Search clinical trials for: Autophagy inhibitor (GNS651)

Total 64508 results

Kamada, Ltd.
Syneos Health

Recruiting

Evaluate Efficacy and Safety of "Kamada-AAT for Inhalation" in Patients With AATD (InnovAATe)

Alpha 1-Antitrypsin Deficiency

United Kingdom, Sweden, Ireland, Netherlands, Belgium, Finland
SINA Health Education and Welfare Trust
Horizon Pharmaceutical Pvt Ltd

Completed

Evaluating the Efficacy and Safety of Empagliflozin Addition to Insulin and Oral Antidiabetic Medication (OAD) Regimen in Poorly Controlled Type 2 Diabetes and Obese Patient

Glucose Metabolism Disorders | Diabetes Mellitus, Type 2 | Hypoglycemic Agents | Empagliflozin

Pakistan
Assistance Publique - Hôpitaux de Paris
Action Research Group; Bristol-Meyers Squibb & Pfizer

Completed

Anti-Thrombotic Strategy After Trans-Aortic Valve Implantation for Aortic Stenosis (ATLANTIS)

Symptomatic Aortic Stenosis | Eligible for Transcatheter Aortic Valve Replacement

France, Germany, Italy, Spain
Southwest Oncology Group
National Cancer Institute (NCI)

Terminated

S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinib

Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer | Adenocarcinoma of the Lung | Large Cell Lung Cancer

United States
Boehringer Ingelheim

Completed

Tipranavir/Ritonavir vs. Genotypically Defined Protease Inhibitor/Ritonavir in HIV Patients (RESIST-2)

HIV Infections

Argentina, Austria, Belgium, Brazil, Denmark, France, Germany, Greece, Ireland, Italy, Mexico, Netherlands, Portugal, Spain, Sweden, Switzerland, United Kingdom
Yongsheng Wang
Jiangsu HengRui Medicine Co., Ltd.

Recruiting

Select the Appropriate Population for Adding CDK4/6i to Neoadjuvant Endocrine Therapy

Locally Advanced Breast Cancer | Hormone Receptor Positive，HER2-negative Breast Cancer

China
National Cancer Institute (NCI)

Active, not recruiting

Ibrutinib in Treating Patients With Refractory Metastatic Cutaneous Melanoma

Metastatic Melanoma | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Recurrent Cutaneous Melanoma

United States
National Cancer Institute (NCI)

Active, not recruiting

Testing Crizotinib as a Potential Targeted Treatment in Cancers With ROS1 Genetic Changes (MATCH-Subprotocol G)

Hematopoietic and Lymphoid Cell Neoplasm | Advanced Lymphoma | Advanced Malignant Solid Neoplasm | Refractory Lymphoma | Refractory Malignant Solid Neoplasm | Refractory Multiple Myeloma

United States
Sun Yat-sen University

Not yet recruiting

Study of Cadonilimab (AK104) Plus Lenvatinib in Patients With Advanced Endometrial Cancer

Endometrial Cancer | Endometrial Adenocarcinoma

China
IDEAYA Biosciences

Recruiting

Study of IDE196 in Patients With Solid Tumors Harboring GNAQ/11 Mutations or PRKC Fusions

Colorectal Cancer | Metastatic Uveal Melanoma | Cutaneous Melanoma | Other Solid Tumors

United States, Australia, Canada
Ain Shams University

Completed

Human Epididymis Protein 4 in Endometrial Carcinoma

Endometrial Cancer

Egypt
Samsung Medical Center

Unknown

Comparison of Proton Pump Inhibitor and H2 Receptor Blocker on Prevention of Bleeding From Iatrogenic Ulcer After Endoscopic Submucosal Dissection for Gastric Neoplasms: A Prospective Randomized Controlled Trial

Delayed Bleeding

Korea, Republic of
Karolinska Institutet
Karolinska University Hospital; Pfizer

Recruiting

imPROving Quality of LIFe In the Long COVID Patient (PROLIFIC)

COVID-19 | Post-COVID-19 Syndrome | Long COVID | Long Covid19 | Post COVID-19 Condition | Post-COVID Syndrome | Post COVID-19 Condition, Unspecified | POTS - Postural Orthostatic Tachycardia Syndrome | Postinfectious Inflammation | Postinfectious Disorder

Sweden
National Cancer Institute (NCI)

Active, not recruiting

Onalespib, Dabrafenib, and Trametinib in Treating Patients With BRAF-Mutant Melanoma or Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery

