Search clinical trials for: calcineurin inhibitor

Total 64709 results

Astellas Pharma Inc

Completed

A Study to Compare the Efficacy and Safety of FK506MR vs Prograf® in Patients Undergoing Liver Transplantation

Liver Transplantation

China
University of Michigan
Bausch & Lomb Incorporated

Completed

Treatment of Ocular Graft-versus-Host Disease (GVHD) With Topical Loteprednol Etabonate 0.5% (Lotemax_BMT)

Dry Eyes
Federico II University

Unknown

Alemtuzumab and Low-Dose Cyclosporine in Treating Patients With Severe Aplastic Anemia or Acquired Marrow Failure

Nonmalignant Neoplasm

Italy
Sigmoid Pharma

Completed

Oral Ciclosporin for Colonic Release in Ulcerative Colitis (CyCol™)

Mild to Moderate Ulcerative Colitis

United Kingdom, Ireland
Universidade Federal do Rio de Janeiro

Unknown

Topical Cyclosporine for the Treatment of Dry Eye in Patients Infected With the Human Immunodeficiency Virus

Dry Eye Syndromes | HIV Seropositivity

Brazil
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Evaluating the Efficacy and Safety of Cyclosporine Reduction in Kidney Transplant Recipients Receiving Sirolimus

Kidney Transplantation
Erasmus Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Recruiting

NMF-CsA-Dupi Trial

Dermatitis, Atopic

Netherlands
National Heart, Lung, and Blood Institute (NHLBI)

Recruiting

Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)

Severe Aplastic Anemia

United States
Research Insight LLC

Completed

The COAT Trial: Cequa's Onset of Action Trial (COAT)

Dry Eye

United States
Sun Pharmaceutical Industries Limited

Completed

Effect of Cequa™ in Subjects With Dry Eye Disease

Dry Eye Disease

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study Comparing Standard Dose and Reduced Dose Tacrolimus With Sirolimus in Renal Transplant Patients

Kidney Transplantation
University College, London

Withdrawn

NOMINATE/ Minimisation of Immunosuppression in Kidney Transplantation

Renal Transplant Rejection | Renal Transplant Infection
Boston Sight
Allergan

Completed

Novel Use of Cyclosporine Ophthalmic Emulsion 0.05% on Application of PROSE Devices for Management of Patients With Ocular Surface Disease

Ocular Surface Disease

United States
Alexion

Completed

Drug-Drug Interaction (DDI) Study of ALXN2050 in Healthy Adult Participants

Healthy

United States
University of Toledo Health Science Campus
Novartis Pharmaceuticals

Completed

Evaluation of Calcineurin-inhibitor Reduction With Conversion at 2 Months to Everolimus/Reduced Tacrolimus in Renal Transplant Recipients Following Campath® Induction

Renal Transplant

United States
Imperial College Healthcare NHS Trust

Completed

Standard Versus Prolonged-release Tacrolimus Monotherapy After Alemtuzumab Induction in Kidney Transplantation (TAESR)

Graft Rejection | End-stage Renal Failure

United Kingdom
Leiden University Medical Center
Aurinia Pharmaceuticals Inc.

Unknown

Anti-Viral Effects of Voclosporin in COVID-19 Positive Kidney Transplant Recipients (VOCOVID)

Covid19 | Kidney Transplant Infection

Netherlands
Allergan

Terminated

Phase 2 Study of a New Ophthalmic Formulation of Cyclosporine (Restasis® X) in Patients With Dry Eye Disease

Dry Eye Syndromes

United States
Edda Spiekerkoetter
Stanford University

Completed

FK506 (Tacrolimus) in Pulmonary Arterial Hypertension (TransformPAH)

Pulmonary Arterial Hypertension

United States
Veloxis Pharmaceuticals

Completed

Double-Blind,Double-Dummy,Efficacy/Safety,LCP-Tacro™ Vs Prograf®,Prevention Rejection,De Novo Adult Kidney Tx (LCPTacro3002)

Renal Failure

United States, Argentina, Australia, Brazil, France, Germany, Italy, Korea, Republic of, Mexico, New Zealand, Poland, Serbia, Singapore, Spain, Sweden
Shandong University

Withdrawn

A Multicenter Investigation of Recombinant Human Thrombopoietin (rhTPO) Combining Cyclosporin A Versus Cyclosporin A in Management of Steroid-Resistant/Relapsed Immune Thrombocytopenia （ITP）

Immune Thrombocytopenia

China
Deana Funaro
Astellas Pharma Inc

Completed

Tacrolimus Versus Clobetasol Propionate in the Treatment of Vulvar Lichen Sclerosus

Vulvar Lichen Sclerosus

Canada
Irmandade Santa Casa de Misericórdia de Porto Alegre
Novartis

Completed

Effect of Switching to Certican® in Viremia of Hepatitis C Virus in Adult Renal Allograft Recipients (CONCERVIC)

Hepatitis C | Renal Allograft

Brazil
Pfizer

Completed

Study Evaluating A Planned Transition From Tacrolimus To Sirolimus In Kidney Transplant Recipients

Renal Transplant | Graft Rejection | Kidney Transplant | Renal Allograft Recipients

United States, Australia, Germany, Italy, Spain, Brazil, Argentina
Centre Hospitalier Universitaire de Nice

Completed

AADAPT - Analysis of Advagraf Dose Adaptation Post Transplantation (AADAPT)

Renal Transplantation

France
Allergan

Completed

Safety and Efficacy of Cyclosporine Ophthalmic Emulsion in Patients With Primary Pterygium

