Clinical Trials on Vaginosis, Bacterial in South Africa

Total 1193 results

Queen Mary University of London
University of Cape Town

Completed

Trial of Vitamin D Supplementation in Cape Town Primary Schoolchildren (ViDiKids)

Latent Tuberculosis

South Africa
University of Cape Town
University of Stellenbosch; University of Cape Town Lung Institute; Ospedale... and other collaborators

Not yet recruiting

Test to Treat TB: Impact of Sputum Sequencing-guided Individualised Therapy on Outcomes in Drug-resistant Tuberculosis (T3-RCT)

Tuberculosis, Multidrug-Resistant

South Africa
Boston University
National Institute of Allergy and Infectious Diseases (NIAID); Centers for... and other collaborators

Completed

Efficacy and Safety of Levofloxacin for the Treatment of MDR-TB (Opti-Q)

Tuberculosis, Multidrug-Resistant

South Africa, Peru
National Institute of Allergy and Infectious Diseases...

Completed

Study of Pre-clearance of Latent Tuberculosis Infection And BCG Revaccination

Tuberculosis

South Africa
University of KwaZulu
Centre for the AIDS Programme of Research in South Africa

Recruiting

Pharmacokinetics of Twice or Once Daily DTG (50mg) in Children With HIV and TB (ORCHID)

Tuberculosis | Hiv

South Africa
Aeras
University of Oxford; European and Developing Countries Clinical Trials Partnership...

Completed

Efficacy Against TB Disease, Safety, and Immunogenicity of MVA85A/AERAS-485 in HIV-Infected Adults (C-030-485)

HIV Infections | Tuberculosis

South Africa, Senegal
CIPRA SA
National Institute of Allergy and Infectious Diseases (NIAID); Comprehensive...

Completed

Characteristics and Prevalence of Tuberculosis and HIV in Masiphumelele Township, Cape Town, South Africa

HIV Infections | Tuberculosis

South Africa
Case Western Reserve University
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Interferon-Gamma Release Assays in Tuberculosis (TB) - HIV Co-infected Children

HIV | Tuberculosis

South Africa
Farzanah Laher
Sanofi

Active, not recruiting

Pertussis Vaccination Among HIV-infected and HIV-uninfected Pregnant Women

dTap Vaccine

South Africa
University of Cape Town
Medical Research Council; University of Stellenbosch; Rockefeller Foundation

Completed

Isoniazid Prophylaxis With Concomitant Cotrimoxazole in HIV-infected Children

Tuberculosis

South Africa
University of Cape Town

Recruiting

Testing New Strategies for Patients Hospitalised With HIV-associated Disseminated Tuberculosis (NEW-STRAT TB)

HIV | Disseminated Tuberculosis

South Africa
Michael Hoelscher
Radboud University Medical Center; German Federal Ministry of Education and... and other collaborators

Completed

BTZ-043 - Multiple Ascending Dose (MAD) to Evaluate Safety, Tolerability and Early Bactericidal Activity (EBA)

Pulmonary Tuberculoses | Other Specified Pulmonary Tuberculosis

South Africa
University of Witwatersrand, South Africa

Completed

Effect of HIV and/or Active Tuberculosis on the Immune Responses to Trivalent Influenza Vaccine (TIV) in Adults (TIV_HIV_TB)

HIV | Tuberculosis | Influenza

South Africa
TASK Applied Science

Completed

Evaluating the EBA of Meropenem With Amoxicillin/Clavulanate and Pyrazinamide or Bedaquiline in Adults With PTB (TB_COMBO_01)

Tuberculosis

South Africa
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

Essentiality of INH in TB Therapy

Tuberculosis

South Africa
Novartis Vaccines

Completed

Safety and Immunogenicity of a Group B Streptococcus Vaccine in Non Pregnant and Pregnant Women 18-40 Years of Age

Streptococcal Infections

South Africa
Columbia University
Centre for the AIDS Programme of Research in South Africa

Not yet recruiting

An Adaptive Randomized Controlled Trial (ADAP-TIV)

HIV Infections | Multi Drug Resistant Tuberculosis

South Africa
Johns Hopkins University
National Institute of Allergy and Infectious Diseases (NIAID); University of...

