Search clinical trials for: [14C]-TVB-2640

Total 4220 results

Sagimet Biosciences Inc.

Active, not recruiting

Open-label Study of the Absorption, Metabolism, and Excretion of [14C]TVB-2640 Following a Single Oral Dose in Healthy Male Subjects

Healthy Volunteers

United States
Sagimet Biosciences Inc.

Completed

A Phase 1, First-In-Human Study of Escalating Doses of Oral TVB-2640 in Patients With Solid Tumors

Solid Malignant Tumor

United Kingdom, United States
David E Gerber
Cancer Prevention Research Institute of Texas; Sagimet Biosciences Inc.

Recruiting

Phase 2 Study of TVB-2640 in KRAS Non-Small Cell Lung Carcinomas

KRAS Gene Mutation

United States
Ascletis Pharmaceuticals Co., Ltd.

Completed

Ascending Single-dose Study to Evaluate TVB-2640 in Chinese Healthy Subjects

Healthy

China
Weill Medical College of Cornell University
Sagimet Biosciences Inc.

Recruiting

Study of TVB-2640 in Men With Metastatic Castration-Resistant Prostate Cancer

Prostatic Neoplasms, Castration-Resistant

United States
Sagimet Biosciences Inc.

Completed

A Phase I Pharmacokinetic Study of TVB-2640 (Denifanstat) in Subjects With Mild, Moderate, or Severe Hepatic Impairment Compared to Subjects With Normal Hepatic Function

Cirrhosis | Hepatic Impairment | Non-alcoholic Steatohepatitis

United States, Hungary
Sagimet Biosciences Inc.

Completed

Study of TVB 2640 in Subjects With Non-Alcoholic Steatohepatitis (NASH)

Non-Alcoholic Fatty Liver Disease

China, United States
Sagimet Biosciences Inc.

Completed

Study of TVB-2640 in Subjects With Nonalcoholic Steatohepatitis (NASH)

Nonalcoholic Fatty Liver Disease

United States, Canada, Puerto Rico, Poland
Hoffmann-La Roche

Completed

Mass Balance and Absolute Bioavailability Study of RO7049389 in Healthy Volunteers

Healthy Volunteers

United Kingdom
Mark Evers
National Cancer Institute (NCI)

Recruiting

TVB 2640 for Resectable Colon Cancer Other Resectable Cancers; a Window Trial.

Colon Cancer

United States
Genentech, Inc.

Completed

Evaluation Comparing Tau PET Radiotracers, [18F]GTP1 and [18F]PI-2620 or [18F]MK-6240 in Subjects With Normal Cognition or Prodromal to Moderate Alzheimer's Disease

Alzheimer Disease (AD)

United States
University of Southern California
National Institute on Aging (NIA); Northern California Institute of Research... and other collaborators

Recruiting

Alzheimer's Disease Neuroimaging Initiative 4 (ADNI4)

Dementia | Alzheimer Disease | Mild Cognitive Impairment

United States, Canada
Vivozon, Inc.

Completed

Absorption, Metabolism, Excretion, and Mass Balance Study of [14C]-VVZ-149 in Healthy Adult Male Subjects

Healthy Adult Male

United States
Drugs for Neglected Diseases

Completed

ADME Study of Acoziborole in Healthy Subjects

Trypanosomiases, African

United Kingdom
Rachel Lieberman

Terminated

Capsular Tension Rings in Intraocular Lens Rotation

Cataract | Ophthalmoplegia | Ophthalmologic Complication

United States
The University of Texas Health Science Center at...

Completed

TVB- 2640 in Combination With Bevacizumab in Patients With First Relapse of High Grade Astrocytoma

Astrocytoma

United States
Ascletis Pharmaceuticals Co., Ltd.

Recruiting

Study to Evaluate the Safety and Efficacy of ASC40 Tablets in Combination With Bevacizumab in Subjects With rGBM

Recurrent Glioblastoma

China
Taisho Pharmaceutical Co., Ltd.

Completed

Mass Balance Study of TS-142 in Healthy Adult Subjects.

Healthy Male Subjects

Japan
Teva Branded Pharmaceutical Products R&D, Inc.
Covance

Terminated

A Study to Investigate the Absorption, Metabolism and Excretion of Talampanel

Healthy

United States
Hoffmann-La Roche

Completed

A Study to Determine the Excretion Balance, Pharmacokinetics, Metabolism and Absolute Oral Bioavailability of a Single Oral Dose of [14C]-Labeled Idasanutlin and an Intravenous Tracer Dose of [13C]-Labeled Idasanutlin in a Single Cohort of Participants With Solid Tumors (Malignancies)

Solid Tumors

Hungary
Jose Gutierrez, MD, MPH

Enrolling by invitation

Accelerated Non-Atherosclerotic Brain Arterial Aging Relationship to Alzheimer's Disease

Dementia | Alzheimer Disease

United States
University of Southern California
National Institute on Aging (NIA); Alzheimer's Therapeutic Research Institute; Alzheimer's Clinical Trials Consortium

Recruiting

Trial-Ready Cohort-Down Syndrome (TRC-DS) (TRC-DS)

Dementia | Alzheimer Disease | Down Syndrome

United States, Spain, United Kingdom
José A. Luchsinger
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); Albert... and other collaborators

Terminated

Brain Imaging in the Diabetes Prevention Program Outcomes Study (DPPOS-Brain)

Alzheimer Disease

United States
University of Missouri-Columbia
Sagimet Biosciences Inc.

