Search clinical trials for: BCX7353 digoxin

Total 217 results

BioCryst Pharmaceuticals

Completed

A Drug-Drug Interaction Study to Evaluate Drug Transporter Interactions

Hereditary Angioedema

United Kingdom
First Affiliated Hospital Xi'an Jiaotong University

Completed

The Pharmacokinetic Study of the Combination of Digoxin and Polythylene Glycol Loxenatide Injection in Healthy Subjects

Healthy

China
BioCryst Pharmaceuticals

Completed

First-in-Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of BCX7353 in Healthy Western and Japanese Volunteers

Hereditary Angioedema

United Kingdom
Assistance Publique - Hôpitaux de Paris
Cancer Research and Personalized Medicine (Carpem); Laboratoire d'excellence...

Unknown

Potentiation of Cisplatin-based Chemotherapy by Digoxin in Advanced Unresectable Head and Neck Cancer Patients (DIGHANC)

Head and Neck Cancer

France
Jiangsu Hansoh Pharmaceutical Co., Ltd.

Completed

Evaluate the Pharmacokinetics of Digoxin When Coadministered With PEX168 in Healthy Adult Subjects

Healthy

China
BioCryst Pharmaceuticals

Completed

A Relative Bioavailability Study of Two Formulations of BCX7353

Hereditary Angioedema

United Kingdom
AstraZeneca

Completed

Investigate the Effect of AZD1656 on the Pharmacokinetics of Digoxin in Type 2 Diabetes Mellitus Patients

Type 2 Diabetes Mellitus

United States
BioCryst Pharmaceuticals

Approved for marketing

Oral Berotralstat Expanded Access Program

Hereditary Angioedema | Prophylaxis | HAE
University of California, Los Angeles

Completed

Transvaginal Versus Transabdominal Digoxin Prior to Second-trimester Abortion

Abortion, Induced
Hospital Ana Nery

Unknown

Intensive Versus Conventional Digoxin Use in Patients With Heart Failure (ICHF)

Heart Failure

Brazil
Cairo University

Completed

A Prospective Study of Different Digoxin Treatment Regimens in Egyptian Hospital

Atrial Fibrillation
BioCryst Pharmaceuticals

Completed

A Long Term Safety Study of BCX7353 in Hereditary Angioedema (APeX-S)

Hereditary Angioedema | Prophylaxis | HAE

Austria, Denmark, France, Germany, Hungary, Israel, Italy, North Macedonia, Poland, Switzerland, United Kingdom, United States, Australia, Hong Kong, Korea, Republic of, New Zealand, Serbia, Slovakia, South Africa, Spain
BioCryst Pharmaceuticals

Completed

Study to Evaluate the Efficacy and Safety of BCX7353 as an Oral Treatment for the Prevention of HAE Attacks in Japan (APeX-J)

Hereditary Angioedema, HAE

Japan
Genzyme, a Sanofi Company

Completed

A Phase 1 Study Evaluating Eliglustat's Effects on Pharmacokinetics, Safety & Tolerability of Digoxin in Healthy Adults

Healthy Volunteer

United States
White, Katharine O'Connell, M.D., M.P.H.
Society of Family Planning

Completed

A Trial of Digoxin Before Second-Trimester Abortion

Induced Abortion

United States
GlaxoSmithKline

Completed

An Open-label, Single-centre Study Evaluating the Pharmacokinetics of Digoxin Alone and When Administered at Various Doses of Ezogabine/Retigabine in Healthy Adults. The Pharmacokinetics of Ezogabine/Retigabine and the N-acetyl Metabolite of Ezogabine/Retigabine (NAMR) Will Also be Assessed

Epilepsy

United States
BioCryst Pharmaceuticals

Completed

Study of BCX7353 as a Treatment for Attacks of Hereditary Angioedema

Hereditary Angioedema (HAE)

Austria, Denmark, France, Germany, Hungary, Israel, Italy, North Macedonia, Poland, Romania, Switzerland, United Kingdom
Assistance Publique - Hôpitaux de Paris

Unknown

Phase II Multicentric Study of Digoxin Per os in Classic or Endemic Kaposi' s Sarcoma (KADIG 01)

Kaposi' s Sarcoma | Classic Kaposi' s Sarcoma | Endemic Kaposi' s Sarcoma | Lymph Angio Proliferations

France
University of Monastir

Completed

Role of SNP and DIGOXIN Response in Atrial Fibrillation Patients

Atrial Fibrillation

Tunisia
Hoffmann-La Roche

Completed

A Pharmacokinetics Study of Aleglitazar in Combination With Digoxin in Healthy Volunteers

Healthy Volunteer

United Kingdom
Pfizer
Medivation, Inc.

Completed

Dimebon (PF-01913539)-Digoxin Drug-Drug Interaction Study In Healthy Subjects

Alzheimer Disease | Huntington Disease

United States
Cocco, Giuseppe, M.D.
Cardiology Office, Rheinfelden, Switzerland

Completed

Digoxin Versus Ivabradine in Heart Failure With Preserved Systolic Function (DIGvsIVA)

Heart Failure | Atrial Fibrillation

Switzerland
University of Leeds

Not yet recruiting

Digoxin and Senolysis in Heart Failure and Diabetes Mellitus

Diabetes Mellitus, Type 2 | Heart Failure, Systolic

United Kingdom
The Alfred

Completed

Digoxin Withdrawal in Stable Heart Failure

Heart Failure

Australia
AnHeart Therapeutics Inc.

