Search clinical trials for: complex intervention

Total 21943 results

AstraZeneca
Bristol-Myers Squibb

Completed

Pharmacokinetic Drug Interaction Study of Dapagliflozin and Glimepiride or Sitagliptin in Healthy Subjects

Type 2 Diabetes Mellitus

United States
The George Institute
National Health and Medical Research Council, Australia; University of Sydney; Institut de Recherches Internationales Servier

Completed

Blood Pressure and Glucose Lowering for the Prevention of Vascular Disease in High Risk Patients With Type 2 Diabetes

Diabetes Mellitus, Type 2

Australia, Canada, China, Netherlands, United Kingdom
New Valley University

Recruiting

Comorbidities in Type 2 Diabetes Mellitus

Type 2 Diabetes

Egypt
Ipsen

Terminated

Study of Lanreotide in Non Metastatic Castration-resistant Prostate Cancer Patients (POSEIDON)

Prostate Cancer

Italy
Bayer

Completed

Interaction With HIV Antiretroviral Agents

HIV-DDI

United States
Hospital Central Dr. Luis Ortega

Completed

Oxycodone Extended-release in the Treatment of Perioperative Pain in Patients Undergoing Orthopaedic Surgery

Surgery

Venezuela
Arjun Mittra
National Cancer Institute (NCI)

Recruiting

Intraperitoneal Oxaliplatin and Fluorouracil for the Treatment of Patients With Peritoneal Metastases From Colorectal Cancer

Metastatic Colorectal Carcinoma | Stage IV Colorectal Cancer AJCC v8 | Metastatic Malignant Neoplasm in the Peritoneum

United States
University of KwaZulu

Not yet recruiting

Anti-Inflammatory Reliever South Africa (AIRSA001)

Asthma
Hoffmann-La Roche

Completed

A Study to Evaluate the Safety and Efficacy of Obinutuzumab Compared With Placebo in Participants With Lupus Nephritis (LN)

Lupus Nephritis

United States, Colombia, Israel, Brazil, Argentina, Costa Rica, France, Italy, Mexico, Panama, Peru, Spain
I.M. Sechenov First Moscow State Medical University

Completed

Sodium-glucose Cotransporter Type 2 Inhibitors for Acute Cardiorenal Syndrome Prevention

Congestive Heart Failure

Russian Federation
GlaxoSmithKline

Completed

This Study Will Evaluate the Immunogenicity, Reactogenicity and Safety of the Routine Infant Vaccines Pediarix®, Hiberix® and Prevenar 13® When Co-administered With GlaxoSmithKline (GSK) Biologicals' Liquid Human Rotavirus Vaccine (HRV) as Compared to GSK's Licensed Lyophilized Vaccine

Rotavirus Infection | Rotavirus Vaccines

United States
Novartis Vaccines

Completed

Safety and Immunogenicity of Different Meningitis Vaccine Formulations in Adolescents and Young Adults

Invasive Meningococcal Disease

United States, Poland
U.S. Army Medical Research and Development Command
GlaxoSmithKline; Walter Reed Army Institute of Research (WRAIR)

Withdrawn

TDENV PIV and LAV Dengue Prime-boost Strategy Using AS03B Adjuvant

Dengue

United States
University of Rochester

Not yet recruiting

Efficacy of Methylene Blue Photodynamic Therapy for Treatment of Deep Tissue Abscesses

Abscess

United States
University of Belgrade

Completed

Effect of Preemptive Etoricoxib and Dexamethasone on Wound Healing and Clinical Parameters After Third Molar Surgery

Surgical Wound | Post Operative Pain

Serbia
Sinovac Biotech Co., Ltd

Completed

A Clinical Trial With Influenza A/H1N1 Vaccines

Influenza

China
GlaxoSmithKline

Completed

Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age

Measles; Mumps; Rubella | Measles-Mumps-Rubella Vaccine

United States, Finland, Taiwan, Estonia, Puerto Rico
GlaxoSmithKline

Completed

Pneumococcal Vaccine Booster Study in Healthy Children 11-18 Months Old Previously Primed With the Same Vaccines

Hepatitis B | Tetanus | Diphtheria | Acellular Pertussis | Poliomyelitis | Streptococcus Pneumoniae Vaccines

Spain, Germany, Poland
Peking Union Medical College Hospital
Peking Union Medical College

Unknown

The Role of Dysbiosis of Gut Microbiota in the Pathogenesis of PCOS.

