Clinical Trials on ctDNA Genotype

Total 179 results

University of Southern Denmark
Odense University Hospital

Terminated

Development of Cocktail for Measuring the Activity of Important Cytochrome P450 Enzymes

Cytochrome P450 Phenotype and Genotype Metrics

Denmark
Peking University

Recruiting

Targeted Treatment Plus Tislelizumab and HAIC for Advanced CRCLM Failed From Standard Systemic Treatment

Liver Metastasis Colon Cancer | MSS | ctDNA Genotype | Failed From Standard Treatment

China
Fudan University

Unknown

Multi Dimensional Precise Exploration of Immunoconsolidation Therapy for Locally Advanced NSCLC After Chemo-radiotherapy (NSCLC)

NSCLC | Chemoradiotherapy | ctDNA

China
Chinese Academy of Sciences
LanZhou University

Completed

Cytochrome P450 2C19 Variant is Related to Pharmacokinetics of Glipizide Extended Release Tablet in Chinese Subjects

Pharmacokinetic | Genotype

China
Biohaven Pharmaceuticals, Inc.

Active, not recruiting

Trial in Adult Subjects With Spinocerebellar Ataxia

Spinocerebellar Ataxias | Spinocerebellar Ataxia Genotype Type 1 | Spinocerebellar Ataxia Genotype Type 2 | Spinocerebellar Ataxia Genotype Type 3 | Spinocerebellar Ataxia Genotype Type 6 | Spinocerebellar Ataxia Genotype Type 7 | Spinocerebellar Ataxia Genotype Type 8 | Spinocerebellar Ataxia Genotype...

United States
Bristol-Myers Squibb

Completed

Study of the Safety & PK of INX-08189 in Chronically-infected HCV, Treatment-naïve Subjects

HCV (Genotype 1)

United States, Puerto Rico
Sequenom, Inc.
NAFTNet

Completed

A Noninvasive Test for Fetal RHD Genotype (NAFTnet RHD)

Rhesus D Genotype

United States, Canada
Sequenom, Inc.
Sequenom Center for Molecular Medicine

Completed

Evaluation of a Noninvasive Fetal RHD Genotyping Test (IRIS)

Rhesus D Genotype

United States
Matthias Schwab

Completed

Open Label Study for the Functional Characterization of Drug Metabolism and Transport (IKP243)

Genotype-related Drug Metabolism

Germany
California Pacific Medical Center Research Institute
Children's Mercy Hospital Kansas City

Withdrawn

The Impact of Genetic Variation in CYP2D6 on the Pharmacokinetics and Pharmacodynamics of Methamphetamine

Methamphetamine Metabolism, CYP2D6 Genotype

United States
Samsung Medical Center

Unknown

Isoniazid Dosage Prediction Model Development

NAT2 Genotype

Korea, Republic of
National Research Council, Spain
IMDEA Food; CEIP (primary school) Jara Carrillo (Alcantarilla, Murcia, Spain); IES (secondary school) Alcántara (Alcantarilla, Murcia, Spain)

Completed

Genotype, Metabotype and Diet in a Cohort of Children and Adolescents From the Southeast of Spain. (PolyMicroBio)

Genotype, Metabotype and Dietary Habits

Spain
Inje University

Completed

STUDY The Effect of HNF-4A G60D Variant on the In VIVO CYP2D6 Activity By Tolterodine Pharmacokinetic Study (HNF4a)

Healthy Subjects | Genotype Guided(HNF4a)
Bispebjerg Hospital
University of Copenhagen; Duke University; The Ministry of Science, Technology... and other collaborators

Completed

Metabolism of Methylphenidate and Enalapril Based on CES1 Genotype

Carboxylesterase 1 (CES1) Genotype | CES1 Activity

Denmark
Second Affiliated Hospital of Soochow University

Unknown

Preoperative and Postoperative ctDNA Comparison in Early Stage Lung Cancer

Preoperative and Postoperative ctDNA Comparison in Early Stage Lung Cnacer

China
National Taiwan University Hospital

Not yet recruiting

UGT1A1 Genotyping in Taiwanese Cancer Patients

The Influence of the UGT1A1 Genotype
Bispebjerg Hospital
University of Copenhagen; Duke University; The Ministry of Science, Technology... and other collaborators

Completed

Impact of CES1 Genotype on Metabolism of Methylphenidate

Carboxylesterase 1 (CES1) Genotype | CES1 Activity

Denmark
University of Southern Denmark

Completed

Impact of CYP2C19*17 on the Pharmacokinetics of Proguanil and Clopidogrel

CYP2C19 Genotypes

Denmark
Northwell Health

Terminated

1/2-MC4R Genotype and Pediatric Antipsychotic Drug- Induced Weight Gain

High Risk MC4R Genotype | Low Risk MC4R Genotype | One Week or Less Antipsychotic Lifetime Exposure

