Search clinical trials for: Complement C1s

Total 1931 results

Penn State University

Withdrawn

C1-INH Compared to Placebo at the Time of Prodromal Symptoms for Hereditary Angioedema (HAE) Exacerbation

Hereditary Angioedema
Pharming Technologies B.V.

Terminated

Prevention of Acute Kidney Injury in Patients With NSTEMI (AKI)

Non-ST Elevation Myocardial Infarction (NSTEMI)

Switzerland
Shire

Completed

Safety and Efficacy Study of CINRYZE for Prevention of Angioedema Attacks in Children Ages 6-11 With Hereditary Angioedema

Hereditary Angioedema (HAE)

Israel, Germany, Mexico, United States, Romania
University Hospital, Basel, Switzerland
Pharming Technologies B.V.

Terminated

Conestat Alfa in the Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19

Coronavirus Infections

Switzerland, Brazil, Mexico
National Taiwan University Hospital

Completed

Anesthetic Management and Remote Reperfusion Injuries

Heart Valve Diseases

Taiwan
Shire

Completed

Study of C1 Inhibitor (Human) for the Prevention of Angioedema Attacks and Treatment of Breakthrough Attacks in Japanese Subjects With Hereditary Angioedema (HAE)

Hereditary Angioedema (HAE)

Japan
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Hereditary Angioedema | Angioneurotic Edema

Netherlands
Pharming Technologies B.V.

Completed

Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema

Hereditary Angioedema | Genetic Disorders | Angioneurotic Edema

Netherlands, Romania
Spine Centre of Southern Denmark

Completed

Biomarkers in Early-stage Spondyloarthritis

Ankylosing Spondylitis | Spondyloarthritis
University Hospital, Basel, Switzerland
Swiss National Science Foundation; Pharming Technologies B.V.

Recruiting

Recombinant Human C1 Esterase Inhibitor (Conestat Alfa) in the Prevention of Acute Ischemic Cerebral and Renal Events After Transcatheter Aortic Valve Implantation (PAIR-TAVI)

Acute Renal Injury | Acute Ischemic Stroke

Switzerland
Melbourne Health
Sanofi

Withdrawn

Complement Activation in the Lysosomal Storage Disorders (CATALYST)

Lysosomal Storage Diseases | Fabry Disease | Niemann-Pick Disease, Type C | Gaucher Disease

Australia
NMP Medical Research Institute
Aarogyam UK

Completed

Cholesterol Lowering Effect of Cardio-Complement, an Ayurveda Formulation

Hypercholesterolemia

India
University College, London

Unknown

TTP and aHUS in Complicated Pregnancies

Thrombotic Microangiopathies | Thrombotic Thrombocytopenic Purpura | Thrombocytopenia | Pre-Eclampsia | HELLP Syndrome | Stillbirth | Atypical Hemolytic Uremic Syndrome | IUGR

United Kingdom
Travere Therapeutics, Inc.

Active, not recruiting

Pegtibatinase as an Enzyme Therapy for Patients With Homocystinuria Caused by Cystathionine Beta-Synthase Deficiency (COMPOSE)

Homocystinuria

United States
TNO
Netherlands: Ministry of Health, Welfare and Sports

Completed

Body Fat Distribution and Fat Metabolism

Obesity | Metabolic Disease

Netherlands
Francis Corazza

Completed

Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome

COVID-19

Belgium
University of Extremadura

Active, not recruiting

Influence of Co-diagnosis of Chronic Fatigue Syndrome in Patients With Fibromyalgia.

Fibromyalgia | Chronic Fatigue Syndrome | Comorbidities and Coexisting Conditions

Spain
National Institute of Diabetes and Digestive and...

Completed

Kidney Transplant for HIV-Infected Patients in Renal Failure

HIV Infection | Chronic Kidney Failure

United States
Catholic University of Murcia

Completed

Health Parameters in Soccer Players and Sedentary Individuals After Consuming a Synbiotic

Sedentary Behavior | Athlete

Spain
Assiut University

Unknown

Acute Post Streptococcal Glomerulonephritis

PSGN - Post-Streptococcal Glomerulonephritis
National Institute of Allergy and Infectious Diseases...

Completed

A Clinical Trial To Evaluate the Toxicity and Antiviral Effects of a Range of Doses of Ampligen in p24 Antigen Positive HIV-Infected Patients With AIDS or ARC

HIV Infections

United States
Icahn School of Medicine at Mount Sinai
IRRAS

Recruiting

Intraventricular Catheter System for IVH (DIVE)

Intraventricular Hemorrhage (IVH)

United States
GCS Ramsay Santé pour l'Enseignement et la Recherche

Completed

Evaluation of the Effects of Bradykinin Antagonists on Pulmonary Manifestations of COVID-19 Infections (AntagoBrad-Cov Study). (AntagoBrad)

Covid19

France
Investigación en Hemofilia y Fisioterapia

Withdrawn

Weight Implements to Improve Throwing Speed and Shoulder Mobility in Baseball Pitchers

Baseball Pitcher

Spain
Amgen

Completed

A Phase 1 First-in-Human Study Evaluating AMG 900 in Advanced Solid Tumors

Cancer | Advanced Solid Tumors | Solid Tumors | Tumors | Advanced Malignancy

United States, Australia
Matrouh University

Completed

Home Injuries, Early Childhood, Rural Mothers, First Aid, Matrouh Governorate

Home Injury

Egypt
T. van der Poll
ZonMw: The Netherlands Organisation for Health Research and Development; Prothya...

Terminated

C1-inhibitor in Allergic ASThma Patients (CAST)

Asthma

Netherlands
Complement Theory Inc.

