Search clinical trials for: CXCR4 Antagonist BL-8040

Total 94 results

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Completed

Pembrolizumab and CXCR4 Antagonist BL-8040 in Treating Patients With Metastatic Pancreatic Cancer

Metastatic Pancreatic Adenocarcinoma | Stage IV Pancreatic Cancer AJCC v6 and v7 | Recurrent Pancreatic Adenocarcinoma

United States
BioLineRx, Ltd.

Completed

A Phase I Study Evaluating Safety, Tolerability, PK and PD of BL-8040 for Stem Cell Mobilization in Healthy Volunteers

Mobilization of Hematopoietic Stem Cells (HSC) to Peripheral Blood (PB)

Israel
Washington University School of Medicine
National Cancer Institute (NCI); National Institutes of Health (NIH); The Leukemia...

Terminated

BL-8040 and Nelarabine for Relapsed or Refractory T-Acute Lymphoblastic Leukemia/ Lymphoblastic Lymphoma

T-Acute Lymphoblastic Leukemia | Adult T Lymphoblastic Lymphoma

United States
BioLineRx, Ltd.

Completed

Efficacy, Pharmacodynamics, Safety and Tolerability of Oral BL-7040 in Patients With Moderately Active Ulcerative Colitis

Ulcerative Colitis

Israel
Washington University School of Medicine
BioLineRx, Ltd.

Completed

Safety and Efficacy of BL-8040 for the Mobilization of Donor Hematopoietic Stem Cells and Allogeneic Transplantation in Patients With Advanced Hematological Malignancies

Multiple Myeloma | Hodgkin Disease | Non-Hodgkin's Lymphoma | Acute Lymphoblastic Leukemia | Non-Hodgkin Lymphoma | Myelodysplastic Syndrome | Acute Myelogenous Leukemia | Chronic Myelogenous Leukemia | Myeloproliferative Neoplasm | Hodgkin's Disease | Hodgkins Disease

United States
BioLineRx, Ltd.
Sheba Medical Center

Unknown

Safety and Feasibility of the Injectable BL-1040 Implant

Cardiovascular Disease

Germany
Sheba Medical Center

Withdrawn

Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in Chronic Myelogenous Leukemia

Chronic Myeloid Leukemia

Israel
BioLineRx, Ltd.
Celerion

Completed

Study to Investigate the Effect of BL-8040 (Motixafortide) on the QTc Interval in Healthy Subjects

Healthy Subjects

United States
BioLineRx, Ltd.
Genentech, Inc.

Terminated

A Phase Ib/II, Multicenter, Single Arm, Open-Label Study, To Evaluate the Safety, Tolerability and Efficacy of the BL-8040 and Atezolizumab Combination for Maintenance Treatment in Subjects With Acute Myeloid Leukemia Who Are 60 Years or Older - The BATTLE Study

Acute Myeloid Leukemia

Israel, Spain, United States, Czechia, Poland, Slovakia
Dr. Petra Tschanter
BioLineRx, Ltd.

Unknown

BL-8040 Addition to Consolidation Therapy in AML Patients (BLAST)

Acute Myeloid Leukemia

Germany
Washington University School of Medicine
Biogen; BioLineRx, Ltd.

Recruiting

Motixafortide and Natalizumab to Mobilize CD34+ Hematopoietic Stem Cells for Gene Therapies in Sickle Cell Disease (SCD)

Sickle Cell Disease

United States
BioLineRx, Ltd.

Active, not recruiting

A Phase III, Safety, Tolerability and Efficacy of Combination Treatment of BL-8040 and G-GSF as Compared to Placebo and G-CSF for the Mobilization of Hematopoietic Stem Cells for Autologous TransplantatIon in Subjects With MM (GENESIS)

Multiple Myeloma

United States, Spain, Hungary, Germany, Italy
BioLineRx, Ltd.

Completed

Extension Study To Evaluate The Long-Term Safety, Tolerability, And Efficacy Of Low And High Doses Of Bl-1020

Schizophrenia

United States
BioLineRx, Ltd.