United States
Indiana University
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Evaluate Pharmacokinetics and Safety of Slow Release DHEA (DHEA)

Asthma | Genotype

United States
University Medical Center Ho Chi Minh City (UMC)

Recruiting

Detection of Plasma Circulating Tumor DNA in Gastric Cancer

Gastric Cancer | Circulating Tumor DNA (ctDNA)

Vietnam
chenwu

Recruiting

Potential Clinical Utilities of Circulating Tumor DNA in Advanced HER2 Negative Gastric Cancer

Gastric Cancer | Circulating Tumor DNA (ctDNA)

China
Krishnadevaraya College of Dental Sciences & Hospital

Not yet recruiting

Comparison of Microneedling and CTG for Gingival Augmentation- A RCT

Gingival Phenotype
Central Hospital, Nancy, France

Recruiting

FAMILY INHERITANCE, GENE-GENE AND GENE-ENVIRONMENT INTERACTIONS IN THE FIELD OF CARDIOVASCULAR AND RENAL DISEASES. Fifth Visit of the STANISLAS Cohort

Cardiovascular Diseases | Risk Factors | Nutrition | Cohort Studies | Genotype

France
London School of Hygiene and Tropical Medicine
University of Ulster

Terminated

Pilot Evaluation of the Effect of Riboflavin Supplementation on Blood Pressure and Possible Effect Modification by the MTHFR C677T Genotype (RiboBP)

High Blood Pressure | MTHFR C677T Genotype

Gambia
Hacettepe University

Completed

Can Modified Coronally Advanced Tunnel be an Alternative in Gingival Phenotype Modification?

Gingival Phenotype

Turkey
Gilead Sciences

Completed

Efficacy and Safety of Ledipasvir/Sofosbuvir Fixed-Dose Combination in Treatment-Naive and Treatment-Experienced Subjects With Chronic Genotype 4 or 5 HCV Infection

Chronic Genotype 4 HCV | Chronic Genotype 5 HCV

France
National Eye Institute (NEI)

Recruiting

Genotype-Phenotype Study of Patients With Plaquenil -Induced Retinal Toxicity, With Evaluation of the ABCA4 Gene

Retinal Disease | Genotype

United States
Children's Mercy Hospital Kansas City
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

Biomarkers of CYP2D6 and CYP3A4 Variability in Pediatrics

Drug Metabolism Phenotype

United States
Korea University Anam Hospital
National Cancer Center, Korea; Korean Breast Cancer Study Group

Unknown

CYP2D6 Genotype on the Clinical Effect of Tamoxifen (ASTRRA-CYP2D6)

Breast Neoplasms | Genotype | Tamoxifen | CYP2D6

Korea, Republic of
Shenzhen People's Hospital

Enrolling by invitation

Significance of MRD After Surgery in Driver Gene-positive and Driver Gene-negative Stage IB-IIA NSCLC

NSCLC MRD ctDNA

China
Herlev Hospital

Completed

Study of the Correlation Between Specific Genes and Cognitive Dysfunction After Surgery

Cognitive Impairment | Genotype

Denmark
Fudan University
Guangzhou Burning Rock Dx Co., Ltd.

Recruiting

Predictive Value of ctDNA for NED Status in mCRC and Its Utility in Guiding Therapeutic Intervention

Metastatic Colorectal Cancer | No Evidence of Disease Status | ctDNA Monitoring

China
University Medical Center Ho Chi Minh City (UMC)

Recruiting

Monitoring Minimal Residual Disease in Gastric Cancer by Liquid Biopsy Study Description

Gastric Cancer | ctDNA

Vietnam
Misr International University

Recruiting

Assessment of Gingival Thickness Using Colored Periodontal Probe

Gingival Phenotype

Egypt
Sixth Affiliated Hospital, Sun Yat-sen University

Unknown

The Implication of ctDNA in the Recurrence Surveillance of Stage II and III Colorectal Cancer

Colorectal Cancer | Surveillance | ctDNA

China
Soroka University Medical Center

Completed

Measurement of Circulating Cell-free DNA (cfDNA) for Diagnosis and Prognosis of Various Diseases and Evaluation of Tissue Damage

Correlation of cFDNA During CPB to Laboratories SIRS Parameters and Clinical Outcomes
Seoul National University Hospital

Completed

Clinical Trial to Evaluate the Influence of Genotype on the Pharmacokinetics/Pharmacodynamics of Clopidogrel

Influence of Genotype of Drug Metabolizing Enzyme or Transporter on the Pharmacokinetics/Pharmacodynamics of Clopidogrel | Influence of Aspirin on the Pharmacokinetics/Pharmacodynamics of Clopidogrel

Korea, Republic of
National Institute of Mental Health (NIMH)

Completed

Magnetic Resonance Imaging (MRI) of Neuropsychiatric Patients and Healthy Volunteers

fMRI | Brain Disease | Brain Mapping | Genotype | Allelic Frequencies of Genetic Markers

United States
The University of Hong Kong
The Hong Kong Polytechnic University; Griffith University

Completed

Physical Exercise Training to Enhance Executive and Social Functions

Broad Autism Phenotype

Hong Kong
Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.

