advanced Solid Tumors

Italy, Spain, United States, France, Korea, Republic of, Taiwan, Australia, Netherlands, Portugal
MedImmune LLC

Active, not recruiting

A Study of Durvalumab (MEDI4736) and Monalizumab in Solid Tumors

Advanced Solid Tumors

United States, Spain, Belgium, Italy, Korea, Republic of, Canada, Australia, Hungary, United Kingdom, France, New Zealand
Incyte Corporation

Recruiting

A Study to Evaluate the Efficacy and Safety of Pemigatinib Versus Chemotherapy in Unresectable or Metastatic Cholangiocarcinoma (FIGHT-302)

Metastatic Cholangiocarcinoma | Unresectable Cholangiocarcinoma

United States, Canada, Belgium, France, Germany, Italy, China, Spain, Japan, United Kingdom, Netherlands, Switzerland, Austria, Denmark, Finland, Ireland, Israel, Norway, Sweden
Astellas Pharma Global Development, Inc.
Merck Sharp & Dohme LLC

Completed

A Multiple-dose Study of ASP8374, an Immune Checkpoint Inhibitor, as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Advanced Solid Tumors

United States, Korea, Republic of, Taiwan, Portugal, Spain, United Kingdom, Italy, Canada, Japan
Bambino Gesù Hospital and Research Institute

Recruiting

Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors

Sarcoma | Osteosarcoma | Ewing Sarcoma | Neuroblastoma | Neuroblastoma Recurrent | GD2-positive Solid Tumors

Italy

Clinical Trials on Unresectable Solid Neoplasm in Italy

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