Completed

Phase IIa Study Evaluating Safety and Efficacy of BL-8040 in Relapsed/Refractory AML Patients

Acute Myeloid Leukemia

United States, Israel
BioLineRx, Ltd.
Merck Sharp & Dohme LLC

Completed

Study Assessing Safety and Efficacy of Combination of BL-8040 and Pembrolizumab in Metastatic Pancreatic Cancer Patients (COMBAT/KEYNOTE-202) (COMBAT)

Metastatic Pancreatic Adenocarcinoma

United States, Israel, Korea, Republic of, Spain
Gulam Manji
Regeneron Pharmaceuticals; BioLine Rx

Recruiting

Chemo4METPANC Combination Chemokine Inhibitor, Immunotherapy, and Chemotherapy in Pancreatic Adenocarcinoma

Adenocarcinoma | Pancreatic Cancer | Adenocarcinoma of the Pancreas

United States
Dong-A ST Co., Ltd.

Completed

The Food Effect on Pharmacokinetics of DA-8010 After a Single Administration of DA-8010 2.5 mg or 5 mg in Healthy Subjects

Healthy

Korea, Republic of
Dong-A ST Co., Ltd.

Active, not recruiting

A Study to Evaluate the Efficacy and Safety of DA-8010 in Patients With Overactive Bladder

Overactive Bladder

Korea, Republic of
Dong-A ST Co., Ltd.

Completed

A Therapeutic Exploratory Clinical Study of DA-8010 in Patients With Overactive Bladder

Overactive Bladder

Korea, Republic of
BioLineRx, Ltd.

Completed

Safety and Tolerability of BL-1020 in Hospitalized Subjects With Chronic Schizophrenia or Schizo-Affective Disorder

Schizophrenia | Schizoaffective Disorder

Israel, Romania
Bristol-Myers Squibb

Completed

Anti-CXCR4 (BMS-936564) Alone and in Combination With Lenalidomide/Dexamethasone or Bortezomib/Dexamethasone in Relapsed/Refractory Multiple Myeloma

Multiple Myeloma

United States
BioLineRx, Ltd.

Terminated

Phase IIb-III Study of BL-1020 Small Molecule for Schizophrenia (CLARITY)

Schizophrenia | Cognitive Effect on Schizophrenic Patients

India, Moldova, Republic of, Romania
BioLineRx, Ltd.

Completed

A Six-week, Randomized, Double-blind, Placebo-controlled, Parallel Group, Multi-center, Phase II Study

Schizophrenia

United States
Sichuan Baili Pharmaceutical Co., Ltd.
Baili-Bio (Chengdu) Pharmaceutical Co., Ltd.

Recruiting

A Study Comparing BL-B01D1 With Platinum Based Chemotherapy in Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer

Non-small Cell Lung Cancer

China
Dong-A ST Co., Ltd.

Recruiting

A Study to Evaluate the Effects of Renal Function on Pharmacokinetics and Safety of DA-8010

Healthy | Renal Impairment

Korea, Republic of
EyeD Pharma

Recruiting

Safety and Tolerability of a Timolol Releasing Intraocular Implant in Subjects With Primary Open-angle Glaucoma

Primary Open-angle Glaucoma

Germany, Belgium
Dong-A ST Co., Ltd.

Unknown

A Study to Evaluate Safety, Tolerability and Pharmacokinetics of DA-8010 in Healthy Subjects

Overactive Bladder
BioLineRx, Ltd.

Completed

A Positron Emission Tomography (PET) Study to Assess the Degree of Dopamine-2 (D2) Receptor Occupancy in the Human Brain After Single Doses of BL-1020 or Perphenazine in Healthy Male Subjects Using [11C]Raclopride as PET Tracer

Healthy

Sweden
BioLineRx, Ltd.

Completed

Phase IIA Open Label Study to Evaluate Efficacy and Safety of BL-8040 Followed by (hATG), Cyclosporine and Methyprednisolone in Adult Subjects With Aplastic Anemia or Hypoplastic Myelodysplastic Syndrome

Aplastic Anemia | Hypoplastic Myelodysplastic Syndrome

United States
Bukwang Pharmaceutical
Dyna Therapeutics

Completed

A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of SOL-804 in Healthy Male Subjects

Prostate Cancer

Korea, Republic of
Instituto Nacional de Ciencias Medicas y Nutricion...