Recruiting

A Randomised Controlled Trial to Evaluate the Impact of Complement Theory's Live 1:1 Exercise Coaching and Personalised Digital Application on Cancer Survivors' Cost of Care

Breast Cancer | Colorectal Cancer | Lung Cancer | Prostate Cancer | Other Cancer

United States
University of Calgary

Completed

Family Integrated Care (FICare) in Level II NICUs (FICare)

Premature Birth

Canada
Paion UK Ltd.
Premier Research Group plc

Completed

Multiple Dose Safety and Efficacy Study Evaluating CNS 7056 Versus Midazolam in Patients Undergoing Colonoscopy

Sedation

United States
University Hospital Inselspital, Berne
University of Bern

Completed

Characterizing the Immune Response and Neuronal Damage in COVID-19

Covid-19 | SARS-CoV Infection

Switzerland
VA Office of Research and Development

Completed

Treatment of Veterans With Chronic Low Back Pain (CLBP)

Low Back Pain, Recurrent

United States
Javier Garcia Campayo

Completed

Efficacy of a MBI Programme With or Without Virtual Reality Support to Reduce Stress in University Students

Mental Health Wellness 1

Spain
Sohag University

Enrolling by invitation

Comparison Between Early-onset and Late-onset Patients With Systemic Lupus Erythematosus.

Systemic Lupus Erythematosus

Egypt
Alexion Pharmaceuticals, Inc.

Completed

A Phase 3 Open-Label Study of Eculizumab in Pediatric Participants With Refractory Generalized Myasthenia Gravis (gMG)

Myasthenia Gravis | Myasthenia Gravis, Generalized | Myasthenia Gravis, Juvenile Form

United States, Japan, Netherlands
Brigham and Women's Hospital

Active, not recruiting

Ravulizumab and COVID-19

Covid19 | Thrombotic Microangiopathies | Acute Kidney Injury

United States
Assistance Publique - Hôpitaux de Paris

Unknown

CORIMUNO19-ECU: Trial Evaluating Efficacy and Safety of Eculizumab (Soliris) in Patients With COVID-19 Infection, Nested in the CORIMUNO-19 Cohort (CORIMUNO19-ECU)

SARS-CoV-2 | COVID19

France
Samsung Bioepis Co., Ltd.

Completed

Pharmacokinetic, Safety, Tolerability, Immunogenicity, and Pharmacodynamic Study of SB12 in Healthy Subjects

Healthy

Germany
National Heart, Lung, and Blood Institute (NHLBI)

Completed

Eculizumab to Treat Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Hemoglobinuria, Nocturnal

United States
Alexion Pharmaceuticals

Completed

The Safety and Efficacy of Eculizumab in Japanese Patients With Atypical Hemolytic Uremic Syndrome (aHUS)

Atypical Hemolytic Uremic Syndrome (aHUS)

Japan
Alexion Pharmaceuticals

Completed

Open Label Controlled Trial of Eculizumab in Adolescent Patients With Plasma Therapy-Resistant aHUS (aHUS)

Atypical Hemolytic Uremic Syndrome

France, United States, Austria, Germany, United Kingdom
Coventry University
The University of Hong Kong; Radboud University, Donders Institute for Brain... and other collaborators

Not yet recruiting

From the Heart: Comparing the Effects of Spiritual and Secular Meditation on Psychophysiology, Cognition, Mental Health, and Social Functioning in Healthy Adults

Depression | Pain | Stress | Anxiety | Mental Well-being | Prosocial Behavior | Attention | Empathy | Forgiveness

China, India
Baylor College of Medicine

Withdrawn

Stem Cells for the Improvement of Erectile and Cardiac Function in Aging Men

Erectile Dysfunction | Cardiac Disease

United States
Alexion Pharmaceuticals, Inc.
AstraZeneca

Recruiting

Eculizumab in Pediatric and Adult Participants With Atypical Hemolytic Uremic Syndrome (aHUS) in China (Soliris)

Atypical Hemolytic Uremic

China
Hudson Medical

Available

Eculizumab (Soliris) in Covid-19 Infected Patients (SOLID-C19)

Coronavirus
Alexion

Completed

An Open-label, Multi-center Clinical Trial of Eculizumab in Adult Patients With Atypical Hemolytic-uremic Syndrome

Atypical Hemolytic-Uremic Syndrome

United Kingdom, United States, France, Italy, Germany, Spain, Belgium
Alexion Pharmaceuticals

Completed

Open Label Controlled Trial of Eculizumab in Adult Patients With Plasma Therapy-Resistant aHUS (aHUS)

Atypical Hemolytic Uremic Syndrome

France, United States, Austria, Germany, United Kingdom
Alexion Pharmaceuticals

Completed

An Open-Label, Multi-Center Clinical Trial of Eculizumab in Pediatric Patients With Atypical Hemolytic-Uremic Syndrome (aHUS)

Atypical Hemolytic-Uremic Syndrome

United Kingdom, Belgium, United States, Germany, Italy, France, Netherlands, Australia, Canada
University of Texas Southwestern Medical Center
Alexion Pharmaceuticals, Inc.

Recruiting

Study of the Clinical and Radiological Impact of Ravulizumab in People With Neuromyelitis Optica Spectrum Disorder (AMAZE)

Neuromyelitis Optica

United States
Hoffmann-La Roche
Chugai Pharmaceutical

Active, not recruiting

A Phase III Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors. (COMMODORE 2)

Paroxysmal Nocturnal Hemoglobinuria

Spain, Korea, Republic of, France, Sweden, Thailand, Malaysia, China, Turkey, Netherlands, Japan, Australia, United Kingdom, Germany, South Africa, Brazil, Romania, Argentina, Poland, Greece, Hong Kong, Lithuania, Mexico, Philippines, Portuga... and more

Search clinical trials for: Complement C1s

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