Search clinical trials for: Discontinuation of therapy

Total 169737 results

Assistance Publique - Hôpitaux de Paris
Groupe Hospitalier Pitie-Salpetriere

Terminated

ACE Inhibitors or ARBs Discontinuation in Context of COVID-19 Pandemic (ACORES-2)

History of Cardiovascular Disease Treated With RAS Blockers and With SARS-CoV-2 Infection

France
University of Colorado, Denver
Patient-Centered Outcomes Research Institute; University of Alabama at Birmingham and other collaborators

Completed

Discontinuation of Disease Modifying Therapies (DMTs) in Multiple Sclerosis (MS) (DISCOMS)

Multiple Sclerosis

United States
Mayo Clinic
Patient-Centered Outcomes Research Institute

Completed

The MOTS (Medication Overuse Treatment Strategy) Trial (MOTS)

Migraine

United States
Kaiser Permanente

Completed

Radiologic Evaluation and Breast Density (READ)

Breast Cancer

United States
University of Zurich

Completed

Photosensitivity of the Skin Under Azathioprin in Renal Transplant Recipients

Skin Cancer

Switzerland
Cindy Hutnik

Completed

Effects of Prostaglandin Analogue Washout Following Long-term Therapy in Adults With Primary Open Angle Glaucoma

Ocular Hypertension | Glaucoma, Suspect | Primary Open-Angle Glaucoma, Mild Stage

Canada
Fundación Pública Andaluza para la gestión de la...

Completed

Study to Reduce Duration of Antibiotic Therapy in Haematological Patients With Fever and Neutropenia (HOWLONG)

Febrile Neutropenia

Spain
West Virginia University

Recruiting

Discontinuing CRRT in Patients With Acute Kidney Injury (DC-CRRT)

Acute Kidney Injury

United States
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Chronic Therapies in People With Cystic Fibrosis on Highly Effective CFTR Modulator Therapy (SIMPLIFY)

Cystic Fibrosis

United States
Leiden University Medical Center
ZonMw: The Netherlands Organisation for Health Research and Development

Active, not recruiting

REduction of LEvothyroxine in Adults; a SElf Controlled Study (RELEASE)

Hypothyroidism

Netherlands
Baxter Healthcare Corporation

Completed

Remotely Monitoring Patients With Chronic Conditions in Their Home

CHF

United States
University of Milan
University of Milano Bicocca

Unknown

Duration of Antibiotic Therapy in Community - Acquired Pneumonia (DURATION)

Pneumonia, Viral | Pneumonia | Pneumonia, Bacterial | Pleuropneumonia | Bronchopneumonia

Italy
Weill Medical College of Cornell University
Novartis

Terminated

End of EXTEND: Discontinuation of Medication for Patients With Immune Thrombocytopenia

Immune Thrombocytopenia

United States
Utrecht Institute for Pharmaceutical Sciences
UCB Pharma

Terminated

Seasonal Allergic Rhinitis and Driving Ability

Seasonal Allergic Rhinitis

Netherlands
Fondazione Policlinico Universitario Agostino Gemelli...
Fundacion Clinic per a la Recerca Biomédica; Newcastle University; University...

Recruiting

Dissecting the Cellular and Molecular Atlas of Rheumatoid Arthritis in Sustained Remission to Identify Pathways Maintaining Remission and Triggering Flares (FLARE-RA)

Rheumatoid Arthritis

Italy, Spain, United Kingdom
Assistance Publique - Hôpitaux de Paris

Completed

Prospective Evaluation of Adult Pulmonary Langerhans Cell Histiocytosis (LCHA1)

Adult Pulmonary Langerhans Cell Histiocytosis

France
Centre Hospitalier Régional Metz-Thionville

Recruiting

Impact of Discontinuing Contact Precautions for Extended-spectrum β-lactamase Enterobacteriaceae in a Geriatric Unit (Ger-SP)

Infection, Hospital

France
Assistance Publique - Hôpitaux de Paris
Institut National de la Santé Et de la Recherche Médicale, France; Pierre and...