Metastatic Melanoma | Stage III Cutaneous Melanoma AJCC v7 | Stage IV Cutaneous Melanoma AJCC v6 and v7 | Metastatic Malignant Solid Neoplasm | Stage IIIC Cutaneous Melanoma AJCC v7 | Unresectable Solid Neoplasm | BRAF V600E Mutation Present | BRAF V600K Mutation Present | Stage IIIA Cutaneous Melanoma... and other conditions

United States
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Sildenafil Therapy for Pulmonary Hypertension and Sickle Cell Disease

Sickle Cell Disease | Pulmonary Hypertension

United States, United Kingdom
American University of Beirut Medical Center

Withdrawn

Aromatase Inhibitors for Treatment of Uterine Leiomyomas

Symptomatic or Large Uterine Fibroids

Lebanon
The Netherlands Cancer Institute

Not yet recruiting

LB-100 (PP2A Inhibitor) and Atezolizumab (PD-L1 Inhibitor) in Metastatic Colorectal Cancer Patients (CoLBAt)

Metastatic Microsatellite-stable Colorectal Cancer
Fudan University

Recruiting

Sintilimab Combined With Chidamide in Treating Peripheral T Cell Lymphoma (Sincerely20)

Peripheral T-cell Lymphoma

China
Emory University
Eisai Inc.

Terminated

Lenvatinib and Iodine Therapy in Treating Patients With Radioactive Iodine-Sensitive Differentiated Thyroid Cancer

Differentiated Thyroid Gland Carcinoma | Thyroid Gland Follicular Carcinoma | Thyroid Gland Papillary Carcinoma

United States
Incyte Corporation

Terminated

GRAVITAS-119: Itacitinib in Combination With Calcineurin Inhibitor-Based Interventions for the Prophylaxis of Graft-Versus Host Disease

Hematologic Malignancies

United States, Spain, France, Italy
Sanofi

Completed

A Single-Arm Study Evaluating Carboplatin/Gemcitabine in Combination With BSI-201 in Patients With Platinum-Resistant Recurrent Ovarian Cancer

Ovarian Cancer

United States
Rempex Pharmaceuticals (a wholly owned subsidiary...

Completed

Safety, Tolerability, Pharmacokinetics of Intravenous RPX7009 in Healthy Adult Subjects

Bacterial Infections | Healthy Volunteers

Australia
Advanced Center for Specialty Care
Takeda

Unknown

Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy

Laryngopharyngeal Reflux | Hypertrophy of Lingual Tonsil

United States
Emory University
National Cancer Institute (NCI)

Recruiting

MRX-2843 and Osimertinib for the Treatment of Advanced EGFR Mutant Non-small Cell Lung Cancer

Metastatic Lung Non-Small Cell Carcinoma | Stage IVA Lung Cancer AJCC v8 | Stage IVB Lung Cancer AJCC v8 | Stage IV Lung Cancer AJCC v8 | Advanced Lung Non-Small Cell Carcinoma

United States
M.D. Anderson Cancer Center

Completed

Combined Modality Treatment for Resectable Non-Small Cell Superior Sulcus Tumors

Lung Cancer

United States
Royal Devon and Exeter NHS Foundation Trust
NIHR Exeter Clinical Research Facility

Completed

Glucose Response, Excursions And Treatment (GREAT) Study (GREAT)

Type 2 Diabetes

United Kingdom
Memorial Sloan Kettering Cancer Center
National Cancer Institute (NCI)

Completed

High-Dose Chemotherapy and Radiation Therapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Acute Leukemia in Remission

Leukemia | Bone Marrow Ablation

United States
National Cancer Institute (NCI)

Completed

Trametinib in Treating Patients With Epithelioid Hemangioendothelioma That is Metastatic, Locally Advanced, or Cannot Be Removed by Surgery

Locally Advanced Epithelioid Hemangioendothelioma | Metastatic Epithelioid Hemangioendothelioma | Unresectable Epithelioid Hemangioendothelioma

United States
Zaiwen Fan

Unknown

Endostar Plus EGFR-TKI（Epidermal Growth Factor Receptor-Tyrosine-Kinase Inhibitor） as a Treatment of EGFR Mutation-positive NSCLC

Advanced Cancer | Lung Cancer, Nonsmall Cell
Bayer

Completed

Safety and Efficacy Study of a New Chemotherapy Agent to Treat Metastatic Melanoma

Melanoma
Seoul National University Bundang Hospital

Terminated

The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection

Helicobacter Infection

Korea, Republic of
Mayo Clinic
National Cancer Institute (NCI)