Completed

Quantiferon Gold Test for Detecting Tuberculosis (TB) Infection in HIV/AIDS Patients in South Africa

HIV | Latent Tuberculosis

South Africa
University of Stellenbosch

Recruiting

Evaluation of New Biomarker-based Approaches for Improving the Diagnosis of Childhood Tuberculous Meningitis (TBMBIOMARKER)

Tuberculous Meningitis

South Africa
IDRI
South African Tuberculosis Vaccine Initiative; Aeras

Completed

Phase 1 ID93 + GLA-SE Vaccine Trial in BCG-Vaccinated Healthy Adult Volunteers

Pulmonary Tuberculosis

South Africa
French National Agency for Research on AIDS and...

Completed

Pharmacokinetics of Rifabutin Combined With Antiretroviral Therapy in Patients With TB/HIV Co-infection in South Africa

HIV Infections | Tuberculosis

South Africa
Klaus Reither
Radboud University Medical Center; Charite University, Berlin, Germany; Institute... and other collaborators

Recruiting

Tuberculosis Diagnostic Trial of CAD4TB Screening Alone Compared to CAD4TB Screening Combined With a CRP Triage Test, Both Followed by Confirmatory Xpert MTB/RIF Ultra in Communities of Lesotho and South Africa

Tuberculosis

Lesotho, South Africa
Aeras
Sanofi Pasteur, a Sanofi Company

Completed

Evaluation of Safety, Immunogenicity, and Prevention of TB With AERAS-404 and BCG Revaccination in Healthy Adolescents

Tuberculosis

South Africa
Global Alliance for TB Drug Development

Completed

Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis (TMC207-CL001)

Pulmonary Tuberculosis

South Africa
Centers for Disease Control and Prevention
Boston University; Pfizer; Columbia University; University of Texas; University of... and other collaborators

Completed

Linezolid Pharmacokinetics (PK) in Multi-Drug Resistant (MDR)/Extensively-Drug Resistant (XDR) Tuberculosis (TB) (S30PK)

Multi-Drug Resistant Tuberculosis | Extensively Drug Resistant Tuberculosis

South Africa
Otsuka Pharmaceutical Development & Commercialization...
Bill and Melinda Gates Foundation

Completed

A Phase 1/2 Trial of Multiple Oral Doses of OPC-167832 for Uncomplicated Pulmonary Tuberculosis

Pulmonary TB

South Africa
Case Western Reserve University
Thrasher Research Fund

Completed

Diagnosis of Tuberculosis Infection in HIV Co-infected Children (ThrasherIGRA)

HIV Infections | Tuberculosis | Latent Tuberculosis Infection

South Africa
IDRI
Wellcome Trust; South African Tuberculosis Vaccine Initiative

Completed

Phase 2a ID93 + GLA-SE Vaccine Trial in TB Patients After Treatment Completion

Pulmonary Tuberculosis

South Africa
University of Stellenbosch

Completed

Xpert Ultra and Xpert HIV-VL in People Living With HIV

HIV/AIDS | TB - Tuberculosis | Antiretroviral Therapy, Highly Active

South Africa
AIDS Clinical Trials Group
National Institute of Allergy and Infectious Diseases (NIAID)

Completed

High-Dose Isoniazid Among Adult Patients With Different Genetic Variants of INH-Resistant Tuberculosis (TB)

Tuberculosis

Haiti, South Africa
University of Cape Town
Baylor Research Institute

Completed

Pharmacometric Optimization of Second Line Drugs for MDR Tuberculosis Treatment (PODrtb)

Multidrug-resistant Tuberculosis

South Africa
The Aurum Institute NPC
Ludwig-Maximilians - University of Munich; Chris Hani Baragwanath Academic...

Completed

Tuberculosis as a Risk Factor for a Worse Outcome Post-Sars-CoV-2 Infection (Co-TB)

COVID-19 | Tuberculosis | Post-acute COVID-19 Syndrome

South Africa
Boston Medical Center
Boston University; National Institute of Allergy and Infectious Diseases (NIAID) and other collaborators

Completed

The Impact of Alcohol Consumption on Tuberculosis Treatment Outcomes

Tuberculosis | Alcohol Consumption | Treatment Adverse Effect

South Africa
Archivel Farma S.L.
Parexel

Completed

Clinical Trial to Investigate the Safety, Tolerability, and Immunogenicity of the Novel Antituberculous Vaccine RUTI® Following One Month of Isoniazid Treatment in Subjects With Latent Tuberculosis Infection

Tuberculosis | Latent Tuberculosis Infection

South Africa
Helen Reynolds
Desmond Tutu HIV Centre; Infectious Disease Institute, Kampala, Uganda