Unknown

Impact of the Decrease of Exposure to Hypnosedative Drugs in the Elderly Through the Discontinuation of Hospital-initiated Prescription (HYPAGE)

Sleep Disorders

France
University of Miami

Recruiting

Discontinuation of Maintenance HER-2 Directed Therapy in Long-Term Survivors of Metastatic HER-2 Positive Breast Cancer (Free-HER)

Stage IV Breast Cancer | HER2-positive Metastatic Breast Cancer

United States
University of Copenhagen
Deerland Probiotics and Enzymes

Completed

Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation

Gingivitis

Denmark
University of Texas at Austin

Recruiting

Urinary Catheter Self-Discontinuation After Urogynecology Surgery (CATH)

Pelvic Organ Prolapse | Stress Urinary Incontinence | Urinary Retention | Catheter Related Complication

United States
Josep Rodes-Cabau

Recruiting

Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke (HALTI)

Ischemic Stroke | Patent Foramen Ovale | Bleeding Ulcer

Canada
University of Pittsburgh
National Institute on Drug Abuse (NIDA)

Terminated

Distress Tolerance for Benzodiazepine Discontinuation (DT-BD)

Substance Use Disorders

United States
University of Michigan Rogel Cancer Center

Terminated

Discontinuation of Imatinib Mesylate in Patients With Chronic-Phase Chronic Myeloid Leukemia Previously Treated With Interferon-Alpha

Chronic Myeloid Leukemia

United States
Alliance for Clinical Trials in Oncology
National Cancer Institute (NCI)

Active, not recruiting

Testing Interruption of Hormonal Medications in Patients Responding Exceptionally to Therapy for Metastatic Prostate Cancer, (A-DREAM) (A-DREAM)

Metastatic Prostate Carcinoma | Stage IV Prostate Cancer AJCC v8 | Stage IVA Prostate Cancer AJCC v8 | Stage IVB Prostate Cancer AJCC v8 | Castration-Sensitive Prostate Carcinoma

United States
University of Chicago

Recruiting

Study to Assess for Measurable Residual Disease (MRD) in Multiple Myeloma Patients

Multiple Myeloma

United States
University of Copenhagen
Rigshospitalet, Denmark; The Forsyth Institute

Completed

Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene

Mouth Diseases
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Dornase Alfa in People With CF on Highly Effective CFTR Modulator Therapy-A SIMPLIFY Sub-Study (SIMPLIFY-DN)

Cystic Fibrosis

United States
Nicole Hamblett
University of Washington; Dartmouth-Hitchcock Medical Center; Cystic Fibrosis...

Completed

Impact of Discontinuing Hypertonic Saline in People With CF on Highly Effective CFTR Modulators- A SIMPLIFY Sub-Study (SIMPLIFY-HS)

Cystic Fibrosis

United States
Radboud University Medical Center
Innovatiefonds Zorgverzekeraars; Pro Persona

Completed

Discontinuation of Antidepressant Medication in Primary Care.

Antidepressants

Netherlands
Assistance Publique - Hôpitaux de Paris

Completed

Impact of Renin-Angiotensin System Inhibitors Continuation on Outcome After Major Surgery (STOPORNOT)

Surgery | Renin Angiotensin System

France
University College Cork
Cancer Research@UCC

Recruiting

Discontinuation Study

Cancer | Multiple Myeloma | Hematologic Cancer

Ireland
Hospices Civils de Lyon

Not yet recruiting

Effectiveness of CFTR Modulators According to Co-therapy (MODUCO)

Cystic Fibrosis
McMaster University
Canadian Institutes of Health Research (CIHR); David Braley and Nancy Gordon... and other collaborators

Recruiting

Team Approach to Polypharmacy Evaluation and Reduction (Pharmacy)

Polypharmacy | Multi-morbidity | Medication Therapy Management

Canada
McMaster University
Health Canada; David Braley and Nancy Gordon Chair in Family Medicine; RxISK; The...

