Search clinical trials for: ACT-280778

Total 3068 results

Stiefel, a GSK Company
GlaxoSmithKline

Completed

Two-week Study to Compare the Tolerance and Irritation Potential of Two Combination Topical Gel Acne Medications

Acne Vulgaris

United States
National Heart Centre Singapore
National Taiwan University Hospital; Mackay Memorial Hospital; Peking University... and other collaborators

Recruiting

Asian Diabetes Outcomes Prevention Trial (ADOPT)

Cardiovascular Diseases | Diabetes Mellitus

Singapore
Alere San Diego

Terminated

HF Assessment With BNP in the Home: Part II (HABIT-II)

Heart Failure

United States, Netherlands, New Zealand, United Kingdom, Ireland, Sweden
ADC Therapeutics S.A.

Withdrawn

A Study to Evaluate the Tolerability, Safety, Pharmacokinetics, and Antitumor Activity of Loncastuximab Tesirine in Combination With Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated Diffuse Large B-cell Lymphoma (LOTIS-8) (LOTIS-8)

Diffuse Large B-Cell Lymphoma

United States
Servier Russia

Completed

The Use of TrIple Fixed-dose Combination in the Treatment of Arterial Hypertension (TRICOLOR)

Arterial Hypertension

Russian Federation
AbbVie

Completed

A Study Comparing Efficacy of Levodopa-Carbidopa Intestinal Gel/Carbidopa-Levodopa Enteral Suspension and Optimized Medical Treatment on Dyskinesia in Subjects With Advanced Parkinson's Disease (DYSCOVER) (DYSCOVER)

Parkinson's Disease (PD)

United States, Finland, Greece, Hungary, Italy, Slovakia, Spain
NYU Langone Health

Terminated

Risk Factor Control Before Orthopedic Surgery (OPTMIZE-OS)

Cardiovascular Disease | Osteoarthritis

United States
Brigham and Women's Hospital
Novartis

Terminated

Pulmonary Artery Pressure Reduction With ENTresto (Sacubitril/Valsartan) (PARENT)

Congestive Heart Failure

United States
GlaxoSmithKline

Completed

Chronic Obstructive Pulmonary Disease (COPD)-Related Outcomes and Costs for Patients on Combination Fluticasone Propionate-Salmeterol Xinafoate 250/50mcg Versus Anticholinergics in a COPD-Comorbid Depression/Anxiety Population

Pulmonary Disease, Chronic Obstructive
AbbVie (prior sponsor, Abbott)

Completed

Long-term Study of Duodopa (Levodopa/Carbidopa) in Advanced Parkinson's: Health Outcomes & Net Economic Impact (DAPHNE)

Advanced Idiopathic Parkinson's Disease
National Cancer Institute (NCI)

Completed

Monoclonal Antibody Therapy With Sargramostim and Interleukin-2 in Treating Children With Neuroblastoma

Recurrent Neuroblastoma | Disseminated Neuroblastoma | Regional Neuroblastoma

United States
Cosmetique Active International
Innovaderm Research Inc.

Completed

Efficacy and Tolerance of a Derivative of Salicylic Acid and 5% Benzoyl Peroxide in Facial Acne Vulgaris

Acne Vulgaris

Canada
Nuon Therapeutics, Inc.

Completed

Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia

Hyperuricemia | Gout

United States
Mayo Clinic

Recruiting

SBRT Versus Hypofractionated Radiotherapy for Biochemically Recurrent or Oligometastatic Prostate Adenocarcinoma

Biochemically Recurrent Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIB Prostate Cancer AJCC v8 | Oligometastatic Prostate Carcinoma | Recurrent Prostate Adenocarcinoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing the Addition of Navitoclax to the Combination of Dabrafenib and Trametinib in People Who Have BRAF Mutant Melanoma

Malignant Solid Neoplasm | Metastatic Melanoma | Unresectable Melanoma | Clinical Stage III Cutaneous Melanoma AJCC v8 | Clinical Stage IV Cutaneous Melanoma AJCC v8

United States
National Cancer Institute (NCI)

Active, not recruiting

Veliparib, Cyclophosphamide, and Doxorubicin Hydrochloride in Treating Patients With Metastatic or Unresectable Solid Tumors or Non-Hodgkin Lymphoma

Ann Arbor Stage III Non-Hodgkin Lymphoma | Ann Arbor Stage IV Non-Hodgkin Lymphoma | Solid Neoplasm

United States
National Cancer Institute (NCI)

Withdrawn

Daratumumab, Bortezomib, and Dexamethasone With or Without Venetoclax in Treating Patients With Relapsed or Refractory Multiple Myeloma

Refractory Plasma Cell Myeloma | Recurrent Plasma Cell Myeloma

United States
John O'Toole

Recruiting

Regional Anesthesia in Minimally Invasive Lumbar Spine Surgery

Synovial Cyst | Lumbar Disc Herniation | Degenerative Disc Disease | Lumbar Spinal Stenosis | Lumbar Spondylolisthesis | Lumbar Radiculopathy | Lumbar Spondylosis | Degenerative Spondylolisthesis | Lumbar Spine Instability | Degenerative Intervertebral Discs

United States
Altimmune, Inc.