Completed

Evaluation of 3-V Bioscience-2640 to Reduce de Novo Lipogenesis in Subjects With Characteristics of Metabolic Syndrome

Metabolic Syndrome

United States
Laekna Limited

Completed

Human Mass Balance and Biotransformation Study of [14C]Afuresertib

Healthy Volunteer

China
Arcus Biosciences, Inc.
Gilead Sciences

Completed

A Study Investigating the Safety, Absorption, and Elimination of Radioactively Labeled Etrumadenant, a New Compound in the Treatment of Cancer

Healthy Participants

Netherlands
Indivior Inc.

Completed

Single Dose Study of [14C]-IDV184001AN ([14C]-IDV184001) in Healthy Adult Male Participants

Opioid Use Disorder

United States
Biogen
Denali Therapeutics Inc.

Completed

A Study of Mass Balance, Pharmacokinetics, Metabolite Profile, and Metabolite Identification of BIIB122/DNL151 in Healthy Male Subjects

Healthy Volunteers

United States
Reata, a wholly owned subsidiary of Biogen

Completed

A Human AME Study for Omaveloxolone

Healthy Male Subjects

United States
Cyclerion Therapeutics

Completed

A Trial to Study the Absorption, Metabolism, and Excretion of [14C]-Olinciguat in Healthy Male Volunteers

Healthy Volunteers

United States
Athira Pharma
Alturas Analytics, Inc.; Labcorp Drug Development Inc

Completed

A Study of the Absorption, Metabolism, and Excretion of [14C]-Fosgonimeton (ATH-1017)

Healthy Volunteers

United States
Denovo Biopharma LLC

Completed

A Study of LY2140023 in Healthy Participants

Healthy Participants

United Kingdom
Biogen
Denali Therapeutics Inc.

Completed

A Study to Determine the Absolute Bioavailability of BIIB122/DNL151 in Healthy Subjects

Healthy Volunteers

United States
AstraZeneca
Quotient Sciences

Completed

Study Evaluating the Pharmacokinetic and Mass Balance of Single Dose [14C] AZD5718 in Volunteers

Cardiovascular Disease

United Kingdom
Merck Sharp & Dohme LLC

Completed

[18F]MK-6240 Positron Emission Tomography (PET) Tracer First-in-Human Validation Study (MK-6240-001)

Alzheimer's Disease | Amnestic Mild Cognitive Impairment
Adam Brickman
National Institute on Aging (NIA)

Completed

Alzheimer's PET Imaging in Racially/Ethnically Diverse Adults

Alzheimer Disease

United States
Tammie L. S. Benzinger, MD, PhD

Enrolling by invitation

Study of Tau Imaging With the Use of [18F]MK-6240 Tracer (MKADAD)

Alzheimer Disease

United States
University of Pennsylvania
National Institutes of Health (NIH)

Recruiting

PET Imaging Tau Accumulation in FTLD and Atypical Alzheimer's Using PI-2620

Alzheimer Disease | Frontotemporal Lobar Degeneration | Cognitively Normal

United States
Blade Therapeutics

Withdrawn

Healthy Volunteer Study Comparing Tablet and Capsule Formulations

Fibrosis

Australia
Alma Lasers Inc.

Unknown

Epidermal Delivery of Ani-Aging Ingredients

Acne Scars | Wrinkles | Pigmentation

United States
Celgene

Not yet recruiting

A Study to Evaluate the Drug Levels, Metabolism and Excretion, and Absolute Bioavailability of BMS-986365 in Healthy Male Participants

Healthy Volunteers

United States
Pfizer
Arvinas Estrogen Receptor, Inc.

Completed

A Study to Understand How the Study Medicine Called ARV-471 is Processed in Healthy Adults

Healthy

United States
Alkermes, Inc.

Recruiting

A Study to Evaluate the Safety and Effectiveness of ALKS 2680 in Subjects With Narcolepsy Type 1 (ALKS 2680-201) (Vibrance-1)

Narcolepsy Type 1

United States
Life Molecular Imaging Ltd

Recruiting

[18F]PI-2620 Phase 3 Histopathological Study

Alzheimer Disease

United States
Life Molecular Imaging SA
Walter Reed National Military Medical Center

Terminated

Imaging [18F]PI-2620 and [18F]Florbetaben in Military Service Members With Blast Related Mild Traumatic Brain Injury

Mild Traumatic Brain Injury

United States
Clinica Universidad de Navarra, Universidad de...
DNAtrix, Inc.

Terminated

DNX-2440 Oncolytic Adenovirus for Recurrent Glioblastoma

Glioblastoma | Glioblastoma, Adult

Spain
Theodor Bilharz Research Institute
Cairo University

Completed

PVB Versus TAP in Hepatic Patients Undergoing Laparoscopic Cholecystectomy

Hepatic Impairment | Laparoscopic Cholecystectomy | Ultrasound Therapy

Egypt
H. Lundbeck A/S

Completed

Study Investigating the Safety and Tolerability of Lu AF88434 in Healthy Young Men

Healthy

Netherlands
Sciton

Recruiting

Laser Treatment for Lichen Sclerosus

Lichen Sclerosus Lesion

Canada
Merck Sharp & Dohme LLC

Active, not recruiting

A Study to Evaluate Zilovertamab Vedotin (MK-2140) for Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) (MK-2140-004)

Relapsed or Refractory Diffuse Large B-Cell Lymphoma

United States, China, Poland, Israel, Canada, Chile, Czechia, Estonia, France, Greece, Italy, Korea, Republic of, Norway, Spain, Sweden, Thailand, Turkey

Search clinical trials for: [14C]-TVB-2640

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