Search clinical trials for: Cytochrome P-450 CYP3A Inhibitors

Total 7156 results

Germans Trias i Pujol Hospital
Fundación FLS de Lucha Contra el Sida, las Enfermedades Infecciosas y la...

Completed

Antiretroviral Treatment Simplification Study With Efavirenz + Abacavir + 3TC Once Daily

HIV Infections

Spain
French National Agency for Research on AIDS and...
Gilead Sciences; Institut de Médecine et d'Epidémiologie Appliquée - Fondation...

Completed

Simple Once Daily Triple Regimen Including Tenofovir, Emtricitabine and Efavirenz in HIV-1 Infected Patients (ANRS 1207)

HIV Infection

Senegal
Triangle Pharmaceuticals

Suspended

A Comparison of Emtricitabine and Abacavir Used in a Three-Drug Combination in HIV-Infected Patients Who Have Never Taken Anti-HIV Drugs

HIV Infections

United States
Janssen-Cilag International NV

Completed

A Clinical Trial Comparing the Efficacy of Tenofovir Disoproxil Fumarate/Emtricitabine/Rilpivirine (TDF/FTC/RPV) Versus TDF/FTC/Efavirenz (TDF/FTC/EFV) in Patients With Undetectable Plasma HIV-1 RNA on Current First-line Treatment (SALIF)

Human Immunodeficiency Virus-type 1 Infection

South Africa, Kenya, Thailand, Uganda, Cameroon, Senegal
Kirby Institute

Completed

Safety and Efficacy of Reduced Versus Standard Dose Efavirenz (EFV) Plus Two Nucleotides in Antiretroviral-naïve Adults. (ENCORE1)

HIV Infections

Australia
Shanghai Public Health Clinical Center

Completed

ART Drug Dosage Adjustment in HIV-infected Population

HIV Infections

China
Vanderbilt University

Completed

Genetic Determinants of the Metabolism of Non-nucleoside Reverse Transcriptase Inhibitors

HIV Infections
National Institute of Allergy and Infectious Diseases...

Completed

Effectiveness of Directly Observed Therapy in Combined HIV and Tuberculosis Treatment in Resource-limited Settings

HIV Infections | Tuberculosis

South Africa
French National Agency for Research on AIDS and...

Completed

Feasibility Study of a Once Daily Antiretroviral Regimen in Vietnam (ANRS 1210 VIETAR)

HIV Infection

Vietnam
Dupont Merck

Completed

A Study of Efavirenz in Combination With Stavudine and Didanosine

HIV Infections

United States
French National Agency for Research on AIDS and...
Gilead Sciences; Hoffmann-La Roche

Completed

Intensification With Enfuvirtide in Naive HIV-infected Patients (ANRS130)

HIV Infections | AIDS

France
Vertex Pharmaceuticals Incorporated

Completed

A Phase 1 Study to Examine the Drug-Drug Interaction of Ciprofloxacin, Itraconazole, and Rifampin on the Combination of Lumacaftor With Ivacaftor in Healthy Adult Subjects

Cystic Fibrosis

United States
Takeda

Completed

A Study of Soticlestat and Rifampin in Healthy Adults

Healthy Volunteers

United Kingdom
SecuraBio

Completed

Phase 1 Study in Healthy Subjects to Evaluate the Effect of Rifampin on the Pharmacokinetics of IPI-145 (DDI)

Healthy

United States
Johns Hopkins University

Withdrawn

Epidemiology and Treatment of Small-colony Variant Staphylococcus Aureus in Cystic Fibrosis

Cystic Fibrosis | MRSA

United States
Hoffmann-La Roche

Completed

A Study to Investigate the Effect of Rifampicin on the PK of Multiple Doses of Balovaptin In Healthy Volunteers

Healthy Volunteers

Netherlands
Eli Lilly and Company

Completed

A Study of LY2835219 in Healthy Participants

Healthy Volunteers

United States
Bristol-Myers Squibb

Completed

An Investigational Study to Evaluate the Effect of Rifampin on the Singe Dose of Experimental Medication BMS-986224 in Healthy Participants

Healthy Participants

United States
University of Oulu
Oulu University Hospital

Completed

The Effects of PXR Activation on Hepatic Fat Content

Non-alcoholic Fatty Liver Disease

Finland
National Institute of Allergy and Infectious Diseases...

Completed

TMC207 +/- Rifabutin/Rifampin

Tuberculosis

United States
Hoffmann-La Roche

Completed

A Study of the Effect of Multiple Doses of Rifampin on the Single Dose Pharmacokinetics of RO5424802

Healthy Volunteer

United States
Nivalis Therapeutics, Inc.
Davita Clinical Research

Completed

A Drug-Drug Interaction Study of N91115 +/- Rifampin in Healthy Adult Subjects

Drug Interaction Potentiation

United States
Janssen Research & Development, LLC

Completed

A Study to Assess the Effect of Rifampin on the Pharmacokinetics of PCI-32765 in Healthy Participants

Healthy Participants

United States
University of North Carolina, Chapel Hill
Eunice Kennedy Shriver National Institute of Child Health and Human Development...

Terminated

Safety and Pharmacokinetics of Single and Multiple Dose Rifampin in Infants

Infection

United States
Wyeth is now a wholly owned subsidiary of Pfizer

Completed

Study to Determine the Impact of Multiple Doses of Rifampin on Single-dose Pharmacokinetics of HCV-796

Healthy
Brigham and Women's Hospital
University of Cape Town; APIN Public Health Initiatives

Recruiting

Dolutegravir Pharmacokinetics Among HIV/TB Coinfected Children Receiving Standard and High-dose Rifampicin

Tuberculosis Infection | Pediatric HIV Infection

Nigeria
Jiangsu HengRui Medicine Co., Ltd.