Completed

A Study on the Effect of AB-106 on the Pharmacokinetics of Digoxin

Solid Tumor

China
BioCryst Pharmaceuticals

Completed

Efficacy and Safety of BCX7353 to Prevent Angioedema Attacks in Subjects With Hereditary Angioedema (APeX-1)

Hereditary Angioedema (HAE)

Canada, United Kingdom, Germany, Spain, Australia, Hungary, Italy, Austria, North Macedonia, Denmark, Switzerland
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess the Effects of Canagliflozin (JNJ-28431754) on the Pharmacokinetics and Safety of Digoxin in Healthy Volunteers.

Healthy
University Hospital, Basel, Switzerland
ETH Zurich - The Aceto Lab

Completed

Digoxin Induced Dissolution of CTC Clusters

Breast Cancer | Circulating Tumor Cells (CTCs)

Switzerland
University of Illinois at Chicago
American College of Clinical Pharmacy

Completed

Digoxin Dosing in Heart Failure: A Simplified Nomogram Versus Standard Care

Heart Failure

United States
Meir Medical Center

Unknown

Intra Amniotic Injection of DIGOXIN for Feticide in Second Trimester Termination of Pregnancy

Arrhythmia | Hypotension | ECG Changes

Israel
National Institute on Aging (NIA)
University of Toledo Health Science Campus

Unknown

Marinobufagenin as a Target for DIGIBIND in Hypertensive Patients With End-stage Renal Disease

Hypertension | Hemodialysis

United States
Boehringer Ingelheim

Completed

to Evaluate Effect of Multi Doses Flibans 100 mg Film-c Tablets on Single Dose PK of Digoxin 0.5 mg, Healthy Volunteers

Healthy

Germany
Boryung Pharmaceutical Co., Ltd

Completed

A Study to Evaluate the Effect of Fimasartan on Pharmacokinetics, and the Safety of Digoxin in Healthy Male Volunteers

Essential Hypertension
The Affiliated Nanjing Drum Tower Hospital of Nanjing...
Yale University

Withdrawn

Digoxin for Patients With Non-alcoholic Steatohepatitis (NASH)

Nonalcoholic Steatohepatitis

China
AMAG Pharmaceuticals, Inc.

Terminated

Study of the Efficacy and Safety of AMAG-423 (Digoxin Immune Fab) in Antepartum Subjects With Severe Preeclampsia

Severe Preeclampsia

United States, Poland, South Africa
Chun-Yao Huang

Unknown

Efficacy of Ivabradine in Patient With Both Persistent Atrial Fibrillation and Heart Failure With Reduce Ejection Fraction

Heart Failure | Atrial Fibrillation | Ivabradine

Taiwan
Radboud University Medical Center

Completed

Digoxin for the Reinduction of Radioiodine Uptake in Metastatic or Locally Advanced Non-medullary Thyroid Carcinoma (DIGUP-TC)

Non-Medullary Thyroid Carcinoma

Netherlands
Atea Pharmaceuticals, Inc.
Hoffmann-La Roche

Completed

Drug-drug Interaction Study of Digoxin and AT-527 (R07496998)

Healthy Volunteers Study

Canada
Jiangsu HengRui Medicine Co., Ltd.

Completed

A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Transporter Pgp Substrate Digoxin in Advanced Solid Tumor Subjects

Advanced Solid Tumor

China
Novo Nordisk A/S

Completed

Investigating the Influence of Oral Semaglutide on Pharmacokinetics of Metformin and Digoxin in Healthy Subjects

Healthy | Diabetes

Germany
University of Texas Southwestern Medical Center

Completed

A Phase 1B Clinical Trial of Trametinib Plus Digoxin in Patients With Unresectable or Metastatic BRAF Wild-type Melanoma

Melanoma

United States
Yale University

Recruiting

Digoxin In Treatment of Alcohol Associated Hepatitis (DIGIT-AlcHep)

Alcohol-Induced Disorders | Chemical and Drug Induced Liver Injury | Acute Alcoholic Hepatitis | Steatohepatitis Caused by Ingestible Alcohol

United States
University of Maryland, Baltimore

Completed

Preop Digifab in CABG to Reduce Ouabain Levels and Prevent AKI

Acute Kidney Injury

United States
BioCryst Pharmaceuticals

Completed

Efficacy and Safety Study of BCX7353 as an Oral Treatment for the Prevention of Attacks in HAE (APeX-2)

Hereditary Angioedema | HAE

United States, Austria, Canada, Czechia, France, Germany, Hungary, North Macedonia, Romania, Spain, United Kingdom
Astellas Pharma Global Development, Inc.
Basilea Pharmaceutica International Ltd

Completed

Drug Interaction Study of Isavuconazole and Digoxin

Healthy Volunteers | Pharmacokinetics of Isavuconazole | Pharmacokinetics of Digoxin

United States
BioCryst Pharmaceuticals

Active, not recruiting

Berotralstat Treatment in Children With Hereditary Angioedema (APeX-P)

Hereditary Angioedema | Pediatric

Spain, Austria, Canada, France, Germany, Israel, Italy, Poland, Romania, United Kingdom
GlaxoSmithKline

Completed

A Drug Interaction Study of Albiglutide and Digoxin

Diabetes Mellitus, Type 2

United States
Adolfo Fontenla
Carlos III Health Institute; Spanish Clinical Research Networt (SCReN)

Completed

IvaBRAdine blocK of Funny Current for Heart Rate Control in permanEnt Atrial Fibrillation. (BRAKE-AF Study). (BRAKE-AF)

Heart Diseases | Atrial Fibrillation

Spain
Boehringer Ingelheim

Completed

Drug Interaction Study of Digoxin and BI 10773

Healthy

Germany
University of Texas Southwestern Medical Center

Withdrawn

A Clinical Trial of Patients With Melanoma

Melanoma

United States

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