Terminated

Low-Dose Decitabine in Treating Patients With Symptomatic Myelofibrosis

Chronic Myeloproliferative Disorders | Secondary Myelofibrosis

United States
Nicolai Jacob Wewer Albrechtsen

Completed

The Effects of Neprilysin on Glucagon-like Peptide-1 (NEP)

Heart Failure | Diabetes

Denmark
Sun Yat-sen University

Recruiting

Transarterial Infusion of PD-1 Antibody Plus TACE-HAIC for Unresectable HCC: a Single-arm, Phase 2 Clinical Trial (AIPD-1)

Hepatocellular Carcinoma

China
Jonsson Comprehensive Cancer Center
National Cancer Institute (NCI)

Withdrawn

BAY 56-3722 in Treating Patients With Recurrent, Unresectable, or Metastatic Kidney Cancer

Stage IV Renal Cell Cancer | Recurrent Renal Cell Cancer

United States
Tongji Hospital
Wuhan University; Sun Yat-sen University; Wuhan Union Hospital, China

Suspended

Radiotherapy Combined With Immunotherapy for Brain Metastases of Non-small Cell Lung Cancer

Non Small Cell Lung Cancer

China
Chroma Therapeutics
Quintiles, Inc.

Completed

Safety and Anti-Disease Activity of Oral Tosedostat (CHR-2797) in Elderly Subjects With Refractory or Relapsed AML (OPAL)

Acute Myeloid Leukemia | AML

United States, Canada, Netherlands
Stanford University
National Institutes of Health (NIH)

Active, not recruiting

Serial Ultrasound in Metastatic Renal Cell Carcinoma (mRCC)

Kidney Cancer | Renal Cell Carcinoma | Metastatic Renal Cell Carcinoma

United States
Vanderbilt-Ingram Cancer Center
National Cancer Institute (NCI)

Active, not recruiting

BYL719 and Letrozole in Post-Menopausal Patients With Hormone Receptor-Positive Metastatic Breast Cancer

Stage IV Breast Cancer | Recurrent Breast Cancer | Estrogen Receptor-positive Breast Cancer | Progesterone Receptor-positive Breast Cancer | HER2-negative Breast Cancer | Invasive Ductal Breast Carcinoma

United States
Bayer

Withdrawn

Study to Test the Safety of an Investigational Drug Given Repeatedly to Adult Men With Severe Hemophilia

Hemophilia
Sun Yat-sen University

Recruiting

PD-1 Inhibitor or PD-1 Inhibitor Plus GVD for Relapsed/Refractory CHL

Classical Hodgkin Lymphoma | Refractory or Relapsed Classical Hodgkin Lymphoma

China
Priyanka Sharma
Bristol-Myers Squibb; Celgene Corporation

Active, not recruiting

Cisplatin Plus Romidepsin & Nivolumab in Locally Recurrent or Metastatic Triple Negative Breast Cancer (TNBC)

Breast Cancer | Triple-Negative Breast Cancer

United States
University of Pittsburgh
Novartis

Completed

Effect of a Proton Pump Inhibitor on Gleevec® in Healthy Volunteers

Healthy

United States
Mt. Sinai Medical Center, Miami
Amgen

Completed

Combined Modality Therapy With Growth Factor Support in Locally Advanced Non-small Cell Lung Cancer (NSCLC)

Unresectable Locally Advanced NSCLC

United States
Boehringer Ingelheim
Eli Lilly and Company

Active, not recruiting

Comparative Effectiveness of Empagliflozin in the US

Diabetes Mellitus, Type 2

United States
Pfizer

Active, not recruiting

Real-world Treatment Patterns and Effectiveness of Palbociclib and AI Therapy

Metastatic Breast Cancer

United States
University of Colorado, Denver
Omni Bio Pharmaceutical, Inc.

Completed

The Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 Diabetes

Diabetes | Type 1 Diabetes

United States
Technische Universität Dresden

Unknown

Helicobacter - Lymphoma - Radiation Part I: Eradication, Part II: Radiation

Lymphoma | Lymphoma, Non-Hodgkin

Germany
Eli Lilly and Company

Completed

Oral Baricitinib (LY3009104)Treatment in Japanese Participants With Active Rheumatoid Arthritis on Background Methotrexate Therapy

Arthritis, Rheumatoid

Japan
Jiangsu Simcere Pharmaceutical Co., Ltd.

Recruiting

Phase I Study to Evaluate SIM0270 Alone or in Combination in ER+, HER2- Locally Advanced or Metastatic Breast Cancer

Breast Cancer

China

Search clinical trials for: Autophagy inhibitor (GNS651)

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