Completed

A Phase III Study to Evaluate Efficacy and Safety of TG-2349 in Combination With DAG181 and RBV for HCV Type I Patients

Cirrhosis | Chronic Hepatics C Virus (HCV) Genotype 1 | Non-Cirrhotic | Treatment naïve

China
Eunice Kennedy Shriver National Institute of Child...

Not yet recruiting

Implications of Maternal 45,X Mosaicism as a Secondary Genomic Finding Following Cell-Free DNA Sequencing During Pregnancy: A Deep Phenotype Study

Cardiovascular Phenotype | Metabolic Phenotype | Hypertensive Disease | Psychological Phenotype | Audio

United States
Dongguan HEC TaiGen Biopharmaceuticals Co., Ltd.
Peking University People's Hospital

Completed

To Evaluate Efficacy and Safety in TG-2349 Combination With DAG181 (± Ribavirin) in HCV Genotype I Infected Patients

Cirrhosis | Chronic Hepatics C Virus (HCV) Genotype 1 | Non-Cirrhotic | Treatment naïve

China
University of Alabama at Birmingham
National Institutes of Health (NIH); Mereo BioPharma

Completed

Alvelestat (MPH966) for the Treatment of ALpha-1 ANTitrypsin Deficiency (ATALANTa)

Emphysema or COPD | Alpha-1 Antitrypsin Deficiency (AATD) | Pi*ZZ, Pi*SZ, Pi*Null, Another Rare Phenotype/Genotype Known to be Associated With Either Low or Functionally Impaired AAT Including F or I Mutations

United States
Claus Lindbjerg Andersen
University of Aarhus

Recruiting

ctDNA-guided Surveillance for Stage III CRC, a Randomized Intervention Trial (IMPROVE-IT2)

Gastrointestinal Neoplasms | Colonic Diseases | Colorectal Neoplasms | Rectal Diseases | Colorectal Cancer | Rectal Cancer | Rectal Neoplasms | Colonic Neoplasms | Gastrointestinal Cancer | Colo-rectal Cancer | Colonic Cancer | Digestive System Neoplasm | Digestive System Disease | Gastro-Intestinal Disorder | ctDNA

Denmark
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Clofarabine, Idarubicin, Cytarabine, Vincristine Sulfate, and Dexamethasone in Treating Patients With Newly Diagnosed or Relapsed Mixed Phenotype Acute Leukemia

Recurrent Mixed Phenotype Acute Leukemia | Acute Leukemia of Ambiguous Lineage | Acute Undifferentiated Leukemia | Acute Bilineal Leukemia | Acute Biphenotypic Leukemia | Mixed Phenotype Acute Leukemia | Mixed Phenotype Acute Leukemia, B/Myeloid, Not Otherwise Specified | Mixed Phenotype Acute Leukemia...

United States
Universitas Padjadjaran

Completed

Disorders of Sex Development (DSD) 46.XY in Three Siblings

Genotype

Indonesia
ANRS, Emerging Infectious Diseases
Bristol-Myers Squibb

Completed

Therapy With Asunaprevir, Daclatasvir, Ribavirin and Pegylated Interferon Alpha-2a in HCV Genotype 4-infected Patients Who Have Failed to a Previous Therapy With Peg-Interferon/Ribavirin (ANRS HC32 QUATTRO)

Hepatitis C Virus Genotype 4 Infection

France
University of Ulster
DSM Nutritional Products, Inc.

Unknown

RIBOGENE: Optimisation of Riboflavin Status in Hypertensive Adults With a Genetic Predisposition to Elevated Blood Pressure (RIBOGENE)

Participants With the MTHFR 677TT Genotype

United Kingdom
University Hospital, Montpellier

Not yet recruiting

French Assessment of MRD by Liquid Biopsies in Colorectal With Liver Metastasis Patients (FRENCH.MRD.CRLM)

Colorectal Cancer | Liver Metastases | Minimal Residual Disease | Liquid Biopsy | Stage IV Colorectal Cancer | ctDNA

Clinical Trials on ctDNA Genotype

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in United Arab Emirates

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations