Search clinical trials for: Agonist

Total 13819 results

National Institute of Mental Health (NIMH)

Recruiting

Effects of an ER Beta Agonist (Lilly Compound LY500307) on Estradiol-Withdrawal-Induced Mood Symptoms in Women With Past Perimenopausal Depression

Perimenopause-Related Depression

United States
Istituto Clinico Humanitas

Completed

RESCUE PROTOCOL AND FRESH EMBRYO TRANSFER

GnRH Trigger and Rescue Protocol
University of California, San Diego

Recruiting

ADRB3 Signaling Pathway in Human Adipose Tissue

Obesity, Prediabetes

United States
Ain Shams University

Recruiting

Evaluating the Outcome of Cardio Selective beta1- Blockers Use in Patients With Copd

Copd

Egypt
National Taiwan University Hospital

Completed

Predictors for Retreatement of OAB After DC Mirabegron

Recurrence of Overactive Bladder Syndrome

Taiwan
Astellas Pharma Inc

Completed

Long-Term Specified Drug Use-results Survey of Betanis Tablets

Overactive Bladder

Japan
Rochester Center for Behavioral Medicine
Shire

Completed

Efficacy and Safety Eval of Guanfacine Hydrochloride in Combination With Psychostimulants in Adults (18-65). (ADINT2012)

Adult Attention-Deficit Hyperactivity Disorder

United States
Ferring Pharmaceuticals

Completed

Therapy Pathways in the Treatment of Hormone Naïve Prostate Cancer Patients With and Without Comorbidities Treated With Degarelix or Luteinizing-Hormone-Releasing-Hormone (LHRH) Agonists. (ProComD)

Advanced Prostate Cancer

Germany
Giulio Stefanini
Agenzia Italiana del Farmaco

Active, not recruiting

Cardioprotective Effects of Nebivolol Versus Placebo in Patients Undergoing Chemotherapy With Anthracyclines (CONTROL)

Lymphoma, Large B-Cell, Diffuse | Breast Cancer | Chemotherapy Effect | Cardiotoxicity | Left Ventricular Dysfunction

Italy
Galderma R&D

Completed

Mirvaso in Use Study

Rosacea

United States
Shire

Completed

SPD503 (Guanfacine Hydrochloride) in ADHD Plus Oppositional Symptoms

ADHD

United States
Shire

Completed

Safety, Tolerability and Efficacy of SPD503 in Treating ADHD in Children Aged 6-17

Attention Deficit Disorder With Hyperactivity
Massachusetts Eye and Ear Infirmary

Completed

Effect of Alphagan on Retinal Blood Flow Autoregulation and Motion Detection in Patients With Normal Pressure Glaucoma

Glaucoma

United States
Neurology Group of Bergen County, P.A.
Shire

Completed

Language-based Learning Skills and Attention Deficit Hyperactivity Disorder (ADHD): Impact of Treatment With Sustained-release Guanfacine

Attention-deficit/Hyperactivity Disorder

United States
Forest Laboratories

Completed

Nebivolol in Patients With Systolic Stage 2 Hypertension (NEB-MD-20)

Hypertension

United States
University of Parma

Completed

Brimonidine vs ALTP in Progressing Human Glaucoma

Glaucoma

Italy
University of Pittsburgh

Completed

Dexmedetomidine and Adenosine: Therapeutic Use for SVT

Supraventricular Tachycardia

United States
Daniel Burdick, MD
Astellas Pharma US, Inc.

Completed

A Pilot Study of Mirabegron and Behavioral Modification Including Pelvic Floor Exercise for Overactive Bladder in Parkinson's Disease (MAESTRO) (Maestro)

Parkinsons Disease

United States
HealthPartners Institute

Completed

Mirabegron in Parkinson Disease and Impaired Cognition (MICT-PD)

Overactive Bladder | Parkinson Disease | Impaired Cognition

United States
Astellas Pharma Inc

Completed

Pharmacokinetics of Oral Mirabegron With Different Release Rates Versus Intravenous (IV) Mirabegron

Healthy | Pharmacokinetics of Mirabegron

United States
Icahn School of Medicine at Mount Sinai
Forest Laboratories

Completed

Effect of Nebivolol on the Blood Flow in Hearts of Adults With High Blood Pressure and Abnormal Filling of Heart

Hypertension | Left Ventricular Diastolic Dysfunction

United States
Medical University of Vienna

Completed

Effects of Topical Clonidine vs. Brimonidine on Choroidal Blood Flow and Intraocular Pressure During Isometric Exercise

Ocular Physiology | Regional Blood Flow

Austria
Rachel G. Greenberg, MD, MB, MHS
Eunice Kennedy Shriver National Institute of Child Health and Human Development... and other collaborators

Not yet recruiting

Guanfacine for Hyperactivity in Children With Down Syndrome (HYPEbeGONE_DS) (HYP01)

Hyperactivity in Children With Down Syndrome | Impulsivity in Children With Down Syndrome

United States
Astellas Pharma Europe B.V.

Completed

Open-label Phase 3 Study With Mirabegron in Children From 3 to Less Than 18 Years of Age With Neurogenic Detrusor Overactivity (Crocodile)

Neurogenic Detrusor Overactivity

Belgium, Croatia, Turkey, Australia, Denmark, Israel, Jordan, Korea, Republic of, Latvia, Lithuania, Malaysia, Mexico, Norway, Philippines, Poland, Romania, Serbia, Slovakia, Taiwan
NYU Langone Health
Winthrop University Hospital

Withdrawn

Dose Clinical Trial of Guanfacine Extended Release for the Reduction of Aggression and Self-injuries Behavior Associated With Prader-Willi Syndrome

Prader-Willi Syndrome

United States
Minneapolis Heart Institute Foundation
Forest Laboratories

Terminated

Alternative in Beta Blocker Intolerance: The ABBI Trial (ABBI)

Coronary Artery Disease

United States
Velicept Therapeutics, Inc.

Completed

Evaluate the Safety, Tolerability and PK of Different Formulations of Orally Administered Solabegron in Healthy Male Subjects

Healthy Subjects, Overactive Bladder
Astellas Pharma Inc

Completed

To Evaluate the Blood and Urine Concentration and the Safety and Tolerability of Increasing Repeated Doses of Mirabegron (YM178) OCAS in Healthy Young and Elderly Males and Healthy Young and Elderly Females

Healthy Subjects | Pharmacokinetics

Netherlands
Oxford University Hospitals NHS Trust

Completed

Assessment of the Effects of Pressors on Graft Blood Flow After Free Tissue Transfer Surgery (Free4Flow)

Head and Neck Cancer | Hypotension | Oral Cancer | Free Flap

United Kingdom
Maimonides Medical Center

Recruiting

Guanfacine Extended Release for the Reduction of Aggression and Self-injurious Behavior Associated With Prader-Willi Syndrome (PWS-GXR)

Aggression | Behavioral Symptoms | Pathologic Processes | Nervous System Diseases | Obesity | Neurologic Manifestations | Neurobehavioral Manifestations | Congenital Abnormalities | Overnutrition | Nutrition Disorders | Genetic Diseases, Inborn | Intellectual Disability | Self-Injurious Behavior | Abnormalities, Multiple and other conditions

United States
GE Healthcare
Covance

Recruiting

A Study to Evaluate the Safety and Pharmacokinetics of Regadenoson in Pediatric Patients (Rapiscan PIP)

Myocardial Ischemia | Coronary Artery Disease

France, Greece, Italy, United Kingdom
M.D. Anderson Cancer Center
Astellas Scientific & Medical Affairs, Inc.