Completed

Team Approach to Polypharmacy Evaluation and Reduction (TAPER)

Medication Therapy Management | Comorbidity

Canada
Danish Procalcitonin Study Group
Copenhagen University Hospital, Denmark

Completed

Procalcitonin To Reduce Antibiotics in Chronic Obstructive Lung Disease (ProToCOLD) (ProToCOLD)

Chronic Obstructive Lung Disease

Denmark
Radboud University Medical Center
Zorgverzekeraar CZ; Scientific Institute for Dutch Pharmacists, The Netherlands

Completed

Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies

Benzodiazepines Therapeutic Use

Netherlands
Fundación Marques de Valdecilla
Centro de Investigación Biomédica en Red de Salud Mental; Instituto de Investigación...

Unknown

10-year Follow-up of Clinical Outcome After Antipsychotic Treatment Discontinuation in Psychosis Individuals (ADARFEP_10Y)

Schizophrenia | Schizophrenia Spectrum and Other Psychotic Disorders | Schizophrenia Relapse

Spain
McMaster University
Canadian Institutes of Health Research (CIHR); David Braley and Nancy Gordon... and other collaborators

Recruiting

Team Approach to Polypharmacy Evaluation and Reduction (TAPER-RCT)

Polypharmacy | Multi-morbidity | Medication Therapy Management

Canada
McMaster University
Canadian Frailty Network; Labarge Optimal Aging

Terminated

Team Approach to Polypharmacy Evaluation and Reduction in a Long-Term Care Setting (TAPER-LTC)

Frailty | Polypharmacy | Long-term Care

Canada
Italian Sarcoma Group
PharmaMar

Withdrawn

Study on Leiomyosarcoma, Liposarcomas and Synovial Sarcoma With Trabectedin (TRADITIONS)

Leiomyosarcoma | Liposarcoma | Synovial Sarcoma

Italy
European LeukemiaNet
Ludwig-Maximilians - University of Munich; Heidelberg University

Active, not recruiting

2nd or 3rd TKI-stop After 2 Years Nilotinib Pre-treatment in CML-patients (NAUT)

Chronic Myeloid Leukemia

Germany, Netherlands
Assistance Publique - Hôpitaux de Paris

Unknown

Rate of Prolonged Response After Stopping Thrombopoietin-receptor Agonists Treatment in ITP (STOP-AGO)

Persistent or Chronic ITP

France
Institut für Klinische Krebsforschung IKF GmbH...

Recruiting

Discontinuation of CDK4/6 Inhibitors in Patients With Metastatic HR Positive, HER2 Negative Breast Cancer

Breast Cancer

Germany
Boston Medical Center
National Institute on Drug Abuse (NIDA)

Completed

Benzodiazepine Discontinuation in Opioid Agonist Therapy (BZD-OAT)

Substance Use Disorders

United States
ANRS, Emerging Infectious Diseases
IMEA Leon M'Ba Foundation; Unit 1136 INSERM, Faculty of medecine, University...

Unknown

Antiretroviral Treatment Taken 4 Days Per Week Versus Continuous Therapy 7/7 Days Per Week in HIV-1 Infected Patients (QUATUOR)

HIV Infections

France
The Hospital for Sick Children

Completed

Treatment of Obstructive Sleep Apnea in Children: An Opportunity for Cardiovascular Risk Modification (TREAT)

Obesity | Cardiovascular Disease | Obstructive Sleep Apnea | Sleep Disorders

Canada
UCB Pharma

Completed

A 16 Week Study Evaluating Levetiracetam in the Treatment of Post Herpetic Neuralgia (PHN)

Neuralgia, Postherpetic
Rigshospitalet, Denmark

Recruiting

Cardiac Implantable Electronic Device Lifelong Antibiotic thErapy vs Stop and See (CIEDLESS)

Cardiac Implantable Electronic Device Infection

Denmark
University at Buffalo

Completed

Natalizumab Temporary Discontinuation Study (NaTDS)

Multiple Sclerosis

United States

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