Clinical Trials on Xerostomia in Canada

Total 27 results

MeiraGTx, LLC

Active, not recruiting

Long-Term Follow-Up Study of AAV2hAQP1 for Radiation Induced Xerostomia

Radiation-induced Xerostomia

United States, Canada
Ottawa Hospital Research Institute

Unknown

Coconut Oil: Managing Radiation-Induced Xerostomia

Xerostomia

Canada
MeiraGTx UK II Ltd

Completed

A Phase 1 Open-Label, Dose Escalation Study to Determine the Optimal Dose, Safety, and Activity of AAV2hAQP1 in Subjects With Radiation-Induced Parotid Gland Hypofunction and Xerostomia

Head and Neck Cancer | Radiation-Induced Parotid Gland Hypofunction | Xerostomia Due to Radiotherapy

United States, Canada
AHS Cancer Control Alberta
Cross Cancer Institute

Unknown

A Pilot Study to Evaluate the Feasibility of Combining Submandibular Salivary Gland Tx & IMRT Tomo to Reduce Xerostomia

Head and Neck Cancer

Canada
Brock University
Dr. Peter C. Fritz, Periodontal Wellness & Implant Surgery

Completed

Periodontal Outcomes After Sanative Therapy

Periodontal Diseases | Xerostomia | Periodontal Pocket | Dry Mouth

Canada
Alberta Health services
Ottawa Hospital Research Institute; Jewish General Hospital; CancerCare Manitoba and other collaborators

Completed

Trial Comparing Oral Pilocarpine (Salagen) Versus Submandibular Salivary Gland Transfer Protocol, For the Prevention of Radiation (XRT) Induced Xerostomia in Head and Neck Cancer Patients

Cancer | Head and Neck Cancer

Canada
MeiraGTx, LLC

Recruiting

A Study of AAV2-hAQP1 Gene Therapy in Participants With Radiation-Induced Late Xerostomia (AQUAX2)

Grade 2 and 3 Late Xerostomia Caused by Radiotherapy for Cancers of the Upper Aerodigestive Tract, Excluding the Parotid Glands

United States, Canada
AHS Cancer Control Alberta
Cross Cancer Institute

Completed

Xerostomia in Head and Neck Cancer Patients Receiving Radiation as the Primary Treatment Versus Patients Who Will Not Have Such a Procedure

Head and Neck Cancer

Canada
University of Toronto
University Health Network, Toronto; Sunnybrook Health Sciences Centre; Unity... and other collaborators

Completed

De-adoption of Oral Chlorhexidine Prophylaxis and Implementation of an Oral Care Bundle (CHORAL) (CHORAL)

Mortality | Oral Health | Pain, Orofacial | Dryness, Mouth

Canada
Universidad de Granada
Instituto de Salud Carlos III

Completed

Drug-induced Xerostomia. Evaluation of Malic Acid 1%, Salivary Mucins and Buffering Capacity

Depression | Hypertension | Xerostomia

Spain
Universidad de Granada

Recruiting

Photobiomodulation Therapy Plus M-health in Head and Neck Cancer Patients: LAXER Study (LAXER)

Head and Neck Cancer | Head and Neck Neoplasms | Xerostomia

Spain
Universidad de Granada

Completed

Photobiomodulation Therapy in Patients With Head and Neck Cancer Post-Radiotherapy

Head and Neck Cancer | Head and Neck Neoplasms | Xerostomia

Spain
Alcon Research

Completed

Assessment of Inflammatory Biomarkers Expressed in a Sjogren's Population: Effect of a Topical Steroid Intervention

Sjogren's Syndrome

Canada
University of Waterloo
Sjogren's Society of Canada

Completed

Effect of Debridement-scaling on the Relief of Dry Eye Signs and Symptoms in Sjogren's Syndrome (TOYOTA)

Sjogren's Syndrome

Canada
University of Waterloo
Alcon Research

Completed

Assessment of Inflammatory and Functional Changes in the Ocular Surface Associated With Dry Eye Disease (JADE)

Dry Eye | Sjogren's Syndrome

Canada
Radiation Therapy Oncology Group
National Cancer Institute (NCI); NRG Oncology

Completed

Acupuncture-Like Transcutaneous Electrical Nerve Stimulation (ALTENS) or Pilocarpine in Treating Early Dry Mouth in Patients Undergoing Radiation Therapy for Head and Neck Cancer

Head and Neck Cancer | Xerostomia

United States, Canada
Radiation Therapy Oncology Group
National Cancer Institute (NCI)

Completed

Salivary Gland Surgery Before Radiation Therapy in Preventing Radiation-Caused Xerostomia in Patients With Head and Neck Cancer

Head and Neck Cancer | Xerostomia | Radiation Toxicity

United States, Canada
Alpine Immune Sciences, Inc.