Completed

ALT-801 DDI Study in Healthy Volunteers

NASH - Nonalcoholic Steatohepatitis

Australia
Yonsei University

Terminated

Safety and Efficacy of Left Atrial Appendage Closure Versus Antithrombotic Therapy in Patients With Atrial Fibrillation Undergoing Drug-Eluting Stent Implantation Due to Complex Coronary Artery Disease

Coronary Artery Disease | Atrial Fibrillation

Korea, Republic of
NYU Langone Health
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Occluded Artery Trial (OAT) (OAT)

Myocardial Infarction | Heart Diseases | Cardiovascular Diseases | Heart Failure | Heart Failure, Congestive

United States
Shaheed Faghihi Hospital
Shiraz University of Medical Sciences

Completed

Effect of Turmeric on Diabetic Nephropathy

Diabetic Nephropathy | Proteinuria

Iran, Islamic Republic of
G. d'Annunzio University

Completed

Prospective Study on the Treatment of Unsuspected Pulmonary Embolism in Cancer Patients

Unsuspected Pulmonary Embolism

Spain, France, Netherlands, Italy, United States, Austria, Canada, Germany
Kirsehir Ahi Evran Universitesi

Completed

Comparison of IPACK Block and PCI for Postoperative Analgesia and Function Recovery Following Total Knee Arthroplasty

Total Knee ArthroplastyKnee Pain, Functionality

Turkey
Imperial College London
Aristotle University Of Thessaloniki

Completed

Anti-hypertensive Medication Dosing Regimen in Effective Blood Pressure Control (HARMONY)

Hypertension

Greece, United Kingdom
Jun Wang

Completed

the Effect of Different Drugs and Infusion Ways on Degree of Postoperative Comfort

Analgesia, Patient-Controlled

China
Alexion Pharmaceuticals
Celerion; Achillion, a wholly owned subsidiary of Alexion

Completed

A Drug Interaction Study of ACH-0145228

Healthy

United States
Sidney Kimmel Cancer Center at Thomas Jefferson...
Susan G. Komen Breast Cancer Foundation

Completed

Carboplatin and Combination Chemotherapy With or Without Veliparib in Treating Patients With Stage IIB-IIIC Breast Cancer

Stage II Breast Cancer | Stage IIIA Breast Cancer | Stage IIIB Breast Cancer | Triple-negative Breast Cancer | Stage IIIC Breast Cancer | Estrogen Receptor-negative Breast Cancer | Progesterone Receptor-negative Breast Cancer | HER2-negative Breast Cancer

United States
Liaoning University of Traditional Chinese Medicine
Shengjing Hospital; First Hospital of China Medical University

Unknown

Cohort Study on Traditional Chinese Medicine Diagnosis and Treatment of Children With Henoch-Schonlein Purpura Nephritis (CSTCMDTCHSPN)

Henoch-Schonlein Purpura Nephritis

China
University of California, San Diego

Completed

Mechanisms of Increased Androgen Production Among Women With Polycystic Ovary Syndrome

Polycystic Ovary Syndrome

United States
Johns Hopkins University
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Reducing Total Cardiovascular Risk in an Urban Community (COACH)

Heart Diseases | Cardiovascular Diseases | Coronary Disease | Hypertension | Diabetes Mellitus | Atherosclerosis | Cerebral Arteriosclerosis

United States
National Institute of Mental Health (NIMH)

Completed

CATIE- Schizophrenia Trial

Schizophrenia

United States
Riyadh Elm University

Not yet recruiting

White Spot Lesions Treatment in Orthodontic (WSL)

White Spot Lesion
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Antiandrogen Therapy With or Without Axitinib Before Surgery in Treating Patients With Previously Untreated Prostate Cancer With Known or Suspected Lymph Node Metastasis

Metastatic Malignant Neoplasm in Lymph Node | Prostate Ductal Adenocarcinoma | Stage III Prostate Adenocarcinoma AJCC v7 | Stage IV Prostate Adenocarcinoma AJCC v7

United States
Jonsson Comprehensive Cancer Center
Viewray Inc.