Completed

Effect of Rifampicin on the Pharmacokinetics of HRS-1167 in Healthy Subjects

Advanced Solid Tumor

China
Institute of Tropical Medicine, Belgium
Leiden University Medical Center; Damien Foundation; Instituto Fernandes Figueira and other collaborators

Completed

Post ExpOsure Prophylaxis for LEprosy in the Comoros and Madagascar (PEOPLE)

Leprosy

Comoros, Madagascar
Amgen

Completed

A Study to Evaluate the Drug-drug Interaction Effect of Rifampin on the Pharmacokinetics of AMG 510 in Healthy Participants

Healthy Participants

United States
Phathom Pharmaceuticals, Inc.

Withdrawn

Evaluation of Effect of Rifampin on the Pharmacokinetics of Vonoprazan in Healthy Participants

Healthy Participants

United States
Shanghai Public Health Clinical Center

Completed

The Drug Interaction Between Albuvirtide (ABT) and Rifampin（RIF） in Healthy Adult Subjects

Drug Interaction

China
Millennium Pharmaceuticals, Inc.

Completed

A Study to Evaluate the Effect of Single-Dose Intravenous Rifampin as a Prototypic Inhibitor of Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 on the Single-Dose Pharmacokinetics (PK) of Oral TAK-906 in Healthy Adult Participants

Healthy Volunteers

United States
Eli Lilly and Company

Completed

A Study of Baricitinib and Rifampicin in Healthy Participants

Healthy Volunteers

United Kingdom
National University Hospital, Singapore

Suspended

Whole Blood Bactericidal Activity (WBA) Against Mycobacterium Tuberculosis of Rifampicin in Healthy Volunteers

Tuberculosis

Singapore
Hoffmann-La Roche

Completed

A Study to Investigate the Effects of Rifampicin on the Pharmacokinetics of Aleglitazar in Healthy Volunteers

Healthy Volunteer

United Kingdom
Janssen Research & Development, LLC

Completed

A Drug Interaction Study in Healthy Participants to Assess the Effect of Rifampin on the Pharmacokinetics of JNJ-42847922

Healthy

United States
Bristol-Myers Squibb

Withdrawn

A Study of the Interaction of Rifampin and Vinflunine in Subjects With Advanced Cancer

Cancer

United States
University Medicine Greifswald

Completed

Impact of Two Genetic Variants of OATP1B3 or MRP2 or Rifampin on Systemic Disposition and Biological Efficacy of CCK-8

Gastrointestinal Hormones

Germany
Pfizer

Completed

Understanding The Effect Of A Strong CYP3A4 Inducer On Glasdegib Pharmacokinetics

Healthy Volunteers

United States
AstraZeneca

Completed

To Assess the Effect of Rifampicin on the Pharmacokinetics of Selumetinib in Healthy Male Volunteers

Solid Tumours

United States
Michael Hoelscher
Quintiles, Inc.; German Federal Ministry of Education and Research; Parexel; European... and other collaborators

Completed

Early Bactericidal Activity (EBA) of SQ109 in Adult Subjects With Pulmonary TB (SQ109EBA)

Tuberculosis, Pulmonary

South Africa
AstraZeneca

Completed

Effects of Administration of Fostamatinib on Blood Concentrations of Rifampicin in Healthy Subjects.

Rheumatoid Arthritis | Healthy Volunteers

United States
Bristol-Myers Squibb
PRA Health Sciences

Completed

Drug-Drug Interaction Study With Rifampin

Alzheimer Disease

India
Shanghai Public Health Clinical Center
Yunnan Provincial Infectious Disease Hospital; The Second Hospital of Nanjing...

Completed

Optimization of Antiretroviral Therapy (OAT)

HIV Infections

China
ViiV Healthcare
GlaxoSmithKline

Terminated

Dose-finding Study of GSK2248761 in Antiretroviral Therapy-Naive Subjects (SIGNET) (SIGNET)

Infection, Human Immunodeficiency Virus

Spain, France, Germany
Centre for the AIDS Programme of Research in South...

Completed

Trial to Assess the Impact of PrEP to Tenofovir Gel on the Efficacy of Tenofovir-containing ART on Viral Suppression (TOAST)

Antiretroviral Treatment Outcomes

South Africa
Centers for Disease Control and Prevention
US Department of Veterans Affairs

Completed

TBTC Study 23C: Pharmacokinetics of Intermittent Rifabutin and Isoniazid With Daily Efavirenz

HIV Infections | Tuberculosis

United States, Canada
Tibotec BVBA

Completed

VX-950-TiDP24-C134: Drug-drug Interaction Trial Between Combination of Efavirenz and Tenofovir Disoproxil Fumarate and Different Dosages of Telaprevir on Healthy Volunteer

Hepatitis C | HIV | HCV | AIDS
Clinical Trial Agency of HIV Study Group

Completed

Once a Day (QD) - Twice a Day (BID) Clinical Trial: Didanosine, Lamivudine and Efavirenz Versus Zidovudine, Lamivudine and Efavirenz in the Starting Treatment of HIV

HIV Infections

Spain
Triangle Pharmaceuticals

Unknown

A Comparison of Emtricitabine and Stavudine Used With Didanosine Plus Efavirenz in HIV-Infected Patients Who Have Not Taken Anti-HIV Drugs

HIV Infections

United States, Puerto Rico, Canada, Argentina, Chile, Mexico

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