Completed

Cell Surface Marker Expression in Autoimmune Diseases (CASCADE)

Multiple Sclerosis | Systemic Lupus Erythematosus | Systemic Sclerosis | Crohn's Disease | Ulcerative Colitis | Sjogren's Syndrome | Inflammatory Myositis

Canada
GlaxoSmithKline

Completed

Safety and Efficacy Study of Subcutaneous Belimumab and Intravenous Rituximab Co-administration in Subjects With Primary Sjogren's Syndrome

Sjogren's Syndrome

Spain, France, Germany, Netherlands, United Kingdom, Sweden, Argentina, Italy, Canada, Norway
Sanofi

Completed

Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS) (phaethuSA)

Sjogren's Syndrome | Sjögren's Syndrome

Belgium, Taiwan, Korea, Republic of, United States, Argentina, Canada, Chile, France, Germany, Hungary, Mexico, Spain
Amgen

Recruiting

A Study to Evaluate the Efficacy and Safety of Dazodalibep in Participants With Sjögren's Syndrome (SS) With Moderate-to-severe Systemic Disease Activity

Sjogren's Syndrome

Israel, Chile, United States, Argentina, Canada, Japan, Korea, Republic of
Novartis Pharmaceuticals

Active, not recruiting

Study of Safety and Tolerability of CFZ533 in Patients With Sjögren's Syndrome (TWINSS Extn)

Sjogren's Syndrome

United Kingdom, Netherlands, Australia, Austria, Israel, France, Germany, Greece, Hungary, Italy, United States, Korea, Republic of, Japan, Portugal, Russian Federation, Turkey, Canada, Colombia, Romania, Argentina, Chile, Brazil, S...
Novartis Pharmaceuticals

Recruiting

A Randomized, Double-blind 2-arm NEPTUNUS Extension Study to Assess the Long-term Safety and Efficacy of Ianalumab in Patients With Sjogrens Syndrome. (NEPTUNUS-Ext)

Sjogrens Syndrome

United States, Spain, Austria, Belgium, Japan, Poland, Germany, Turkey, Hungary, Israel, Italy, France, Argentina, Portugal, Taiwan, Australia, Slovakia, United Kingdom, Guatemala, Brazil, Czechia, Bulgaria, Canada, Lithuania, Romania
Novartis Pharmaceuticals

Completed

Study of Safety and Efficacy of Multiple Doses of CFZ533 in Two Distinct Populations of Patients With Sjogren's Syndrome (TWINSS)

Sjögren Syndrome

United States, United Kingdom, Netherlands, Australia, Austria, Israel, France, Germany, Greece, Hungary, Italy, Korea, Republic of, Japan, Portugal, Russian Federation, Turkey, Canada, Colombia, Romania, Argentina, Chile, Brazil, S...
Bristol-Myers Squibb

Recruiting

A Study to Evaluate the Efficacy and Safety of Deucravacitinib in Adults With Active Sjögren's Syndrome (POETYK SjS-1)

Sjögren's Syndrome

United States, Australia, Germany, Korea, Republic of, Austria, China, Japan, Puerto Rico, Poland, Canada, Hungary, Spain, Argentina, Chile, Denmark, France, Italy, Mexico, Peru, Netherlands, Belgium, Brazil, Colombia, United Kingdom, P... and more
Novartis Pharmaceuticals

Recruiting

Three-arm Study to Assess Efficacy and Safety of Ianalumab (VAY736) in Patients With Active Sjogren's Syndrome (NEPTUNUS-2)

Sjogren Syndrome

United States, Spain, Hungary, Germany, Brazil, Israel, Canada, Chile, Colombia, Argentina, Greece, United Kingdom, Australia, Bulgaria, Japan, Mexico, South Africa, China, Lebanon, Taiwan, Italy, France, Romania, India, Poland, Slovakia, S...
National Cancer Institute (NCI)

Recruiting

Nivolumab in Treating Patients With Autoimmune Disorders and Advanced, Metastatic, or Unresectable Cancer

Hematopoietic and Lymphoid Cell Neoplasm | Malignant Solid Neoplasm | Multiple Sclerosis | Rheumatoid Arthritis | Systemic Lupus Erythematosus | Psoriasis | Systemic Scleroderma | Crohn Disease | Ulcerative Colitis | Dermatomyositis | Psoriatic Arthritis | Inflammatory Bowel Disease | Autoimmune Disease | Sjogren...

United States, Canada

Clinical Trials on Xerostomia in Canada

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