Active, not recruiting

Stereotactic Body Radiation Therapy in Treating Patients With Localized Prostate Cancer That Have Undergone Surgery

PSA Progression | Stage III Prostate Adenocarcinoma AJCC v7 | Stage II Prostate Adenocarcinoma AJCC v7 | PSA Level Greater Than 0.03 | Stage I Prostate Adenocarcinoma AJCC (American Joint Committee on Cancer ) v7

United States
City of Hope Medical Center
National Cancer Institute (NCI)

Recruiting

Acalabrutinib, Obinutuzumab, and Glofitamab for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma

Mantle Cell Lymphoma

United States
Academic and Community Cancer Research United
National Cancer Institute (NCI)

Recruiting

Tafasitamab, Lenalidomide and Venetoclax for the Treatment of Relapsed or Refractory Mantle Cell Lymphoma (V-MIND)

Recurrent Mantle Cell Lymphoma | Refractory Mantle Cell Lymphoma

United States
M.D. Anderson Cancer Center

Recruiting

Venetoclax to Improve Outcomes of Fractionated Busulfan Regimen in Patients With High-Risk AML and MDS

Acute Myeloid Leukemia | Chronic Myelomonocytic Leukemia | Myelodysplastic Syndrome

United States
University of Birmingham
Regeneron Pharmaceuticals; Cancer Research UK; Fight Kids Cancer; ADC Therapeutics...

Not yet recruiting

A Global Study of Novel Agents in Paediatric and Adolescent Relapsed and Refractory B-cell Non-Hodgkin Lymphoma (Glo-BNHL)

B-cell Non Hodgkin Lymphoma
Fudan University
Chongqing University Cancer Hospital; Sun Yat-sen University; Peking University... and other collaborators

Recruiting

SNF Platform Study of HR+/ HER2-advanced Breast Cancer

Breast Cancer | Advanced Breast Cancer | Breast Neoplasm | HER2-negative Breast Cancer | Hormone Receptor Positive Tumor

China
Mansoura University

Completed

Are There Protective Effects of Antioxidants, Calcium Channel Blocker and Angiotensin Receptor Blocker Against Extracorporeal Shockwaves Lithotripsy Induced Renal Injury? (SWL)

Kidney Calculi

Egypt
Abbott

Completed

Tarka vs. Hyzaar in Patients With Metabolic Syndrome (STAR) (STAR)

Hypertension | Metabolic Syndrome
National Institutes of Health Clinical Center (CC)

Completed

Impact of Once-Weekly Rifapentine and Isoniazid on the Steady State Pharmacokinetics of Dolutegravir and Darunavir Boosted With Cobicistat in Healthy Volunteers

HIV Infected Population With Latent Tuberculosis

United States
M.D. Anderson Cancer Center

Recruiting

Androgen Ablation Therapy With or Without Niraparib After Radiation Therapy for the Treatment of High-Risk Localized or Locally Advanced Prostate Cancer

Prostate Carcinoma | Stage IIIA Prostate Cancer AJCC v8 | Stage IIIB Prostate Cancer AJCC v8 | Stage IIC Prostate Cancer AJCC v8 | Stage III Prostate Cancer AJCC v8 | Stage IIIC Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8

United States
University of Washington
AbbVie

Suspended

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

Acute Myeloid Leukemia | Refractory Acute Myeloid Leukemia | Refractory Mixed Phenotype Acute Leukemia | Myeloid Neoplasm | Acute Biphenotypic Leukemia | Refractory Acute Biphenotypic Leukemia | Relapsed Acute Myeloid Leukemia | Mixed Phenotype Acute Leukemia | Relapsed Acute Biphenotypic Leukemia | Relapsed... and other conditions

United States
M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

Venetoclax and Sequential Busulfan, Cladribine, and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Acute Myeloid Leukemia | Myelodysplastic Syndrome

United States
National Cancer Institute (NCI)

Active, not recruiting

FOLFIRI or Modified FOLFIRI and Veliparib as Second Line Therapy in Treating Patients With Metastatic Pancreatic Cancer

Metastatic Pancreatic Adenocarcinoma | Recurrent Pancreatic Carcinoma | Stage IV Pancreatic Cancer AJCC v6 and v7

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Oral Decitabine and Cedazuridine (ASTX727) in Combination With Venetoclax for Higher-Risk Acute Myeloid Leukemia Patients

Acute Myeloid Leukemia

United States
HTL-Strefa S.A.

Completed

Capillary Blood Volume and Pain Perception Obtained in a Process of Puncturing With Different Safety Lancets

Healthy

Poland
University of Vermont

Recruiting

Atrial Fibrillation: Chronic Beta-blocker Use Versus As-needed Rate Control Guided by Implantable Cardiac Monitor

Atrial Fibrillation | Diastolic Dysfunction | HFpEF - Heart Failure With Preserved Ejection Fraction

United States

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