Polycystic Ovary Syndrome

China
Sanofi Pasteur, a Sanofi Company

Completed

Concomitant Administration of a New Hexavalent Vaccine With a Meningococcal Serogroup C Conjugate Vaccine in Healthy Infants During Primary Series Immunisation Followed by Booster Vaccination

Virus Diseases | Bacterial Infections | Neisseria Meningitidis

Finland
University of Calgary

Unknown

Low Dose Dexamethasone in Supraclavicular Blocks

Osteoarthritis | Rheumatoid Arthritis | Ligament Injury | Nerve Entrapment

Canada
Case Comprehensive Cancer Center

Terminated

A Cognitive- Behavioral Play Intervention for Siblings of Children Diagnosed With Cancer

Any Cancer Diagnosis

United States
National Cancer Institute (NCI)

Terminated

Vaccine Therapy and Sargramostim With or Without Docetaxel in Treating Patients With Metastatic Lung Cancer or Metastatic Colorectal Cancer

Extensive Stage Small Cell Lung Cancer | Recurrent Small Cell Lung Cancer | Stage IV Colon Cancer | Stage IV Rectal Cancer | Recurrent Colon Cancer | Recurrent Rectal Cancer | Recurrent Non-small Cell Lung Cancer | Stage IV Non-small Cell Lung Cancer

United States
University of Maryland, Baltimore

Withdrawn

Standard Therapy Using Tacrolimus, Mycophenolate Mofetil and Prednisone For Chronic Lung Transplant Rejection (BOS)

Chronic Rejection of Lung Transplant | Disorder Related to Lung Transplantation | Decreased Immunologic Activity
Mundipharma Pharmaceuticals S.L.
Alpha Bioresearch S.L.; Dynamic Solutions

Withdrawn

Efficiency Control of Fluticasone/Formoterol K-haler (Medium Strength) vs ICS/LABA (High Strength) in Asthma Patients

Persistent Asthma
Ohio State University Comprehensive Cancer Center
National Cancer Institute (NCI)

Not yet recruiting

Informing Oral Nicotine Pouch Regulations to Promote Public Health

Tobacco-Related Carcinoma

United States
Edgar Jaeggi
Canadian Institutes of Health Research (CIHR)

Completed

Prospective Randomized Clinical Trial of Fetal Atrial Flutter & Supraventricular Tachycardia Therapy (FAST RCT)

Fetal Atrial Flutter Without Hydrops | Fetal Supraventricular Tachycardia Without Hydrops | Fetal Supraventricular Tachycardia With Hydrops

United States, Canada, Germany, Australia, Netherlands, United Kingdom
Radboud University Medical Center
The PATH Malaria Vaccine Initiative (MVI)

Terminated

Safety and Efficacy of NF135 CPS Immunization (CPS135)

Malaria,Falciparum | Controlled Human Malaria Infection | Immunization; Infection

Netherlands
Columbia University
National Heart, Lung, and Blood Institute (NHLBI); Duke University; HealthPartners... and other collaborators

Completed

Comparison of Depression Identification After Acute Coronary Syndrome: Quality of Life and Cost Outcomes (CODIACSQoL)

Depressive Symptoms | Acute Coronary Syndrome

United States
Ludwig Institute for Cancer Research
Cancer Research Institute, NY, USA

Terminated

NY-ESO-1 Vaccine in Combination With Ipilimumab in Patients With Unresectable or Metastatic Melanoma

Unresectable or Metastatic Melanoma

United States, Australia
Abramson Cancer Center of the University of Pennsylvania

Terminated

Autologous T-Cells Combined With Autologous OC-DC Vaccine in Ovarian Cancer

Fallopian Tube Cancer | Primary Peritoneal Cancer | Ovarian Carcinoma

United States
Merck Sharp & Dohme LLC

Completed

A Study to Evaluate the Efficacy and Safety of Sitagliptin and MK0431A in Comparison to a Commonly Used Medication in Patients With Type 2 Diabetes (0431-068)(COMPLETED)

Type 2 Diabetes Mellitus
Novartis Vaccines

Completed

Extension Study of V72P13 to Evaluate the Safety, Tolerability and Immunogenicity of Novartis Meningococcal B Recombinant Vaccine When Administered as a Booster or as a Two-dose Catch-up to Healthy Toddlers

Meningococcal Disease

Austria, Finland, Germany, Italy, Czech Republic
Eckhard Podack

Withdrawn

Combination of gp96-Ig Vaccine, Theophylline and Oxygen for the Treatment of Patients With Advanced, Relapsed or Metastatic Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer | NSCLC | Lung Cancer | Non-small-cell Lung Carcinoma
Vrije Universiteit Brussel

Completed

Unraveling the Nature of Impaired Pain Inhibition in Patients With Chronic Whiplash-associated Disorders

Whiplash Injuries

Belgium
Lawson Health Research Institute
University of Western Ontario, Canada

Unknown

When Cooling a Patient After Cardiac Arrest, Does Use of a Neuromuscular Blocking Agent Make Your Job Easier?