Pterygium

Singapore, United States, Australia
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Gemtuzumab Ozogamicin and Cyclosporine in Treating Older Patients With Relapsed Acute Myeloid Leukemia

Leukemia

United States
Shandong University
National Natural Science Foundation of China

Unknown

Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Severe Aplastic Anemia

Aplastic Anemia

China
Fred Hutchinson Cancer Center
National Cancer Institute (NCI)

Completed

Tacrolimus and Mycophenolate Mofetil in Preventing Acute Graft-Versus-Host Disease in Patients With Advanced Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplantation

Lymphoma | Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Myelodysplastic/Myeloproliferative Diseases | Graft Versus Host Disease

United States
University of Medicine and Dentistry of New Jersey
Biogen

Completed

Transitioning From Cyclosporine to Alefacept in Psoriasis

Psoriasis

United States
Office of Rare Diseases (ORD)
Rare Diseases Clinical Research Network

Unknown

Sirolimus and Cyclosporine for Treatment-Resistant Aplastic Anemia

Anemia, Aplastic

United States
Bristol-Myers Squibb

Completed

A Study of BMS-224818 (Belatacept) in Patients Who Have Undergone a Kidney Transplant and Are Currently on Stable Cyclosporine or Tacrolimus Regimen With or Without Corticosteroids

Renal Transplant

Argentina, Australia, India, United States, Belgium, Brazil, Poland, Mexico, Canada, France, Germany, Spain
Pfizer

Completed

A Phase I Open-Label Study of the Effects of Tacrolimus and Cyclosporine on CP-690,555 in Healthy Volunteers

Healthy Volunteers

Singapore
Thomas Jefferson University
Bristol-Myers Squibb

Completed

Drug Interaction Study of Apixaban With Cyclosporine and Tacrolimus (ACT)

Healthy | Venous Thromboembolism | Pharmacokinetics

United States
National Institute of Allergy and Infectious Diseases...
Clinical Trials in Organ Transplantation

Terminated

Immune Monitoring and CNI Withdrawal in Low Risk Recipients of Kidney Transplantation

Kidney Transplant Recipients

United States, Canada
Johnson & Johnson Pharmaceutical Research & Development...

Completed

A Study to Assess the Effects of Cyclosporine on the Pharmacokinetics and Safety of Canagliflozin (JNJ-28431754) in Healthy Volunteers

Healthy

Belgium
Hoffmann-La Roche

Completed

A Drug-Drug Interaction Study Between Danoprevir/Low-Dose Ritonavir and Cyclosporine in Healthy Volunteers

Healthy Volunteer

United States
Assistance Publique Hopitaux De Marseille

Unknown

Study to Evaluate the Value of the Follow-up of CALCIneurin Activity to MOdulate Calcineurin Inhibitors-induced Immunosuppression in Lung Transplantation (CalciMo-TP)

Lung Diseases

France
University of Miami
Wyeth-Ayesrst Pharmaceuticals, Roche Laboratories, and Fujusawa Healthcare...

Completed

Tacrolimus/Sirolimus Versus Tacrolimus/Mycophenolate Mofetil (MMF) Versus Neoral/Sirolimus in Adult, Primary Kidney Transplantation

Adult Primary Kidney Transplantation

United States
University of Leeds

Completed

Irinotecan With or Without Panitumumab or Cyclosporine in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did Not Respond to Fluorouracil

Colorectal Cancer

United Kingdom
University Hospital, Limoges

Not yet recruiting

Evaluation of the Benefits of Administering Immunosuppressive Drugs as Single Daily Doses Over the First Year After Liver Transplantation (EASY) (EASY)

Liver Transplantation | Immunosuppression

France
Instituto de Investigación Hospital Universitario...

Recruiting

Optimization of Cyclosporin in Atopic Dermatitis Through Multiomic Predictive Models of Treatment Response (DermAtOmics)

Atopic Dermatitis

Spain
Farwaniya Hospital

Completed

Topical Cyclosporin A 0.05% Eye Drops for Management of Symptomatic Acquired Punctal Stenosis. A Prospective, Controlled Clinical Study.

Management of Punctal Stenosis

Kuwait
Chang Gung Memorial Hospital

Completed

Twice-daily Tacrolimus and Everolimus Convert to Once-daily Tacrolimus and Everolimus in Liver Transplant Recipient

Liver Transplantation

Taiwan
Assiut University

Unknown

Predictors of Rejection in Pediatric Kidney Transplantation

Rejection Acute Renal
Assistance Publique - Hôpitaux de Paris

Completed

Conversion Prograf® to Advagraf® at D7 Versus D90 After Liver Transplantation (Conversion)

Immunosuppression After Liver Transplantation

France
Chulalongkorn University

Unknown

Study of Cyclosporine Withdrawal Regimen in Thai Renal Transplant Recipients

Renal Transplant

Thailand
Sun Yat-sen University

Unknown

A Controlled Study of Steroids Plus Cyclosporin Therapy for Patients of Idiopathic Membranous Nephropathy

Proteinuria | Idiopathic Membranous Nephropathy | Spontaneous Remission | Steroid Nephropathy | Cyclosporin Overdose

China
Astellas Pharma Inc

Completed

A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Liver Transplant Patients

Liver Transplantation

United States
National Institute of Allergy and Infectious Diseases...

Completed

Antibody and Delayed Cyclosporine Versus Initial Cyclosporine Alone in Patients Receiving Kidney Transplants

Kidney Transplantation | Chronic Allograft Nephropathy

United States

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