Unknown

Chemo Sensitization Before Hematopoietic Stem Cell Transplantation in Patients With Acute Leukemia in Complete Remission

Acute Myeloid Leukemia | Acute Lymphoid Leukemia

Mexico
Takeda

Completed

A Study to Determine the Bioequivalence of Alogliptin and Pioglitazone When Administered as Individual Tablets and as Fixed-Dose Combination (FDC)-SYR-322-4833 BL Tablets to Healthy Russian Participants

Healthy Volunteers

Russian Federation
Hoffmann-La Roche

Active, not recruiting

A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer)

Pancreatic Adenocarcinoma

United States, Spain, Korea, Republic of, Germany, Japan
Hoffmann-La Roche
BioLineRx, Ltd.; Halozyme Therapeutics

Active, not recruiting

A Study of Multiple Immunotherapy-Based Treatment Combinations in Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Cancer (G/GEJ) or Esophageal Cancer (Morpheus-Gastric and Esophageal Cancer)

Gastric Adenocarcinoma or Gastroesophageal Junction Adenocarcinoma or Esophageal Carcinoma

United States, United Kingdom, Australia, Korea, Republic of, Taiwan, Israel, Spain
University of Alabama at Birmingham
National Heart, Lung, and Blood Institute (NHLBI)

Terminated

Preventing Sickle Cell Kidney Disease

Hypertension | Proteinuria | Sickle Cell Disease | Anemia, Sickle Cell | Kidney Disease

United States
Chih-Hui Chiu

Completed

Caffeinated Gum Softball Performance

Caffeine

Taiwan
Chih-Hui Chiu

Recruiting

Caffeine & Bodybuilding Dehydration Ability

Caffeine | Placebo

Taiwan
Chih-Hui Chiu
National Science and Technology Council

Enrolling by invitation

Caffeinated Chewing Gum on 400-meter Performance

Caffeine | Placebo

Taiwan
Elena N.Parovichnikova

Recruiting

R-BL-M-04 Versus R-(DA)-EPOCH and Autologous Stem Cells Transplantation in Patients With High-Grade B-cell Lymphoma Double-hit (HGBL DH) and High-Grade B-cell Lymphoma Not Otherwise Specified (HGBL NOS)

Lymphoma, High-Grade

Russian Federation
SOLTI Breast Cancer Research Group
Pierre Fabre Laboratories

Completed

Phase 0 Study of Metronomic Oral Vinorelbine and Letrozole in HR+/HER2-negative Early Breast Cancer Patients (VENTANA)

Breast Cancer

Spain
Dong-A ST Co., Ltd.

Completed

Drug Interactions When DA-8010 is Co-administered With Paroxetine or Mirabegron in Healthy Adults

Healthy

Korea, Republic of
Western Regional Medical Center

Terminated

Neoadjuvant Hormonal Therapy Combined With Chemoimmunotherapy (Neohttp)

HER2-positive Breast Cancer | ER-positive Breast Cancer

United States
Actavis Inc.

Completed

A Relative Bioavailability Study of Gabapentin Tablets 800 mg Under Fasting Conditions

Healthy

United States
Actavis Inc.

Completed

A Relative Bioavailability Study of Gabapentin Tablets 800 mg Under Non-fasting Conditions

Healthy

United States
Centre Hospitalier Universitaire de Besancon
Pierre Fabre Medicament

Terminated

A Open Study of Metronomic Oral Vinorelbine in Combination With Aromatase Inhibitors for the Treatment of Postmenopausal Women With Hormone Receptor Positive,HER2-negative, Advanced Breast Cancer Who Received no Prior Therapy for Advanced Disease (VICTORIANE)

Breast Cancer

France
Gynuity Health Projects

Completed

Letrozole and Misoprostol for Termination of Pregnancy up to 63 Days' Gestation

Pregnancy

United States
University Health Network, Toronto
National Cancer Institute (NCI)

Completed

GTI-2040, Docetaxel, and Prednisone in Treating Patients With Prostate Cancer

Prostate Cancer

Canada
Federal University of São Paulo

Unknown

Influence of Perception of Patients Suffering of Knee Osteoarthritis Regarding Effectiveness of Intra-articular Injection

Knee Osteoarthritis
University of Washington
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Completed

ITT4 Intratesticular Hormonal Milieu in Man (ITT4) (ITT4)

Healthy Males

United States
Dong-A ST Co., Ltd.

Completed

Evaluate the Effect of Clarithromycin/Rifampicin on the Pharmacokinetics of DA-8010 in Healthy Adults

Healthy

Korea, Republic of

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