Postcardiac Arrest Therapeutic Hypothermia

Canada
Sanofi

Completed

A Study of Dengue Vaccine in Healthy Toddlers Aged 12 to 15 Months in the Philippines

Dengue Fever | Dengue Hemorrhagic Fever

Philippines
Sun Yat-sen University

Recruiting

FOLFOX Via HAI Plus Intravenous Irinotecan With or Without Bevacizumab Versus Systemic FOLFOXIRI With or Without Bevacizumab in Initially Unresectable RAS-mutated CRLM Patients

Colorectal Cancer Metastatic

China
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Recruiting

mFOLFIRINOX Versus mFOLFOX With or Without Nivolumab for the Treatment of Advanced, Unresectable, or Metastatic HER2 Negative Esophageal, Gastroesophageal Junction, and Gastric Adenocarcinoma

Clinical Stage III Gastric Cancer AJCC v8 | Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8 | Clinical Stage IV Gastric Cancer AJCC v8 | Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8 | Metastatic Gastric Adenocarcinoma | Metastatic Gastroesophageal Junction... and other conditions

United States, Puerto Rico
ImmunityBio, Inc.

Withdrawn

QUILT-3.047: NANT Head and Neck Squamous Cell Carcinoma (HNSCC) Vaccine: Combination Immunotherapy in Subjects With HNSCC Who Have Progressed on or After Chemotherapy and PD-1/PD-L1 Therapy

Head and Neck Squamous Cell Carcinoma
ImmunityBio, Inc.

Withdrawn

QUILT-3.044: NANT Non-small Cell Lung Cancer (NSCLC) Vaccine: Combination Immunotherapy in Subjects With NSCLC Who Have Progressed After Treatment With PD-1/PD-L1 Inhibitors

Non-small Cell Lung Cancer
University of Miami

Terminated

Chemotherapy for Relapsed Epstein Barr Virus Associated Lymphoma

Epstein Barr Virus Associated Non Hodgkin's Lymphoma | Epstein Barr Virus Associated Hodgkin's Lymphoma | Post-Transplant Lymphoproliferative Disease

United States
M.D. Anderson Cancer Center

Withdrawn

Panobinostat Combined With High-Dose Gemcitabine/Busulfan/Melphalan With Autologous Stem Cell Transplant for Patients With Refractory/Relapsed Lymphoma

Lymphoma
City of Hope Medical Center
National Cancer Institute (NCI)

Terminated

Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer

Liver Metastases | Recurrent Colon Cancer | Recurrent Rectal Cancer | Stage IVA Colon Cancer | Stage IVA Rectal Cancer | Stage IVB Colon Cancer | Stage IVB Rectal Cancer

United States
Cancer Research UK

Unknown

Combination Chemotherapy and Rituximab in Treating Patients With Diffuse Large B-Cell Non-Hodgkin Lymphoma

Lymphoma

United Kingdom
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI)

Terminated

Removal of T Cells to Prevent Graft-Versus-Host Disease in Patients Undergoing Bone Marrow Transplantation

Myelodysplastic Syndromes | Leukemia | Chronic Myeloproliferative Disorders | Multiple Myeloma and Plasma Cell Neoplasm | Graft Versus Host Disease

United States
Eastern Cooperative Oncology Group
National Cancer Institute (NCI)

Completed

Bevacizumab and Oxaliplatin Combined With Irinotecan or Leucovorin and Fluorouracil in Treating Patients With Metastatic or Recurrent Colorectal Cancer

Colorectal Cancer

United States
National Cancer Institute (NCI)

Completed

Comparison of Adjuvant Chemotherapy Regimens in Treating Stage II/III Rectal Cancer

Recurrent Rectal Carcinoma | Stage IIIA Rectal Cancer AJCC v7 | Stage IIIB Rectal Cancer AJCC v7 | Stage IIIC Rectal Cancer AJCC v7 | Stage IVA Rectal Cancer AJCC v7 | Stage IVB Rectal Cancer AJCC v7 | Rectal Mucinous Adenocarcinoma | Rectal Signet Ring Cell Adenocarcinoma | Stage IIA Rectal Cancer... and other conditions

United States
Dana-Farber Cancer Institute
Columbia University; Boston Children's Hospital; McMaster University; University... and other collaborators

Completed

Treatment of Acute Lymphoblastic Leukemia in Children

Acute Lymphoblastic Leukemia

United States
University of Aarhus
Novartis; Danish Heart Foundation; Danish Cardiovascular Research Academy

Terminated

Effects of Intensive Long-Term Vasodilation in Hypertensive Patients With Microvascular Angina Pectoris

Hypertension | Microvascular Angina

Denmark

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