Active, not recruiting

Drug Interactions Between Dolutegravir and Escalating Doses of Rifampicin (DoRIS)

Tuberculosis | Hiv

Uganda, South Africa
Thirty Respiratory Limited

Recruiting

Evaluating the Early Bactericidal Activity, Safety and Tolerability of Nebulised RESP301 in Adults With Tuberculosis

Rifampicin Susceptible Pulmonary Tuberculosis

South Africa
University of Stellenbosch
University of Pittsburgh

Unknown

TB-IRIS NSAID Cox-2 Inhibitor Prevention Trial

Tuberculosis

South Africa
University of Cape Town
Wellcome Trust; Medecins Sans Frontieres, Netherlands

Completed

Standard Versus Double Dose Dolutegravir in Patients With HIV-associated Tuberculosis (RADIANT-TB)

HIV Infections | Tuberculosis

South Africa
University of Cape Town
Imperial College London; Institute of Tropical Medicine, Belgium; European and... and other collaborators

Completed

Preventing TB-IRIS in High-risk Patients: a Randomized Placebo-controlled Trial of Prednisone (Pred-ART)

HIV | Tuberculosis | Immune Reconstitution Inflammatory Syndrome

South Africa
TASK Applied Science
GlaxoSmithKline; European and Developing Countries Clinical Trials Partnership...

Recruiting

EBA, Safety and Tolerability of Sanfetrinem Cilexetil

Tuberculosis, Pulmonary

South Africa
Aeras
Statens Serum Institut

Completed

A Phase I/IIa AERAS-456 in HIV-Negative Adults With & Without Latent Tuberculosis Infection (C-035-456)

Latent Tuberculosis | Latent Tuberculosis Bacteriology and Histology Unknown

South Africa
Sanofi Pasteur, a Sanofi Company

Completed

DTaP-IPV-HB-PRP-T Combined Vaccine as a Primary Series and a Second Year of Life Booster in HIV-Exposed Infected and Uninfected Infants

Hepatitis B | Pertussis | Tetanus | Diphtheria | Polio | Human Immunodeficiency Virus Infection

South Africa
University of Cape Town
University of Stellenbosch; University of Cape Town Lung Institute; University... and other collaborators

Completed

An Open-label RCT to Evaluate a New Treatment Regimen for Patients With Multi-drug Resistant Tuberculosis (NEXT)

Tuberculosis | Multidrug Resistant Tuberculosis | Extensively-drug Resistant Tuberculosis

South Africa
Johns Hopkins University
National Institute of Allergy and Infectious Diseases (NIAID); University of... and other collaborators

Recruiting

Bring BPaL2Me Trial Comparing Nurse-Led RR-TB Treatment to Physician-Led RR-TB Treatment

Drug Resistant Tuberculosis

South Africa
University of Stellenbosch
London School of Hygiene and Tropical Medicine; Makerere University; Leiden University... and other collaborators

Recruiting

Point-of-care Triage Test for Active Tuberculosis (TriageTB)

Tuberculosis | Tuberculosis, Pulmonary

South Africa
University of Stellenbosch
Fundació Institut Germans Trias i Pujol

Recruiting

Nyaditum Resae® as a Co-adjuvant During Treatment for Active Pulmonary Tuberculosis and Its Impact on the Gut Microbiota

Tuberculosis

South Africa
TASK Applied Science
GlaxoSmithKline; Research Center Borstel; Eduardo Mondlane University; Barcelona...

Completed

Phase 2 Trial to Evaluate the Early Bactericidal Activity, Safety and Tolerability of Meropenem Plus Amoxycillin/CA and Faropenem Plus Amoxycillin/CA in Adult Patients With Newly Diagnosed Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
Global Alliance for TB Drug Development

Completed

PA-824-CL-007: Phase IIa Evaluation of Early Bactericidal Activity in Pulmonary Tuberculosis

Pulmonary Tuberculosis

South Africa
Foundation for Professional Development (Pty) Ltd
National Institutes of Health (NIH); University of California, Irvine; National... and other collaborators

Completed

Acceptability and Feasibility of Home-based TB Testing

Tuberculosis, Pulmonary | Households

South Africa
BioNTech SE

Recruiting

Safety and Immune Responses After Vaccination With Two Investigational RNA-based Vaccines Against Tuberculosis in BCG Vaccinated Volunteers

Tuberculosis

South Africa

Clinical Trials on Vaginosis, Bacterial in South Africa

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