Active, not recruiting

Accuracy of an Echo-Stress Protocol Using Regadenoson With Speckle Tracking

Ischemia

United States
Shire

Completed

Maintenance of Efficacy of Extended-Release Guanfacine HCl in Children and Adolescents With Attention-deficit/Hyperactivity Disorder (ADHD)

Attention-deficit/Hyperactivity Disorder

Spain, Belgium, United States, Netherlands, United Kingdom, Italy, Germany, Canada, France, Sweden
University of Illinois at Chicago
Astellas Pharma Inc

Completed

Assessment of Global Myocardial Perfusion Reserve Using Coronary Sinus Flow Measurements

Coronary Artery Disease

United States
Samsung Medical Center

Completed

Prospective Study for Patient Perception of Treatment Satisfaction After Switching to Mirabegron in Patients With Overactive Bladder Who Were Unsatisfied With Efficacy of Antimuscarinic Therapy or Adverse Event.

Overactive Bladder

Korea, Republic of
Jack Rubinstein
Forest Laboratories

Terminated

An Advanced Echocardiographic Evaluation of Nebivolol

Hypertension

United States
Kathy Miller

Terminated

Study Evaluating the Biologic Activity of Guanabenz in Bone Metastasis

Bone Cancer | Metastasis

United States
Bausch & Lomb Incorporated
ORA, Inc.

Completed

Pharmacokinetics and Safety of Topical Administration of Brimonidine Tartrate Ophthalmic Solution 0.025%.

Hyperemia

United States
The University of Texas Health Science Center at...
Shire

Completed

Electrophysiological Effects of Guanfacine Extended Release in Attention Deficit Hyperactivity Disorder (ADHD)

Attention Deficit Disorder With Hyperactivity

United States
Mylan Bertek Pharmaceuticals

Completed

Dosing Study of the Effects of Nebivolol on Blood Pressure in Black Patients With Mild to Moderate Hypertension

Hypertension

United States
Szeged University
Department of Oral and Maxillofacial Surgery, University of Szeged; Institute...

Completed

Effects of Intraoperative, Goal-directed Crystalloid vs. Colloid Fluid Resuscitation on Free Flaps

Optimal Tissue Perfusion

Hungary
University Hospital, Grenoble

Unknown

Impact of Cardiac Blood Flow on Cerebral Blood Flow in Patients With Severe Traumatic Brain Injury (DEBITC)

Severe Traumatic Brain Injury With High Cerebral Pressure

France
Westlake Eye Specialists
Sengi

Recruiting

Effect of Netarsudil vs Brimonidine in NTG Patients on Latanoprost

Normal Tension Glaucoma

United States
Astellas Pharma Global Development, Inc.

Recruiting

A Study of Mirabegron in Young Children With Neurogenic Detrusor Overactivity

Neurogenic Detrusor Overactivity

Philippines, Turkey, Belgium, Denmark, Poland
Tianjin Medical University General Hospital

Recruiting

Efficacy and Safety of Mirabegron in Intracerebral Hemorrhage

Intracerebral Haemorrhage

China
Paul Kim

Recruiting

Allograft Dysfunction in Heart Transplant

Heart Transplant Failure and Rejection

United States
Denver Health and Hospital Authority

Completed

Pupil Dilation for Treatment of IFIS

Intraoperative Floppy Iris Syndrome

United States
Timothy M. Bateman
Saint Luke's Health System; Saint Luke's Cardiovascular Consultants

Completed

Characterization of Changes in Ventricular Mechanics in Response to Lexiscan Stress Using Tagged Cine Cardiac Magnetic Resonance Imaging

Coronary Artery Disease

United States
Washington University School of Medicine
Astellas Pharma US, Inc.

Completed

Development of a PET-MR Myocardial Perfusion Examination Using Regadenoson (PET/MR-P)

Ischemic Heart Disease

United States
Icahn School of Medicine at Mount Sinai
Brain & Behavior Research Foundation

Completed

CRT-Guanfacine for SPD

Schizotypal Personality Disorder | SPD

United States

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